Azadeh Goodarzi; Elham Behrangi; Mohammadreza Ghassemi; Golnaz Mehran; Niloofar Teymoori; Amir Pouyan Ghahremani; Maryam Biglari Abhari
Abstract
Background: Acne vulgaris is among common bothersome skin problems. Recognition of contributing factors would help to prevent acne. Some dietary and inflammatory factors are among suggested etiologies. Accordingly, in this study, the serum levels of calcium, vitamin D, phosphorous ...
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Background: Acne vulgaris is among common bothersome skin problems. Recognition of contributing factors would help to prevent acne. Some dietary and inflammatory factors are among suggested etiologies. Accordingly, in this study, the serum levels of calcium, vitamin D, phosphorous and C-reactive protein (CRP) were determined and compared in acne patients and healthy subjects. Methods: In this case-control study, 144 consecutive subjects with and without acne (moderate-very severe) referred to Rasoul Akram Hospital in 2016 were enrolled. In this regard, the serumcalcium, phosphorous, CRP, vitamin D were determined in the subjects and compared between the groups. Results: The results indicated that serum CRP, calcium, and phosphorous level were alike between the groups (P > 0.05) without any relation to acne severity except CRP. The serum vitamin D level was significantly different (P = 0.0001), but it was not associated with acne severity. Serum calcium levels of males were significantly higher in both groups. Conclusions: Based on our results, it may be concluded that calcium, phosphorous, and CRP levels are not associated with acne incidence, but the serum vitamin D is related to acne presentation. CRP levels were positively associated with acne vulgaris severity.
Golnaz Mehran; Saba Sepasgozar; Masoomeh Rohaninasab; Azadeh Goodarzi; Mohammadreza Ghassemi; Mahrokh Fotooei; Elham Behrangi
Abstract
Background: Microneedling has been shown to be a clinically effective and safe treatment for comedonal acne vulgaris. The aim of the present study was to compare the clinical effectof microneedling and the most commonly used topical drug, tretinoin, in the treatment of comedonal acne.Methods: ...
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Background: Microneedling has been shown to be a clinically effective and safe treatment for comedonal acne vulgaris. The aim of the present study was to compare the clinical effectof microneedling and the most commonly used topical drug, tretinoin, in the treatment of comedonal acne.Methods: Patients with comedonal acne (n = 82) were randomized to receive topical tretinoin (n = 41) or 6 sessions of microneedling (n = 41) over a period of 3 months. Objective assessments suchas changes in acne severity score by global acne grading system (GAGS) and patients’ subjective satisfaction were investigated at the baseline, at the end of the treatment period, and at the3-month follow up.Results: GAGS was significantly reduced in both microneedling (7.8±3.8 to 3.5±2.6) and tretinoin (8±3.8 to 6.6±3.2) groups at the end of the treatment course compared with the baseline. Theoverall acne severity index reduction in microneedling group was significantly higher than that of the tretinoin group (P<0.001). Improvement in acne severity was also more permanent bymicroneedling. The severity of acne in tretinoin recipients was increased to 8.2±3.2 at the follow-up visit, while it remained nearly unchanged in the microneedling group. (3.3±2.4). Patients’subjective assessment concerning acne improvement was significantly more satisfactory in microneedling group (P<0.001).
Conclusion: Compared with tretinoin, microneedling seems to be a more effective, permanent and satisfactory treatment in the treatment of comedonal acne.