Emadodin Darchini-Maragheh; Sara Fakhraei; Pouran Layegh
Abstract
Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal dominant hereditary syndrome caused by mutations of the MEN1 tumor suppressor gene. We describe a patient with a prior confirmed diagnosis of pemphigus vulgaris (PV), who presented with new cutaneous manifestations that led to the diagnosis ...
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Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal dominant hereditary syndrome caused by mutations of the MEN1 tumor suppressor gene. We describe a patient with a prior confirmed diagnosis of pemphigus vulgaris (PV), who presented with new cutaneous manifestations that led to the diagnosis of MEN1. A man in his early forties with a history of PV from 11 years ago presented with some cutaneous lesions six months ago, diagnosed as angiofibroma and collagenoma. Moreover, he suffered from recurrent renal stones and gout for several years. Laboratory analysis showed hypercalcemia, which led us to confirm the diagnosis of a parathyroid adenoma by sestamibi scintigraphy. Contrast-enhanced computed tomography (CT) of the abdomen revealed hyper-enhancing pancreatic lesions while the patient had no related symptoms. Thus, the clinical diagnosis of MEN1 syndrome was settled, and the patient underwent surgical and medical management. A hitherto unreported cooccurrence between MEN-1, as a hereditary syndrome, and PV, as an autoimmune bullous cutaneous dermatosis, opens a hazy challenging issue: whether MEN-1 has any association with autoimmune bullous cutaneous diseases like PV or increases the incidence of such conditions.
N Naderi; M Mahdavi Mazdeh; AR Firooz; M Heydari Seraj
Volume 8, Issue 6 , 2006, , Pages 489-495
Abstract
Background and aim: New modalities in the treatment of end-stage renal disease (ESRD) patients have increased their life expectancy and quality of life. A wide range of cutaneous manifestations are seen in ESRD patients. This study was conducted to determine the prevalence of cutaneous manifestations ...
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Background and aim: New modalities in the treatment of end-stage renal disease (ESRD) patients have increased their life expectancy and quality of life. A wide range of cutaneous manifestations are seen in ESRD patients. This study was conducted to determine the prevalence of cutaneous manifestations in ESRD patients on maintenance hemodialysis in the dialysis department of Imam Khomeini hospital.Materials and Methods: One hundred and four hemodialysis patients on maintenance hemodialysis in April, May, and June 2003 were interviewed and examined for skin problems.Results: Almost all patients had at least one cutaneous lesion. The most common cutaneous findings were changes in skin color and nail disorders (79.8%). The other common cutaneous manifestations were xerosis (74%) and pruritus (51%). Xerosis was more common in those patients with serum calcium level greater than 9.3 gr/dl (P<0.05). Hyperpigmentation was more frequent in patients with urine volume<500 ml (P<0.05) and in those who were more than 24 months on continuous hemodialysis (P<0.05). Pruritus was more common in those patients with a history of drinking alcohol (P<0.05). Nail involvement was seen in all 14 patients who were positive for HCV Ab, but was absent in those 5 patients who were positive for HBs Ag.Conclusion: Cutaneous manifestations are very common in ESRD patients on maintenance hemodialysis.
MJ Yazdan Panah; M Ebrahimi Rad; MJ Mojahedi
Volume 8, Issue 4 , 2005, , Pages 281-286
Abstract
Background and objective: Renal transplantation is an appropriate treatment for end stage renal disease and helps prolongation of patients survival with better quality, but immunosuppressive drugs that are used for inhibition of rejection after transplantation may cause some adverse effects in other ...
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Background and objective: Renal transplantation is an appropriate treatment for end stage renal disease and helps prolongation of patients survival with better quality, but immunosuppressive drugs that are used for inhibition of rejection after transplantation may cause some adverse effects in other organs such as the skin. Apparently, early recognition of those side effects and their appropriate management can reduce morbidity and mortality. This study was designed to study cutaneous complications in renal transplantation recipients. Materials and Methods: In this descriptive study cutaneous side effects in one hundred kidney transplant patients who admitted to transplantation clinics of Ghaem and Imam Reza hospital of Mashhad during a six-month period (April to September 2003) were studied. Results: Sixty-five patients were males and 35 cases were female. The mean age was 36 years (SD=14). Totally, cutaneous manifestations were observed in 88% of patients. In an descending order they included hypertrichosis, cushingoid appearance, gingival hypeplasia, steroid acne, common warts, herpes simplex infection, superficial fungal infection, candidiasis. Actinic keratosis, porokeratosis, lymphoma, stria, telangiectasia and sebaceous hyperplasia. Conclusion: Early recognition of these complications and appropriate treatment of them can reduce probable mortality and morbidity.
N Esmaeili; M Safaei Pourzamani; F Rahimi
Volume 6, Issue 3 , 2003, , Pages 24-26
Abstract
Background: To get accustomed with cutaneous manifestations related to AIDS is effective in early diagnosis of this disease. Objective: To evaluate the cutaneous manifestations in HIV seropositive patients. Patients and Methods: A prospective, descriptive and cross-sectional study was performed on HIV-positive ...
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Background: To get accustomed with cutaneous manifestations related to AIDS is effective in early diagnosis of this disease. Objective: To evaluate the cutaneous manifestations in HIV seropositive patients. Patients and Methods: A prospective, descriptive and cross-sectional study was performed on HIV-positive male prisoners in Kermanshah central prison and in addiction camp, referred to skin disease center of Kermanshah University, during eleven months; and their cutaneous manifestations were analyzed. Results: 43 out of 79 patients (54.4%) had mucocutaneous manifestations. 26 patients (32.9%) had herpes zoster infection. Two patients (4.6%) developed recurrent herpes zoster and five patients (11.6%) showed wide scar in low back area and shoulder because of previous herpes zoster. Other manifestations included acne (23.3%), generalized pruritus (11.6%) and oral herpes simplex infection, scabies and tinea versicolor in few cases. The majority of patients (32.6%) were in the age group of 30-34 years. Conclusion: The most common cutaneous disease in this study was herpes zoster. Herpes zoster infection in patients without any obvious risk factor could be a predictor of probable HIV infection.