G Sadeghian; F Iraji; MA Nilforoosh Zadeh
Volume 8, suppl , 2004, , Pages 31-34
Abstract
Cutaneous leishmaniasis (CL) is a parasitic disease, which is hyperendemic in Isfahan, usually caused by L.major and L.tropica. Herein we report a patient with post-mastectomy lymphedema on right upper limb accompanying with the lesions of cutaneous leishmaniasis on the right and left forearms. Following ...
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Cutaneous leishmaniasis (CL) is a parasitic disease, which is hyperendemic in Isfahan, usually caused by L.major and L.tropica. Herein we report a patient with post-mastectomy lymphedema on right upper limb accompanying with the lesions of cutaneous leishmaniasis on the right and left forearms. Following radiotherapy, the lesions on the limb with lymphedema were disseminated. But the lesions on left side showed no change. This finding may be the result of immune disorder due lymphedema and radiotherapy.
F Iraji; M Rezazadeh
Volume 6, Issue 3 , 2003, , Pages 8-12
Abstract
Background: Topical corticosteroids are currently used for treatment of diaper dermatitis. Previous studies have shown the efficacy of sucralfate in the treatment of diaper dermatitis and contact dermatitis in peri-stomy areas. Objectives: To evaluate the efficacy of topical sucralfate in comparison ...
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Background: Topical corticosteroids are currently used for treatment of diaper dermatitis. Previous studies have shown the efficacy of sucralfate in the treatment of diaper dermatitis and contact dermatitis in peri-stomy areas. Objectives: To evaluate the efficacy of topical sucralfate in comparison with hydrocortisone cream in the treatment of diaper dermatitis. Patients and Methods: In a double-blind, randomized clinical trial, 64 patients with diaper dermatitis were treated with sucralfate cream 4% or hydrocortisone cream. The duration of treatment was 8 weeks and patients were evaluated every two weeks until complete healing. The results were evaluated with chi-square test. Results: Complete healing (More than 50% improvement) occurred in 90.6% and partial healing (20-50% improvement) in 9.4% of patients in each group (P>0.05). Conclusion: Topical sucralfate is an effective, available and cheap therapeutic intervention for diaper dermatitis, which has equal efficacy with topical hydrocortisone cream.
A Asilian; MR Omid Ghaemi; A Momeni; F Iraji
Volume 5, Issue 3 , 2002, , Pages 22-28
Abstract
Background: Acitretin therapy is frequently associated with reversible, dose-related side effects. Recent studies claimed that combining vitamin E with high-dose isotretinoin reduced isotretinoin-induced side effects. Objective: The purpose of this clinical trial study was to determine the effect of ...
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Background: Acitretin therapy is frequently associated with reversible, dose-related side effects. Recent studies claimed that combining vitamin E with high-dose isotretinoin reduced isotretinoin-induced side effects. Objective: The purpose of this clinical trial study was to determine the effect of a fixed or adjusted dose of vitamin E on the side effects of acitretin. Patients and Methods: Fifty five subjects were randomly assigned to one of the two treatment programs including with acitretin (0.7-1 mg/kg/day) together with either vitamin E (13 IU/kg/day) or alone for 3 months. The incidence of side effects of acitretin in two groups were assessed and compared. Results: The study was completed in thirty-nine patients. Vitamin E did not decreased the incidence of side effects associated with acitretin. Conclusion: Vitamin E did not significantly ameliorate retinoid side affects when combined with 0.7-1 mg/kg of acitretin in treatment of skin disorders.
F Iraji; R Tavakoli
Volume 4, Issue 4 , 2001, , Pages 3-7
Abstract
Background: Evaluation of the impacts cutaneous of leishmaniasis (CL) on the patients, their family and government are necessary. Unfortunately these evaluations have not been done. Objective: Due to increased incidence of CL in Isfahan province especially in rural areas, this study was done to assess ...
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Background: Evaluation of the impacts cutaneous of leishmaniasis (CL) on the patients, their family and government are necessary. Unfortunately these evaluations have not been done. Objective: Due to increased incidence of CL in Isfahan province especially in rural areas, this study was done to assess the expenses of this disease in Isfahan in 1999. Patients and Methods: 196 patients were selected randomly from four areas of Isfahan province (2 rural and 2 urban), on the basis of data from Health Center in 1999. The amount of money that was paid for physician visit, traveling, accessory expenses (For example to buy insecticide), injections, dressing and drugs for treatment of CL were asked and recorded. Results: The mean amount paid in rural and urban areas were 208307 and 457327 Rials, respectively. Conclusion: Incidence of CL is about 10-30 thousands of patients in Isfahan each year, therefore the yearly expense of treatment is about 3-6 milliard Rials. We must change our strategies for controlling and eradicating this problem.
F Iraji; A Kiani; Sh Shahidi; R Vahabi
Volume 4, Issue 4 , 2001, , Pages 29-33
Abstract
Background: Warts are common in renal allograft recipients (RAR) with reported incidence of 24% to 100%. These patients also demonstrate an accelerated malignant transformation of warts. Although in immunocompetent patients, the histology of common warts is quite predictable, this is not so in RAR. Objective: ...
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Background: Warts are common in renal allograft recipients (RAR) with reported incidence of 24% to 100%. These patients also demonstrate an accelerated malignant transformation of warts. Although in immunocompetent patients, the histology of common warts is quite predictable, this is not so in RAR. Objective: The purpose of this study was to evaluate the histopathologic findings of warty lesions in RAR. Patients and Methods: We examined 55 RARs for warty lesions. We took biopsy specimens from lesions that clinically appeared to be common warts and evaluated their histopathologic features. Results: Among 55 RARs, 17 cases (30.9%) had warty lesions, and among 50 biopsied lesions, 47 lesions (94%) showed changes of verruca vulgaris and only 3 Lesions (6%) showed warts with dysplasia. No malignant transformation was reported. All patients were under treatment with prednisolone, cyclosporin and azathioprine. The median time passed from transplantation was 49 months. Conclusion: We couldn’t find evidence of dysplasia or malignancy in most verrucous lesions of RAR. This maybe due to relatively short time passed from transplantation in our patients.
F Iraji; M Saghaei; H Mokhtari
Volume 4, Issue 1 , 2000, , Pages 31-35
Abstract
Background: Urticaria is very common and most of the current treatments are only partially successful. Objective: As the efficacy of acupuncture in the treatment of chronic urticaria has not been studied in Iran, we decided to do this study. Patients and Methods: In a randomized, controlled, double-blind ...
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Background: Urticaria is very common and most of the current treatments are only partially successful. Objective: As the efficacy of acupuncture in the treatment of chronic urticaria has not been studied in Iran, we decided to do this study. Patients and Methods: In a randomized, controlled, double-blind clinical trial, 40 patients with chronic urticaria referred to skin clinics of Isfahan University in 1378 were studied. The patients had idiopathic urticaria, resistant to conventional treatment, and had not received any medication in the last month. We randomly divided them in two equal groups. One group was treated with acupuncture and the other with placebo for 3 weeks. Data entry and analysis was performed by Systat and T-test was used for data analysis. Results: The mean numbers of the episodes of urticaria in 3 weeks were 4.81 times in the control group and 3.62 times in the acupuncture group (P=0.01). The mean duration of urticarial episodes in the third week was 5.08 hours in the control group and in received acupuncture group was 2.37 hours in the acupuncture group (P=0.03). Conclusion: Acupuncture induced remission of chronic urticaria in the majority of the patients. Its efficacy was greatest in the third week of treatment.
F Iraji; H Azampour; F Fatemi
Volume 3, Issue 4 , 2000, , Pages 2-6
Abstract
Background: Palmoplantar eczema is a common clinical problem involving 2% of the population. There are many treatment modalities for palmoplantar eczema, each with specific local and systemic side effects. Objective: To evaluate methoxsalen bath in the treatment of palmoplantar eczema. Patients and Methods: ...
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Background: Palmoplantar eczema is a common clinical problem involving 2% of the population. There are many treatment modalities for palmoplantar eczema, each with specific local and systemic side effects. Objective: To evaluate methoxsalen bath in the treatment of palmoplantar eczema. Patients and Methods: In a randomized, double-blind, placebo controlled clinical trial, 60 patients with palmoplantar eczema referred to skin clinics of Isfahan University in 1376-78 were divided in two equal groups. One group received PUVA-bath and the other one received placebo-bath. Hands or feet or both were soaked for 15 minutes in warm water containing 0.0001% 8-methoxypsoralen or placebo. Then the skin was exposed to sun for 30 minutes. This was performed 4 times a week up to a total of 25 treatments. Results: Excellent or good therapeutic effects were achieved in 86.7% of PUVA bath group but only in 6.7% of placebo (P=0). No phototoxic reactions were observed. Conclusion: PUVA-bath is a safe, cheap, effective and comfortable method in the management of palmoplantar eczema.
SM Meghdadi; M Moslemi; F Iraji
Volume 3, Issue 3 , 2000, , Pages 7-13
Abstract
Background: Considering the prevalence of skin lesions and drug eruptions in intensive care units and the absence of research about it, we decided to study skin lesions of patients admitted in intensive care unit. Patients and Methods: In this descriptive study all patients admitted in intensive care ...
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Background: Considering the prevalence of skin lesions and drug eruptions in intensive care units and the absence of research about it, we decided to study skin lesions of patients admitted in intensive care unit. Patients and Methods: In this descriptive study all patients admitted in intensive care units of Al-Zahra Hospital in Isfahan in 1376-78 were observed and examined by a resident in Dermatology. Skin biopsy and bacterial and fungal smears were done in selected cases. Data were collected, entered in SPSS and analyzed by ANOVA, Chi-square and Discriminant methods. Results: 197 of a total of 406 patients had skin lesions. Skin lesions were most frequent in the age range of 21-40 years (37%) and least frequent in age groups under 10 years (2.5%) and over 80 years (3%). 116 of patients (58.9%) were male and 81 (41.1%) were female. The most common skin lesions were hemorrhagic cutaneous lesions (23.4%) and steroid acne (22.8%). The rarest was toxic epidermal necrolysis (0.5%). The most common causes of hospitalization were intracranial and subarachnoid hemorrhage (11.2% each). Conclusion: Skin lesions are common in patients admitted in ICUs. Frequent and continuous examinations of these patients are recommended in order to prevent and treat them promptly.
A Kiani; F Iraji; F Shariati
Volume 3, Issue 2 , 2000, , Pages 39-42
Abstract
Cutaneous leishmaniasis may present as unusual manifestations in renal transplant patients receiving immunosuppressive therapy. This misleading presentation, may delay the diagnosis and treatment. Moreover special caution must be taken in renal transplant recipients because of possible interactions between ...
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Cutaneous leishmaniasis may present as unusual manifestations in renal transplant patients receiving immunosuppressive therapy. This misleading presentation, may delay the diagnosis and treatment. Moreover special caution must be taken in renal transplant recipients because of possible interactions between antimony compounds and cyclosporine metabolites. We report a 45-year old man with 5 years history of kidney transplantation receiving immunosuppressive drugs who had an extensive, painful ulcer on the left and upper side of his chest. Laboratory evaluation confirmed the diagnosis of cutaneous leishmaniasis. The patient was treated successfully with a 3-week period of intramuscular Glucantime.
SM Meghdadi; F Iraji; M Adabi
Volume 3, Issue 1 , 1999, , Pages 58-62
Abstract
A 24-year old female patient with the history of pressure ulcers in distal extremities resulted in severe deformity will be reported. Her disease started when she was 9 years old and a similar history was found in her brother. In physical examination, pain and temperature sensations were impaired in ...
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A 24-year old female patient with the history of pressure ulcers in distal extremities resulted in severe deformity will be reported. Her disease started when she was 9 years old and a similar history was found in her brother. In physical examination, pain and temperature sensations were impaired in distal extremities. Nerve conduction velocity showed impaired sensory and normal motor responses confirming the diagnosis of hereditary sensory-autonomic neuropathy.
A Asilian; F Iraji
Volume 2, Issue 2 , 1999, , Pages 41-44
Abstract
A 9-year old boy had severe muscle weakness and typical skin rash and EMG with diagnosis of dermatomyositis associated with erythrodermia with islands of normal skin and palmoplantar hyperkeratosis, which was reported. As PRP in skin biopsy. Association dermatomyositis with PRP is very rare.
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A 9-year old boy had severe muscle weakness and typical skin rash and EMG with diagnosis of dermatomyositis associated with erythrodermia with islands of normal skin and palmoplantar hyperkeratosis, which was reported. As PRP in skin biopsy. Association dermatomyositis with PRP is very rare.
A Momeni; A Asilian; M Meghdadi; Sh Enshaieh; F Shariati; MA Nilforoush Zadeh; F Iraji; F Fatemi; M Amin Javaheri
Volume 2, Issue 1 , 1998, , Pages 21-26
Abstract
Hypersensitivity to anticonvulsant drugs have been reported many times. But anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatal drug reaction with cutaneous and systemic reaction to the arene oxide-producing anticonvulsants, phenytoin, carbamazepine, and Phenobarbital sodium. The hall-mark ...
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Hypersensitivity to anticonvulsant drugs have been reported many times. But anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatal drug reaction with cutaneous and systemic reaction to the arene oxide-producing anticonvulsants, phenytoin, carbamazepine, and Phenobarbital sodium. The hall-mark features of this syndrome are: Fever, rash and lymphadenopathy. The epoxide hydrolase enzyme may be lacking or mutated in persons in whom AHS develops. The reaction may be genetically determined and familial occurrence of hypersensitivity was observed. The timely recognition of AHS is important, because accurate diagnosis avoids potentially fatal re-exposure and affects subsequent anticonvulsant treatment options. We report two cases of AHS and review the clinical and pathophysiologic features.