MR Mortazavi; Z Safaei Naraghi
Volume 9, Issue 3 , 2006, , Pages 289-293
Abstract
Acquired port-wine stain is a rare vascular lesion that mimics a congenital port-wine stain clinically and histologically, but is acquired after birth. A survey on more than 60 reported cases in the literature reveals that most of these cases are idiopathic, but some of the cases developed after physical ...
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Acquired port-wine stain is a rare vascular lesion that mimics a congenital port-wine stain clinically and histologically, but is acquired after birth. A survey on more than 60 reported cases in the literature reveals that most of these cases are idiopathic, but some of the cases developed after physical or mechanical trauma, hormonal changes, chronic sun exposure, and medications (OCP, isotretinoin, etc). The pathogenesis of acquired port-wine stain like its congenital counterpart is obscure, but is thought to be related to a functional deficit of perivascular sympathetic neural control after mechanical trauma or other possible factors. Laser is the first choice of treatment in both congenital and acquired port-wine stains.We, herein report two rare cases of acquired port-wine stains. Both of the cases presented at the age of 15 years. One of them was idiopathic and the other one developed after a mild electrical burn on her hand. The histopathological findings of their biopsy specimens were compatible with the diagnosis of port-wine stain.
M Barzegari; Z Safaei Naraghi; M Akhyani; AH Ehsani; R Mahmoud Robati; S Bagheri Nejad
Volume 9, Issue 2 , 2006, , Pages 159-164
Abstract
Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency ...
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Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency of BCC in 1368-69 and 1378-79.Materials and Methods: This descriptive and retrospective study was performed as an existing data study and all files in department of pathology in Razi Hospital from 1368-69 and 1378-79 were assessed with regards of BCC frequency, patient age and gender as well as history of radiation and the collected data were compared.Results: A total of 1503 BCCs were studied, 507 were from 1368-69 and 996 from 1378-79 period. In the years 1368-69, relative frequency of BCC was 11.1%. On the other hand in years 1378-79 relative frequency of BCC was increased to 15.2%, which was not associated with gender. BCC occurance showed a significant decrease in 20-30-year age group and a significant increase in over 60 years age group. Among histologic subtypes, nodular form showed an increase, which was statistically significant on face region (P<0.005), but was not linked to patient gender. In male patients significant decrease of BCC frequency on face and increase on head and neck areas was observed, but there was not any significant change in tumor location in female patients.Conclusion:During a 10-year period the frequency of BCC has increased significantly requiring more attention to develop educational programs regarding prevention, diagnosis and early treatment.
AH Ehsani; Z Safaei Naraghi; R Mahmoud Robati; S Toosi
Volume 8, suppl , 2004, , Pages 35-38
Abstract
Patients with keratotic lesions distributed in a unilateral, linear, zosteriform or localized pattern and revealing histopathologic features of dyskeratotic acantholysis have been reported previously. There is some controversy in the appropriate nosologic classification of this entity. Some authors consider ...
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Patients with keratotic lesions distributed in a unilateral, linear, zosteriform or localized pattern and revealing histopathologic features of dyskeratotic acantholysis have been reported previously. There is some controversy in the appropriate nosologic classification of this entity. Some authors consider it as a localized form of Darier’s disease while others place it as a variant of epidermal nevus. We report a 19-year-old girl who presented with 14 years history of an asymptomatic, hyperkeratotic area of skin-colored papules in a dermatomal distribution on the dorsum of her left hand and forearm. Pathological evaluation showed acantholysis and dyskeratosis. The controversy regarding the correct classification of such a patient is discussed.
MR Mortazavi; Z Safaei Naraghi; M Mohammad Zadeh
Volume 7, Issue 1 , 2003, , Pages 38-42
Abstract
Actinic lichen planus is a clinical variant of lichen planus, involving mainly sun-exposed areas and manifested as annular lesions with a pigmented center surrounded by a hypopigmented zone. A rare presentation of actinic lichen planus mimics melasma but have distinctive histopathologic picture in favour ...
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Actinic lichen planus is a clinical variant of lichen planus, involving mainly sun-exposed areas and manifested as annular lesions with a pigmented center surrounded by a hypopigmented zone. A rare presentation of actinic lichen planus mimics melasma but have distinctive histopathologic picture in favour of actinic lichen planus. Herein, we report a 14-year-old boy who presented with a melasma-like patch on the left side of forehead. Histopathologic findings including pigmentation of basal layer accompanied with vacuolization and also pigmentary macrophages in dermis were in favour of actinic lichen planus.
H Mortazavi; AH Ehsani; Z Safaei Naraghi; M Asgari
Volume 4, Issue 4 , 2001, , Pages 34-40
Abstract
We report of a 29-year-old man presented with yellow-red, scaling papules on the skin of scalp, retro-auricular folds, inguinal, axillary, chest and abdomen. The lesions had a poikilodermatious appearance in some areas, such as trunk. The patient also had diabetes insipidus and skull osteolytic lesions. ...
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We report of a 29-year-old man presented with yellow-red, scaling papules on the skin of scalp, retro-auricular folds, inguinal, axillary, chest and abdomen. The lesions had a poikilodermatious appearance in some areas, such as trunk. The patient also had diabetes insipidus and skull osteolytic lesions. The diagnosis of langerhans cell histiocytosis (LCH) was suggested based on H and E staining of skin biopsy specimen. S-100 staining was positive in immunohistochemistry. Birbeck granules were seen in electron microscopic examination confirming the diagnosis of LCH. Considering the systemic involvement, he is a case of an extensive LCH in new classification and a case of Hand-Schuller-Christian in the old classification. The cutaneous lesions of the patients responded to oral thalidomide 200 mg daily after 2 months and did not recur after 6 months follow up.
Z Safaei Naraghi; Z Hallaji; M Danesh Pajooh; H Moslehi; K Jazayeri
Volume 4, Issue 1 , 2000, , Pages 12-18
Abstract
Background: Bullous pemphigoid (BP) is the prototype of subepidermal autoimmune bullous dermatoses (SABDs). Direct immunofluorescence on salt split skin substrate (DIF-SS) is one of the methods used to differentiate this group of dermatoses. Objective: We conducted this study in order to delineate the ...
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Background: Bullous pemphigoid (BP) is the prototype of subepidermal autoimmune bullous dermatoses (SABDs). Direct immunofluorescence on salt split skin substrate (DIF-SS) is one of the methods used to differentiate this group of dermatoses. Objective: We conducted this study in order to delineate the results of DIF-SS in SABD patients. Patients and Methods: Seventeen patients with a BP-like clinical picture referred to Razi Hospital in 1378, who had linear immunodeposits along basement membrane zone in direct immunofluorescence, were studied. Considering only histopathologic and clinical data, a final diagnosis was established for each patient. DIF-SS was performed on perilesional skin sample of patients. DIF-SS and histopathology results and the final diagnosis were recorded and compared for each patient. Results: In DIF-SS, eleven patients (65%) had combined (Epidermal and dermal), two patients (12%) had epidermal and four patients (23%) had dermal pattern. The final diagnoses were BP in ten patients and epidermolysis bullosa acquisita (EBA) in two others. We were unable to differentiate BP from EBA in two patients. In ten patients who were diagnosed finally as BP, nine patients (90%) had combined pattern and only one case (10%) showed epidermal staining in DIF-SS. Conclusion: Surprisingly, in contrast to the results of the previous studies on pemphigoid patients using either IIF-SS or DIF-SS in which the epidermal pattern had been reported to be much more common than the combined pattern, the combined pattern was nine times more frequent than the epidermal pattern in this study. Perhaps, the difference in target antigens in our patients may be the underlying reason for the difference in our results.
