Ehsani Amir Houshang; Noormohammadpour Pedram; Nasiri Nafiseh; Faraz Parastoo Tavasoli; Goodarzi Azadeh
Volume 19, Issue 2 , 2016, , Pages 45-49
Abstract
Background: Approximately 0.77% to 2% of cutaneous ulcers and post-burn scars will develop malignant degeneration. When squamous cell carcinoma (SCC) emerges in a chronic scar or ulcer, it often is referred to as Marjolin’s ulcer (MU). Methods: This cross-sectional study assessed demographic information ...
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Background: Approximately 0.77% to 2% of cutaneous ulcers and post-burn scars will develop malignant degeneration. When squamous cell carcinoma (SCC) emerges in a chronic scar or ulcer, it often is referred to as Marjolin’s ulcer (MU). Methods: This cross-sectional study assessed demographic information and pathological features of MU in Razi Hospital during 2009 to 2014. We reviewed 5150 chronic scar/ulcer cases and found 30 MU cases. Results: Patients had an average age of 59.2±19.9 years. Most cases were males Among 30 cases of MU, well-differential SCC accounted for 43.3% of cases. Moderately-differentiated SCC comprised 13.3% of cases, whereas there was invasive SCC in 10% of MUs. Only 3.3% of patients showed poorly-differentiated SCC and 9 (30%) had undifferentiated SCC. The average latency between burn and malignancy was 32.4±18.5 years In the majority (90%) of cases, the initial injury was a burn. The lower and upper limbs comprised 53.3% and 26.7% of cases, respectively. There was one case with a history of melanoma. Among the 4 measured concurrent risk factors for malignancy, sun exposure was the most prevalent. Conclusion: Since there is a high possibility of SCC formation in burn lesions and other identical lesions, rapid follow-up and appropriate treatment in acute burn lesions is necessary.
Seirafi Hassan; Ehsani Amirhooshang; Jesri Shabboo; Gholamali Fatemeh; Noormohammadpour Pedram
Volume 15, Issue 4 , 2012, , Pages 117-121
Abstract
Background: Infantile hemangioma is a congenital vascularmalformation. Although almost all cases are self-limiting, treatmentis sometimes necessary. According to previous studies, topicalimiquimod induces resolution of lesions with an acceptable safetyprofile. The aim of the present study was to evaluate ...
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Background: Infantile hemangioma is a congenital vascularmalformation. Although almost all cases are self-limiting, treatmentis sometimes necessary. According to previous studies, topicalimiquimod induces resolution of lesions with an acceptable safetyprofile. The aim of the present study was to evaluate the effect ofthis topical treatment on Iranian infantile hemangioma patients.Method: Patients under two years of age with infantile hemangiomawho were not candidates for immediate systemic therapy withsteroids were selected if the lesions were not ulcerated. Topical5% imiquimod was applied on the lesions for 16 weeks. All thelesions were photographed before the commencement of the studyand at the end of the treatment. Photographs were compared bytwo associate dermatology professors to evaluate the effect oftreatment using a visual analogue scale.Result: A total of 15 patients including five males (33.3%) andten females (66.7%), with an age range of two to 18 months anda mean age of 9.1 (± 6.3) months, were enrolled in the study.The mean diameter of the lesions was 2.6 cm (± 1.8 cm). Ninepatients (60%) had moderate response and five patients (33.3%)had good response while one patient had excellent response.Complications were mild local irritation and pruritus.Conclusion: It seems that topical imiquimod could be a suitableoption in the treatment of some infantile hemangioma lesions notcandidate for systemic treatment and/or other local measuressuch as laser and intra lesional steroid or when other drugs areuseless or harmful..
Rastegar Hosein; Ashtiani Hamidreza Ahmadi; Baghaei Mohammad; Bokaei Saeid; Ehsani Amirhoushang; Noormohammadpour Pedram; Azizahari Sahar; hanmohammad Ramin
Volume 12, Issue 3 , 2009, , Pages 82-85
Abstract
Background: Dandruff especially with itching and inflammation is a common complaint among patients in the clinic and its treatment is much challenging. Chemical anti fungal substances used in antidandruff shampoos are common treatments. The aim of this study was to compare the clinical efficacy of two ...
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Background: Dandruff especially with itching and inflammation is a common complaint among patients in the clinic and its treatment is much challenging. Chemical anti fungal substances used in antidandruff shampoos are common treatments. The aim of this study was to compare the clinical efficacy of two of these anti dandruff substances, climbazole and piroctone olamine in the treatment of dandruff and seborrheic dermatitis in shampoos with herbal extracts. Methods: One hundred and twenty men with scalp dandruff of the same severity, between 20-30 years old and in the same occupational condition in terms of sun exposure or environmental pollution were selected and divided randomly into two 60-subject groups. After each shampoo was applied 3 times a week for 5 weeks one in group 1 and the other in group 2, patients were assessed for existence of itching and redness of scalp and reduction in dandruff and results were compared between two groups. Results: Itching and redness were completely cured in both groups after treatment. Dandruff was completely cured in 80% of patients and reduced in 20% of patients in climbazole group (p < 0.001), though completely cured in 55% of patients and reduced in 45% of patients in piroctone olamine group (p < 0.001). Climbazole was over piroctone olamine in reduction of dandruff with significant difference (p < 0.01). Conclusion: Both shampoos containing climbazole or piroctone olamine beside herbal extracts are effective in the reduction of dandruff and relief of other seborrheic dermatitis symptoms but climbazole seems to be more effective than piroctone olamine in the treatment of dandruff.
Shahshahani Mostafa Mirshams; Esmaily Nafiseh; Hallaji Zahra; Kamyab Kambiz; Kalaghchi Bita; Maghsoudnia Gholamreza; Kashani Mansour Nasiri; Narraghi Zahra; Razzaghi Mahmoud; Noormohammadpour Pedram
Volume 11, Issue 2 , 2008, , Pages 73-75
Abstract
Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. UV light is an important risk factor for BCC, as well as X-ray and other ionizing radiations. The aim of this study was evaluation and risk factor assessment of BCC cases referred to Razi hospital tumor clinic. Methods: Patients ...
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Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. UV light is an important risk factor for BCC, as well as X-ray and other ionizing radiations. The aim of this study was evaluation and risk factor assessment of BCC cases referred to Razi hospital tumor clinic. Methods: Patients referred from general clinics with skin biopsies consistent with Basal Cell Carcinoma were enrolled. A questionnaire including epidemiologic data, risk factor exposure and specification of skin lesions was completed for each patient. Results: From October 2005 to October 2006, a total of 476 patients with cutaneous malignancy referred to Tumor clinic of Razi hospital. Of them, 367 patients had BCC. 215 were male (58%) and 152 were female (42%). Mean age of patients was 62 (±12.7) and 62 (±13.4) years for men and women, respectively. The most common risk factors for BCC were radiotherapy and chronic sun exposure. The most common tumor sites were scalp, nose and ears. Of different clinico-pathologic types, noduloulcerative type was the most common. Conclusion: It seems that radiotherapy is an important risk factor in Iranian BCC patients and it is useful to have a screening program for case finding and treating patients in early stages.