S Shamsoddini; AR Fekri; H Ebrahimi; ME Zeinodini
Volume 6, Issue 4 , 2003, , Pages 17-23
Abstract
Background: Due to infections, cardio-vascular involvement and renal insufficiency, patients with systemic lupus erythematosus live shorter than usual. Objective: To determine the mean survival rate of SLE patients. Patients and Methods: 62 SLE patients admitted in the hospitals of Kerman University ...
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Background: Due to infections, cardio-vascular involvement and renal insufficiency, patients with systemic lupus erythematosus live shorter than usual. Objective: To determine the mean survival rate of SLE patients. Patients and Methods: 62 SLE patients admitted in the hospitals of Kerman University of Medical Sciences from 1369 to 1380 were included in this study. The demographic variables, which were effective on disease survival time, evaluated. Results: Mean survival time, regardless of other descriptive variables, was 9.2±0.89 years. The cases who had skin lesions first, in comparison with those who had rheumatic signs at first, revealed lower survival rate and more morbidity. The mean survival rate of cases who received combination of corticosteroid and anti-malarial drugs, corticosteroid drugs alone, and cyclophosphamide plus anticoagulants, were 12.0, 9.5 and 8.5 years, respectively. Conclusion: The prognosis in SLE patients with early skin manifestations was poorer than those with early rheumatic presentation. Best prognosis was noted in patients who received systemic steroids in comparison to other treatment modalities.
AR Fekri; S Shamsaddini; A Maghsoodloo Nejad
Volume 3, Issue 4 , 2000, , Pages 7-17
Abstract
Background: Beta-thalassemia major (BTM) is a genetic disorder, which is common in Kerman province of Iran. New methods of care has increased their survival. Objective: The objective of this descriptive study was to assess the frequency of skin and mucosal complications of BTM patients. Patients and ...
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Background: Beta-thalassemia major (BTM) is a genetic disorder, which is common in Kerman province of Iran. New methods of care has increased their survival. Objective: The objective of this descriptive study was to assess the frequency of skin and mucosal complications of BTM patients. Patients and Methods: All BTM patients referred to Kerman-Darman Hospital in 1377 (150 cases) were evaluated. Dermatologic signs and symptoms were diagnosed by physical examination and serum ferritin levels were measured. Results: Skin hyperpigmentation (65.3%), mucosal hyperpigmentation (41.3%), coarse nail (34%) and coarse hair (20.7%) were the most common signs. They were related to the age and serum ferritin levels but sex of patients and dose of desferral had no significant relation with skin complications. Conclusion: Skin and mucosal lesions are common in BTM. An exact exam and control of serum ferritin level with desferral is recommended to prevent skin complications.
AR Fekri; S Shamsaddini; H Tabrizchi
Volume 2, Issue 4 , 1999, , Pages 35-38
Abstract
Pyoderma gangrenosum is characterized by a chronic, non-infectious, destructive ulcer which is mostly seen on distal lower extremities, but it can be found anywhere on body. We report an 18-year old man who developed keloids after healing of his ulcers. He was a known case of chronic relapsing pyoderma ...
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Pyoderma gangrenosum is characterized by a chronic, non-infectious, destructive ulcer which is mostly seen on distal lower extremities, but it can be found anywhere on body. We report an 18-year old man who developed keloids after healing of his ulcers. He was a known case of chronic relapsing pyoderma gangrenosum. His previous ulcers were used to heal leaving atrophic, cigarette-paper scars. But since a year ago, following using clofazimine for his disease, he has developed keloids after healing the ulcers. Alterations in the immune system of the patient might be involved. Development of keloids in ulcers of pyoderma gangrenosum has not been reported previously.