Ghandi Narges; Tavassoli Shaghayegh; Ghiasi Maryam; Lajevardi Vahideh; Abedini Robabeh; Tohidinik Hamid-Reza; Daneshpazhooh Maryam
Volume 19, Issue 75 , 2016, , Pages 35-13
Abstract
Background: Prolactin (PRL) appears to play a role in the pathogenesis of autoimmune diseases. Limited evidence showed an association between serum PRL levels and the activity of pemphigus vulgaris (PV). This study intends to determine PRL level changes in pemphigus patients during therapy and its correlation ...
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Background: Prolactin (PRL) appears to play a role in the pathogenesis of autoimmune diseases. Limited evidence showed an association between serum PRL levels and the activity of pemphigus vulgaris (PV). This study intends to determine PRL level changes in pemphigus patients during therapy and its correlation with disease type and severity. Methods: In this cohort study, we measured serum PRL levels by enzyme-linked immunosorbent assay (ELISA) in newly diagnosed PV patients at three time points: before therapy initiation and after two and four months. Concomitantly, we estimated disease severity by the Pemphigus Disease Area Index (PDAI). Results: We examined 42 new cases of PV. Among 32 cases who completed the study, mean serum PRL levels at the three time points were 15.9±14.1 ng/mL (before treatment), 16.7±9.8 ng/ mL (2 months after initiation of treatment), and 15.2±9.2 ng/mL (4 months after initiation of treatment). Mean PDAI values were 19.3±12.8 (before treatment), 3.7±6.2 (2 months after initiation of treatment), and 0.6±1.5 (4 months after initiation of treatment). Although the disease activity decreased significantly (P
Ghandi Narges; Daklan Soroush; Goodarzi Azadeh; Hesari Kambiz Kamyab; Ghanadan Alireza
Volume 18, Issue 1 , 2015, , Pages 33-35
Abstract
The histiocytoses are a group of proliferative disorders of themonocyte-macrophage lineage that are neoplastic or reactive innature. Based on immunophenotyping and electron microscopy,two main groups have been recognized namely 1) Langerhanscell histiocytosis (LCH) and 2) non- Langerhans cell histiocytosis(non-LCH). ...
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The histiocytoses are a group of proliferative disorders of themonocyte-macrophage lineage that are neoplastic or reactive innature. Based on immunophenotyping and electron microscopy,two main groups have been recognized namely 1) Langerhanscell histiocytosis (LCH) and 2) non- Langerhans cell histiocytosis(non-LCH). In this study, a fairly rare disease of the non-LCHgroup, generalized eruptive histiocytosis, has been reported.
Ghandi Narges; Balighi Kamran; Ghiasi Maryam; Soori Tahereh; Kiani Pardis
Volume 15, Issue 3 , 2012, , Pages 74-79
Abstract
Background: Preexisting guidelines about clinical managementof cutaneous wounds are based on wound dressing and avoidingwater exposure for at least 48 hours. In this study, infectionrate in the patients who underwent melanocytic nevus surgerywith dressed dry wounds were compared with the patients whoallowed ...
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Background: Preexisting guidelines about clinical managementof cutaneous wounds are based on wound dressing and avoidingwater exposure for at least 48 hours. In this study, infectionrate in the patients who underwent melanocytic nevus surgerywith dressed dry wounds were compared with the patients whoallowed their wounds to become wet.Method: In a controlled randomized clinical trial study, theincidence rate of infection in facial melanocytic nevi surgery inthe wounds that became wet 24 hours after surgery (234 wounds)were compared with similar wounds that were kept dry for atleast for 48 hours (234 wounds).Result: The infection rate was 3.4 % (8 wounds) for the drywounds versus 2.6 % (6 wounds) for the wet wounds; comparisonof these two rates showed no statistically significant difference(P=0.548, odds ratio= 1.345, CI 95%: 0.459-3.939).Conclusion: The results of this study showed that it was safe toremove the dressing of the wounds within 24 hours after minorsurgery without concern about infections and allow wounds tobecome wet after 24 hours under normal circumstances.