Azadeh Goodarzi; Mahsa Farshidzadeh; Elham Behrangi; Mohammadreza Ghassemi; Masoumeh Roohaninasab
Abstract
Viral skin diseases range from simple superficial exanthems to complex systemic diseases, affecting people of all ages. Careful assessment of infectious contacts and immunization status is of considerable importance along with a thorough physical examination. Recent research has linked a deficiency of ...
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Viral skin diseases range from simple superficial exanthems to complex systemic diseases, affecting people of all ages. Careful assessment of infectious contacts and immunization status is of considerable importance along with a thorough physical examination. Recent research has linked a deficiency of vitamin D to an increased risk of autoimmune, infectious, and atopic disorders. Intralesional vitamin D3 may be an effective treatment option for warts. Vitamin D3 derivatives are effective for various skin conditions, including psoriasis, transient acantholytic dermatosis, actinic porokeratosis, and keratosis palmaris et plantaris. Vitamin D3 treatment has been shown to decrease chemokine synthesis and monocyte trafficking, as well as to downregulate toll-like receptors (TLRs) 2 and 4 of monocytes. This suggests an association between TLRs and vitamin-D-mediated innate immunity. The effect of vitamin D derivatives was speculated to be derived from its potential to regulate epidermal cell proliferation and differentiation and to modulate cytokine production. According to some studies gathered here, not only we can use different forms of vitamin D as therapy for viral skin disease, but also there is an important relationship between them. Therefore, we should consider the serum level of vitamin D for better management of these disorders. Also, keeping vitamin D levels within the normal range may be a preventative healthcare strategy.
Mohammadreza Ghassemi; Abbas Zamanian; Gholamhossein Ghaffarpour; Nasrin Shayanfar; Shiva Ghods; Azadeh Goodarzi
Abstract
Heterotopic ossification is the formation of bone tissue at an abnormal site. The ossification of soft tissue outside the skeletal system can occur anywhere and can be found in mucosal tissues. This is the first case report of an osteoma mucosalis affecting the nail bed. We also reviewed the heterotopic ...
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Heterotopic ossification is the formation of bone tissue at an abnormal site. The ossification of soft tissue outside the skeletal system can occur anywhere and can be found in mucosal tissues. This is the first case report of an osteoma mucosalis affecting the nail bed. We also reviewed the heterotopic ossification and calcification of cutaneous and mucosal sites in the PubMed, Scopus, and Google Scholar databases.
Azadeh Goodarzi; Elham Behrangi; Mohammadreza Ghassemi; Golnaz Mehran; Niloofar Teymoori; Amir Pouyan Ghahremani; Maryam Biglari Abhari
Abstract
Background: Acne vulgaris is among common bothersome skin problems. Recognition of contributing factors would help to prevent acne. Some dietary and inflammatory factors are among suggested etiologies. Accordingly, in this study, the serum levels of calcium, vitamin D, phosphorous ...
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Background: Acne vulgaris is among common bothersome skin problems. Recognition of contributing factors would help to prevent acne. Some dietary and inflammatory factors are among suggested etiologies. Accordingly, in this study, the serum levels of calcium, vitamin D, phosphorous and C-reactive protein (CRP) were determined and compared in acne patients and healthy subjects. Methods: In this case-control study, 144 consecutive subjects with and without acne (moderate-very severe) referred to Rasoul Akram Hospital in 2016 were enrolled. In this regard, the serumcalcium, phosphorous, CRP, vitamin D were determined in the subjects and compared between the groups. Results: The results indicated that serum CRP, calcium, and phosphorous level were alike between the groups (P > 0.05) without any relation to acne severity except CRP. The serum vitamin D level was significantly different (P = 0.0001), but it was not associated with acne severity. Serum calcium levels of males were significantly higher in both groups. Conclusions: Based on our results, it may be concluded that calcium, phosphorous, and CRP levels are not associated with acne incidence, but the serum vitamin D is related to acne presentation. CRP levels were positively associated with acne vulgaris severity.
Azadeh Goodarzi; Masoumeh Roohaninasab; Najmol Sadat Atefi; Afsaneh Sadeghzadeh Bazargan; Mohammadreza Ghassemi; Amir Pouyan Ghahremani; Niloofar Teymoori; Maryam Biglari Abhari
Abstract
Background: Acne vulgaris is a dermatologic disorder with a wide variety of distribution and presentation. Its high prevalence and important cosmetic and psychological concerns focusing on contributing factors would be of great value for better approach and prevention of acne vulgaris. ...
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Background: Acne vulgaris is a dermatologic disorder with a wide variety of distribution and presentation. Its high prevalence and important cosmetic and psychological concerns focusing on contributing factors would be of great value for better approach and prevention of acne vulgaris. There are many articles that argue the role of some dietary and inflammatory factors in acnevulgaris. In this study, the serum levels of zinc in acne patients were determined and compared with healthy subjects. Methods: In this age and gender matched case-control study, 200 consecutive subjects with and without acne (moderate-very severe) referring to Rasoul Akram Hospital, 2016, were enrolled,and their serum zinc levels were determined and compared across the groups. Results: Serum zinc levels were alike across the groups (P > 0.05), and the severity of acne was not related to zinc level. The levels of zinc were significantly different between genders in the casegroup (men had lower levels). In female patients with acne, the level of zinc was inversely correlated with acne severity. Conclusion: Zinc is not related to acne incidence or its grade, but men with acne have lower levels of zinc compared with women. Also, acne severity in women is inversely correlated with zinc level. It can be assumed that zinc supplementation may be a good trend in men with acne or alleviate the severity of acne in women, which needs more evaluation and work up.
Azadeh Goodarzi; Masoumeh Roohaninasab; Elham Behrangi; Mohammadreza Ghassemi; Amir Pouyan Ghahremani; Niloofar Teymoori
Abstract
Skin as an outer layer of body and a main connection between the body and the environment is a way that pathogens can access the body; Therefore, it has a crucial protecting role for the body because of obstacle functioning and micobiota. Factors that seem to commonly contribute to ...
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Skin as an outer layer of body and a main connection between the body and the environment is a way that pathogens can access the body; Therefore, it has a crucial protecting role for the body because of obstacle functioning and micobiota. Factors that seem to commonly contribute to the disease are follicular hyperkeratinization, propionibacterium acnes, sebum production, and inflammation; however, pathogenesis of acne vulgaris as an inflammatory skin disorder is still poorly understood. Google Scholar and PubMed databases were searched for all related articles, using the key words of zinc, diet, vitamin D, BMI, and acne vulgaris.
Golnaz Mehran; Saba Sepasgozar; Masoomeh Rohaninasab; Azadeh Goodarzi; Mohammadreza Ghassemi; Mahrokh Fotooei; Elham Behrangi
Abstract
Background: Microneedling has been shown to be a clinically effective and safe treatment for comedonal acne vulgaris. The aim of the present study was to compare the clinical effectof microneedling and the most commonly used topical drug, tretinoin, in the treatment of comedonal acne.Methods: ...
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Background: Microneedling has been shown to be a clinically effective and safe treatment for comedonal acne vulgaris. The aim of the present study was to compare the clinical effectof microneedling and the most commonly used topical drug, tretinoin, in the treatment of comedonal acne.Methods: Patients with comedonal acne (n = 82) were randomized to receive topical tretinoin (n = 41) or 6 sessions of microneedling (n = 41) over a period of 3 months. Objective assessments suchas changes in acne severity score by global acne grading system (GAGS) and patients’ subjective satisfaction were investigated at the baseline, at the end of the treatment period, and at the3-month follow up.Results: GAGS was significantly reduced in both microneedling (7.8±3.8 to 3.5±2.6) and tretinoin (8±3.8 to 6.6±3.2) groups at the end of the treatment course compared with the baseline. Theoverall acne severity index reduction in microneedling group was significantly higher than that of the tretinoin group (P<0.001). Improvement in acne severity was also more permanent bymicroneedling. The severity of acne in tretinoin recipients was increased to 8.2±3.2 at the follow-up visit, while it remained nearly unchanged in the microneedling group. (3.3±2.4). Patients’subjective assessment concerning acne improvement was significantly more satisfactory in microneedling group (P<0.001).
Conclusion: Compared with tretinoin, microneedling seems to be a more effective, permanent and satisfactory treatment in the treatment of comedonal acne.