Nasiri Soheila; Hejazi Somayeh; Safoura Shakoei; Zahra Asadi; Nazi Saljoughi
Abstract
Granuloma faciale (GF) is a benign disease that presents as solitary or multiple asymptomatic plaques on the face. We report a 25-year-old male patient with asymptomatic papular, pustular, and nodular lesions on both cheeks. Diagnosis of GF was made based on the histopathological findings. He was treated ...
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Granuloma faciale (GF) is a benign disease that presents as solitary or multiple asymptomatic plaques on the face. We report a 25-year-old male patient with asymptomatic papular, pustular, and nodular lesions on both cheeks. Diagnosis of GF was made based on the histopathological findings. He was treated with cryotherapy and intralesional triamcinolone injections every month. After 3 months, the lesions became paler and less indurated.
Nasiri Soheila; Iranmanesh Behzad; Gheisari Mehdi; Abdollahimajd Fahimeh; Nobari Niloufar
Abstract
Background: Alopecia Areata (AA) is an autoimmune disease affecting hair follicles. Although many details are well specified in the pathogenesis of the disease, there exist certain aspects which require more investigations. Given the fact that the increase in Th-1 immunity is the essential part of the ...
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Background: Alopecia Areata (AA) is an autoimmune disease affecting hair follicles. Although many details are well specified in the pathogenesis of the disease, there exist certain aspects which require more investigations. Given the fact that the increase in Th-1 immunity is the essential part of the pathogenesis, the incrimination of osteopontin, as a Th-1 cytokine, is considered appropriate in the pathogenesis of the disease. The aim of the present research was to evaluate the role of osteopontin in alopecia areata and its correlation with disease pattern and severity.
Methods: This case-control study consisted of 45 patients with alopecia areata and 45 health individuals. The level of osteopontin was measured through blood sampling and ELISA method.
Results: The mean plasma level of osteopontin was significantly lower in patients with alopecia areata than controls (P<0.05)
Conclusions: The plasma level of osteopontin in patients with alopecia areata is lower than healthy controls. Moreover, there is no significant relationship between the plasma level of osteopontin and disease severity. The clinical manifestations of alopecia areata might be a sign of the altered protective effects of osteopontin. Needless to say, more investigation is required to clarify the correlation between alopecia areata and osteopontin.
Nasiri Soheila; Rahimi Hoda; Farnaghi Ali
Volume 12, Issue 4 , 2009, , Pages 123-126
Abstract
Background: Cutaneous drug reaction is a common side effect of antiepileptic drugs (AEDs). In recent years, a significant increase in cases of cutaneous drug reaction due to AEDs and some changes in its pattern in our department have been noticed. Therefore, we carried out this study to present clinical ...
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Background: Cutaneous drug reaction is a common side effect of antiepileptic drugs (AEDs). In recent years, a significant increase in cases of cutaneous drug reaction due to AEDs and some changes in its pattern in our department have been noticed. Therefore, we carried out this study to present clinical and paraclinical characteristics of these cases. Methods: All records of patients who were hospitalized at our hospital with a diagnosis of cutaneous drug reaction due to anticonvulsant therapy between March 2006 and September 2009 were reviewed. Results: The most common offending drug was lamotrigine. The main indication of anticonvulsant therapy was for idiopathic seizures. The most frequent type of cutaneous reaction was maculopapular and/or erythrodermic rash. Eosinophilia was detected in 56.5% of the patients. Conclusions: Although serious reactions with AEDs are not common, they may be life threatening. So, timely and accurate diagnosis can prevent fatal reactions and affects subsequent anticonvulsant treatment options.
Nasiri Soheila; Rahimi Hoda; Farnaghi Ali; Asadi-kani Zahra; Qaisari Mehdi
Volume 12, Issue 4 , 2009, , Pages 131-133
Abstract
Granuloma faciale (GF) is a rare cutaneous disorder categorized as a localized form of small-vessel vasculitis. Clinically, it manifests as single or multiple well-demarcated red-brown plaques, papules and nodules, nearly always confined to the face. Herein, we report a 39-year-old man with multiple ...
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Granuloma faciale (GF) is a rare cutaneous disorder categorized as a localized form of small-vessel vasculitis. Clinically, it manifests as single or multiple well-demarcated red-brown plaques, papules and nodules, nearly always confined to the face. Herein, we report a 39-year-old man with multiple red-brown infiltrated plaques on face and extrafacial lesions on back, shoulders and both arms. Skin biopsy revealed typical histopathological findings of GF. The patient failed to respond to pulsed dye laser but intralesional triamcinolone combined with cryotherapy led to an acceptable response.
Malekzad Farhad; Qeisari Mehdi; Nasiri Soheila; Rahmati-Roudsari Mohammad; Saeedi Marjan; Sarlak Mojdeh
Volume 12, Issue 1 , 2009, , Pages 9-12
Abstract
Background: An elevated homocysteine level is an independent risk factor for cardiovascular disorders. Psoriatic patients have an increased risk of cardiovascular diseases; In addition, hyperhomocysteinemia is a complication of methotrexate treatment. We undertook a study to evaluate the plasma levels ...
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Background: An elevated homocysteine level is an independent risk factor for cardiovascular disorders. Psoriatic patients have an increased risk of cardiovascular diseases; In addition, hyperhomocysteinemia is a complication of methotrexate treatment. We undertook a study to evaluate the plasma levels of homocysteine, vitamin B12 and folate in patients with psoriasis before and after short-term low-dose methotrexate treatment. Methods: Twenty six patients with psoriasis were recruited. The plasma levels of homocysteine, vitamin B12 and folate were evaluated before and 8 weeks after methotrexate therapy (in the peak of methotrexate effect). Results: No significant difference was found between the plasma profile of homocysteine, vitamin B12 and folate before and after methotrexate treatment. Conclusion: In the short-term treatment of psoriasis, methotrexate does not increase homocysteine level.
Nasiri Soheila; Sedigha Afshin; Farshi Hamideh Moravej; Nabai Leyla; Ebrahimzadeh Simin
Volume 10, Issue 2 , 2007, , Pages 130-134
Abstract
Background and aim: Psoriasis is a common chronic inflammatory and proliferative disease that genetic and environmental factors have a role in its pathogenesis and duration. The objective of this study was to compare the levels of vitamin A and E in the serum of psoriasis patients and control group.Materials ...
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Background and aim: Psoriasis is a common chronic inflammatory and proliferative disease that genetic and environmental factors have a role in its pathogenesis and duration. The objective of this study was to compare the levels of vitamin A and E in the serum of psoriasis patients and control group.Materials and methods: We evaluated 30 psoriasis patients and 30 healthy persons. Vitamin A and E levels were detected with the use of HPLC method. P value less than 0.05 (P<0.05) was considered as significant.Results: Demographic features were matched between groups. Vitamin A level was 1.09×0.27 in control group and 1.08×0.36 in patient group which did not have a meaningful statistical difference (p=0.91). Vitamin E level was 15.52×8.36 in control group and 9.02×5.41 in patient group and the difference was statistically significant (p=0.001). Comparing vitamin A and E levels according to disease severity showed no statistically significant difference.Conclusion: Our results show that vitamin E level in psoriasis patients is lower than healthy group that were matched by age and gender; although vitamin A level was not different between patient and control groups.