Seirafi Hassan; Farahani Farzaneh; Farnaghi Farshad; Ehsani Amirhooshang; Hashemi Pantea; Farahani Amir
Volume 11, Issue 1 , 2008, , Pages 1-6
Abstract
Background: Narrow band Ultraviolet B (NBUVB) has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been used as immunotherapy or as a part of combination therapies. The aim of this study was to compare the clinical efficacy and safety of NBUVB and NBUVB plus ...
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Background: Narrow band Ultraviolet B (NBUVB) has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been used as immunotherapy or as a part of combination therapies. The aim of this study was to compare the clinical efficacy and safety of NBUVB and NBUVB plus topical calcipotriol in the treatment of generalized vitiligo.Methods: NBUVB phototherapy was given to 26 patients with generalized, symmetrical vitiligo three times weekly. Topical calcipotriol cream was only applied on the lesions located on one side of the body. Treatment was continued until cosmetically acceptable repigmentation occurred, but total cumulative dose of NBUVB did not increase from the mean of 113.4 ± 47.0 j/cm. The efficacy of treatment was evaluated by visually scoring the percentage of regimentation of the lesions at 12-session intervals by an investigator unaware of the side of calcipotriol application. Results: The mean daily dose of NBUVB was 1.4 ± 0.6 j/cm. The median number of exposure for initial regimentation was 26.5 (range 14-38) on the side of combination therapy with calcipotriol and 25.3 (range 20-40) on the other side. After 24 sessions of treatment, 14 patients (53.9%) showed minimal to moderate improvement on the calcipotriol treated side as compared to 21 patients ( 80.8 %) on the other side. After 60 sessions of treatment, 16 patients (16.5 %) showed moderate to marked regimentation on the side of combination therapy with calcipotriol as compared to 19 patients (73 %) on the other side.Conclusion: These findings indicate that concurrent use of topical calcipotriol does not enhance the efficacy of NBUVB in the treatment of vitiligo.
Seirafi Hassan; Fateh Soheil; Farnaghi Farshad; Ehsani Amir Hooshang; Noormohammadpoor Pedram
Volume 13, Issue 1 , 2010, , Pages 1-5
Abstract
Background: Although cryotherapy is still the first-line therapy for solar lentigines, due to side effects such as post-inflammatory hyperpigmentation (PIH), especially in patients with darker skin types, pigment specific lasers should be considered as initial treatment. The aim of this study was to ...
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Background: Although cryotherapy is still the first-line therapy for solar lentigines, due to side effects such as post-inflammatory hyperpigmentation (PIH), especially in patients with darker skin types, pigment specific lasers should be considered as initial treatment. The aim of this study was to evaluate the efficacy and safety of cryotherapy in comparison with 595-nm pulsed dye laser (PDL) with cutaneous compression in the treatment of solar lentigines. Method: Twenty two patients (skin type II- IV) with facial or hand lentigines completed this study. Lesions of one side of the face or each hand were randomly assigned and treated with either cryotherapy or PDL. Treatments were performed with radiant exposures of 10 J/cm2, 7mm spot size and 1.5ms pulse duration with no epidermal cooling. Photographs were taken before treatment and one month later. The response rate and side effects were compared. Results: PDL was more likely to produce substantial lightening of solar lentigines than cryotherapy, especially in skin types III and IV (n=8, n=9; P0.05). PIH was only seen in the cryotherapy group. PDL group only showed minimal erythema. No purpura was observed. Conclusion: PDL with compression is superior to cryotherapy in the treatment of solar lentigines in darker skin types.
Mostafa Mirshams Shahshahani; Mahmood Razzaghi; Amir Houshang Ehsani; Pedram Normohamadpour; Zahra Naraghi; Kambiz Kamyab; Sara Sabouri Rad
Volume 14, Issue 1 , 2011, , Pages 1-5
Abstract
Background: Surgery is the most frequent treatment modality for basal cell carcinoma but in spite of its high cure rate, the frequency of incomplete excision varies widely (0.7-50%) among dermatologic centers. Our case series was designed to determine the frequency of incompletely excised basal cell ...
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Background: Surgery is the most frequent treatment modality for basal cell carcinoma but in spite of its high cure rate, the frequency of incomplete excision varies widely (0.7-50%) among dermatologic centers. Our case series was designed to determine the frequency of incompletely excised basal cell carcinoma and the related risk factors. Methods: A total of 1424 basal cell carcinoma (1040 patients) lesions which were excised in Razi Dermatology Hospital of Tehran from 2006 to 2008 were evaluated in this case series and their findings were analyzed with SPSS software. Results: Incidence of incomplete excision was 12% and involvement of the deep margin was observed in 54% of these lesions. Factors related to incomplete excision were infiltrative, morpheic and micronodular subtypes, lesions larger than 20 mm, those repaired by skin grafts and those that received local anesthesia. There was no statistically significant difference in age, sex, site of lesions and childhood history of radiotherapy for tinea capitis. Conclusion: Recognizing the risk factors related to incomplete excision of BCCs would help us consider a wider excision margin for high risk tumors.
Nassiri Soheila; Saffarian Zahra; Younespour Shima
Volume 16, Issue 1 , 2013, , Pages 1-5
Abstract
Background: Alopecia areata (AA) is an autoimmune disorder ofhair follicles. We aimed to find the association between VitaminD level and AA.Method: Eligible AA patients and controls were enrolled inthis case-control study and serum samples were assessed for25-hydroxy vitamin D (25-(OH)-D3). The levels ...
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Background: Alopecia areata (AA) is an autoimmune disorder ofhair follicles. We aimed to find the association between VitaminD level and AA.Method: Eligible AA patients and controls were enrolled inthis case-control study and serum samples were assessed for25-hydroxy vitamin D (25-(OH)-D3). The levels of 25-(OH)-D3were categorized as deficient (<10ng/ml), insufficient (10 to<30 mg/ml) and sufficient (>30ng/dl) and the SALT (Severityof Alopecia Tool) score was used to assess the severity of thedisease. The data was analysed and the association betweenvitamin D levels and AA, disease distribution, and the patternof hair loss was investigated.Result: Twenty eight patients (19 males, 9 females) and 44healthy controls (16 males, 28 females) were assessed. Therewas no statistically significant difference between patients andcontrols with regard to the level of 25(OH)D3 when the data wasadjusted for gender (Ordinal odds ratio: 0.49 (0.18-1.34 and 95%CI, p-value=0.16). The level of 25(OH)D3 was lower in patientswith nail involvement in contrast to those without it (P=0.02);moreover, no significant difference was found between patientswith different patterns of hair loss.Conclusion: After adjustment for gender, there was no associationbetween AA and the level of vitamin D.
Taheri Ahmad Reza; Farmanbar Mohammad Ali; Kiafar Bita; Khajedaluee Mohammad; Javidi Zari; Nahidi Yalda; Maleki Masoud
Volume 17, Issue 1 , 2014, , Pages 1-7
Abstract
Background: The standard patch test is known as the most reliable test to identify and confirm causative agents of allergic contact dermatitis (ACD). Previous studies have shown that the prevalence of specific allergens varies by geographic area. The results of patch test in patients visiting our dermatology ...
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Background: The standard patch test is known as the most reliable test to identify and confirm causative agents of allergic contact dermatitis (ACD). Previous studies have shown that the prevalence of specific allergens varies by geographic area. The results of patch test in patients visiting our dermatology clinics with suspected ACD were prospectively investigated and compared with those reported in the literature of Iran.Method: We performed the European Standard Series patch test produced by Almiral Hermal GmbH, containing 28 allergens in a group of 100 patients (55 females and 45 males) with suspected ACD who were referred to Emam Reza and Ghaem Hospitals, Mashhad, in 2010-2011. The tests were read after 2 and 4 days.Result: Fifty-four percent of the patients had 1 or more positive reactions of which 65% were relevant to current or past dermatitis. Positive reactions were due to 12 allergens. The most frequent allergens were nickel sulfate (25%) and potassium
Jahangir Majid; Qayoom Seema; Peerzada Sajad; Naseer Choh; Rifat Ara; Kafeel Khan
Volume 18, Issue 1 , 2015, , Pages 1-5
Abstract
Background: Hirsutism, a common clinical condition, not onlycauses cosmetic concern but may also be a sign of underlyingdisease. Polycystic ovary syndrome (PCOS) is an importantand common cause of hirsutism. In fact, many women withPCOS present as hirsutism. This study assessed young Kashmiriwomen presenting ...
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Background: Hirsutism, a common clinical condition, not onlycauses cosmetic concern but may also be a sign of underlyingdisease. Polycystic ovary syndrome (PCOS) is an importantand common cause of hirsutism. In fact, many women withPCOS present as hirsutism. This study assessed young Kashmiriwomen presenting as hirsutism, for ultrasonographic evidence ofpolycystic ovaries (PCO), in addition to recording their clinical andhormonal profile. The purpose of this study was to determine theprevalence of polycystic ovary syndrome using ultrasonography,in young Kashmiri women presenting as hirsutism.Method: In total, one hundred and seventy (170) consecutive youngKashmiri women presenting with chief complaint of hirsutismwere assessed. A total of eighty (80) age matched non- hirsutefemales having normal menstrual cycles, served as controls. Theovaries were visualised by transabdominal ultrasonography (USG).The serum was analysed for luteinizing hormone (LH), folliclestimulating hormone (FSH), total testosterone (tT), prolactin(PRL) and thyroid stimulating hormone (TSH).Result: The study showed prevalence of 61.18% PCOS in youngKashmiri women presenting as hirsutism. PCOS was diagnosed in35.11% hirsute women with regular menses and ultrasonographywas used to identify PCO in 90.35% patients. Biochemicalhyperandrogenemia was present in 70.15% of the patients andthe LH/FSH ratio increased in 81.73% of the patients.Conclusion: The results of this study show a high prevalence ofPCOS in young Kashmiri women presenting as hirsutism andalso highlights the fact that PCOS is not necessarily associatedwith menstrual disturbances. Therefore, all hirsute women, evenwith regular menses, should be evaluated for PCOS.
Nahidi Yalda; Layegh Pouran; Naser Tayyebi Meibodi; Vida Vakili; Golsan Kardan
Abstract
Background: Vitiligo is a pigmentation disorder of the skin characterized by the loss of melanocytes through different mechanisms. Narrow band UVB (NBUVB) is a safe and effective treatment for vitiligo that acts by inducing the synthesis of cytokines involved in melanogenesis. NBUVB appears to be involved ...
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Background: Vitiligo is a pigmentation disorder of the skin characterized by the loss of melanocytes through different mechanisms. Narrow band UVB (NBUVB) is a safe and effective treatment for vitiligo that acts by inducing the synthesis of cytokines involved in melanogenesis. NBUVB appears to be involved in the treatment of vitiligo by increasing the synthesis of vitamin D, which prevents the apoptosis of melanocytes; accordingly, we set out to compare the serum level of vitamin D and its variations following NBUVB treatment according to the degree of response to treatment.
Methods: Thirty-eight patients with vitiligo were subject to phototherapy with NBUVB. Photographs of vitiligo lesions were taken prior to and after completing 60 phototherapy sessions. Further measured were the serum level of 25-hydroxyvitamin D3, VASI score and repigmentation rate before and after the treatment period. Finally, the relationship between the changes in serum vit D3 levels and variations of VASI score was investigated.
Results: Mean serum level of vitamin D3 was 20.78 ng/ml after treatment, which is significantly more compared to the period before the treatment (15.42, P=0.001). Mean VASI score was 5.45 before the treatment, yet was reduced to 2.24 after treatment, which is a significant change (P<0.001); however, the changes in vitamin D3 levels were not significantly correlated with VASI score (P=0.137).
Conclusion: The repigmentation rate in vitiligo lesions are not significantly correlated with serum vitamin D3 levels. Therefore, NBUVB is not likely to improve vitiligo lesions through the increase in serum vitamin D levels.
H Ansarin; N Shahbazi; Z Naraghi; SZ Latif Zadeh
Volume 8, suppl , 2004, , Pages 1-4
Abstract
Provisional hypomyopathic juvenile dermatomyositis is a subgroup of clinically amyopathic juvenile dermatomyositis provisional. The diagnostic criteria include: Classic dermatomyositis skin lesions – which have to be confirmed by biopsy –, no involvement of proximal muscles, subclinical involvement ...
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Provisional hypomyopathic juvenile dermatomyositis is a subgroup of clinically amyopathic juvenile dermatomyositis provisional. The diagnostic criteria include: Classic dermatomyositis skin lesions – which have to be confirmed by biopsy –, no involvement of proximal muscles, subclinical involvement of these muscles and normal level of muscle enzymes. These criteria should be present for a minimum of 6 months and maximum of 24 months. Here a 13-year-old boy is presented who developed non-Hodgkin lymphoma 15 months after the diagnosis of his dermatomyositis.
Mohammad Shahidi–Dadras; Parviz Toossi; Nima Sarrafi–Rad; Reza Mahmoud Robati; Marjan Saeedi; Sima Kavand
Volume 12, Issue 1 , 2009, , Pages 1-3
Abstract
Background: The aggravating role of Staphylococcus aureus is well known in atopic dermatitis but has not yet been proven in psoriasis. The role of Staphylococcus aureus superantigens is emphasized in the initiation, maintenance and complications of psoriasis. We investigated the frequency of nasal, axillary, ...
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Background: The aggravating role of Staphylococcus aureus is well known in atopic dermatitis but has not yet been proven in psoriasis. The role of Staphylococcus aureus superantigens is emphasized in the initiation, maintenance and complications of psoriasis. We investigated the frequency of nasal, axillary, and perineal carriage of Staphylococcus aureus (SA) in patients with psoriasis and its possible influence on the severity of the disease. Methods: one hundred patients with the clinical diagnosis of psoriasis participated in the study. Cultures of the bacterial flora were obtained from the right and left axilla and nasal nares and perineum, inoculated on standard bacterial medium (blood agar), and incubated at 37°C degrees for 48 h. Results: one hundred patients with the clinical diagnosis of psoriasis (42% female and 58% male) comprised the study group. Mean age of the patients was 41.1±17.1 years. About 42 % of the patients carried S. aureus; of these, 32 % were from the nose, 13 % from axilla, and 11% from the perineum. Three patients were carriers in all 3 sites. There was no significant difference in the severity of the disease between the carriers and non-carriers measured by the psoriasis area and severity index (PASI) score. Conclusions: According to our findings, S.aureus carriage in psoriasis had no significant influence on disease severity. It might be relevant for a subgroup of patients only when superantigen productions are found.
S Kavousi; M Ghiasi; S Toosi
Volume 8, suppl , 2005, , Pages 1-4
Abstract
Primary cutaneous CD30+ T cell lymphoma is rare lymphoma originally in and confined to the skin. These lymphomas usually present as a large solitary and often ulcerated nodule. Its prognosis is a good and has a good response to radiotherapy. We report a 34- year- old man who had primary cutaneous CD30+T ...
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Primary cutaneous CD30+ T cell lymphoma is rare lymphoma originally in and confined to the skin. These lymphomas usually present as a large solitary and often ulcerated nodule. Its prognosis is a good and has a good response to radiotherapy. We report a 34- year- old man who had primary cutaneous CD30+T cell lymphoma on his face, which presented as an ulcerated nodule.
Razieh Bokaiean; Mahnoush Momeni; Parisa Sabrjoo; Mostafa Dahmardehei; Maryam Roham; Hossein Rahber
Abstract
Background: Active Leptospermum honey has non-peroxide antibacterial and anti-inflammatory effects, rendering it suitable for wound healing. Leptospermum honey is endemic in New Zealand belonging to the manuka bush (Leptospermum scoparium). The objective of the present research was to compare the efficacy ...
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Background: Active Leptospermum honey has non-peroxide antibacterial and anti-inflammatory effects, rendering it suitable for wound healing. Leptospermum honey is endemic in New Zealand belonging to the manuka bush (Leptospermum scoparium). The objective of the present research was to compare the efficacy of manuka honey dressing with conventional dressing regarding skin graft donor sites following a burn injury.Methods: This study was carried out in the department of surgery, Iran University of Medical Sciences, Tehran, Iran. It is a noncontrolled prospective trial, and an open-label study, analyzing Leptospermum honey and conventional dressing for the treatment of donor site areas for skin grafts. Data were collected from 15 eligible patients with burn wound. Two independent donor sites were formed, one of which was treated with active Leptospermum honey dressing and the other covered through the conventional method. Further collected was information regarding subjects’ demographics, self-reported pain (VAS scale), wound surface areas and bacterial wound culture.Results: In the treatment of skin graft donor sites, honey proved to be less painful compared with the conventional group (P=0.001). Three and seven days following treatment, a significant decrease was observed in the mean wound surface areas in the honey group (P=0.001). There was no significant difference between honey and conventional dressings with regards to the rate of infection (20% in honey dressing versus 40% in conventional group; P=0.068).Conclusions: Active Leptospermum honey dressing accelerates the healing process, decreases pain and has antimicrobial activity and can be used for care of skin graft donor sites.
Saman Ahmad Nasrollahi; Taraneh Yazdanparast; Setareh Ameri; Shadi Marami Zonouz; Mansour i Nassiri-Kashan; Alireza Firooz
Volume 20, Issue 1 , 2017, , Pages 1-5
Abstract
Background: Various fillers have been used for the correction of nasolabial folds. This study investigated the efficacy and safety assessment of two hyaluronic acid (HA) fillers on moderate nasolabial folds. Methods: This study randomized 10 volunteers, aged 35 to 49 years, with moderate nasolabial folds. ...
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Background: Various fillers have been used for the correction of nasolabial folds. This study investigated the efficacy and safety assessment of two hyaluronic acid (HA) fillers on moderate nasolabial folds. Methods: This study randomized 10 volunteers, aged 35 to 49 years, with moderate nasolabial folds. Volunteers received injections of HA A and HA B gels into the right or left skin folds. The volume and surface of nasolabial folds were analyzed using CSI computer software and high frequency ultrasonography of these folds before, and 2, 12, and 24 weeks after the injection. The obtained data were analyzed using SPSS software version 20. P≤0.05 was considered significant. Results: Evaluation of the nasolabial folds before and after treatment showed significant reduction in volume of wrinkles 24 weeks after injection in both the HA gel A (-29.93±32%, P=0.022) and gel B (-23.60±26%, P=0.019). The surfaces of the wrinkles significantly decreased 24 weeks after injection of HA gel A (-29.90±31%, P=0.012) and gel B (-21.96±26%, P=0.026). Conclusion: These HA fillers provided a significant, long-lasting correction of moderate nasolabial folds. Overall, we observed no statistically significant differences in any of the measurements between the 2 gels. However, there were more observed changes made by gel A compared to gel B.
Ameneh Yazdanfar; Kamran Kaveh
Volume 9, suppl.1 , 2006, , Pages 1-1
Abstract
Palmoplantar keratodermas are a heterogenous group of diseases, one of them is Papillon-Lefevre Syndrome (PLS). This rare disease is inherited as autosomal recessive and characterized by focal hyperkeratotic plaques on elbows and knees, severe periodontal disease resulting in premature loss of teeth. ...
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Palmoplantar keratodermas are a heterogenous group of diseases, one of them is Papillon-Lefevre Syndrome (PLS). This rare disease is inherited as autosomal recessive and characterized by focal hyperkeratotic plaques on elbows and knees, severe periodontal disease resulting in premature loss of teeth. We report two brothers with PLS who did not have a history of this disease in their family.
Amir Hooshang Ehsani; Katrin Kiavash
Volume 10, Suppl.2 , 2007, , Pages 1-1
Abstract
Pachyonychia congenital (PC) is a rare genodermatosis affecting the nails, skin, oral mucosae, larynx, hair, and teeth. General clinical presentation includes thickening of finger and toenails, painful plantar keratoderma, hyperhidrosis, oral leukokeratosis, follicular keratosis, palmar keratoderma, ...
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Pachyonychia congenital (PC) is a rare genodermatosis affecting the nails, skin, oral mucosae, larynx, hair, and teeth. General clinical presentation includes thickening of finger and toenails, painful plantar keratoderma, hyperhidrosis, oral leukokeratosis, follicular keratosis, palmar keratoderma, cutaneous cysts, hoarseness, twisted hair and prenatal or natal teeth. Clinically, PC is divided into 4 distinct subtypes. Here, we present a three-year-old girl with PC type II.
Atul Salodkar; Sanjiv Choudhary; Sankha Koley
Volume 12, Suppl.3 , 2009, , Pages 1-4
Abstract
Kindler syndrome (KS) is a rare autosomal recessive genodermatosis. We report two cases of KS with classical clinical presentations involving skin and mucus membranes. Clinically, both patients had four major features of KS in the form of acral skin blistering, photosensitivity, progressive poikiloderma, ...
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Kindler syndrome (KS) is a rare autosomal recessive genodermatosis. We report two cases of KS with classical clinical presentations involving skin and mucus membranes. Clinically, both patients had four major features of KS in the form of acral skin blistering, photosensitivity, progressive poikiloderma, and diffuse cutaneous atrophy. Case 1 had associated features in the form of urethral stenosis, skin fragility and palmoplantar keratoderma with extension of the scaling onto the flexor aspect of the wrist and loss of palmar creases. Case 2 had associated features in form of anal stenosis, oesophageal stenosis, skin fragility and palmoplantar keratoderma with loss of palmar creases. An Interesting finding in our report is that both cases have prominent telengectasia involving face and neck regions.
Najmossadat Atefi; Mehdi Tabaie; Samile Noorbakhsh; Azarmidokht Tabatabaie; Mohammadreza Rezaee; Masomeh Rohaninasab
Volume 15, Issue 1 , 2012, , Pages 1-3
Abstract
Background: T cell activation is discussed as an important factor in the pathogenesis of psoriasis. Recently, a lot of attention has been paid to the role of superantigens in T cell activation in the pathogenesis of psoriasis. In this study, the role of staphylococcal superantigens in the pathogenesis ...
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Background: T cell activation is discussed as an important factor in the pathogenesis of psoriasis. Recently, a lot of attention has been paid to the role of superantigens in T cell activation in the pathogenesis of psoriasis. In this study, the role of staphylococcal superantigens in the pathogenesis of psoriasis with identification of staphylococcal toxin levels in the skin lesions of patients with chronic plaque psoriasis has been studied. Method: In this case-control study, biopsies were taken from the skin of 40 patients with chronic plaque type psoriasis and 40 controls. Staphylococcal superantigens such as staphylococcus enterotoxin A, staphylococcus enterotoxin C, and toxic shock syndrome toxin 1 were investigated using polymerase chain reaction. Result: Staphylococcus aureus was isolated from 6.5% of the psoriasis patients and 2.5% of the individuals in the control group and all of them were toxin producer. There was a significant difference between controls and patients. Conclusion: Bacterial superantigens probably play an important role in the pathogenesis of chronic plaque type psoriasis.
Omid Zargari
AR Gholami; A Khamesipour; A Momeni; T Ghazanfari; MA Nilforoush Zadeh; Z Darajeh; Y Dowlati
Volume 3, Issue 3 , 2000, , Pages 2-6
Abstract
Background: Cutaneous leishmaniasis (CL) is a protozoan disease of the skin caused by a wide range of italic species. The disease is endemic in many countries. It has been recognized as a major public health problem in Iran. Many treatments have been suggested for it but none of them was fully effective. ...
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Background: Cutaneous leishmaniasis (CL) is a protozoan disease of the skin caused by a wide range of italic species. The disease is endemic in many countries. It has been recognized as a major public health problem in Iran. Many treatments have been suggested for it but none of them was fully effective. Objective: The objective of this study was to compare the efficacy of a 5% garlic cream with placebo in CL. Patients and Methods: A double blind, placebo controlled study was performed in Isfahan and Jahrom in 1997 and 1998. 197 patients were randomly selected. Exclusion criteria were: pregnancy, lactation, age less than 5 years and duration of disease more than 100 days. Each patient received garlic cream 5% or placebo for 3 weeks and was followed for another period of 40 days. Results: The study was completed as planned in 171 patients. 96 were treated with garlic 5% cream and 75 with placebo. Complete healing occurred in 18 (18.75%) of garlic group in comparison with 15 (20%) of placebo group. The difference was not significant (P=0.9865). Conclusion: 5% garlic cream was not effective in treatment of cutaneous leishmaniasis. Further studies with higher concentrations or different vehicle are needed.
F Iraji; H Azampour; F Fatemi
Volume 3, Issue 4 , 2000, , Pages 2-6
Abstract
Background: Palmoplantar eczema is a common clinical problem involving 2% of the population. There are many treatment modalities for palmoplantar eczema, each with specific local and systemic side effects. Objective: To evaluate methoxsalen bath in the treatment of palmoplantar eczema. Patients and Methods: ...
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Background: Palmoplantar eczema is a common clinical problem involving 2% of the population. There are many treatment modalities for palmoplantar eczema, each with specific local and systemic side effects. Objective: To evaluate methoxsalen bath in the treatment of palmoplantar eczema. Patients and Methods: In a randomized, double-blind, placebo controlled clinical trial, 60 patients with palmoplantar eczema referred to skin clinics of Isfahan University in 1376-78 were divided in two equal groups. One group received PUVA-bath and the other one received placebo-bath. Hands or feet or both were soaked for 15 minutes in warm water containing 0.0001% 8-methoxypsoralen or placebo. Then the skin was exposed to sun for 30 minutes. This was performed 4 times a week up to a total of 25 treatments. Results: Excellent or good therapeutic effects were achieved in 86.7% of PUVA bath group but only in 6.7% of placebo (P=0). No phototoxic reactions were observed. Conclusion: PUVA-bath is a safe, cheap, effective and comfortable method in the management of palmoplantar eczema.
M Radmanesh; S Shafiei
Volume 5, Issue 3 , 2002, , Pages 2-6
Abstract
Background: A high percentage of the patients referred to dermatologic clinics are either suffer from self inflicted disorders or from misinterpretation about their own health and organ integrity and or may suffer from different skin sensations including itching, pain, and burning; all of which may develop ...
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Background: A high percentage of the patients referred to dermatologic clinics are either suffer from self inflicted disorders or from misinterpretation about their own health and organ integrity and or may suffer from different skin sensations including itching, pain, and burning; all of which may develop as a result of their underlying psychopathologies. Objective: Identification of underlying psychopathology of psychocutaneous disorders. Patients and Methods: 109 dermatologic patients who clinically diagnosed as psychocutaneous disorders referred to psychiatric clinic for identification of their mood, personality and thought disorders. The impression of psychocutaneous disorder was made according to clinical interview and physical examinations in dermatology office. A semi-structured interview based on DSM-IV criteria performed on all patients to evaluate their mood, personality and thought. They also filled the Beck’s and Tailor inventories for further evaluation of their possible depression and anxiety. Results: 107 out of 109 cases studied, suffered from mood disorders including anxiety, depression or a combination of them. Of the remaining two cases one suffered from attention deficit hyperactivity disorder (ADHD) and the second one had no psychiatric disorder. 17 out of these 107 cases also suffered from personality disorder and 3 cases had delusional thoughts. Conclusion: All psychocutaneous patients may suffer from one or more psychiatric disorders which should be identified and approached properly.
J Movaffagh; MR Jafari; MH Amouzegar; SA Tabatabaei
Volume 9, Issue 1 , 2006, , Pages 2-16
Mostafa Mirshams Shahshahani; Nafiseh Esmaili; Pedram Mehryan; Amir Houshang Ehsani; Siavash Toosi
Volume 10, Issue 1 , 2007, , Pages 2-8
Abstract
Background and aim : The clinical management of verrucae vulgaris is often challenging and no treatment is always effective. Early studies have suggested that pulsed-dye laser (PDL) may be highly effective in the treatment of verrucae through obliteration of dilated vessels in papillary dermis. The objective ...
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Background and aim : The clinical management of verrucae vulgaris is often challenging and no treatment is always effective. Early studies have suggested that pulsed-dye laser (PDL) may be highly effective in the treatment of verrucae through obliteration of dilated vessels in papillary dermis. The objective of this study was to compare safety and efficacy of 585 nm with 595 nm PDL in the treatment of warts.Materials and methods: The randomized controlled trial was done on forty patients with warts referred to Razi Hospital in Tehran. Almost symmetrically distributed warts were randomized to receive PDL 585 nm or 595 nm on their left or right side and a similar lesion with respect to size, thickness and location was not treated as control. Each patient was treated in three sessions at three- week intervals. Warts were individually examined at the time of each treatment session and their size and adverse effects of treatment recorded. Complete response was defined as complete disappearance of lesions.Results: Thirty-six patients completed the trial. The mean size of the lesions before the treatment were 19.7±13.2 mm2 in PDL 585 nm group and 21.7±15.4 mm2 in PDL 595 nm group. After the last treatment the mean reduction in size of warts were 18.1±12.3 mm2 and 18.1±11.2 mm2 and the lesions cleared in 27 (75%) and 25 (69%) patients in PDL 585 nm and PDL595 nm groups, respectively (P value =0.83). Variable degrees of purpura and pain were observed in all patients which was classified as severe in 15 and 16 cases in PDL 585 nm group and 19 and 18 cases in PDL 595 nm group, respectively (P=0.8).Conclusion: The PDL is an effective treatment for verrucae vulgaris and there are no statistically significant differences between 585 nm and 595 nm with respect of their efficacy and adverse effects.
M Bayat; SN Razavi; A Hosseini
Volume 4, Issue 2 , 2001, , Pages 3-8
Abstract
Background: Positive effects of Kombucha tea (An old folkloric drink of Asian people) on wound healing process have been observed. Objective: To study its effects on the number of mast cells of wound bed. Materials and Methods: The study design was experimental. 42 male adult rats were randomly divided ...
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Background: Positive effects of Kombucha tea (An old folkloric drink of Asian people) on wound healing process have been observed. Objective: To study its effects on the number of mast cells of wound bed. Materials and Methods: The study design was experimental. 42 male adult rats were randomly divided into control and experimental groups. Each group was divided into 3 subgroups. The time of study of first subgroups were 4 days (Represents inflammation phase of wound healing process), of second subgroups were 7 days (Proliferation phase) and of third subgroups were 15 days (Remodeling phase) after wounding. Both groups drank Kombucha tea for 30 days. Then under general anesthesia and sterile conditions, a full thickness wound was made on the dorsum of all rats. The wounding day was considered as day zero. Rats of experimental group drank Kombucha tea after surgery until they were killed by ether at the end of above-mentioned durations. Samples were obtained from rats and prepared for light microscopical study and stained with 1% watery solution of toluidine blue. Mast cells and its grades (According to it’s degranulations) were counted. Data were analyzed by students t test method. Results: Main results were: 1) Total number of most cells of experimental group decreased from 7th day toward 15th day and on 15th day, the difference with control group was significant (P<0.01); 2) In most cases the numbers of mast cells of experimental group were lower than control group and the difference were significant for the 4th day grade 1, 15th day grade 2 (P<0.05) and total number of grades 2 and 3 (P<0.01). Conclusion: Daily consumption of Kombucha tea by rats caused a decreased number of mast cells during skin wound healing and the difference with control group at remodeling phase was significant.
AM Namian; M Rahimi Nejad
Volume 4, Issue 3 , 2001, , Pages 3-10
Abstract
Background: Discoid Lupus Erythematosus (DLE) is chronic, recurrent and relatively benign skin disorder. Objective: The purpose of this study was to investigate the laboratory tests (ANA, LE-Cell, ESR, CRP, RF, VDRL, WBC, PLT) in patients with DLE. Patients and Methods: In this study, laboratory tests ...
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Background: Discoid Lupus Erythematosus (DLE) is chronic, recurrent and relatively benign skin disorder. Objective: The purpose of this study was to investigate the laboratory tests (ANA, LE-Cell, ESR, CRP, RF, VDRL, WBC, PLT) in patients with DLE. Patients and Methods: In this study, laboratory tests of 51 patients with DLE who referred to the Dermatology clinic of Shahid Faghihi Hospital in Shiraz since Mehr 1377 to Shahrivar 1379, were investigated. Results: Positive ANA was found in 20% of patients (9.46) and 33% of patients (15.45) had ESR>20 mm/hr. Leukopenia, leukocytosis and thrombocytosis was found in 8% (4.51), 2% (1.51), and 2.5% of patients (1.40) respectively and none of the patients (From 45 patients) had thrombocytopenia. One patient from 40 patients (2.5%) showed positive RF test. LE-cell preparation, CRP and VDRL tests were done in 40, 41 and 42 patients respectively and were negative in all of them. Conclusion: Some of the patients with DLE show abnormalities in laboratory tests. ANA positively and high ESR are more common than others.
F Iraji; R Tavakoli
Volume 4, Issue 4 , 2001, , Pages 3-7
Abstract
Background: Evaluation of the impacts cutaneous of leishmaniasis (CL) on the patients, their family and government are necessary. Unfortunately these evaluations have not been done. Objective: Due to increased incidence of CL in Isfahan province especially in rural areas, this study was done to assess ...
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Background: Evaluation of the impacts cutaneous of leishmaniasis (CL) on the patients, their family and government are necessary. Unfortunately these evaluations have not been done. Objective: Due to increased incidence of CL in Isfahan province especially in rural areas, this study was done to assess the expenses of this disease in Isfahan in 1999. Patients and Methods: 196 patients were selected randomly from four areas of Isfahan province (2 rural and 2 urban), on the basis of data from Health Center in 1999. The amount of money that was paid for physician visit, traveling, accessory expenses (For example to buy insecticide), injections, dressing and drugs for treatment of CL were asked and recorded. Results: The mean amount paid in rural and urban areas were 208307 and 457327 Rials, respectively. Conclusion: Incidence of CL is about 10-30 thousands of patients in Isfahan each year, therefore the yearly expense of treatment is about 3-6 milliard Rials. We must change our strategies for controlling and eradicating this problem.