Alireza Ghanadan; Reza Shirkoohi; Reza Shahsiah; Samira Alihosseini; Reza Amiri; Nika Kianfar; Shahriar Hadadi Abianeh; Elham Sabbagh; Behzad Khodaei; Maryam Nasimi
Abstract
Background: NRAS and BRAF mutations are commonly reported in melanoma with various frequencies in different countries. However, their correlation with the development of malignant melanoma and tumor prognosis has not previously been studied in the Iranian population. This study determined the prevalence ...
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Background: NRAS and BRAF mutations are commonly reported in melanoma with various frequencies in different countries. However, their correlation with the development of malignant melanoma and tumor prognosis has not previously been studied in the Iranian population. This study determined the prevalence of these mutations and their association with tumor-related factors.Methods: This cross-sectional study involved 50 patients admitted to two dermatology hospitals with a definitive diagnosis of melanoma (primary or metastatic) who received surgery as a selective therapeutic option. The genomics of the BRAF and NRAS mutations were determined with the real-time PCR technique.Results: BRAF and NRAS mutations were presented in 30% and 26% of patients, respectively. The NRAS mutation correlated with mitosis (P = 0.026), while the BRAF mutation correlated with visceral involvement (P = 0.023). None of the mutations correlated with gender, age, melanoma type (primary vs. metastasis), ulcer, microsatellitosis, and lymph node involvement.Conclusion: BRAF and NRAS mutations demonstrated relatively high prevalence in Iranian patients with melanoma, which may be valuable prognostic tools in predicting tumor prognosis and metastasis.
Soheila Nasiri; Niloufar Najar Nobari; Shirin Zaresharifi; Nooshin Zaresharifi
Abstract
B-cell lymphomas represent most non-Hodgkin lymphomas (NHLs) arising within lymph nodes, and about 27% of patients have extranodal involvement. Primary cutaneous lymphoma is defined as malignant lymphoma limited to the skin at diagnosis. Diffuse large B-cell lymphoma (DLBCL) is the most common form of ...
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B-cell lymphomas represent most non-Hodgkin lymphomas (NHLs) arising within lymph nodes, and about 27% of patients have extranodal involvement. Primary cutaneous lymphoma is defined as malignant lymphoma limited to the skin at diagnosis. Diffuse large B-cell lymphoma (DLBCL) is the most common form of NHL, accounting for over one-third of all lymphomas. Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL) is a type of non-Hodgkin’s lymphoma with skin involvement as the first and only site of involvement. Primary cutaneous diffuse large B-cell lymphoma typically presents as a rapid-growing, red or bluish nodule or tumor on the legs, though around 10–15% of patients present with lesions elsewhere. This case report illustrates a rare manifestation of PCDLBCL presenting as a non-healing, rapidly progressive ulcer in the groin area diagnosed based on histopathology and immunohistochemical expression. The patient was treated successfully with systemic chemotherapy. This report could have implications for clinicians to consider the diagnosis of PCDLBCL in patients with unusual, non-healing, chronic ulcers, especially in the elderly, despite the anatomic site of the lesions.
Fatemeh Parvizifard; Massoumeh Zargaran; Verisheh Rastin
Abstract
Background: Basal cell carcinoma (BCC), the most common human malignancy, can cause significant morbidity through extensive tissue destruction. This study aimed to determine the frequency and clinicopathological features of BCC in an Iranian population.Methods: Histopathological reports with a definitive ...
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Background: Basal cell carcinoma (BCC), the most common human malignancy, can cause significant morbidity through extensive tissue destruction. This study aimed to determine the frequency and clinicopathological features of BCC in an Iranian population.Methods: Histopathological reports with a definitive diagnosis of BCC in all pathology centers of Sanandaj, Kurdistan province, during 2009–2019 were reviewed. Data on age, gender, site, size, and clinical and histopathological types of tumors were collected and analyzed using SPSS software. P-values < 0.05 were consideredsignificant.Results: We found 832 BCC lesions in 779 patients, including 453 males and 326 females aged 65.36 ± 14.35 years and 62.77 ± 13.79 years, respectively. The mean tumor size was 14.52 ± 10.08 mm in men and 11.79 ± 7.89 mm in women. The most common location was the head (95.23%), with the nose representing the most involved area. Males and females differed regarding age (P = 0.012), tumor size (P < 0.001), and the anatomical distribution of tumors on various parts of the head (P < 0.001). Ulcerative (58.36%) and nodular (54.45%) BCCs were the most frequent clinical and histopathological types, respectively, both in males and females, without a significant difference between the genders (P > 0.05).Conclusions: Our findings suggest that age, gender, and the tumor site in various head areas could be risk factors for BCC. Appropriate knowledge of BCC and its risk factors can help design prevention strategies and provide the necessary training for healthcare staff and the public to identify the disease in susceptible individuals.
