Original Article
Pezeshkpoor Fakhrozaman; Tohidi Mohammad; Layegh Pouran; Shahabi Majid
Volume 16, Issue 2 , 2013, Pages 45-48
Abstract
Background: Accurate diagnosis of cutaneous leishmaniasis wouldavoid unnecessary treatment and scar formation. Direct smear isthe most common method for the diagnosis of this disease but itsnegative result could not rule out the infection; so, the need formore sensitive methods is obvious. We conducted ...
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Background: Accurate diagnosis of cutaneous leishmaniasis wouldavoid unnecessary treatment and scar formation. Direct smear isthe most common method for the diagnosis of this disease but itsnegative result could not rule out the infection; so, the need formore sensitive methods is obvious. We conducted this study tocompare the efficiency of direct skin smear with smears preparedby fine needle aspiration (FNA) using polymerase chain reaction(PCR) as a reference method.Methods: In this cross-sectional study, which was conductedduring two years from May 2008 to May 2010, 33 patients withsuspicious acute cutaneous leishmaniasis based on clinical studieswere randomly selected. Direct skin smears and FNA smearswere taken from each patient and PCR was performed on biops
Original Article
Radmanesh Mohammad; Azar-Beig Mohsen
Volume 16, Issue 2 , 2013, Pages 49-52
Abstract
Background: The cold-induced inflammation of cryotherapy mayalter the immunologic processes and structural components ofthe hair follicles responsible for AA. The aim of this study was tostudy the efficacy of cryotherapy in alopecia areata, and totalis.Method: Forty-four patients with recalcitrant scalp ...
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Background: The cold-induced inflammation of cryotherapy mayalter the immunologic processes and structural components ofthe hair follicles responsible for AA. The aim of this study was tostudy the efficacy of cryotherapy in alopecia areata, and totalis.Method: Forty-four patients with recalcitrant scalp alopeciaareata or totalis were treated with cryotherapy. The cryo-systemchosen was a closed contact CO2 system with metallic probes.The patients were evaluated for 4-8 weeks for hair growth.Satisfactory hair growth after 8 weeks was an indication forperforming cryotherapy for the remaining untreated areas.Result: Varying degrees of hair growth were detected in 52.50%of the patients four weeks and in 65.90 % eight weeks aftertreatment. About 38.64% of the patients showed more than 50%hair regrowth 8 weeks after therapy.Conclusion: Cryotherapy is effective for about two-thirds of thepatients with alopecia areata, many of whom are unresponsiveto conventional therapies.
Original Article
Mahnaz Banihashemi; Masoud Maleki; Fakhrozaman Pezeshkpoor; Amir Hossein Jafarian; Mohammad Reza Sharghi; Sara Hashemzadeh
Volume 16, Issue 2 , 2013, Pages 53-56
Abstract
Background: Pemphigus is a group of autoimmune blistering skin diseases that is related to auto antibodies against desmoglein 1 and 3. Many reports have shown that HSV1, HSV2, VZV, EBV, CMV, HHV8, and HIV are triggering agents for the activation and exacerbation of pemphigus. In this ...
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Background: Pemphigus is a group of autoimmune blistering skin diseases that is related to auto antibodies against desmoglein 1 and 3. Many reports have shown that HSV1, HSV2, VZV, EBV, CMV, HHV8, and HIV are triggering agents for the activation and exacerbation of pemphigus. In this study, we decided to evaluate the frequency of HSV1, HSV2, HHV8, and EBV in paraffin-embedded specimens of the new cases of pemphigus patients using immunohistochemical methods.Method: Thirty patients with pemphigus whose diagnosis was proved with direct immunofluorescens studies (20 cases of pemphigus vulgaris and 10 cases of pemphigus foliaceus) and 10 specimens from the free margins of excised melanocytic nevi were collected. Immunohistochemical staining was performed for HSV1 and EBV (using Novo Castra kit) and for HSV2 and HHV8 (using Dako kit).Result: The results showed a significance difference in the frequency of positive staining for HSV1 in skin lesions of pemphigus vulgaris, foliaceus, and controls (P= 0.041), foliaceus group more positive staining than vulgaris group and both more than controls, but not for HSV2, EBV, and HHV8 markers. Positive staining for HHV8 occurred in 30% of PF patients and 15% of PV patientsbut P value was not significant (0.171).Conclusion: Like previous studies, our research also indicated significant prevalence of HSV1 in lesions of pemphigus patients, especially in pemphigus foliaceus. We collected new cases ofpemphigus before starting immunosuppressive therapy, so we think that the presence of HSV1 in skin lesions of patients can act as a triggering factor for the disease which could not be attributed to the suppressive therapy.
Original Article
Nahidi Yalda; Meibodi Naser Tayyebi; Layegh Pouran; Esmaeeli Habiballah; Hosseini Fatemeh Sadat
Volume 16, Issue 2 , 2013, Pages 57-63
Abstract
Background: Melasma is a common acquired hyperpigmentationdisorder often appearing on the face of young women. Melasmais classified into four groups based on Wood’s lamp examination:epidermal, dermal, mixed, and indeterminate. The goal of this studywas to evaluate the relationship between clinicoepidemiologicalcharacteristics ...
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Background: Melasma is a common acquired hyperpigmentationdisorder often appearing on the face of young women. Melasmais classified into four groups based on Wood’s lamp examination:epidermal, dermal, mixed, and indeterminate. The goal of this studywas to evaluate the relationship between clinicoepidemiologicalcharacteristics of melasma and the level of involvement underWood’s lamp examination.Method: In a cross sectional study, 50 melasma patients whowere visited at the dermatology clinic of Imam Reza Hospitalfrom March 2010 to September 2011 were studied. The levelof melasma involvement in all patients was determined usinga Wood’s lamp, and the patients’ information such as age,occupation, location of melasma, marital status, pregnancy, oralcontraceptive pill consumption and Fitzpatrick skin type wascollected in a questionnaire.Result: In single patients, dermal involvement and in marriedpatients, epidermal involvement was more common. Involvementwas more frequently dermal in jobs with exposure to sun andmore epidermal in indoor jobs. In the malar region, epidermalinvolvement was more common. In patients with a history ofpregnancy, epidermal involvement was more prevalent as well,while in the participants without a history of pregnancy, dermalinvolvement was more frequent. In the pregnant patients withmelasma, epidermal involvement was more frequent. In patientswithout a family history of melasma, epidermal involvement wasmore frequently observed than the other two levels of involvement.Conclusion: Based on the findings of this study, melasma in caseswith the involvement of the malar region, starting in pregnancy,in patients without a family history of melasma, and in theindividuals who have indoor occupations is most likely to beepidermal and may have a better response to treatment. On theother hand, melasma in single persons and in those who haveoutdoor occupations and are exposed to sun light is mostly dermalwith a worse response to treatment according to previous studies.
Original Article
Maleki Masoud; Farhat Ahmad-Shah; Nahidi Yalda; Herizadeh Nafiseh-Sadat; Ahrani Saeedeh
Volume 16, Issue 2 , 2013, Pages 64-68
Abstract
Background: Birthmarks are common reasons for parents’ concern.Some of them may need further investigation to find out theunderlying systemic disorders or their potential for malignanttransformation. The purpose of this study was to determine thefrequency of vascular and pigmented birthmarks in ...
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Background: Birthmarks are common reasons for parents’ concern.Some of them may need further investigation to find out theunderlying systemic disorders or their potential for malignanttransformation. The purpose of this study was to determine thefrequency of vascular and pigmented birthmarks in infants fromthe Northeast of Iran.Method: This descriptive study was conducted on 1000 healthyinfants born in a University Hospital in the Northeast of Iran from2003 to 2005. The cutaneous lesions of neonates were examinedby a dermatologist.Result: The salmon patch was reported as the most commonbirthmark (233 cases). The most common site of involvementwas the eyelid. A case of congenital hemangioma and a case ofthe port-wine stain were also observed both in the fifth n
Shahidi-Dadras Mohammad; Hashemi Reza; Saeidpour Mehdi; Khademi Faeze
Volume 16, Issue 2 , 2013, Pages 69-24
Abstract
Reactive perforating collagenosis is one of the perforatingdermatoses; the acquired form is characterized by transepithelialelimination of altered collagen bundles. It has been seen inassociation with multiple disorders including diabetes mellitus,renal failure, hyperparathyroidism, liver disease, neurodermatitis,IgA ...
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Reactive perforating collagenosis is one of the perforatingdermatoses; the acquired form is characterized by transepithelialelimination of altered collagen bundles. It has been seen inassociation with multiple disorders including diabetes mellitus,renal failure, hyperparathyroidism, liver disease, neurodermatitis,IgA nephropathy, and periampullary carcinoma with jaundice.According to the literature, there is no report of reactiveperforating collagenosis in association with pulmonary papillaryadenocarcinoma, and our study is the first to report it.
Layegh Pouran; Abadian Mohammad; Zabolinejhad Naghmeh; Momenzadeh Akram; Mousavi Seyed Reza; layegh Parvin
Volume 16, Issue 2 , 2013, Pages 73-76
Abstract
Autoimmune polyendocrine syndromes are a heterogeneousgroup of rare diseases characterized by autoimmune activityagainst more than one endocrine organ, although non-endocrineorgans can also be affected. We report the association of APS Iwith erythema annulare centrifugum in an 18-years-old male whopresented ...
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Autoimmune polyendocrine syndromes are a heterogeneousgroup of rare diseases characterized by autoimmune activityagainst more than one endocrine organ, although non-endocrineorgans can also be affected. We report the association of APS Iwith erythema annulare centrifugum in an 18-years-old male whopresented with multiple figurate erythema spreading on his trunkand extremities along with a history of multiple endocrine disorderssuch as diabetes mellitus, hypothyroidism, hypoparathyroidism,hypogonadism, and adrenal insufficiency from one year ago. Toour knowledge this is a very rare association.
Dadrass Mohammad Shahidi-; Mozafari Nikoo; Abdollahimajd Fahimeh; Asadi-Kani Zahra
Volume 16, Issue 2 , 2013, Pages 77-79
Abstract
A 61-year-old man was referred to our dermatology departmentfor the evaluation of a single asymptomatic plaque on hisleft lower back that has been present for one year. The lesionbegan as an erythematous scaly plaque that
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A 61-year-old man was referred to our dermatology departmentfor the evaluation of a single asymptomatic plaque on hisleft lower back that has been present for one year. The lesionbegan as an erythematous scaly plaque that
Jowkar Farideh; Saki Nasrin; Shanehsaz Siavash Mohammadzadeh; Kardeh Sina; Bittar Roshan
Volume 16, Issue 2 , 2013, Pages 26-82
Abstract
A 12 years old boy, diagnosed with psoriasis since childhoodwas referred to the dermatology clinic of Aleppo UniversityHospital,Syria with the chief complaint of erythematoushyperkeratotic lesions on the palms and soles.
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A 12 years old boy, diagnosed with psoriasis since childhoodwas referred to the dermatology clinic of Aleppo UniversityHospital,Syria with the chief complaint of erythematoushyperkeratotic lesions on the palms and soles.