Farajzadeh Saeedeh; Esfandiarpour Iraj; Abbassi Mohammad Mehdi Hayatbatch; Moghaddam Sodaif Darvish; Hosseininasab Fatemeh
Volume 13, Issue 3 , 2010, , Pages 78-81
Abstract
Background: The correlation between coronary artery disease and androgenic alopecia has been demonstrated, but the mechanism of this association still remains to be cleared. Objective: To investigate lipid profile, as an indicator of coronary artery disease, in women with female pattern alopecia. Methods: ...
Read More
Background: The correlation between coronary artery disease and androgenic alopecia has been demonstrated, but the mechanism of this association still remains to be cleared. Objective: To investigate lipid profile, as an indicator of coronary artery disease, in women with female pattern alopecia. Methods: Fifty one women with female pattern alopecia and thirty one healthy women with normal hair status were selected as the case and control groups, respectively. Lipid profile including cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, lipoprotein (a), apolipoprotein A1, and apolipoprotein B were measured in both groups. Results: The most important result of our study was a remarkably higher level of lipoprotein (a) in the case group. On the other hand, 55.3% of the patients and 16.7 % of the controls had lipoprotein (a) level >30 mg/dl, higher than the critical level for atherosclerosis. Conclusion: Lipid profile, especially lipoprotein (a), which is an important risk factor for coronary artery disease, should be investigated in women with androgenic alopecia. Those with disturbance in lipid profile should be referred to a cardiologist.
Esfandiarpour Iraj
Volume 12, Issue 3 , 2009, , Pages 93-95
Abstract
Necrobiosis lipoidica diabeticorum (NLD) is a rare chronic and granulomatous skin disorder that affects 0.3% of diabetic patients. Although the etiology and pathogenesis of NLD is still contraversial, it is thought that microangipathy has an important role. The legs are the most common site for NLD, ...
Read More
Necrobiosis lipoidica diabeticorum (NLD) is a rare chronic and granulomatous skin disorder that affects 0.3% of diabetic patients. Although the etiology and pathogenesis of NLD is still contraversial, it is thought that microangipathy has an important role. The legs are the most common site for NLD, but involvement of other areas such as the abdomen, upper extremities and scalp have been reported. We present a case of scalp and leg NLD which was diagnosed on the clinical and histopathological basis.
Esfandiarpour Iraj; Ekhlasi Ali
Volume 11, Issue 2 , 2008, , Pages 86-88
Abstract
Lichen sclerosus (LS) is a chronic benign inflammatory disorder of skin and mucosa which affects patients of all age groups, sex and race, particularly caucasian prepubertal girls and postmenopausal women. The etiology of LS is unknown, but it has been suggested that genetic predisposition to inflammatory ...
Read More
Lichen sclerosus (LS) is a chronic benign inflammatory disorder of skin and mucosa which affects patients of all age groups, sex and race, particularly caucasian prepubertal girls and postmenopausal women. The etiology of LS is unknown, but it has been suggested that genetic predisposition to inflammatory disorders, immunological constitutions, hormonal influences and local factors might play a role. Extragenital LS are most common on the neck, shoulders and upper portion of the trunk. It is generally asymptomatic, but occasionally pruritic. The Koebner sign is a well-known diagnostic marker in LS. Typical lesions have been noted to occur following surgical operations, infections, rubbing of skin, in old thermal burn scar, sexual abuse and under tight clothing. We describe a 25-year-old Iranian woman presented with a 2-month history of extragenital LS. The multiple classical lesions of disease were presented over her neck, shoulders, upper part of trunk, the medial area of her thighs and feet at the dorsal site. The diagnosis of LS was confirmed by histological findings. Beside LS classical lesions on her back, linear lesions including Koebner phenomenon were observed at the sites of rubbing and itching of skin.
Esfandiarpour Iraj; Rahpima Maryam
Volume 10, Issue 4 , 2007, , Pages 283-289
Abstract
Background and aim: Lichen planus (LP) is an inflammatory papulosquamous disease that affects skin, mucous membranes, nails and hair. As the disease presents in various clinical types, the objective of this study was to determine the frequency of clinical variants of LP in dermatological out-patients ...
Read More
Background and aim: Lichen planus (LP) is an inflammatory papulosquamous disease that affects skin, mucous membranes, nails and hair. As the disease presents in various clinical types, the objective of this study was to determine the frequency of clinical variants of LP in dermatological out-patients in Kerman. Materials and methods: In this study 300 patients with LP were evaluated during 1382-83 in dermatological out-patients in Kerman. Diagnosis was based on clinical features and skin biopsy. The demographic features including age, sex, and the clinical pictures of the disease including clinical types, site of involvement, duration of the disease and associated diseases were assessed. The hepatitis B surface antigen, anti hepatitis B core antibody, hepatitis C antibody and liver function tests were measured. Results: Patients consisted of 167 men (55.5%) and 133 women (44.5%) with a mean age of 32.4 years and a mean duration of 11.6% months. The age of patients ranged from 4 to 78 years, most being in the age range from 30 to 50 years. The majority of patients (70.6%) had classical lesions followed by mucosal (65%), annular (21%), hypertrophic (19%), and lichen nitidus (18%). The dermatomal type obtained the least frequency (2.6%). Upper extremity was the most frequent site of onset (70.6%). Mucosal involvement was observed in 65% and nail and hair changes were observed in 33.6% and 6.6% of patients, respectively. Pruritus was the chief complaint of the majority of patients. Conclusion: Classic LP was the most common type and extremities were the most common site of involvement in this study.
Firooz Alireza; Nassiri-Kashani Mansour; Gorouhi Farzam; Davari Parastoo; Yaghoubi Reza; Farshchian Mahmoud; Esfandiarpour Iraj; Golchai Mohammad Javad; Dowlati Yahya
Volume 10, Issue 3 , 2007, , Pages 187-195
Abstract
Background and aim: The frequency of sensitization to contact allergens varies in different countries because of both genetic and, more importantly, allergen exposure variations. The objective is to determine the frequency of sensitization to contact allergens in Iranian patients with dermatitis.Materials ...
Read More
Background and aim: The frequency of sensitization to contact allergens varies in different countries because of both genetic and, more importantly, allergen exposure variations. The objective is to determine the frequency of sensitization to contact allergens in Iranian patients with dermatitis.Materials and methods: Four hundreds and one patients with a clinical diagnosis of contact dermatitis and/or atopic dermatitis were evaluated with a 24-allergen European standard series in four major cities in Iran. The patches were applied on the back of the patients, removed after 24 hours and the readings were taken on 24, 48 and 72 hours after application.Results: One hundred and seventy six patients (43.8%) showed at least 1 positive reaction with a total positive reactions of 268, and 64 patients (15.9%) had 2 or more positive reactions. The 5 most common allergens were nickel sulfate [64 (15.9%)], potassium dichromate [40 (10.0%)], thiuram mix [27 (6.7%)], cobalt chloride [23 (5.7%)], and Balsam of Peru [17 (4.2%)]. Contact allergy to nickel sulfate was significantly more common in female patients and in patients under 40 years of age (P<0.001).Conclusion: Nickel sulfate is the most common contact allergen in Iran, mostly affecting women and younger patients probably because of more exposure. Thiuram had a significant increase in its prevalence during the previous years and further studies need to distinguish its causes.
Esfandiarpour Iraj; Yavari Hossein
Volume 10, Issue 2 , 2007, , Pages 119-124
Abstract
Background and aim: Vitiligo is an acquired idiopathic hypomelanotic disease. The purpose of this study was to review clinical characteristics of vitiligo and their significance in the progression of vitiligo.Materials and methods: Eight hundreds and sixteen cases of vitiligo were studied from February ...
Read More
Background and aim: Vitiligo is an acquired idiopathic hypomelanotic disease. The purpose of this study was to review clinical characteristics of vitiligo and their significance in the progression of vitiligo.Materials and methods: Eight hundreds and sixteen cases of vitiligo were studied from February 2005 to October 2006. All of the patients were referred to dermatology clinics in Kerman city. Questionnaires were completed regarding progression, sex, family history, clinical type, age at onset,site of lesions, duration of disease, Koebner phenomenon, leukotrichia, and mucosal involvement.Results: Six hundreds and seven patients (74.39%) showed progression of disease and 209 patients (25.61%) did not show progression. There was no significant difference between the two groups in regard to sex, age at onset, leukotrichia, positive family history or longer duration; however, in patients with non-segmental clinical type, Koebner phenomenon and mucous membrane involvement indicated more progressive course of vitiligo (p<0.05).Conclusion: The progression or prognosis of vitiligo may be related to clinical characteristics such as clinical type, Koebner phenomenon, and mucous membrance involvement.