Maryam Akhiani; Hasan Seyrafi; Farshad Farnaghi; Parastoo Banan; Vahideh Lajvardi
Volume 11, Issue 3 , 2008, , Pages 103-107
Abstract
Background: Topical immunotherapy with diphencyprone (DPCP) for the treatment of severe alopecia areata has been used since 1983 and is felt to be the treatment of choice for chronic extensive alopecia areata. Highly variable results have been reported. The purposes of this study were to evaluate the ...
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Background: Topical immunotherapy with diphencyprone (DPCP) for the treatment of severe alopecia areata has been used since 1983 and is felt to be the treatment of choice for chronic extensive alopecia areata. Highly variable results have been reported. The purposes of this study were to evaluate the efficacy of DPCP in the treatment of chronic, extensive alopecia areata and to assess the long-term overall benefit of treatment.Methods: In a retrospective study, 54 patients with chronic extensive alopecia areata who had used DPCP for more than 1.5 years between 2001 and 2005 were studied. Patients' information and results of treatment after every session were collected from record files.Results: The response to treatment was excellent (76-100% terminal hair re-growth) in 40.7%, good (51-75% terminal hair re-growth) in 14.8%, moderate (26-50% terminal hair re-growth) in 14.8%, and mild (1-25% terminal hair re-growth) in 29.6% of patients. However, 33% of them had a relapse. The response to treatment was excellent and good in 62% of the patients with less than 10 years duration of alopecia areata, but in the group with the duration of more than 10 years, a good and/or excellent response was found in 25% of patients and 75% had a poor and/or moderate response (P=0.017). There was no relationship between response to treatment and sex, onset of disease, nail involvement, atopy, extent of hair loss, and family history of alopecia areata.Conclusion: Topical immunotherapy with DPCP has proved to be an effective treatment with prolonged therapeutic results in Iranian population. Duration of disease less than 10 years is a main predictor for a good response rate.
Maryam Akhiani; Vahideh Lajevardi; Fatemeh Moeineddin; Kambiz Kamyab
Volume 11, Issue 3 , 2008, , Pages 126-128
Abstract
Porokeratosis (PK) is an uncommon disorder of epidermal keratinization characterized by annular plaques with an atrophic center surrounded by a raised, keratotic wall, with unknown aetiology and an unpredictable outcome. It has several clinical forms including porokeratosis of Mibelli, giant porokeratosis, ...
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Porokeratosis (PK) is an uncommon disorder of epidermal keratinization characterized by annular plaques with an atrophic center surrounded by a raised, keratotic wall, with unknown aetiology and an unpredictable outcome. It has several clinical forms including porokeratosis of Mibelli, giant porokeratosis, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis and punctate porokeratosis.Genital porokeratosis is a rare and probably underestimated subset of PK that mostly affects middle-aged men. Although there are many clinical variants, coexistence of different variants of porokeratosis in a single patient has been regarded as a rare occurrence. Here we report a rare variant of porokeratosis , genital or ptychotropica porokeratosis, accompanied by superficial actinic porokeratosis in a patient and his family members.
Maryam Akhiani; Katrin Kiavash; Kambiz Kamyab; Hasan Seirafi
Volume 10, Issue 4 , 2007, , Pages 353-354
Abstract
Netherton syndrome is a rare autosomal recessive condition with variable expression. It comprises an ichthyosiform dermatitis and erythroderma of variable intensity associated with hair abnormalities and features of atopy. The pathognomic (required for diagnosis) feature is trichorrhexis invaginata identified ...
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Netherton syndrome is a rare autosomal recessive condition with variable expression. It comprises an ichthyosiform dermatitis and erythroderma of variable intensity associated with hair abnormalities and features of atopy. The pathognomic (required for diagnosis) feature is trichorrhexis invaginata identified by microscopic examination of hair shaft. Ichthyosis linearis circumflexa is another typical lesion that may not always be observed. It comprises an episodic migrating erythematous and scaling annular and polycyclic flat patch with an advancing double edge of peeling scale. Here we present two cases of Netherton syndrome with characteristic manifestations mentioned above.
