G Sadeghian; MA Nilforoush Zadeh
Volume 9, Issue 1 , 2006, , Pages 17-21
MA Nilforoush Zadeh; G Sadeghian; F Jafari; AR Firooz; Sh Moradi; R Derakhshan
Volume 9, Issue 1 , 2006, , Pages 35-39
G Sadeghian; MA Nilfroush Zadeh; M Amini
Volume 8, Issue 6 , 2006, , Pages 466-470
Abstract
Background and aim: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin can have a role in the pathogenesis of this disease and hyperinsulinemia as a consequence of insulin resistance may stimulate the formation of the characteristic plaques of ...
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Background and aim: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin can have a role in the pathogenesis of this disease and hyperinsulinemia as a consequence of insulin resistance may stimulate the formation of the characteristic plaques of AN. In this study insulin resistance was compared in obese women with and without AN.Materials and Methods: Glucose tolerance test (GTT) and fasting blood insulin were measured in two groups of obese women (BMI>30 kg/m2) with AN (32 cases) and without AN (34 cases) and insulin resistance was determined using HOMA formula.Results: The mean fasting blood insulin in two groups with and without AN were 15.5±8.5 and 12.2±4.1 IU/mL; respectively (P<0.05). The mean of insulin resistance in two groups with and without AN were 3.5±1.9 and 2.6±0.9; respectively (P<0.05). The results of GTT showed that the mean fasting blood sugar was 89.5±12 mg/dl and following using glucose were 144±7 mg/dl after 30 minutes, 132±45 mg/dl after 60 minutes, 107±30 mg/dl after 120 minutes in persons with AN and in the other group were 87±8, 130±3, 122±26 and 100±26 mg/dl; respectively. The difference between two groups was only significant after 60 minutes.Conclusion: Acanthosis nigricans maybe a marker of insulin resistance in obese women.
G Sadeghian; MA Nilforoush Zadeh; M Motevali Emami
Volume 8, Issue 4 , 2005, , Pages 251-255
Abstract
Background and objective: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis, but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance and adverse effects, efforts to find ...
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Background and objective: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis, but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance and adverse effects, efforts to find a more effective and safer drug is continuing. The objective of this study was to compare the effect of intra-lesional hypertonic sodium chloride solution and intra-lesional meglumine antimoniate injections in the treatment of cutaneous leishmaniasis.Materials and Methods: This randomized controlled clinical trial with simple sampling method was performed on 72 patients with cutaneous leishmaniasis. The patients were randomly divided in two groups. One group was treated with intra-lesional hypertonic sodium chloride solution and the other one was treated with intra-lesional meglumine antimoniate injections at weekly intervals for 6 to 10 weeks. All patients were followed for 6 months after treatment.Results: After six weeks of treatment, complete improvement, partial improvement, and no response to treatment were 33.3%, 45% and 22% in meglumine antimoniate group and 26%, 23% and 51% in trial group, respectively. In both groups complete improvement was observed in lesions smaller than 2 cm². In lesions with partial improvement the treatment was continued up to 10 weeks and all patients were followed for six months. After six months ultimate cure rate was 52% in meglumine antimoniate group and 25% in hypertonic sodium chloride solution group.Conclusion: Injections of hypertonic sodium chloride solution has less efficacy in comparison with intra-lesional meglumine antimoniate in treatment of cutaneous leishmaniasis, but considering the good response in primary small lesions, it can be used as an alternative therapy in some special cases including small lesions and allergic reactions to meglumine antimoniate.
G Sadeghian; F Iraji; MA Nilforoosh Zadeh
Volume 8, suppl , 2004, , Pages 31-34
Abstract
Cutaneous leishmaniasis (CL) is a parasitic disease, which is hyperendemic in Isfahan, usually caused by L.major and L.tropica. Herein we report a patient with post-mastectomy lymphedema on right upper limb accompanying with the lesions of cutaneous leishmaniasis on the right and left forearms. Following ...
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Cutaneous leishmaniasis (CL) is a parasitic disease, which is hyperendemic in Isfahan, usually caused by L.major and L.tropica. Herein we report a patient with post-mastectomy lymphedema on right upper limb accompanying with the lesions of cutaneous leishmaniasis on the right and left forearms. Following radiotherapy, the lesions on the limb with lymphedema were disseminated. But the lesions on left side showed no change. This finding may be the result of immune disorder due lymphedema and radiotherapy.
G Sadeghian; MA Nilforoosh Zadeh; N Ansari
Volume 7, Issue 2 , 2004, , Pages 112-115
Abstract
Cutaneous leishmaniasis is a parasitic hyperendemic disease in Isfahan. Its lesions can be solitary or multiple depending on the number of insect bites and is usually seen exposed areas. The possibility of insect bite on palpebral area is rare due to the protection by eyelashes and palpebral motion. ...
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Cutaneous leishmaniasis is a parasitic hyperendemic disease in Isfahan. Its lesions can be solitary or multiple depending on the number of insect bites and is usually seen exposed areas. The possibility of insect bite on palpebral area is rare due to the protection by eyelashes and palpebral motion. In this area, lesions are usually presented as chalazion, dacryocystitis and rarely ulcerative and cancerous forms. As there is a chance of dissemination of the parasite to conjunctiva, cornea and sclera from the adjacent skin, and it is also possible that scarring of cutaneous leishmaniasis may cause some ophthalmologic side effects, this kind of leishmaniasis can potentially be very serious for eyes. In this report, a 13 year old boy with upper and lower palpebral cutaneous leishmaniasis who consequently developed conjunctivitis and trichiasis is presented. This patient responded to treatment with systemic glucantime, but ultimately developed conjunctival and palpebral scar, exposure keratitis and loss of eyelashes.
G Sadeghian; MA Nilforoosh Zadeh
Volume 5, Issue 2 , 2002, , Pages 39-42
Abstract
Epidermal changes including hyperkeratosis and epidermal verrucous changes, papillomatosis, secondary infection, recurrent erysipelas and ulceration are complications of chronic lymphedema. Elephantiasis is a term used for these significant changes. Xanthoma may also develop in lymphedematous areas. ...
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Epidermal changes including hyperkeratosis and epidermal verrucous changes, papillomatosis, secondary infection, recurrent erysipelas and ulceration are complications of chronic lymphedema. Elephantiasis is a term used for these significant changes. Xanthoma may also develop in lymphedematous areas. Lymphangiosarcoma is a rare complication of chronic lymphedema. Nodular fibrosis is mentioned as a rare complication of lymphedema of legs and only two cases have been reported in the literature. This article presents a case of multiple lesions of nodular fibrosis on both legs after 40 years history of chronic lymphedema.
G Sadeghian; SH Hejazi; M Kalantari
Volume 5, Issue 1 , 2001, , Pages 39-42
Abstract
Background: Cutaneous leishmaniasis is a common parasitic disease in Isfahan province. A common complication of cutaneous leishmaniasis is bacterial superinfection, which may intensify the disease and produce scarring. Objective: The aim of this study was to determine the bacterial species isolated from ...
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Background: Cutaneous leishmaniasis is a common parasitic disease in Isfahan province. A common complication of cutaneous leishmaniasis is bacterial superinfection, which may intensify the disease and produce scarring. Objective: The aim of this study was to determine the bacterial species isolated from infected lesions of cutaneous leishmaniasis. Patients and Methods: Two hundred out of 874 patients with cutaneous leishmaniasis referred to Dermatology and Leishmaniasis Research Center in Amin Hospital in Isfahan during four months (September to December 1999) who had signs of bacterial superinfection were studied by taking microbial cultures from their lesions. Results: Bacterial cultures were positive in 177 cases (20.7% of all patients and 88.5% of sample patients). The isolated bacterias included S.aureus in 61.5%, S.epidermidis in 20.5%, E.coli in 3.5%, proteus vulgaris in 1.5% and Klebsiella in 1.5%. Eighty seven percent of infected patients had ulcerative nodules. Bacterial super infection was significantly more common in ulcerated lesions than non-ulcerated ones (P=0.00001).
