Arunima Dhabal; Jayanta Kumar Barua; Kingshuk Chatterjee; Ananya Chandra; Sumana Khan; Manab Kumar Ghosh; Saswati Halder
Abstract
Background: Lichen planus (LP) is a chronic inflammatorydisorder involving the skin, mucosa, hair, and nails. Previousreports have shown a possible association between LP andmetabolic derangement, leading to increased cardiovascular riskamong these patients. Our study aimed to assess the prevalenceof ...
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Background: Lichen planus (LP) is a chronic inflammatorydisorder involving the skin, mucosa, hair, and nails. Previousreports have shown a possible association between LP andmetabolic derangement, leading to increased cardiovascular riskamong these patients. Our study aimed to assess the prevalenceof metabolic syndrome (MetS) and its components in LP patientsand to study their relationship with mucosal involvement in LP.Methods: We conducted a cross-sectional observational study of123 LP patients. Demographic and clinical data were obtained,and evaluation was done for the presence of abdominal obesity,hypertension, hyperglycemia, and dyslipidemia. MetS wasdiagnosed according to the modified National CholesterolEducation Program: Adult Treatment Panel III (NCEP-ATP III)criteria for the South Asian population. Data analysis was doneusing appropriate statistical methods.Results: The prevalence of MetS in LP patients was 31%. The meanage of LP patients having MetS was considerably higher thanthose without MetS (44.8 ± 13.6 vs. 33.3 ± 15.9 years; P = 0.0002).Although statistically insignificant, female patients and patients withmucosal involvement showed a higher prevalence of MetS. Centralobesity, hypertension, hyperglycemia, and hypertriglyceridemiawere more prevalent in mucosal LP patients than in those withoutmucosal lesions, with hyperglycemia having a significantly higherprevalence in mucosal LP (41% vs. 18%; P = 0.015).Conclusion: Incre ased age, female gender, and mucosalinvolvement are important predictors of concurrent metabolicderangement in LP patients. Thus, these patients should bescreened for the presence of MetS and its components.
Saman Mohammadi; Nasim Askari; Maryam Khalili; Rezvan Amiri; Mahin Aflatoonian
Abstract
Background: The increased prevalence of metabolic syndrome has been established in chronic inflammatory skin diseases. Patients with metabolic syndrome have a higher mortality rate due to cardiovascular disease and malignancy. In this study, the prevalence of metabolic syndrome was evaluated in lichen ...
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Background: The increased prevalence of metabolic syndrome has been established in chronic inflammatory skin diseases. Patients with metabolic syndrome have a higher mortality rate due to cardiovascular disease and malignancy. In this study, the prevalence of metabolic syndrome was evaluated in lichen planus patients compared with a control group in Kerman, southeast Iran.Methods: This was a cross-sectional study on 90 patients with lichen planus and 90 healthy participants from the Dermatology Clinic of Afzalipour Hospital, Kerman, Iran. Demographic features of the patients and clinical features of the lesions were recorded. Then, parameters of metabolic syndrome were evaluated in both groups. The independent t-test and chi-squared test were used to compare quantitative and qualitative variables, respectively.Results: There was no significant difference in demographic features of the participants between the two groups. Metabolic syndrome was significantly more prevalent in the lichen planus group (62.6%) than in the control group (14.4%) (P = 0.001). Metabolic syndrome parameter values (except waist circumference) were significantly higher in the lichen planus group than in the control group. Lichen planus patients with metabolic syndrome had a significantly higher percentage of mucosal involvement (66.1%) than lichen planus patients without metabolic syndrome (44.1%). Lichen planus patients with metabolic syndrome were significantly older than those without metabolic syndrome.Conclusions: This study observed a higher prevalence of metabolic syndrome in lichen planus patients relative to controls. Furthermore, lichen planus patients with metabolic syndrome had significantly higher age, mucosal involvement, and body mass index than lichen planus patients without metabolic syndrome.