B Nabaei; H Safizadeh; Z Halaji
Volume 5, Issue 3 , 2002, , Pages 15-21
Abstract
Background: The reduction of disability caused by psoriasis is an important issue in dermatology. It is thus important to assess the patients’ appraisal of their quality of life. Objective: The aim of the present study was to assess quality of life among patients with psoriasis and to compare these ...
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Background: The reduction of disability caused by psoriasis is an important issue in dermatology. It is thus important to assess the patients’ appraisal of their quality of life. Objective: The aim of the present study was to assess quality of life among patients with psoriasis and to compare these estimates with general population. Patients and Methods: In this cross-sectional study, 55 patients and 55 control subjects were interviewed in Tehran Razi hospital. Quality of life was assessed by SF-36 and PDI questionnaires. Results: After score calculation in any domain of SF-36, it was seen that psoriasis patients reported significantly lower scores than the normal control subjects in all scales, except for physical functioning. The greatest difference was found in social functioning. The smallest difference was noticed in vitality. The psoriasis disability index score (PDI) was negatively correlated with all of the eight of the SF-36 health measures in psoriatic patients. Conclusion: These results show that psoriasis patients report poorer quality of life than general population. Therefore, in the case of these patients one most pay attention to the impact of this disease on different life domains.
MJ Nazemi Tabrizi; AH Ehsani; Y Sedaghat; P Noormohammad Pour; M Mohajer; P Saheb Nazar
Volume 8, Issue 1 , 2004, , Pages 15-18
Abstract
Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit. The role of Pityrosporum ovale (P.ovale) in the exacerbation of acne is still under debate. Objective: To determine the efficacy of topical 2% ketoconazole cream in comparison to placebo in the treatment of acne vulgaris ...
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Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit. The role of Pityrosporum ovale (P.ovale) in the exacerbation of acne is still under debate. Objective: To determine the efficacy of topical 2% ketoconazole cream in comparison to placebo in the treatment of acne vulgaris in patients with positive smear for P.ovale. Patients and Methods: A smear was obtained from lesions of 84 patients with acne vulgaris referred to Razi Hospital, Tehran. After determination of clinical and mycological grading, patients with positive smear for P.ovale were randomly treated with topical 2% ketoconazole cream or placebo. After 4 weeks the patients were evaluated for the clinical and mycological grading and treated with traditional anti-acne drugs. Results: Fifty-six of 84 patients had positive smears, 29 of them were treated with ketoconazole cream and 27 patients received placebo. Clinical grading before treatment was 2.60 and 2.21 in ketoconazole and placebo groups, which was reduced to 2.16 and 2.05, respectively. Mycological grading reduced from 1.4 to 0.44 in ketoconazole group, but did not change in placebo group (1.42). Conclusion: 2% ketoconazole cream was more effective than placebo in reduction of mycological grading but did not have any effect on clinical grading of acne.
R Yaghoobi
Volume 3, Issue 1 , 1999, , Pages 16-23
Abstract
Background: Pemphigus is an autoimmune disease characterized with intra-epidermal cleavage. Objective: The aim of this study was to examine the clinical and epidemiologic features of pemphigus in Khouzestan province, southwest Iran. Patients and Methods: All new cases of pemphigus admitted in the department ...
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Background: Pemphigus is an autoimmune disease characterized with intra-epidermal cleavage. Objective: The aim of this study was to examine the clinical and epidemiologic features of pemphigus in Khouzestan province, southwest Iran. Patients and Methods: All new cases of pemphigus admitted in the department of dermatology, Sina Hospital, Ahwaz University from October 1990 to September 1999 were studied. The diagnosis of pemphigus was based on clinical and histological findings. Results: One hundred-eleven pemphigus patients represented 4.7% of 2358 patients admitted to this department in this period. The most common presentation was pemphigus vulgaris (81.98%), followed by pemphigus foliaceous (18.02%). Pemphigus was observed more common in women (62 of 111; 55.86%) than in men (49 of 111; 44.14%). The mean age of all variants of pemphigus and in both sex at the time of diagnosis was 42.5 years. The lag time between the onset of illness and final diagnosis in pemphigus vulgaris and pemphigus foliaceous were 4 and 9 months, respectively. In pemphigus vulgaris patients, the onset of lesions were 54.65% and 45.34% from mucous membranes (Mainly oral cavity) and skin in 54.65% and 45.35% of cases, respectively. In all of pemphigus foliaceous patients, the onset of lesions was from the skin. The mortality was 6.30%, more in pemphigus foliaceous than vulgaris. Conclusion: This study showed that pemphigus is relatively common in Khouzestan province, compared with other regions. Pemphigus vulgaris is the most common variant and mortality was higher in pemphigus foliaceous.
M Valikhani; AR Zaker; M Zaker
Volume 5, Issue 4 , 2002, , Pages 16-19
Abstract
Background: Common wart is one of the most prevalent skin diseases, caused by human papilloma virus. Numerous therapeutic modalities have been used in the treatment of warts. Objectives: This study was designed to evaluate and compare the efficacy of 5% 5-fluorouracil (5-FU) ointment with cryotherapy ...
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Background: Common wart is one of the most prevalent skin diseases, caused by human papilloma virus. Numerous therapeutic modalities have been used in the treatment of warts. Objectives: This study was designed to evaluate and compare the efficacy of 5% 5-fluorouracil (5-FU) ointment with cryotherapy in the treatment of common warts of hands. Patients and Methods: In a single blind, prospective clinical trial, 30 patients with bilateral common warts of hands referred to Dermatology Clinic of Razi Hospital, were recruited. The lesions on one hand of the patients were treated by cryosurgery and on the other hand with 5% 5-FU ointment twice daily for about 12 weeks. Results: After 12 weeks, 93% of patients treated by cryotherapy (The mean treatment period 7.5 weeks), and 66.7% of patients received 5% 5-FU ointment (The mean treatment period 6.9 weeks) were completely cured. No significant side effects were noted in patients who received 5% 5-FU ointment. Conclusion: 5% 5-FU ointment can be used as appropriate, household and inexpensive treatment in the management of common warts.
H Seyrafi; F Farnaghi; S Fathabadi
Volume 6, Issue 1 , 2002, , Pages 16-20
Abstract
Background: Due to the chronic nature of atopic dermatitis and dependence of most patients to steroids, finding a suitable alternative treatment is important. Objectives: To determine the efficacy of phototherapy in treatment of atopic dermatitis, also to evaluate possible influencing factors in response ...
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Background: Due to the chronic nature of atopic dermatitis and dependence of most patients to steroids, finding a suitable alternative treatment is important. Objectives: To determine the efficacy of phototherapy in treatment of atopic dermatitis, also to evaluate possible influencing factors in response of patients to psoralen+UVA (PUVA) therapy. Patients and Methods: 13 patients with resistant atopic dermatitis, older than 10 years, were treated with PUVA, 2 or 3 times a week until complete recovery or maximum of 30 sessions. Rate of recovery was determined according to reduction in 6 signs including itching, erythema, lichenification, xerosis, exfoliation and excoriation at the end of the treatment period and 2 months later. Results: 10 patients (77%) at the end of the treatment and 9 patients (69.2%) two months after that, showed more than 50% recovery. There was no significant relationship between the pretreatment serum IgE levels, site of the lesions, age, sex and phototherapy. The patients with family history of atopic dermatitis showed a better response to the treatment. Conclusion: PUVA is a suitable alternative treatment in resistant cases of atopic dermatitis.
Z Eslami
Volume 2, Issue 1 , 1998, , Pages 17-20
Abstract
Atopic dermatitis (AD) is a pruritic, relapsing, chronic disease that arises most commonly during infancy, childhood, or adolescence. It is clear that genetic factors are important in AD, a family history of AD, allergic rhinitis, and/or asthma and other “Atopic” phenomena being common in ...
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Atopic dermatitis (AD) is a pruritic, relapsing, chronic disease that arises most commonly during infancy, childhood, or adolescence. It is clear that genetic factors are important in AD, a family history of AD, allergic rhinitis, and/or asthma and other “Atopic” phenomena being common in patient with AD. The two main pathogenetic characteristic of AD are: I) IgE-mediated antigen dependent “Specific” reactivity, and II) altered non-immunological “Non-specific” reactivity. Because there are no single distinguishing features of AD, the clinical diagnosis is based on a combination of historic and morphologic finding. In this article the immunological aspects in patients with AD will be briefly reviewed.
M Omidian
Volume 2, Issue 4 , 1999, , Pages 17-21
Abstract
Background: Dermatophyte infections are common contagious diseases found in all over the world specially in tropical regions. Objective: Our objective was to study different forms of dermatophytosis in Ahwaz. Patients and Methods: We studied 100 cases of dermatophytosis whom were visited in a private ...
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Background: Dermatophyte infections are common contagious diseases found in all over the world specially in tropical regions. Objective: Our objective was to study different forms of dermatophytosis in Ahwaz. Patients and Methods: We studied 100 cases of dermatophytosis whom were visited in a private skin clinic in 1372 to 1376 in Ahwaz. Results: Among 266 suspected patients sent for fungal examination, 100 dermatophyte cases (79 men and 21 women) were diagnosed. Tinea capitis was the most common tinea found in 34% specially in the boys and the most common fungal agent was Microsporum canis. Tinea cruris was found in 32% and was the most common form in men. The most important fungal agent was Epidermophyton fluccosum. The incidence of other forms were: tinea corporis 20%, tinea pedis 7%, tinea faciei 4%, tinea mannum 1%. Onychomycosis due to dermatophytes and tinea barbae were not found, but 2 cases of onychomycosis due to non-dermatophyte saprophytes were observed. Conclusion: Tinea capitis was the most common clinical form and zoophilic fungi were the most common etiologic agents of dermatophytosis in Ahwaz.
S Shamsoddini; AR Fekri; H Ebrahimi; ME Zeinodini
Volume 6, Issue 4 , 2003, , Pages 17-23
Abstract
Background: Due to infections, cardio-vascular involvement and renal insufficiency, patients with systemic lupus erythematosus live shorter than usual. Objective: To determine the mean survival rate of SLE patients. Patients and Methods: 62 SLE patients admitted in the hospitals of Kerman University ...
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Background: Due to infections, cardio-vascular involvement and renal insufficiency, patients with systemic lupus erythematosus live shorter than usual. Objective: To determine the mean survival rate of SLE patients. Patients and Methods: 62 SLE patients admitted in the hospitals of Kerman University of Medical Sciences from 1369 to 1380 were included in this study. The demographic variables, which were effective on disease survival time, evaluated. Results: Mean survival time, regardless of other descriptive variables, was 9.2±0.89 years. The cases who had skin lesions first, in comparison with those who had rheumatic signs at first, revealed lower survival rate and more morbidity. The mean survival rate of cases who received combination of corticosteroid and anti-malarial drugs, corticosteroid drugs alone, and cyclophosphamide plus anticoagulants, were 12.0, 9.5 and 8.5 years, respectively. Conclusion: The prognosis in SLE patients with early skin manifestations was poorer than those with early rheumatic presentation. Best prognosis was noted in patients who received systemic steroids in comparison to other treatment modalities.
A Asilian; F Salehi
Volume 3, Issue 4 , 2000, , Pages 18-22
Abstract
Background: Nevus spilus can produce considerable disfigurement. There is no specific and successful treatment for this nevus. Objective: The purpose of this study was to evaluate the efficacy of CO2 laser in the treatment of nevus spilus. Patients and Methods: This quasi-experimental clinical trial ...
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Background: Nevus spilus can produce considerable disfigurement. There is no specific and successful treatment for this nevus. Objective: The purpose of this study was to evaluate the efficacy of CO2 laser in the treatment of nevus spilus. Patients and Methods: This quasi-experimental clinical trial was performed on 47 patients with spilus nevus in Al-Zahra Hospital in Isfahan. The diagnosis of nevus spilus was based an clinical and biopsy findings. The efficacy of treatment was evaluated based on tolerability, side effects, improvement according to patient and physician judgment and comparison of photographies, after one year of follow up. The laser used was Sonic LS 500 (Made in Germany) with power of 3 watts, duration of 0.25 seconds and spot size of 3 millimeters. Results: 45 of the patients were female and 2 were male. The mean age of them was 20 years. All the lesions were on the face. Two patients were withdrawn due to inefficacy or infection of test site treatment. In 43 of the 45 remaining patients (95.5%), the treated site healed uneventfully. Recurrence of nevus spilus was seen in a single patient one year after treatment. Conclusion: CO2 laser is an effective therapy for nevus spilus.
F Malekzad; S Nasiri; T Sabbaghian
Volume 4, Issue 3 , 2001, , Pages 18-23
Abstract
Background: There is no data on the characteristics of patients with localized scleroderma in Iran. Objective: In order to determine the age, sex and type distribution of localized scleroderma in Iran, this study was done on patients referred to Boo-Ali Hospital in Tehran in 1995-1999. Patients and Methods: ...
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Background: There is no data on the characteristics of patients with localized scleroderma in Iran. Objective: In order to determine the age, sex and type distribution of localized scleroderma in Iran, this study was done on patients referred to Boo-Ali Hospital in Tehran in 1995-1999. Patients and Methods: This study was done as an existing data study on 39 patients with localized scleroderma referred to Boo-Ali Hospital in Tehran in 1995-1999. Age, sex, site, type of involvement, and age distribution of each type were recorded. Results: 39 patients with localized scleroderma referred to Boo-Ali Hospital in this period, including 9 male and 30 female patients so female/male ratio was 3/3. Most of the patients (48%) were in the age range of 20-40 years. 77.9% of female patients were in the age range of 10-40 years and 43.4% of male patients were in the first to fourth decade. 2.56% of the patients were younger than 10 years and most were boys. The most common sites of involvement were extremities, trunk, face and neck in order. The plaque type was the most common type but the linear type was seen more in perineal area. The plaque type was the most common type in children, as well. Conclusion: Age and sex distribution and sites of involvement in patients with localized scleroderma referred to Boo-Ali Hospital in Tehran were similar to other reports.
S Shamsaddini; M Nasiri Kashani; I Sharifi; M Khajeh Karimoddini; M Pourlashkari
Volume 4, Issue 1 , 2000, , Pages 19-25
Abstract
Background: Living in colonies and public places may cause increase in infectious diseases. Prisons are places with high-density population. Prisoners don’t persist on moral and social dictum bases and usually have low educational and cultural levels. So they are at high risk of several diseases ...
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Background: Living in colonies and public places may cause increase in infectious diseases. Prisons are places with high-density population. Prisoners don’t persist on moral and social dictum bases and usually have low educational and cultural levels. So they are at high risk of several diseases including contagious skin diseases. Objective: As contagious skin diseases are important for social health care, this study was done to determine the prevalence of these diseases in a prison in Kerman. Patients and Methods: This cross-sectional study was done on 3525 prisoners, comprising about half of the prisoners, in the Central Prison of Kerman. Results: 2851 of the case were male and 674 were female. The mean age of male cases was 36.05±11.3 years and for female was 35.5±14.0 years. Among all prisoners 4.6% had pediculosis. 1.2% had scabies and 3.7% had tinea pedis. Among the prisoners 55.8% were addict and 73.6% were smokers. There were no meaningful relationship between addiction or smoking and the diseases (P=0.576 and P=0.660). Conclusion: Contagious skin diseases are common in prisons. Health and security authorities should plan for a community free of drugs, prisons and prisoners.
F Farnaghi; H Seirafi; AR Firooz; F Jamshidi
Volume 7, Issue 1 , 2003, , Pages 19-23
Abstract
Background: Psoriatic arthropathy is a seronegative arthropathy seen in some patients with psoriasis, a self-limited and genetically determined skin disease. Objective: To determine the prevalence and risk factors of arthropathy in patients with psoriasis. Patients and Methods: In a prospective, cross-sectional ...
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Background: Psoriatic arthropathy is a seronegative arthropathy seen in some patients with psoriasis, a self-limited and genetically determined skin disease. Objective: To determine the prevalence and risk factors of arthropathy in patients with psoriasis. Patients and Methods: In a prospective, cross-sectional study, psoriatic patients referred to Razi Skin Hospital in Tehran, Iran in 2002 were evaluated for the presence of arthropathy, and were referred to a rheumatologist for confirmation of arthropathy. The relationship between and nail involvement were evaluated using chi-square and t tests. Results: Among 320 patients with psoriasis, 29 (9.1%) had joint diseases. The most common was asymmetric polyarthritis. Patients with joint diseases had more nail involvement (96.5% vs. 73.1%, P<0.05) and higher mean PASI scores (24.33±10.35 vs. 10.70±8.44, P<0.05) than those without arthropathy, but the age and sex distribution of two groups were not significantly different. Conclusion: The prevalence of joint diseases in psoriatic patients in this study was similar to other reports. Nail involvement and more extensive disease are risk factors for joint diseases in these patients.
K Nabizadeh; A Nasiri; A Zamanian
Volume 5, Issue 1 , 2001, , Pages 20-26
Abstract
Background: The nails of hands and feet are involved in the course of many dermatoses and some systemic diseases. They may have diagnostic or prognostic value in some diseases. Objective: The aim of this study was to evaluate nail lesions in patients referred to Dermatology Department of Sina Hospital ...
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Background: The nails of hands and feet are involved in the course of many dermatoses and some systemic diseases. They may have diagnostic or prognostic value in some diseases. Objective: The aim of this study was to evaluate nail lesions in patients referred to Dermatology Department of Sina Hospital in Hamadan from April 1999 to April 2000. Patients and Methods: This cross-sectional descriptive study was done by preparation of a checklist and necessary information was collected by examining all the patients and recording the nail changes. The data were analyzed with EP16 software. Results: Among 2269 patients visited during this year, 630 persons (27.7%) had nail lesions. Eczema and psoriasis were the most common dermatosis with nail lesions (23.5% and 12%, respectively). Fifty-five patients (8.7%) had only nail diseases. Ridging was the most common nail lesion in hands (32%) and in feet (42%). Conclusion: Approximately one third of patients referred to the dermatologic clinic of Sina Hospital in Hamadan had nail lesions.
MJ Yazdan Panah; SK Mostoufi; M Soleimani
Volume 6, Issue 2 , 2003, , Pages 20-24
Abstract
Background: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis (CL), but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance, adverse effects and low compliance of patient, ...
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Background: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis (CL), but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance, adverse effects and low compliance of patient, efforts for finding a more effective and safer drug continue. Objectives: To evaluate the efficacy of oral zinc sulfate in the treatment of acute dry CL. Patients and Methods: 31 patients with clinical diagnosis of acute, dry CL and positive direct smear for Leishman bodies were included in the trial. Patients were treated with 10 mg/kg/day oral zinc sulfate for 45 days and evaluated every 3 weeks during the period of treatment and also 1.5 months after cessation of it. Results: 22 patients completed the course of treatment. At the end of 45 days of treatment, only two cases (9%) were cured and the remaining did not show satisfactory response. Conclusion: Oral zinc sulfate has limited therapeutic value in the treatment of dry CL.
A Asilian; Z Haj Heydari
Volume 2, Issue 3 , 1999, , Pages 21-24
Abstract
Introduction: Macular amyloidosis is a relatively rare disease. A basic change appears to be amyloid material deposition in an apparently normal skin. The characteristic features of the disease are reticulate and ripple brown pigmentation in interscapular regions. Shoulder, back and chest. There are ...
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Introduction: Macular amyloidosis is a relatively rare disease. A basic change appears to be amyloid material deposition in an apparently normal skin. The characteristic features of the disease are reticulate and ripple brown pigmentation in interscapular regions. Shoulder, back and chest. There are several reports indicating the association of the disease with rubbing against the skin. According to high frequency of the disease in our area especially among the women and due to its disability such as disfigurement for women, we decided to perform the following study. Materials and Methods: The study is an analytic descriptive one. Twenty-eight patients suffering from macular amyloidosis defined by clinical and laboratory findings were reviewed. The study being performed from October 1995 to October 1998 in University hospital dermatological clinics in Isfahan. Results: Twenty-one females and seven males were considered in the study. The age range was between 15-50 years. There was a positive family history in 43% of patients. Clinically the lesions were composed of reticulate and rippled pigmentation frequently observed in interscapular, upper arms and shoulder regions. The most common association in these patients was seborrheic dermatitis of scalp and face. In this study most of the patients mentioned the use of nylon brush during bathing and some of them relieved their itching with comb and brush. Conclusion: Female to male ratio in our study was three to one, which is compatible with higher frequency of disease among women in recent reports. The age range of patients was frequently between 15-34 years that is in young adults. A direct relationship was present between nylon brush or comb use during bathing and exacerbation of the disease. The traditional habit of using nylon objects during bathing might explain the high prevalence of this disorder in our community.
S Nassiri; F Ghalamkar Pour; A Saberi; P Vessal
Volume 9, Issue 1 , 2006, , Pages 22-27
M Bayat
Volume 3, Issue 2 , 2000, , Pages 23-26
Abstract
Introduction: Positive effects of topical application of honey on open skin wounds have been observed, Mast cell are playing role in normal wound healing and its disturbances but the role of mast cells in wound healing in existence of honey is uncertain. Objective: The aim of this investigation was to ...
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Introduction: Positive effects of topical application of honey on open skin wounds have been observed, Mast cell are playing role in normal wound healing and its disturbances but the role of mast cells in wound healing in existence of honey is uncertain. Objective: The aim of this investigation was to study the effects of two times per day topical application of honey on the number of mast cells in skin wounds. Materials and Methods: 33 male rats were randomly divided into experimental and control groups. Under general anesthesia and sterile conditions, one round full thickness skin wound was made on the dorsum of neck of each rat. The diameter of wounds was about 3cm. Unboiled honey was applied topically on wounds twice per day from surgery day until certain days. On the fourth, seventh, and fourteenth days after surgery according to inflammation, proliferation and remodeling phases of wound healing process, samples were obtained from wound tissue and adjacent skin after rats were killed with ether. Samples were prepared for routine histological study and stained with 1% aqueous toluidine blue. Mast cells of wounds were counted and analyzed by Mann Whitney U test. Results: The mean of mast cells was lower in experimental group in three above-mentioned days. The differences were statistically significant on days 4 and 7 (P<0.05 for fourth day, P<0.01 for seventh day, and P>0.05 for fourteenth day). Conclusion: Twice per day application of honey on open full thickness skin wounds could reduce the number of mast cells significantly, in inflammatory and proliferative phases of wound healing.
S Shamsoddini; H Mohammad Abadi
Volume 2, Issue 2 , 1999, , Pages 26-33
Abstract
Objective: To study of relationship between alopecia areata and finger print dermatoglyphic types in 100 patients with alopecia areata and in 100 controls. Methods: A case control analytical study was done on fingerprints of patients with alopecia areata. The control cases were older than 50 years old ...
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Objective: To study of relationship between alopecia areata and finger print dermatoglyphic types in 100 patients with alopecia areata and in 100 controls. Methods: A case control analytical study was done on fingerprints of patients with alopecia areata. The control cases were older than 50 years old without any history of alopecia areata. Dermatoglyphical trials of total fingers were also studied. Diagnostic criteria for alopecia areata was simultaneous shedding of hair seen by a dermatologist. Results: In patients with alopecia areata, the frequency of finger print types was: whorl in 47.3%, loop in 39.6%, arch in 13.1%. In control group whorl were seen in 56.1%, loop in 37.3% and arch in 6.6%. The statistical difference between fingerprint of thumb finger in right hand, index and small finger in left hand relative to control group were significant (P<0.05). Conclusion: The findings indicate of a genetic relation between alopecia areata and the finger print dermatoglyphics.
افسانه علوی; ایرج اسفندیارپور
Volume 1, 3-4 , 1998, , Pages 29-33
Abstract
Cutaneous leishmaniasis caused by leishmania tropica is endemic in Iran. Kerman is the fifth most infected foci of dry type of cutaneous leishmaniasis after Tehran, Mashhad, Naishabor and Shiraz. We studied the clinical features of this disease in 664 patients referred to the dermatology and private ...
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Cutaneous leishmaniasis caused by leishmania tropica is endemic in Iran. Kerman is the fifth most infected foci of dry type of cutaneous leishmaniasis after Tehran, Mashhad, Naishabor and Shiraz. We studied the clinical features of this disease in 664 patients referred to the dermatology and private clinic during the period March 1992 to March 1993 in Kerman. Females were dominated. The disease was more frequent below 10 years of age (50%). Papule and plaque were the most common clinical presentations of the disease followed by papule+plaque. The face was the most frequent site of involvement (30%); followed by right and left upper extremities. The trunk was the least common site (0.4%). Many of the patients were presented with one lesion, and the highest number of lesions in one patient was ten. The highest number of patients came with acute leishmaniasis (Duration of disease less than 1 year) and few patients with chronic from (Duration of disease more than 1 year).
M Omidian
Volume 1, Issue 1 , 1997, , Pages 34-37
Abstract
Behcet’s disease is a multisystem disease characterized clinically by oral aphthae and occasionally by genital aphthae, cutaneous lesions such as pustular vasculitis, sweet syndrome-like, pyoderma gangrenosum-like and erythema nodosum-like lesions and variably present systemic features such as ...
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Behcet’s disease is a multisystem disease characterized clinically by oral aphthae and occasionally by genital aphthae, cutaneous lesions such as pustular vasculitis, sweet syndrome-like, pyoderma gangrenosum-like and erythema nodosum-like lesions and variably present systemic features such as synovitis, anterior and posterior uveitis, meningoencephalitis and large vessel smaller vessel vascular disease, and Aphthae may occur throughout the entire gastrointestinal tract. We studied 26 cases of Behcet’s disease hospitalized in Sina Hospital, Ahwaz. 20 of these patients were woman (76%) and 6 were men (74%), with an age range of 13 to 43 years. All the patients had oral aphthae, 22 had genital aphthae (84%), 8 had eye disease (30%), 10 had skin lesions (34%), 10 had arthralgia and arthritis and 3 had CNS involvement as head ache.
Ghandi Narges; Tavassoli Shaghayegh; Ghiasi Maryam; Lajevardi Vahideh; Abedini Robabeh; Tohidinik Hamid-Reza; Daneshpazhooh Maryam
Volume 19, Issue 75 , 2016, , Pages 35-13
Abstract
Background: Prolactin (PRL) appears to play a role in the pathogenesis of autoimmune diseases. Limited evidence showed an association between serum PRL levels and the activity of pemphigus vulgaris (PV). This study intends to determine PRL level changes in pemphigus patients during therapy and its correlation ...
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Background: Prolactin (PRL) appears to play a role in the pathogenesis of autoimmune diseases. Limited evidence showed an association between serum PRL levels and the activity of pemphigus vulgaris (PV). This study intends to determine PRL level changes in pemphigus patients during therapy and its correlation with disease type and severity. Methods: In this cohort study, we measured serum PRL levels by enzyme-linked immunosorbent assay (ELISA) in newly diagnosed PV patients at three time points: before therapy initiation and after two and four months. Concomitantly, we estimated disease severity by the Pemphigus Disease Area Index (PDAI). Results: We examined 42 new cases of PV. Among 32 cases who completed the study, mean serum PRL levels at the three time points were 15.9±14.1 ng/mL (before treatment), 16.7±9.8 ng/ mL (2 months after initiation of treatment), and 15.2±9.2 ng/mL (4 months after initiation of treatment). Mean PDAI values were 19.3±12.8 (before treatment), 3.7±6.2 (2 months after initiation of treatment), and 0.6±1.5 (4 months after initiation of treatment). Although the disease activity decreased significantly (P
Vora Deval; Popat Vijay; Bhanvadia Viral; Mehta Dimple A.; Bhetariya Bharat; Kumar Meet
Volume 13, Issue 2 , 2010, , Pages 42-46
Abstract
Background: A clinicopathological study of 75 cases of pemphigus was carried out at Saurashtra region of Gujarat State, India. This study was done to subtype this disease with evaluation of clinical and histopathological presentation. Methods: The study was carried out in a two-year period at skin department ...
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Background: A clinicopathological study of 75 cases of pemphigus was carried out at Saurashtra region of Gujarat State, India. This study was done to subtype this disease with evaluation of clinical and histopathological presentation. Methods: The study was carried out in a two-year period at skin department of Guru Gobind Singh Hospital, Jamnagar. Seventy five patients of pemphigus were examined, admitted and treated. Histopathological examination was done at the department of pathology and direct immunoflouroscence was advised and done at higher centers when it was needed. Result: Out of 75 cases, pemphigus vulgaris constituted the single largest group of cases which made 72 (96%) cases with three (4%) cases of pemphigus foliaceus. The majority of the cases were seen in the age group of 21-60 years, with a slight female predominance. The youngest patient was 18 years while the eldest was 70 years old. Oral mucosal involvement was seen in almost all cases of pemphigus vulgaris while 7 cases of pemphigus vulgaris had mucosal involvement at other sites in addition to oral mucosal involvement. No mucosal involvement was present in cases of pemphigus foliaceus. Flaccid bullae were present in 100% of the cases. Pruritus was present in 15 cases of pemphigus vulgaris. Conclusion: Most of the patients had pemphigus vulgaris followed by pemphigus foliaceus. Pemphigus is more prevalent at certain areas of Saurashtra region showing a geographic distribution.
Nazemi-Tabrizi Mohammad-Javad; Hatami Parvaneh; Ghiasi Maryam; Daneshpazhooh Maryam; Chams-Davatchi Cheyda
Volume 15, Issue 2 , 2012, , Pages 42-46
Abstract
Background: Pemphigus vulgaris is a rare autoimmune disorder characterized by cutaneous and mucosal blistering. Surprisingly, the management of oral lesions has been detailed only infrequently. As current topical therapies for oral lesions are of limited efficacy, application of calcineurin inhibitors ...
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Background: Pemphigus vulgaris is a rare autoimmune disorder characterized by cutaneous and mucosal blistering. Surprisingly, the management of oral lesions has been detailed only infrequently. As current topical therapies for oral lesions are of limited efficacy, application of calcineurin inhibitors is considered to be a potential option. The aim of this essay was to investigate the efficacy of tacrolimus 0.1% ointment (Protopic®) versus triamcinolone acetonide 0.1% paste (Volon-A®) in the treatment of oral pemphigus vulgaris. Method: Fifteen patients were involved in a prospective randomized trial with a split- mouth design. After two weeks of administering study drugs, oral lesions were monitored and quantified pain and mucosal surface involvement scores were obtained. Result: Within 14 days, the degree of involvement and pain scores significantly reduced in both tacrolimus-treated and triamcinolone-treated sites, but there was no significant difference between them. No severe adverse events were observed. Conclusion: This study showed that tacrolimus could be as effective as triamcinolone acetonide in the topical treatment of oral pemphigus vulgaris.
Ehsani Amir Houshang; Noormohammadpour Pedram; Nasiri Nafiseh; Faraz Parastoo Tavasoli; Goodarzi Azadeh
Volume 19, Issue 2 , 2016, , Pages 45-49
Abstract
Background: Approximately 0.77% to 2% of cutaneous ulcers and post-burn scars will develop malignant degeneration. When squamous cell carcinoma (SCC) emerges in a chronic scar or ulcer, it often is referred to as Marjolin’s ulcer (MU). Methods: This cross-sectional study assessed demographic information ...
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Background: Approximately 0.77% to 2% of cutaneous ulcers and post-burn scars will develop malignant degeneration. When squamous cell carcinoma (SCC) emerges in a chronic scar or ulcer, it often is referred to as Marjolin’s ulcer (MU). Methods: This cross-sectional study assessed demographic information and pathological features of MU in Razi Hospital during 2009 to 2014. We reviewed 5150 chronic scar/ulcer cases and found 30 MU cases. Results: Patients had an average age of 59.2±19.9 years. Most cases were males Among 30 cases of MU, well-differential SCC accounted for 43.3% of cases. Moderately-differentiated SCC comprised 13.3% of cases, whereas there was invasive SCC in 10% of MUs. Only 3.3% of patients showed poorly-differentiated SCC and 9 (30%) had undifferentiated SCC. The average latency between burn and malignancy was 32.4±18.5 years In the majority (90%) of cases, the initial injury was a burn. The lower and upper limbs comprised 53.3% and 26.7% of cases, respectively. There was one case with a history of melanoma. Among the 4 measured concurrent risk factors for malignancy, sun exposure was the most prevalent. Conclusion: Since there is a high possibility of SCC formation in burn lesions and other identical lesions, rapid follow-up and appropriate treatment in acute burn lesions is necessary.
Fatma Hussain; Muhammad Arif Mann; Munir Ahmed
Volume 12, Issue 2 , 2009, , Pages 47-51
Abstract
Background: Endocrine disorders occasionally manifest themselves by their associated or induced cutaneous abnormalities. Skin is a frequently overlooked source of pathology. Several cutaneous abnormalities are more prevalent in diabetes mellitus. The purpose of the study was to evaluate the frequency ...
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Background: Endocrine disorders occasionally manifest themselves by their associated or induced cutaneous abnormalities. Skin is a frequently overlooked source of pathology. Several cutaneous abnormalities are more prevalent in diabetes mellitus. The purpose of the study was to evaluate the frequency of skin infections among type 2 diabetic patients and associated risk factors in Faisalabad, PakistanMethods: Type 2 diabetic patients (disease duration >1 year) and healthy volunteers were recruited and skin infections were assessed.Results: Diabetes related skin infections were detected in 43% of type 2 diabetic patients and in 22.5% of the control subjects. Onychomychosis, candida vaginitis and herpes simplex were identified in 9.2 % of the diabetic patients compared to 2.5% of the control subjects. Skin infections had an insignificant association with sex, mean age, age at diabetes diagnosis, diabetes duration, secondary complications of diabetes, blood glucose and cumulative haemoglobin.Conclusion: A broad spectrum of cutaneous disorders was seen in type 2 patients. While the pathogenesis of the most of the skin lesions remains ambiguous, additional studies should be performed to determine whether skin lesions could be used for predicting imminent diabetic complications.
