Zahra Asadi-Kani; Soheila Nasiri; Parvaneh Vessal; Zohreh Tehranchinia; Majidreza Haghzare; Marjan Saeedi
Volume 15, Issue 1 , 2012, , Pages 4-6
Abstract
Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in ...
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Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in the benign melanocytic lesions. Method: Twenty-one patients, 11 with cutaneous melanoma and 10 with benign melanocytic lesions were enrolled in this study. Estrogen receptor beta expression in benign melanocytic lesions and melanoma was analyzed by using immunohistochemical staining. Result: All melanocytic lesions expressed estrogen receptor beta protein. We found lower estrogen receptor beta protein levels in melanoma. Conclusion: These initial observations, to be confirmed by further comprehensive studies, could suggest a role for estrogen receptor beta in melanoma, pointing at the possibility of using estrogen receptor beta expression for differentiating between malignant and benign lesions.
Soheila Nasiri; Marjan Saeedi
Volume 13, Issue 2 , 2010, , Pages 62-63
Abstract
A 40-year old woman was visited at our clinic with a history of palpable purpura appearing after alexandrite laser (Apogee 5500 Alex, 15mm spot shot, 755 nm wave length, 18 j/cm2 fluence) hair removal. The skin lesions were located bilaterally on the lower extremity (Figure1). Other physical examinations ...
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A 40-year old woman was visited at our clinic with a history of palpable purpura appearing after alexandrite laser (Apogee 5500 Alex, 15mm spot shot, 755 nm wave length, 18 j/cm2 fluence) hair removal. The skin lesions were located bilaterally on the lower extremity (Figure1). Other physical examinations were unremarkable. The patient had no history of taking medications, underlying systemic diseases and family history of collagen-vascular diseases. Blood biochemical analysis was normal and all the tests for collagenvascular diseases were negative. The patient declined skin biopsy. After six weeks of conservative therapy, the purpura faded. Laser-assisted hair removal has recently become popular. The number of lasers and light sources currently available for hair removal and their various treatment protocols has created much confusion; but, the fact is that all photoepilation systems target follicular melanin. Therefore, all hair removal devices provide a significant opportunity for epidermal and dermal injury during the epilation process 1. Alexandrite laser system can produce a number of side effects including transient erythema, perifollicular edema, treatment pain, hyperpigmentation, hypopigmentation and crusting 2,3. Other rare side effects of this laser are folliculitis, erosions and purpura 1. The extent of these complications is determined by skin type, seasonal variations, and patient's history of recent sun exposure. Complication rates also vary according to the anatomic location treated. The extremities are most commonly affected. Blistering, fine epidermal crusting, hypopigmentation and purpura are experienced more commonly in darker skin tones (phototypes III and higher) or in tanned skin 1. The prominent point of our report was the appearance of purpura in a patient with skin phototype II and in a sun protected area. This report indicates that it is essential for the laser operator to be well educated upon the potential risks of photoepilation and to have a thorough understanding of laser-tissue interaction before embarking upon the laser-assisted hair removal process.
Zahra Asadi-Kani; Hamideh Moravvej; Mehdi Gaisari; Sima Kavand; Marjan Saeedi
Volume 12, Suppl.3 , 2009, , Pages 27-29
Abstract
Lipomembranous panniculitis is a special type of fat necrosis which has been associated with several clinical conditions, mainly chronic venous insufficiency and connective tissue disorders such as lupus profundus, morphea, systemic sclerosis, and dermatomyositis .We report a 50 yearold woman with known ...
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Lipomembranous panniculitis is a special type of fat necrosis which has been associated with several clinical conditions, mainly chronic venous insufficiency and connective tissue disorders such as lupus profundus, morphea, systemic sclerosis, and dermatomyositis .We report a 50 yearold woman with known rheumatoid arthritis who presented with a painful indurated erythematous plaque on her right leg. Histologic examination demonstrated cystic areas of fat necrosis lined by wavy eosinophilic hyaline membrane with convoluted projections of the membrane into the cysts. This finding is diagnostic of lipomembranous panniculitis. To our knowledge, this is the first report on lipomembranous panniculitis associated with rheumatoid arthritis.
Soheila Nassiri; Farhad Malekzad; Mojdeh Sarlak; Marjan Saeedi; Mehdi Hedayati; Mehdi Qaisari
Volume 12, Issue 2 , 2009, , Pages 56-59
Abstract
Background: The etiology of psoriasis, a chronic inflammatory skin disease, has not been elucidated. However, Oxidant / antioxidant imbalance is suspected.The aim of this study was to evaluate oxidant / antioxidant status in psoriatic patients.Method: forty two psoriatic patients and 42 age and sex matched ...
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Background: The etiology of psoriasis, a chronic inflammatory skin disease, has not been elucidated. However, Oxidant / antioxidant imbalance is suspected.The aim of this study was to evaluate oxidant / antioxidant status in psoriatic patients.Method: forty two psoriatic patients and 42 age and sex matched controls were recruited for this study. Serum total antioxidant capacity (TAC), oxidized light density lipoprotein (Ox-LDL) and malondialdehyde (MDA) levels were determined.Results: A statistically significant increase in the serum level of MDA was found between patients and controls. No significant difference was found in the serum levels of other parameters in the two groups.Conclusion: Our results supported the hypothesis of an imbalance between oxidants and antioxidants in psoriasis and pointed to the probability of an increased risk of cardiovascular diseases in psoriatic patients.
Reza Mahmoud Robati; Marjan Saeedi; Nima Sarrafi-rad
Volume 12, Issue 2 , 2009, , Pages 64-66
Abstract
Hydroa vacciniforme (HV) is a rare acquired photodermatosis, usually with onset in childhood and characterized by vesicles, crust and scar formation that follow exposure to sunlight.Vacciniform scars of face and dorsa of the hands are common features but oral ulcer and eye signs also rarely occur. It ...
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Hydroa vacciniforme (HV) is a rare acquired photodermatosis, usually with onset in childhood and characterized by vesicles, crust and scar formation that follow exposure to sunlight.Vacciniform scars of face and dorsa of the hands are common features but oral ulcer and eye signs also rarely occur. It usually resolves before adult age. A rare manifestation of the disease would be persistence until adult age which is presented in this report.
Soheila Nassiri; Marjan Saeedi; Sima Kavand; Nastaran Namazy; Afsaneh Maarefat
Volume 12, Issue 2 , 2009, , Pages 71-72
Abstract
A 64-year-old Iranian woman presented with a genital erosive skin lesion that she had noticed from two years ago. On physical examination, a 20 to 25 millimeter purplish lesion was observed on the vulval skin (Figure 1). The indurated lesion showed a small central erosion measuring 3 to 5 mm. Inguinal ...
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A 64-year-old Iranian woman presented with a genital erosive skin lesion that she had noticed from two years ago. On physical examination, a 20 to 25 millimeter purplish lesion was observed on the vulval skin (Figure 1). The indurated lesion showed a small central erosion measuring 3 to 5 mm. Inguinal lymph nodules were not palpable. A skin biopsy specimen was obtained from the eroded lesion (Figure 2).
Mohammad Shahidi–Dadras; Parviz Toossi; Nima Sarrafi–Rad; Reza Mahmoud Robati; Marjan Saeedi; Sima Kavand
Volume 12, Issue 1 , 2009, , Pages 1-3
Abstract
Background: The aggravating role of Staphylococcus aureus is well known in atopic dermatitis but has not yet been proven in psoriasis. The role of Staphylococcus aureus superantigens is emphasized in the initiation, maintenance and complications of psoriasis. We investigated the frequency of nasal, axillary, ...
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Background: The aggravating role of Staphylococcus aureus is well known in atopic dermatitis but has not yet been proven in psoriasis. The role of Staphylococcus aureus superantigens is emphasized in the initiation, maintenance and complications of psoriasis. We investigated the frequency of nasal, axillary, and perineal carriage of Staphylococcus aureus (SA) in patients with psoriasis and its possible influence on the severity of the disease. Methods: one hundred patients with the clinical diagnosis of psoriasis participated in the study. Cultures of the bacterial flora were obtained from the right and left axilla and nasal nares and perineum, inoculated on standard bacterial medium (blood agar), and incubated at 37°C degrees for 48 h. Results: one hundred patients with the clinical diagnosis of psoriasis (42% female and 58% male) comprised the study group. Mean age of the patients was 41.1±17.1 years. About 42 % of the patients carried S. aureus; of these, 32 % were from the nose, 13 % from axilla, and 11% from the perineum. Three patients were carriers in all 3 sites. There was no significant difference in the severity of the disease between the carriers and non-carriers measured by the psoriasis area and severity index (PASI) score. Conclusions: According to our findings, S.aureus carriage in psoriasis had no significant influence on disease severity. It might be relevant for a subgroup of patients only when superantigen productions are found.
Reza Mahmoud Robati; Mohammad Rahmati–Roodsari; Marjan Saeedi; Afsaneh Maarefat
Volume 12, Issue 1 , 2009, , Pages 33-34
Abstract
A 43-year-old middle-eastern woman was visited with a 15-year history of multiple painful cutaneous nodules on her back. The first lesion appeared on her back when she was 28 years old. As she aged, the lesions became larger, more numerous, and more painful with cold or physical contact. Her medical ...
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A 43-year-old middle-eastern woman was visited with a 15-year history of multiple painful cutaneous nodules on her back. The first lesion appeared on her back when she was 28 years old. As she aged, the lesions became larger, more numerous, and more painful with cold or physical contact. Her medical history was not significant. The patient’s medications included naproxen, calcium-D, and vitamins. Her family history was notable as her brother had developed similar cutaneous lesions. Physical examination revealed more than 30 pinkish papules, measuring up to 1 cm in diameter, in a grouped arrangement on her back (Figure 1). The complete blood cell count, serum chemistry profile, and serum erythropoietin levels were within normal limits. Abdominal ultrasonography was normal. A skin biopsy specimen was obtained from a nodule on her back (Figure 2).