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1. The relation between Thiopurine Methyl Transferase activity and efficacy and side effects of Azathioprine in patients with Pemphigus Vulgaris

Z Hallaji; Sh Shams Davatchi; M Vali Khani; N Ghandi; M Kar Bakhsh Davari; M Hedayati; AR Firooz

Volume 9, Issue 3 , 2006, , Pages 204-210

Abstract
  Background and aim: Azathioprine is the most widely used immunosuppressive agent as an adjunct to corticosteroids in the treatment of pemphigus vulgaris (PV). Thiopurine methyl transferase (TPMT) is a key enzyme in azathioprine metabolism and a genetic polymorphism controls its activity in human tissue. ...  Read More