A Momeni; MR Kharazi; M Amin Javaheri
Volume 3, Issue 3 , 2000, , Pages 29-34
Abstract
Background: Vitiligo is a common skin disease that clinically presents as depigmented macules due to destruction of melanocytes. Although the cause is unknown, various theories such as autoimmune, autodestruct and neural hypotheses have been proposed. Objective: The objective of this study was to evaluate ...
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Background: Vitiligo is a common skin disease that clinically presents as depigmented macules due to destruction of melanocytes. Although the cause is unknown, various theories such as autoimmune, autodestruct and neural hypotheses have been proposed. Objective: The objective of this study was to evaluate clinical picture of vitiligo in Isfahan, Iran. Patients and Methods: In a descriptive study, all vitiligo patients referred to a private skin clinic in Isfahan during one year (1376) were evaluated. Results: 458 of a total of 6540 patients had vitiligo (7.0%). Most of the patients were female (61.1%). The mean age of disease onset was 20.83 years. The site of onset of lesions was extremities in 41.1%, head and neck in 37.80%, trunk in 16.24% and genitalia in 5.49% of patients. 72% of the patients who had lesions of the face, responded well to topical steroids. Conclusion: Vitiligo is a common skin disease in Isfahan and a large study is needed to show the prevalence of the disease in Iran.
A Momeni; A Khamesipour; A Bagher Zadeh; M Amin Javaheri
Volume 3, Issue 1 , 1999, , Pages 24-30
Abstract
Background: Cell-mediated immunity (CMI) plays an important role in resistance against leishmaniasis. Leishmanin test (Montenegro skin test) is a method in evaluation of immune system reaction against cutaneous leishmaniasis. The TDR/WHO reference Leishmanin produced by the Pasteur Institute of Iran ...
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Background: Cell-mediated immunity (CMI) plays an important role in resistance against leishmaniasis. Leishmanin test (Montenegro skin test) is a method in evaluation of immune system reaction against cutaneous leishmaniasis. The TDR/WHO reference Leishmanin produced by the Pasteur Institute of Iran is used worldwide. Two other antigens produced by Razi Serum Institute of Iran, Killed Leishmania Major (K.L.M) and Autoclaved Leishmania Major (A.L.M), take advantage of vaccine strains of L.major, and under supervision of WHO, have been investigated as leishmaniasis vaccine. Objective: KLM, ALM and standard Leishmanin as skin test wee compared in this study. Patients and Methods: Fifty patients with cutaneous leishmaniasis were randomly selected. They attended the educational clinics of Isfahan University of Medical Sciences. All 3 antigens were injected intradermally in them and the size of erythema and induration were read and recorded after 48 hours. Data were grouped and analyzed with analysis of variance (ANOVA). Results: There was significant difference between mean of erythema and induration sizes of antigens in two by two comparison. The mean of erythema and induration sizes due to K.L.M were greater than A.L.M, and mean of erythema and induration sizes due to A.L.M were greater than Pasteur Institute reference leishmanin (P<0.0001). Conclusion: Although the mean of erythema and induration sizes due to K.L.M were greater than others, use of A.L.M seems to be more practical compared to. K.L.M, because of simple storage method of A.L.M, and more sensitive than Pasteur Institute reference leishmanin.
A Momeni; A Asilian; M Meghdadi; Sh Enshaieh; F Shariati; MA Nilforoush Zadeh; F Iraji; F Fatemi; M Amin Javaheri
Volume 2, Issue 1 , 1998, , Pages 21-26
Abstract
Hypersensitivity to anticonvulsant drugs have been reported many times. But anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatal drug reaction with cutaneous and systemic reaction to the arene oxide-producing anticonvulsants, phenytoin, carbamazepine, and Phenobarbital sodium. The hall-mark ...
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Hypersensitivity to anticonvulsant drugs have been reported many times. But anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatal drug reaction with cutaneous and systemic reaction to the arene oxide-producing anticonvulsants, phenytoin, carbamazepine, and Phenobarbital sodium. The hall-mark features of this syndrome are: Fever, rash and lymphadenopathy. The epoxide hydrolase enzyme may be lacking or mutated in persons in whom AHS develops. The reaction may be genetically determined and familial occurrence of hypersensitivity was observed. The timely recognition of AHS is important, because accurate diagnosis avoids potentially fatal re-exposure and affects subsequent anticonvulsant treatment options. We report two cases of AHS and review the clinical and pathophysiologic features.