Toossi Parviz; Esmaili-Azad Mitra; Saeedi Mohammad
Volume 16, Issue 3 , 2013, , Pages 118-119
Abstract
Treatment of melasma has remained a hottopic in dermatology because of its resistance totherapy and high recurrence rate. For many yearshydroquinone was the foundation of melasmatreatment, but its use has been limited during theseyears due to a number of adverse events, suchas skin irritation, hyper ...
Read More
Treatment of melasma has remained a hottopic in dermatology because of its resistance totherapy and high recurrence rate. For many yearshydroquinone was the foundation of melasmatreatment, but its use has been limited during theseyears due to a number of adverse events, suchas skin irritation, hyper and hypo pigmentation,nail discoloration, conjunctival melanosis andochronosis. Furthermore hydroquinone is quiteunstable and is quickly oxidized and becomeinactive. So Hydroquinone is gradually beingreplaced by new lightning substances, such as kojicacid, phytic acid, azaleic acid, arbutin, mequinol,aleosin, ascorbic acid, soya proteins, N-acetylglucosamine and licorice. In this study weevaluate the effect of a licorice containing product(lightening serum, LANGE Paris) for the treatmentof melasma. There are several active ingredientsin licorice extract effective on melasma. These areliquiritin, glabridin, licochalcone A and isoliquertin.
Shahidi-Dadras Mohammad; Saeedi Mohammad; Ayatollahi Azin
Volume 15, Issue 1 , 2012, , Pages 29-30
Abstract
A 20-year-old girl presented with a one-week history of fever and chills, malaise, generalized erythema (including the face, trunk, back and extremities), edema (initially the face and then lower limbs) and hoarseness (Figure 1). Physical examination revealed low-grade fever, jaundice, lymphadenopathy ...
Read More
A 20-year-old girl presented with a one-week history of fever and chills, malaise, generalized erythema (including the face, trunk, back and extremities), edema (initially the face and then lower limbs) and hoarseness (Figure 1). Physical examination revealed low-grade fever, jaundice, lymphadenopathy (posterior cervical, submandibular, <1 cm, no axillary, no inguinal). Dermatological examination showed diffuse erythema (erythroderma), edema (generalized, especially periorbital and lips), and mild jaundice (scleral and sublingual). No mucosal lesions or nail changes were seen. She had a history of epilepsy since 3 years ago and had been under treatment with sodium valproate until 1.5 month ago when she discontinued the medication. She had an epileptic attack then and therefore carbamazepine was started for her. Positive laboratory findings were anemia, leukocytosis with eosinophilia (20%), elevated liver enzymes, and direct hyperbilirubinemia. Other routine laboratory tests, electrocardiogram, chest x-ray, and viral markers (including HBV, HCV and EBV) were unremarkable. Abdominal sonography revealed thickening of gall bladder and fluid in posterior choledosac. A punch biopsy was taken from her forearm skin.