Nasrin Saki; Seyedeh Yasamin Parvar; Saba Fazel; Fatemehsadat Pezeshkian
Abstract
Genital warts are epithelial tissues infected with human papillomaviruses, the most prevalent sexually transmitted disease worldwide. Topical treatments focus on removing warts rather than eliminating the virus. Curcumin, as a therapeutic option, has been shown to have antiviral activity in treating ...
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Genital warts are epithelial tissues infected with human papillomaviruses, the most prevalent sexually transmitted disease worldwide. Topical treatments focus on removing warts rather than eliminating the virus. Curcumin, as a therapeutic option, has been shown to have antiviral activity in treating a variety of skin diseases, including vitiligo and psoriasis. The present study compared the effectiveness of cryotherapy plus oral curcumin to cryotherapy alone in treating genital warts. This randomized, double-blinded, placebo-controlled trial was performed on patients diagnosed with genital warts, who were divided into two groups. Patients underwent 5-7 sessions of cryotherapy plus oral curcumin or placebo. Outcome measures included the number of warts, the visual analog scale (VAS), and the Persian version of the Dermatology Life Quality Index (DLQI). The data were analyzed using SPSS software, version 21.Twenty-seven patients with a mean age of 34.3 ± 10.3 years were included in each group. The median number of genital warts, DLQI, and VAS improved significantly in both groups. The effect of curcumin was more prominent in a short period, although it was not statistically significant compared to the placebo group. Using curcumin as an adjuvant drug in conjunction with cryotherapy was shown to be ineffective in treating genital warts. According to The Dermatology Life Quality Index, clinical improvement was observed; however, it was not statistically significant. Further studies should be carried out with higher doses of oral curcumin or topical vaginal creams containing curcumin to determine the role of curcumin in treating genital warts.
Narges Alizadeh; Javad Golchai; Atefeh Ghanbari; Behrooz Golchai; Shirin Zaresharifi
Abstract
Background: Anogenital warts are the most prevalent sexually transmitted disease worldwide and are caused by human papillomavirus (HPV). There are more than 100 different types of HPV, of which certain types make the patient more susceptible to malignant neoplasms. This study aimed to determine the frequencies ...
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Background: Anogenital warts are the most prevalent sexually transmitted disease worldwide and are caused by human papillomavirus (HPV). There are more than 100 different types of HPV, of which certain types make the patient more susceptible to malignant neoplasms. This study aimed to determine the frequencies of specific types of HPV in anogenital warts.
Methods: This study included 157 patients diagnosed with anogenital warts that underwent HPV DNA detection using polymerase chain reaction (PCR) with INNO-LiPA genotyping assay.
Results: Of 157 patients with anogenital warts, 122 samples (77.7%) were positive for HPV, with some patients showing mixed HPV subtypes. HPV 6 (n = 99; 68.3%) and HPV 11 (n = 13; 8.9%) were the most prevalent types. 101 patients were male (64.3%). The mean age was 32.02 ± 10.06 years (range: 2 to 72 years). Most patients were infected with the low-risk types (80%); the high-risk HPV type 16 was significantly more common among women (P = 0.0001).
Conclusion: This study showed the higher relative frequency of HPV6 and HPV11 in anogenital warts in Guilan, northern Iran. The frequency of genital HPV infection appears to be higher among men, but the frequency of high-risk types seems to be higher among women.
Tabari Soudabeh Tirgar; Barat Shahnaz; Shakerian Mohammad Ali; Hashemi Kamal; Saeedi Fayyaz
Volume 19, Issue 3 , 2016, , Pages 89-92
Abstract
Background: Genital warts are one of the most common viral sexually transmitted diseases in the world. They are caused by different human papilloma viruses and lesions may have benign to malignant transformation. The main purpose of this study was to determine the prevalence of condyloma acuminata in ...
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Background: Genital warts are one of the most common viral sexually transmitted diseases in the world. They are caused by different human papilloma viruses and lesions may have benign to malignant transformation. The main purpose of this study was to determine the prevalence of condyloma acuminata in the spouses of patients with genital warts. Methods: This cross-sectional study was done on 153 patients with genital warts and their spouses who were referred to dermatology and gynecology clinics of Babol University of Medical Science (North of Iran) between 2009 and 2012. All cases were clinically examined by dermatologists and gynecologists. After obtaining consent, the data including patients’ sex and age, genital wart in the spouse, history of warts in other sites of the body, positive family history of all forms of warts, smoking, addiction, alcohol consumption, and OCP use were collected via a questionnaire and analyzed with t and chi-square tests. P values less than 0.05 were considered significant. Results: In this study, 100 (65.4%) patients were women and 53 (34.6%) were men. Genital warts were detected in 25.5% of the spouses. The mean age of the patients and their spouses was 30.2±8.7 and 31.5 ±7.4 years, respectively. There was no significant correlation between age and genital wart in the spouse. Conclusion: The results showed that genital warts are a relatively highly infectious disease. Our recommendation for prevention of genital warts is education and clinical examination of the patients’ spouses.