Mashayekhi Vahid; Mahmoudi Mahmoud; Rastin Maryam; Tayebi Naser; Taheri Ahmad Reza; Tavakoli Maryam
Volume 15, Issue 3 , 2012, , Pages 69-73
Abstract
Background: Chronic lupoid leishmaniasis (CLL) is a chronicform of cutaneous leishmaniasis that is usually resistant to antileishmania agents and leishmania is not seen in the histologicsections. We used polymerase chain reaction (PCR) to detectleishmania DNA in CLL specimens.Method: This descriptive ...
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Background: Chronic lupoid leishmaniasis (CLL) is a chronicform of cutaneous leishmaniasis that is usually resistant to antileishmania agents and leishmania is not seen in the histologicsections. We used polymerase chain reaction (PCR) to detectleishmania DNA in CLL specimens.Method: This descriptive cross sectional study was done on20 paraffin embedded specimens of CLL cases referred to thedermatology clinic of Imam Reza Hospital, Mashhad, Iran.Patients’ information including age, sex, duration and location ofthe lesion was obtained and then skin specimens were reviewedhistopathologically and assessed for leishmania DNA using PCR.Result: Eleven male and 9 female patients with a mean age of17.95 years were included in our study. The
Mashayekhi Vahid; Maleki Masoud; Javidi Zari; Mahmodi Mahmoud; Taheri Ahmad Reza; Mehrabi Reza
Volume 11, Issue 2 , 2008, , Pages 60-63
Abstract
Background: It appears that chronic lupoid leishmaniasis is the result of type 2 predominant T helper response to parasite and a defect in the down regulation of IL-4 production during infection. The objective of this study was to evaluate the underlying immune status in these patients and their predominant ...
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Background: It appears that chronic lupoid leishmaniasis is the result of type 2 predominant T helper response to parasite and a defect in the down regulation of IL-4 production during infection. The objective of this study was to evaluate the underlying immune status in these patients and their predominant T helper activity we considered serum IgE as an indicator of TH2 activity and IL-4 production as it has been shown in atopic diathesis.Methods: In 34 cases of chronic lupoid leishmaniasis serum IgE level was measured and compared with 34 control cases of age and sex matched healthy individuals without atopic diathesis. P< 0.05 was considered statistically significant.Results: There were 21 females and 13 males with a mean age of 14.35±8.3 years in the patients group. The mean age of the control group was 16.11±8.4 (P>0.05 and matched). Nine patients had atopic diathesis. Mean serum IgE level in patients and in the control group was 102.6±22.4 i.u/ml and 135.6±24.9 i.u/ml, respectively (P>0.05 with no significant difference). Mean serum IgE level in patients without atopic diathesis (25 cases) was 66.8±11.3i.u/ml which was significantly lower than the control group (P<0.05).Conclusion: In this study, serum IgE level in cases with chronic lupoid leishmaniasis was lower than the control group and it seems that in these patients, there is not an underlying Th2 over activity as it is seen in atopic diathesis.
Javidi Zari; Maleki Masood; Mashayekhi Vahid; Meibodi Naser Tayyebi; Nahidi Yalda
Volume 11, Issue 1 , 2008, , Pages 25-29
Abstract
Introduction: Genital infections with human papilloma virus (HPV) are the most common sexually transmitted disease in the United States. Several predisposing factors are known for this infection. So far, no studies on the risk factors and clinico-epidemiologic aspects of genital warts in Iran have been ...
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Introduction: Genital infections with human papilloma virus (HPV) are the most common sexually transmitted disease in the United States. Several predisposing factors are known for this infection. So far, no studies on the risk factors and clinico-epidemiologic aspects of genital warts in Iran have been reported. So, we performed this study to evaluate epidemiologic aspects of anogenital warts in Mashhad, Iran. Methods: In this case-control study, 100 patients with genital warts who referred to the dermatology clinic of Imam-Reza hospital (August 2005 - August 2007) and 100 age, sex and marital status matched healthy controls were included. Clinical and epidemiologic data were recorded using designed questionnaire. Finally, chi-square and t-student tests were used for statistical analysis. Results: Male to female ratio was 0.87. The majority of the patients aged 30-39 years. Glans of the penis and posterior fourchette were the most common sites of involvement. Positive history of sexual contacts and sexual transmitted diseases (STDs), use of condom, pregnancy, addiction, use of swimming pools and number of marriages were significantly different in two groups. Conclusion: Younger age, higher number of marriages, having several partners, non-traditional sexual behavior, pregnancy, use of swimming pools, refuse to use condoms, history of other STDs, immune suppression, use of immunosuppressive drugs and topical steroids were the main risk factors of anogenital warts in this study.
Javidi Zari; Maleki Massoud; Mashayekhi Vahid; Jafari Ghazalleh
Volume 10, Issue 4 , 2007, , Pages 316-319
Abstract
Background and aim: Deficiency of zinc -as a necessary trace element-causes exacerbation of acne and development of acne lesions. Also zinc has been used in acne treatment. In this study serum zinc level was evaluated in severe acne cases. Materials and methods: Severe acne cases as well as sex and age ...
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Background and aim: Deficiency of zinc -as a necessary trace element-causes exacerbation of acne and development of acne lesions. Also zinc has been used in acne treatment. In this study serum zinc level was evaluated in severe acne cases. Materials and methods: Severe acne cases as well as sex and age matched controls were selected from dermatology clinics of Imam Reza and Qaem Hospitals during 2003 to 2005. Five ml of blood was sampled from each individual and serum zinc level was measured by atomic absorption spectrophotometric method. The mean of zinc serum level between the two selected groups was compared by t and Mann-Whitney tests. Results: Thirty patients (16 females and 14 males) with mean age of 19.8±2.05 years and 28 cases in control group (13 females and 15 males) with mean age of 20.78±2.46 years were included in this study. The mean serum zinc level in patients and control groups were 99.85±18.07 and 101.57±10.52µg/dl, respectively. There was no significant difference between the serum zinc level of the two groups.Conclusion: In this study, there was no relation between the serum zinc level and severe acne disease. Considering the high prevalence of acne and the rarity of zinc deficiency in the general population, the etiologic role of zinc deficiency in acne needs a study in a very large sample, or evaluation of acne prevalence in zinc deficient patients.
