K Balighi; Sh Yazdanian; N Ghandi
Volume 9, Issue 3 , 2006, , Pages 284-288
Abstract
Pemphigus vulgaris is a blistering autoimmune disease with suprabasal cleft formation, which is the most common autoimmune blistering disease in eastern countries, such as Middle East. Predisposition to pemphigus is linked to genetic factors. Tuberous sclerosis is also a genetic disorder of hamartoma ...
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Pemphigus vulgaris is a blistering autoimmune disease with suprabasal cleft formation, which is the most common autoimmune blistering disease in eastern countries, such as Middle East. Predisposition to pemphigus is linked to genetic factors. Tuberous sclerosis is also a genetic disorder of hamartoma formation in many organs, particularly the skin, brain, eye, kidney and heart. We report a 17-year-old boy with pemphigus vulgaris associated with tuberous sclerosis, which to our knowledge the first report of this association.
K Balighi; Sh Yazdanian
Volume 9, Issue 2 , 2006, , Pages 189-193
Abstract
Lichen nitidus is an uncommon skin condition that is clinically characterized by the presence of pinpoint papules, which are usually asymptomatic, flesh colored, with a flat, shiny surface. The histopathologic feature of it is characteristic. We report a 30-year-old man with typical skin lesions of lichen ...
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Lichen nitidus is an uncommon skin condition that is clinically characterized by the presence of pinpoint papules, which are usually asymptomatic, flesh colored, with a flat, shiny surface. The histopathologic feature of it is characteristic. We report a 30-year-old man with typical skin lesions of lichen nitidus confirmed with histopathology, who also had multiple palmar pits. Treatment with topical clobetasol propionate resulted in great improvement, flattening of palmar lesions and clearance of the forearn and wrist lesions. To our knowledge, the association of lichen nitidus with palmar pitting has not been reported before.
K Balighi; K Kiani Far; F Farnaghi; SZ Ghodsi; P Mehrian
Volume 8, suppl , 2005, , Pages 53-59
Abstract
Nowadays, Erbium: YAG laser resurfacing of periorbital skin has become a very popular method of wrinkle reduction. Seven patients with Fitzpatrick skin phototypes of II to V were treated with a 2940 nm Erbium: YAG laser system for resurfacing of periorbital wrinkles. Photographic evalution performed ...
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Nowadays, Erbium: YAG laser resurfacing of periorbital skin has become a very popular method of wrinkle reduction. Seven patients with Fitzpatrick skin phototypes of II to V were treated with a 2940 nm Erbium: YAG laser system for resurfacing of periorbital wrinkles. Photographic evalution performed before and after treatment. Patients were visited at 1,2,3,5,7,14,30 and 60 days after laser resurfacing. The results were graded into five categories: no improvement (grade 0), mild (grade 1: up to 25% ), moderate (grade 2: 25-50%), good (grade 3: 50-75%) or excellent (grade 4: 75-100%). Two independent investigators and also the patients themselves evaluated the improvement grades by comparing the photographs. Peri- orbital skin re- epithelization after treatment took a mean duration of 3.7 days. Duration of erythema varied from two to seven weeks with a mean duration of 16.2 days. Eight weeks after the end of the treatment the mean improvement grade was 2.35 (moderate to good) by investigators judgment and 2.14 (moderate to good) by the patients themselves. No pigmentary complications were evident after 8 weeks. No scars or ectropion were observed.
M Danesh Pajouh; K Balighi; F Safar; M Asheghan; M Asadollahi; Gh.R Hassiri
Volume 8, Issue 4 , 2005, , Pages 272-275
Abstract
Background and objective: Psoriasis is chronic inflammatory skin disorder with a wide variety of clinical presentations. Presence of anti-gliadin antibody (AGA) has been reported in 16% of psoriatic patients. This study was designed to determine the frequency of the presence of AGA in psoriatic patients. ...
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Background and objective: Psoriasis is chronic inflammatory skin disorder with a wide variety of clinical presentations. Presence of anti-gliadin antibody (AGA) has been reported in 16% of psoriatic patients. This study was designed to determine the frequency of the presence of AGA in psoriatic patients. Materials and Methods: After recording the demographic data and the severity of disease according to PASI scoring system, serum of 10 psoriatic patients and 100 healthy controls were studied for the presence of AGA using indirect innumofluorescence method. Results: AGA was present in sera of 4 (3 males and one female) psoriatic patient while all controls were negative. Three patients were from 20 to 40 years of age. All four AGA positive patients suffered from plaque type psoriasis. The disease severity was mild in one, moderate in two, and severe in one patient. None of them suffered from gastrointestinal problems. Conclusion: Although AGA may be present in the serum of some psoriatic cases, a significant relation between skin lesion and hypersensivity to gluten has not been determined yet. More studies using more specific and sensitive assessment methods and larger sample sizes are suggested.
SZ Ghodsi; B Bahar; K Balighi; MR Ranj Kesh
Volume 8, Issue 3 , 2005, , Pages 232-236
Abstract
Chronic graft versus host disease (GVHD) remains the most common late complication of allogenic stem cell transplantation and the most frequent cause of morbidity and mortality in these patients. To control this condition, immunosuppressive drugs are usually administered at a high dose and for a long ...
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Chronic graft versus host disease (GVHD) remains the most common late complication of allogenic stem cell transplantation and the most frequent cause of morbidity and mortality in these patients. To control this condition, immunosuppressive drugs are usually administered at a high dose and for a long time, which may result in several side effects. 5 patients with clinically and histopathologically established cGVHD (3 lichenoid, 1 sclerodermoid and 1 mixed lichenoid-sclerodermoid), who failed to respond to conventional immunosuppressive therapy were treated with psoralen and UVA (PUVA). Treatment was administered in a standard protocol three times a week on non-consecutive days and were continued at least for 12 weeks. All 3 lichenoid cases showed complete improvement. In the sclerodermoid case there was partial response and in the mixed type case the partial response of sclerodermoid lesion and complete response of lichenoid lesions were observed. With the exception of a slight increase in liver transferases, no other adverse reactions occurred. In conclusion, PUVA can be a safe and effective therapy in conjunction with systemic agents for chronic GVHD especially in lichenoid form.
Z Halaji; K Balighi; E Abou Saeidi
Volume 8, Issue 2 , 2005, , Pages 101-103
Abstract
Background: Phototherapy is an important modality in dermatology and the number of skin diseases which can be controlled with it is increasing. In order to start treatment, the first dose of phototherapy is determined by measurement of minimal erythema dose (MED) in each patients individually or according ...
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Background: Phototherapy is an important modality in dermatology and the number of skin diseases which can be controlled with it is increasing. In order to start treatment, the first dose of phototherapy is determined by measurement of minimal erythema dose (MED) in each patients individually or according to patient’s skin type. Objective: To determine the relationship of skin type with MED in patients under UV phototherapy referred to Razi hospital in Tehran. Patients and Methods: In patients referred to Razi hospital in 1381 (2002-03) for UVB phototherapy, skin type was determined according to Fitzpatrick’s classification and MED was measured using a UV-meter. Age, sex and the disease of the patients were also recorded. The data were analyzed using one way ANOVA and Welch tests. Results: Eighty patients including 39 males and 41 females were studied. The mean age of the patients was 32 years (SD=15.8). Their diseases include psoriasis, vitiligo, parapsoriasis, pityriasis lichenoides chronica, perforating disorder and patch stage mycosis fungoides. The mean of MED in 17 patients with skin type II was 111.8±39.2, in 42 patients with skin type III was 105.9±43.1, and in 21 patients with skin type IV was 114.3±39.2 mJ/cm², with no significant statistical difference. Conclusion: The first dose of phototherapy could not be determined based on skin type and measurement of MED is necessary in each patient.
D Akbari; K Balighi
Volume 7, Issue 4 , 2004, , Pages 271-273
Abstract
Cutaneous larva migrans is a self-limited cutaneous eruption caused by larva of roundworms that do not normally parasitize humans. Ankylostoma brazielensis, the dog and cat hookworm, is the most common agent. The disease is found in tropical and subtropical regions and may be seen in travelers from these ...
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Cutaneous larva migrans is a self-limited cutaneous eruption caused by larva of roundworms that do not normally parasitize humans. Ankylostoma brazielensis, the dog and cat hookworm, is the most common agent. The disease is found in tropical and subtropical regions and may be seen in travelers from these regions. We report a case of a 37-year-old Iranian man who had cutaneous larva migrans after traveling to Mexico. The patient was successfully treated with oral thiabendazole.