Zahra Asadi-Kani; Soheila Nasiri; Parvaneh Vessal; Zohreh Tehranchinia; Majidreza Haghzare; Marjan Saeedi
Volume 15, Issue 1 , 2012, , Pages 4-6
Abstract
Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in ...
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Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in the benign melanocytic lesions. Method: Twenty-one patients, 11 with cutaneous melanoma and 10 with benign melanocytic lesions were enrolled in this study. Estrogen receptor beta expression in benign melanocytic lesions and melanoma was analyzed by using immunohistochemical staining. Result: All melanocytic lesions expressed estrogen receptor beta protein. We found lower estrogen receptor beta protein levels in melanoma. Conclusion: These initial observations, to be confirmed by further comprehensive studies, could suggest a role for estrogen receptor beta in melanoma, pointing at the possibility of using estrogen receptor beta expression for differentiating between malignant and benign lesions.
Zohreh Tehranchinia; Hoda Rahimi; Mansour Moradloo
Volume 13, Issue 3 , 2010, , Pages 82-86
Abstract
Background: Benign pigmented lesions, including freckles, are common and various treatment modalities including lasers and peeling have been evaluated for their effectiveness in their treatment.Objective: To compare the clinical effects of focal peeling with Trichloroacetic Acid (TCA) and Nd:YAG (532 ...
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Background: Benign pigmented lesions, including freckles, are common and various treatment modalities including lasers and peeling have been evaluated for their effectiveness in their treatment.Objective: To compare the clinical effects of focal peeling with Trichloroacetic Acid (TCA) and Nd:YAG (532 nm) laser on freckles.Methods: Twenty patients with freckles were treated with focal peeling with TCA 25% on their left-sided lesions and Nd:YAG (532 nm, Fluence 9.5 J/cm2, spot size 1.5 mm) on their right-sided lesions. Photographs were taken prior to treatment and at follow-up visits and were evaluated by three dermatologists and the results were analyzed.Results: Eighteen out of the 20 patients (90%) with freckles manifested more than 50% improvement in laser treated areas whereas clinical improvement in focal peeling treated areas was observed in 15 out of 20 (75%). The mean improvement rate for laser and focal peeling was 66.50±12% and 58.3±15%, respectively. No significant difference was observed in the treatment results between these modalities.Conclusion: Focal peeling with TCA 25% could be as effective as frequency-doubled Nd:YAG (532 nm) laser in the treatment of freckles.