F Jafari; Sh Moradi; MA Nilforoush Zadeh; R Derakhshan; N Ansari
Volume 9, Issue 3 , 2006, , Pages 211-216
Abstract
Background and aim: Cutaneous leishmaniasis is an endemic disease in Iran. Although there are many different treatments for this disease, there is not any effective treatment yet. Since there has been a number of different reports on the effectiveness of Cassia fistula plant in the treatment of leishmaniasis, ...
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Background and aim: Cutaneous leishmaniasis is an endemic disease in Iran. Although there are many different treatments for this disease, there is not any effective treatment yet. Since there has been a number of different reports on the effectiveness of Cassia fistula plant in the treatment of leishmaniasis, the efficacy of concentrated boiled extract and hydro alcoholic extract of Cassia fistula on the leishmaniasis disease was compared with intralesional injection of Glucantime in this study.Materials and Methods: In this randomized clinical trial a total of 165 patients, 6 to 60 years old, who had a positive leishmania smear refered to the Isfahan Skin and Leishmaniasis Research Center were divided into three groups using list of random numbers and were treated with: concentrated boiled extract of Cassia fistula, hydroalcholic extract of Cassia fistula, or intralesional injection of Glucantime. The patients were treated for 4 weeks and followed for three months after the study started. The efficacy of treatment was reported as complete cure, partial improvement and no improvement on the basis of clinical and parasitological evidence.Results: In the present study 63/6% of patients treated with the concentrated boiled extract, 52/7% of the hydroalcoholic extract and 45/5% of the Glucantime group were men. 22 patients (40%) of the concentrated boiled extract of Cassia fistula, 20 pateints (36/4%) of the hydroalcoholic extract of Cassia fistula group and 36 patients (65/5%) of the Glucantime group showed complete cure. The efficacy in the third group was much more than the first (P<0.02) and second groups (P<0.005), but there was not any difference between concentrated boiled extract and hydroalcoholic extract of Cassia fistula.Conclusion: The results of this study showed that this plant might be used topically along with Glucantime for decreasing the time and dose of treatment with Glucantime.
MA Nilforoush Zadeh; Sh Moradi; R Derakhshan; E Haft Baradaran; F Jafari
Volume 9, Issue 3 , 2006, , Pages 221-226
Abstract
Background and aim: Cutaneous leishmaniasis (CL) is an edemic disease widely spread in Iran. Although several treatments have been tried, none has been found as simple and effective. Honey has been used in the treatment of chronic ulcers and its anti-leishmanial effects have also been reported. So we ...
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Background and aim: Cutaneous leishmaniasis (CL) is an edemic disease widely spread in Iran. Although several treatments have been tried, none has been found as simple and effective. Honey has been used in the treatment of chronic ulcers and its anti-leishmanial effects have also been reported. So we assessed the efficacy of honey in acute CL.Materials and Methods: In a randomized clinical trial, 100 patients with CL referred to Skin and Leishmaniasis Research Center were treated with either weekly intra-lesional injection of Glucantime alone or combined with twice daily topical application of honey. The patients were evaluated clinically 2 ,3 and 4 months after treatment.Results: Ninety patients completed the study, forty-five patients were treated in each group. At the end of trial, 32 patients (71/1%) of these treated with Glucantime alone and 23 patients (51/1%) treated with honey were cured (P=0.04).Conclusion: Drug interference and inhibition of bioavailability of Glucantime by honey may decrease the efficacy of Glucantime in treatment of CL.
MA Nilforoush Zadeh; G Sadeghian; F Jafari; AR Firooz; Sh Moradi; R Derakhshan
Volume 9, Issue 1 , 2006, , Pages 35-39
MA Nilforoush Zadeh; F Jafari; N Ansari; Z Nilforoushan; AR Firooz
Volume 8, Issue 5 , 2005, , Pages 340-346
MA Nilforoush Zadeh; F Jafari; Sh Rafiei
Volume 8, Issue 5 , 2005, , Pages 358-362
M Bakhshi Zadeh; SH Hejazi; M Baghaei; F Jafari; Z Ghayour; A Khamesi Pour
Volume 8, Issue 4 , 2005, , Pages 260-265
Abstract
Background an objective: Leishmaniasis is a common disease endemic in some parts of Iran. Chemical or physical treatments or a combination of both are used for treatment of the disease. Nitric oxide (NO) is important for healing of leishmaniasis in human and animal. This study was designed to evaluate ...
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Background an objective: Leishmaniasis is a common disease endemic in some parts of Iran. Chemical or physical treatments or a combination of both are used for treatment of the disease. Nitric oxide (NO) is important for healing of leishmaniasis in human and animal. This study was designed to evaluate the beneficial effects of a NO releasing cream on cutaneous leishmaniasis in an animal model. Materials and Methods: Balb/c mice were infected with leishmania major by injecting promastigotes into the base of tails of mice to induce the lesion. Then the animals were divided into 3 groups (Control, placebo and treatment). Mice were treated with the drugs one time daily. The diameter of lesions were measured on days 0, 5, 10, 15, 20, 25, and 30 after the appearance of the lesions. Data were analyzed using one-way ANOVA test and (P<0.05) considered as significant. Results: The diameter of lesions were significantly reduced in 15, 20, 25 and 30 day in NO cream treated animals compared to control and placebo groups (P<0.05). Conclusion: NO releasing compounds may be effective in the treatment of leishmaniasis.
MA Nilforoosh Zadeh; T Jalayer; B Ataei; F Jafari; M Motavali Emami
Volume 7, Issue 2 , 2004, , Pages 78-83
Abstract
Background: Humans, rodents and sandflies have role in transmitted cycle of cutaneous leishmaniasis. To control the disease, promoting the environment, killing the rodent and poisoning the vectors are recommended, individually all over the world. Since, there is no effective vaccine against this disease, ...
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Background: Humans, rodents and sandflies have role in transmitted cycle of cutaneous leishmaniasis. To control the disease, promoting the environment, killing the rodent and poisoning the vectors are recommended, individually all over the world. Since, there is no effective vaccine against this disease, the integration of methods is considerable. Objective: To evaluate the efficacy of integration method in the control of cutaneous leishmaniasis. Patients and Methods: This study was an interventional study, which after knowing the ecosystem around the Imamzadeh Agha Ali Abbas in Natanz in Isfahan, perform the plat covering within a radius of 100m, entrances correction, pool and garbage storage removal and sweepings for the rodents within a radius of 2kms around the Imamzadeh and poisoning the vectors have been done. Results: The incidence of disease was 3.7% in 1996 (Before intervention), which was decreased to 1/17 in 1996 and to 1/12 a year later. Conclusion: Integration method consisting of environment improvement, rodents removal and poisoning as well as training high risk people is recommended to control cutaneous leishmaniasis.
MA Nilforoosh Zadeh; MR Reiss Zadeh; F Jafari
Volume 6, Issue 2 , 2003, , Pages 34-39
Abstract
Background: An easy and effective topical treatment is not yet available for cutaneous leishmaniasis. Objectives: To compare the effect of topical trichloroacetic acid (TCA) and intralesional glucantime injection in the treatment of acute wet cutaneous leishmaniasis. Patients and Methods: Eighty patients ...
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Background: An easy and effective topical treatment is not yet available for cutaneous leishmaniasis. Objectives: To compare the effect of topical trichloroacetic acid (TCA) and intralesional glucantime injection in the treatment of acute wet cutaneous leishmaniasis. Patients and Methods: Eighty patients with clinical diagnosis of wet cutaneous leishmaniasis in the age range of 5 to 75 years were recruited in this open clinical trial. Seven patients were withdrawn during the trial. In TCA group, 38 patients were treated three times (Every 2 weeks) with 50% TCA. In control group, 35 patients received intralesional glucantime injection weekly until healing or for a maximum of 6 weeks. All patients were followed for 3 months after last treatment. Results: After four weeks of treatment, 20 patients (52.6%) in TCA group and 17 patients (48.5%) in glucantime group, and after six weeks, 68% and 65.7% of patients in each respective group were completely cured. There was no important side effect in any groups. Conclusion: The nearly equal efficacy of TCA peeling and intralesional glucantime injection in the treatment of cutaneous leishmaniasis suggests that 50% TCA could be considered as a possible efficient therapeutic alternative in the management of this disease.
M Eslami Danesh Pajooh; F Jafari; M Farivar Sadri; M Valikhani
Volume 3, Issue 2 , 2000, , Pages 10-15
Abstract
Background: Oral ivermectin is recently introduced for the treatment of scabies. Objective: The objective of this clinical trial was to compare the efficacy and safety of oral ivermectin and topical Gamma Benzene Hexachloride (GBH) 1% for the treatment of scabies. Patients and Methods: Fifty-eight cases ...
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Background: Oral ivermectin is recently introduced for the treatment of scabies. Objective: The objective of this clinical trial was to compare the efficacy and safety of oral ivermectin and topical Gamma Benzene Hexachloride (GBH) 1% for the treatment of scabies. Patients and Methods: Fifty-eight cases were randomly assigned in the two treatment groups. In the ivermectin group, patients received a single oral dose of the drug (200 µg/kg). In the case of any signs of active disease, a second dose was administered one week later. All the patients in the GBH group received two topical applications of the drug, one week apart. The patients were seen after 48 hours, 1, 2, and 4 weeks. Results: Of the 37 patients treated with ivermectin, 27 (73%) showed clinical cure with a single dose and 10 (27%) required a second dose one week later. In the 21 patients treated with GBH, 18 (85.7%) received two applications of GBH, and three cases (14.3%) were cured by an additional curse of precipitated sulfur 6%. No serious side effects were seen in either group. The mean time for the drop of pruritus, the sense of well being and the healing of lesions, were each shorter with ivermectin than GBH, and the differences were statistically significant. Conclusion: Although all of the patients treated with ivermectin or topical GBH were cured, ivermectin cured faster than topical treatment.
