Original Article
Nahidi Yalda; Layegh Pouran; Naser Tayyebi Meibodi; Vida Vakili; Golsan Kardan
Abstract
Background: Vitiligo is a pigmentation disorder of the skin characterized by the loss of melanocytes through different mechanisms. Narrow band UVB (NBUVB) is a safe and effective treatment for vitiligo that acts by inducing the synthesis of cytokines involved in melanogenesis. NBUVB appears to be involved ...
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Background: Vitiligo is a pigmentation disorder of the skin characterized by the loss of melanocytes through different mechanisms. Narrow band UVB (NBUVB) is a safe and effective treatment for vitiligo that acts by inducing the synthesis of cytokines involved in melanogenesis. NBUVB appears to be involved in the treatment of vitiligo by increasing the synthesis of vitamin D, which prevents the apoptosis of melanocytes; accordingly, we set out to compare the serum level of vitamin D and its variations following NBUVB treatment according to the degree of response to treatment.
Methods: Thirty-eight patients with vitiligo were subject to phototherapy with NBUVB. Photographs of vitiligo lesions were taken prior to and after completing 60 phototherapy sessions. Further measured were the serum level of 25-hydroxyvitamin D3, VASI score and repigmentation rate before and after the treatment period. Finally, the relationship between the changes in serum vit D3 levels and variations of VASI score was investigated.
Results: Mean serum level of vitamin D3 was 20.78 ng/ml after treatment, which is significantly more compared to the period before the treatment (15.42, P=0.001). Mean VASI score was 5.45 before the treatment, yet was reduced to 2.24 after treatment, which is a significant change (P<0.001); however, the changes in vitamin D3 levels were not significantly correlated with VASI score (P=0.137).
Conclusion: The repigmentation rate in vitiligo lesions are not significantly correlated with serum vitamin D3 levels. Therefore, NBUVB is not likely to improve vitiligo lesions through the increase in serum vitamin D levels.
Original Article
Hajheydari Zohreh; Saeedi Majid; Hosseinzadeh Mohammad
Abstract
Background: Seborrheic dermatitis is a common chronic relapsing inflammatory skin disease with unknown etiology. Using zinc and selenium supplements have shown some relieving effects on the symptoms of the disease. The present study was conducted to determine the relationship between serum selenium, ...
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Background: Seborrheic dermatitis is a common chronic relapsing inflammatory skin disease with unknown etiology. Using zinc and selenium supplements have shown some relieving effects on the symptoms of the disease. The present study was conducted to determine the relationship between serum selenium, zinc, and copper levels with seborrheic dermatitis. Methods: A prospective case-control study was performed on 30 patients with seborrheic dermatitis and 30 age and sex-matched healthy volunteers as a control group. Trace elements were measured by atomic absorption spectrophotometer in both groups. Results: The mean serum selenium, zinc, and copper levels were 98.90 ± 27.61 ?g/dL, 91.27 ± 10.84 ?g/dL, and 100.9 ± 20.06 ?g/ dL in case groups, respectively. In the control group, the mean serum selenium, zinc, and copper levels were 91.61 ± 15.74 ?g/dL, 94.03 ± 11.11 ?g/dL, and 96.5 ± 15.82 ?g/dL, respectively. There was no significant difference between the mean serum selenium, zinc, and copper levels in case and control groups (P>0.05). Conclusions: Although no statistically significant relationship was observed in serum selenium, zinc, and copper levels between the cases and controls, the serum selenium level among patients in case group was higher than that in the healthy subjects.
Original Article
Triana Agustin; Githa Rahmayunita; Rinadewi Astriningrum; Eliza Miranda; Erdina HD Pusponegoro; Sandra Widaty
Abstract
Background: Seborrheic dermatitis (SD) is an inflammatory disease affecting seborrheic areas of the skin. Scalp SD varies from mild, manifesting as dandruff, to erythematous lesions with greasy scales. SD negatively affects patients’ quality of life.Methods: This is a cross-sectional study investigating ...
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Background: Seborrheic dermatitis (SD) is an inflammatory disease affecting seborrheic areas of the skin. Scalp SD varies from mild, manifesting as dandruff, to erythematous lesions with greasy scales. SD negatively affects patients’ quality of life.Methods: This is a cross-sectional study investigating the relationship between quality of life and disease severity in patients with dandruff and scalp SD at the Dermatology and Venereology Outpatient Clinic, of Dr. Cipto Mangunkusumo General Hospital. SD severity was assessed by the modified Seborrheic Dermatitis Area and Severity Index (SDASI), and quality of life was assessed by the Indonesian version of the Dermatology Life Quality Index (DLQI).Results: A total of 96 subjects with scalp SD were recruited, comprising 86 subjects with mild SD and 10 subjects with moderate SD. DLQI scoring revealed 5 subjects (5%) felt no effect of SD at all on their lives, 10 subjects (10%) felt small effect, 38 subjects (40%) felt moderate effect, 32 subjects (33%) felt very large effect, and 2 subjects (2%) felt extremely large effect on their lives. There is no significant difference between SD severity with the average DLQI score in the mild SD group (8.73 ± 4.9) and the moderate SD group (9.30 ± 6.13), P=0.737. Furthermore, no significant difference was found between the DLQI scores in the male (9.86 ± 4.7) and female (8.18 ± 5.13) groups, P=0.116. Spearman’s correlation analysis revealed no significant relationship between age and DLQI scores (r=-0,104, P=0,313).Conclusions: Our study concludes that SD negatively affects the quality of life.
Original Article
Shamsi Hamid; Minoo Shaddel; Yakhchali Mohammad; Akbarzadeh Mahdi; Raoufi Nasrin; Tavakoli Payman; Dastgheib Mona; Dastgheib Mani
Abstract
Background: According to the drug resistance and side effects of the standard treatments for leishmaniasis, achieving effective treatment with less side effects and more benefits is of paramount importance. The present study aimed to evaluate the effect of Aloe vera leaf exudate on Leishmania major under ...
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Background: According to the drug resistance and side effects of the standard treatments for leishmaniasis, achieving effective treatment with less side effects and more benefits is of paramount importance. The present study aimed to evaluate the effect of Aloe vera leaf exudate on Leishmania major under in vitro and in vivo models, in inbred BALB/c mice. Methods: Different concentrations of both Aloe vera leaf exudates (AVL) and the standard drug meglumine antimoniate (Glucantime®;Sanofi-Aventis, France) were prepared (9.375l, 18.75, 37.5, 75, 150, and 300 ?g/ml) for in vitro model and then were applied to the fixed number of promastigotes. The promastigotes were counted after 24, 48, and 72 h. The viability of promastigotes was tested by MTT. A total of 20 mice with cutaneous leishmaniasis were divided into four groups for in vivo model, 1: positive group (treatment with Glucantime®), 2: negative group (without treatment), and 3 and 4: experimental groups (treatment with AVL1% and AVL4%, respectively). The size of the ulcers were recorded at the beginning of the experiment on a weekly basis for four weeks. Results: The results of in vitro model indicated that both AVL and Glucantime® reduced the number of promastigotes such that there was the lowest number of parasites in the concentration 300 ?g/ml of AVL and Glucantime®; however, the difference between them was not statistically significant. In vivo model demonstrated that AVL4% and Glucantime® decreased significantly the size of ulcers more than negative (P=0.000) and AVL1% groups (P=0.000 and P=0.004, respectively). Conclusions: There was no significant difference between AVL4% and Glucantime® (P=0.634). Therefore, AVL could control the Leishmania major.
Original Article
Jamalpour Mahdi; Saki Nasrin; Nozari Farnoosh
Abstract
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown etiology. There is evidence that bacteria may contribute to initiating the inflammatory response in HS patients. To date, data on bacteria found in HS lesions and their resistance rates are rare. Methods: The ...
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Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown etiology. There is evidence that bacteria may contribute to initiating the inflammatory response in HS patients. To date, data on bacteria found in HS lesions and their resistance rates are rare. Methods: The results of bacterial cultures and antibiotic susceptibility of the isolated bacteria obtained from HS lesions of 26 patients at our dermatology department were analyzed. Results: A total of 50 samples were collected from HS patients. Of the 50 lesional samples, 46 were culture-positive. The 50 lesional samples yielded 61 isolates. The most common isolated bacteria were Staphylococcus aureus, Diphtheroid, and Escherichia coli. Most of the isolates were resistant to penicillin G, followed by erythromycin, clindamycin and ampicillin. The lowest resistant rates were observed for ceftriaxone, imipenem, amikacin, tetracycline, and vancomycin. Conclusions: Due to the low susceptibility rate and antiinflammatory properties, tetracycline may represent as an effective antibiotic agent for therapy in HS patients.
Original Article
Meymandi Simin Shamsi; Dabiri Shahriar; Maryam Iranpour; Maryam Khalili; Mahin Aflatoonian
Abstract
Background: Lichen planus (LP) is a common inflammatory skin disease. Pathogenesis of LP includes two possible mechanisms; related or unrelated to antigen. Regarding different clinical features of cutaneous and mucosal types of LP, for the first time, we decided to perform a qualitative and quantitative ...
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Background: Lichen planus (LP) is a common inflammatory skin disease. Pathogenesis of LP includes two possible mechanisms; related or unrelated to antigen. Regarding different clinical features of cutaneous and mucosal types of LP, for the first time, we decided to perform a qualitative and quantitative study of immune cells in different types of cutaneous LP and in comparison with normal skin. Methods: A total of 88 specimens (60 cases of cutaneous LP, 28 cases of normal skin) were selected from 2016 to 2017 in Kerman, Iran. Evaluation of immune cells was carried out based on qualitative and quantitative analysis. These findings were statistically calculated by descriptive statistical tests including frequency and mean ± standard deviation. Quantitative data were analyzed by independent t-test, chi-square, and analysis of variance (ANOVA). Data were analyzed using SPSS16 (SPSS Inc., Chicago, IL, USA). A p value less than 0.05 was considered statistically significant. Results: Our study demonstrated that the mean number of immune cells was significantly higher in lichen planus group in comparison with the control group. Number and staining intensity of Langerhans cells (LCs) in the LP group were significantly greater in epidermal than dermal region. Mastocytes were located mostly within the deep dermis in the LP group. Hypertrophic and atrophic LP had the highest and the lowest number of immune cells (i.e., mastocytes, LCs, and CD3 positive cells), respectively, with a significant difference. Conclusion: Our study demonstrated that immune cells were seen in larger numbers in the hypertrophic type of cutaneous LP which is consistent with the chronicity of this disease.
Case Report
Khalili Maryam; Farajzadeh Saeedeh; Mohammadi Saman; Aflatoonian Mahin; Ahmadi Rahim; Zeinadini Alireza
Abstract
Leishmaniasis is a common parasitic disease classified to acute and chronic types based on the duration of the disease. The acute lesion is presented as ulcerated papule and nodule that heal after a few months with an atrophic scar. The chronic form of cutaneous leishmaniasis is a nonhealing lesion that ...
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Leishmaniasis is a common parasitic disease classified to acute and chronic types based on the duration of the disease. The acute lesion is presented as ulcerated papule and nodule that heal after a few months with an atrophic scar. The chronic form of cutaneous leishmaniasis is a nonhealing lesion that is persistent for more than one year. Here, we describe a chronic case of leishmaniasis developed after a head injury, similar to a keloidal scar.
Case Report
Nasiri Soheila; Hejazi Somayeh; Safoura Shakoei; Zahra Asadi; Nazi Saljoughi
Abstract
Granuloma faciale (GF) is a benign disease that presents as solitary or multiple asymptomatic plaques on the face. We report a 25-year-old male patient with asymptomatic papular, pustular, and nodular lesions on both cheeks. Diagnosis of GF was made based on the histopathological findings. He was treated ...
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Granuloma faciale (GF) is a benign disease that presents as solitary or multiple asymptomatic plaques on the face. We report a 25-year-old male patient with asymptomatic papular, pustular, and nodular lesions on both cheeks. Diagnosis of GF was made based on the histopathological findings. He was treated with cryotherapy and intralesional triamcinolone injections every month. After 3 months, the lesions became paler and less indurated.
