Balighi Kamran; Ghodsi Zahra; Iravani Masoud; Damavandi Maede Rayati; Goodarzi Azadeh; Lajevardi Vahide; Saburi Sara; Kashani Alireza Faghihi
Volume 19, Issue 75 , 2016, , Pages 21-24
Abstract
Background: Chronic graft versus host disease (cGVHD) is a major cutaneous complication of bone marrow transplantation (BMT). Although milder forms of this process may be associated with a lower incidence of tumor recurrences, it is mandatory to develop a more efficient and less harmful therapeutic approach.Methods: ...
Read More
Background: Chronic graft versus host disease (cGVHD) is a major cutaneous complication of bone marrow transplantation (BMT). Although milder forms of this process may be associated with a lower incidence of tumor recurrences, it is mandatory to develop a more efficient and less harmful therapeutic approach.Methods: This case-series study enrolled 7 patients diagnosed with chronic mucocutaneous GVHD. We divided the patients into three major categories based on the type of skin lesions: sclerodermoid, lichenoid, and mixed. Patients received several packs of narrow band UVB (NBUVB) phototherapy. Each pack contained ten sessions of NBUVB (311 nm) with a duration of at least ten seconds and a fixed radiation dosage (6 mj/cm2) during the treatment.Results: There were 3 patients diagnosed with lichenoid skin lesions, 2 with sclerodermoid lesions, and 2 had mixed cGVHD lesions. During the follow up period one patient was excluded due to a lower respiratory tract infection. The mean response ratio was 42% with a mean satisfaction level of 5.5 out of 10. The lichenoid group had the best, most rapid response. There were no serious adverse effects reported.Conclusion: Narrow band UVB phototherapy is useful as an adjuvant therapeutic modality in cutaneous lichenoid and intraoral cGVHD with no serious adverse effects.
Ghiasi Maryam; Lajevardi Vahide; Farahbakhsh Abbas
Volume 18, Issue 2 , 2015, , Pages 45-50
Abstract
Background and Aim: Vitiligo is a hypopigmentation disorder of the skin that is associated with depression and an impaired quality of life. There has been conflicting reports on the association between the disease and the serum levels of homocysteine, vitamin B12, and folic acid.In this study,serum levels ...
Read More
Background and Aim: Vitiligo is a hypopigmentation disorder of the skin that is associated with depression and an impaired quality of life. There has been conflicting reports on the association between the disease and the serum levels of homocysteine, vitamin B12, and folic acid.In this study,serum levels of homocysteine, vitamin B12, and folic acid were evaluated in patients with vitiligo.Methods: Thirty patients with vitiligo and 30 age- and sex-matched healthy controls were recruited. Venous blood samples wereobtained from the study subjects and the levels of homocysteine, vitamin B12, and folic acid were measured. Data were analyzedusing non-parametric statistical tests.Results: No significant differences were found in the levels of serum homocysteine, vitamin B12, and folic acid between vitiligo patients and healthy controls. Moreover, there were no associations between these factors and age, body weight, gender,as well as the extent, duration, and type of vitiligo.Conclusion: It seems that vitiligo is not related to serum levels of homocysteine, vitamin B12, and folic acid.
Lajevardi Vahide; Ghiasi Maryam; Hejazi Pardis; Ansari Mahsa; Akbari Zahra; Shakiba Hasan; Goodarzi Azadeh
Volume 18, Issue 1 , 2015, , Pages 36-37
Abstract
Folate plays an important role in metabolism and its deficiency can lead to cardiovascular problems or carcinogenesis. Some studies show that narrow band UVB (NBUVB) causes folate deficiency by photolysis , while others have different opinions or even the contrary. With regard to paradoxes in this context, ...
Read More
Folate plays an important role in metabolism and its deficiency can lead to cardiovascular problems or carcinogenesis. Some studies show that narrow band UVB (NBUVB) causes folate deficiency by photolysis , while others have different opinions or even the contrary. With regard to paradoxes in this context, we decided to study the effect of NBUVB on folate levels in patients with dermatologic disorders.
Ghiasi Maryam; Lajevardi Vahide; Mortazavi Hossein; Damavandi Maedeh Raiyati
Volume 16, Issue 4 , 2013, , Pages 137-140
Abstract
Background: Systemic isotretinoin is a very effective medication for the treatment of acne, but it has some side effects. One of its side effects is musculoskeletal problems such as increased levels of creatine phosphokinase (CPK), myalgia, and serious muscle damage such as rhabdomyolysis. The aim of ...
Read More
Background: Systemic isotretinoin is a very effective medication for the treatment of acne, but it has some side effects. One of its side effects is musculoskeletal problems such as increased levels of creatine phosphokinase (CPK), myalgia, and serious muscle damage such as rhabdomyolysis. The aim of this study was to evaluate the incidence of myalgia and its relationship with the elevation of serum CPK levels in patients treated with isotretinoin.Method: This study was done on forty acne patients in Razi Hospital. Isotretinoin was administered at a dose of 0.25 mg/kg in all patients. Serum CPK levels were measured before the treatment and every 2 months during treatment. On each visit, the patients were asked about muscular symptoms such as myalgia.Result: Twenty-eight (70%) patients were female. The mean age of the patients was 22.6±5.4 years. The mean serum CPK level did not increase during treatment with isotretinoin. However, 2.5%, 36.8% and 31.5% of the patients had myalgia 2, 4, and 6 months after the initiation of isotretinoin, respectively. There was no significant difference in the mean CPK level of those who had myalgia after treatment with isotretinoin and those who were asymptomatic.Conclusion: It seems that low dose isotretinoin does not induce the elevation of CPK, but can cause myalgia in some patients irrespective of the CPK level. Myalgia in patients under treatment with low dose isotretinoin is a benign phenomenon and is not an alarm for serious muscle damage. Therefore, routine measurement of the CPK level in patients receiving low dose isotretinoin is not recommended.
Kavusi Suzan; Lajevardi Vahide; Moinedin Fateme; Barzegar Mohamad Reza
Volume 11, Issue 2 , 2008, , Pages 93-94
Abstract
Case: A 40–year-old woman referred to the dermatological clinic of Razi hospital with painful lesions on the axillae, between her breasts and intergluteal region since adolescence. The patient had been treated with a variety of antibiotics with only minimal improvement. The lesions reappeared with ...
Read More
Case: A 40–year-old woman referred to the dermatological clinic of Razi hospital with painful lesions on the axillae, between her breasts and intergluteal region since adolescence. The patient had been treated with a variety of antibiotics with only minimal improvement. The lesions reappeared with cessation of treatments. On cutaneous examination, multiple furuncle-like discharging nodules were observed over the axillae, between the breasts, buttock and gluteal region (figure 1). Other findings were giant black comedones and depressed scars which were found between the aforementioned lesions, particularly on her back (figure 2). A number of pits with 2 to 3 mm diameter were seen around the mouth (figure 3). Additionally, there were hyperpigmented macules in a reticular pattern over the axillae, inframammary area and groin (figure 4). Mucosal surfaces and nails were not pigmented. Systemic examination was normal. Laboratory data were all within normal limits. In familial history, one of her sisters, aged 50 years, had a similar pattern of pigmentation from the age of 20.
Ghandi Nargess; Abedini Robabeh; Lajevardi Vahide; Nikoo Azita
Volume 11, Issue 1 , 2008, , Pages 42-43
Abstract
A 55-year-old woman was referred to our outpatient clinic because of bilateral papular lesions on her nose from 2 years ego. In clinical examination, we found three symmetrical dome-shaped, skin-colored, asymptomatic papules on both nasal alas. The lesions made the patient's nose to seem larger with ...
Read More
A 55-year-old woman was referred to our outpatient clinic because of bilateral papular lesions on her nose from 2 years ego. In clinical examination, we found three symmetrical dome-shaped, skin-colored, asymptomatic papules on both nasal alas. The lesions made the patient's nose to seem larger with eroded edges (figures 1, 2). Examination of nasal mucosa was normal. General physical examination was unremarkable. A biopsy was done from the lesion (figure 3).
