Rezazadeh Fahimeh; Sokhakian Mahshid
Abstract
Background: Oral lichen planus (OLP) is a common inflammatory disease of unknown origins. Recent studies have considered nutritional factors concerning the pathogenesis of many autoimmune disorders. The objective of the present study was to investigate the plasma levels of magnesium (Mg), calcium (Ca), ...
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Background: Oral lichen planus (OLP) is a common inflammatory disease of unknown origins. Recent studies have considered nutritional factors concerning the pathogenesis of many autoimmune disorders. The objective of the present study was to investigate the plasma levels of magnesium (Mg), calcium (Ca), zinc (Zn), copper (Cu), and iron (Fe) in this disorder. Methods: Included in this observational case-control study was 40 patients with OLP and 40 age and sex matched healthy control subjects. Plasma levels of Mg, Ca, Zn, Cu, and Fe were specified using an autoanalizer. Results: The serum level of Ca was higher, but Mg, Cu, Fe and Zn serum concentration did not differ significantly between the patients with OLP and the healthy controls. Mean Zn concentration was lower in patients with erosive lichen planus compared to the non-erosive group and the healthy controls. However, only the difference between erosive lichen planus patients and healthy participants was significant. The mean Zn level was lower than the normal range (70 µg/dl) in both the cases and controls. The concentration of Fe was significantly higher in men male patients than in females; however, the difference between men and women was not significant in the healthy control group. The mean Cu/Zn ratios in erosive and patient groups were slightly higher compared with the controls. Conclusion: Trace elements such as Ca may play a role in the ethiopathogenesis of OLP. Nevertheless, other elements such as Zn or Cu may influence OLP, which requires further evaluation on larger samples.
Soori Tahereh; Esmaeili Nafiseh; Najmeh Rajabi; Amir Houshang Ehsani
Volume 18, Issue 2 , 2015, , Pages 56-60
Abstract
Background and Objective: Genital warts, the most common sexually transmitted disease (STD), are caused by human papillomavirus (HPV). Few studies have been performed on Iranian women with genital warts or cervix cancer but there isno documented data about genital warts and HPV genotyping in Iranian ...
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Background and Objective: Genital warts, the most common sexually transmitted disease (STD), are caused by human papillomavirus (HPV). Few studies have been performed on Iranian women with genital warts or cervix cancer but there isno documented data about genital warts and HPV genotyping in Iranian men. In this study, we determined HPV genotypesin 108 male and females with anogenital warts in an STD clinic in Tehran.Methods: In this cross sectional study, HPV genotypes were determined by the PCR method in 108 males and females withanogenital warts who were visited at an STD clinic in Tehran within January–June 2012. Age, sex, number of sexual partners,education level, and marital status were recorded in the questionnaires.Results: We determined HPV genotypes in 108 patients including 36 men and 72 women. The mean age of the patients was 31.5±12.3 years. The most common type was type 6 (62%). Other common genotypes were 11 (28.7%), 18 (15.7%), 16 (14.8%), 31 (4.6%), 33 (0.9%), 51 (0.9%), 56 (0.9%), and 66 (0.09%). We found that genotypes 16 (P=0.003) and 31 (P=0.013) were more prevalent in the patients with a higher number of sexual partners. In addition, there was a statistically significant association between the number of sexual partners and multi type HPV infection (P=0.045). Genotypes 16 (P=0.036) and 11 (P=0.039) were significantly associated with the female gender.Conclusion: Our results showed that HPV 6 was the most prevalent HPV type followed by HPV 11, 18, and 16.
Nahidi Yalda; Meibodi Naser Tayyebi; Layegh Pouran; Esmaeeli Habiballah; Hosseini Fatemeh Sadat
Volume 16, Issue 2 , 2013, , Pages 57-63
Abstract
Background: Melasma is a common acquired hyperpigmentationdisorder often appearing on the face of young women. Melasmais classified into four groups based on Wood’s lamp examination:epidermal, dermal, mixed, and indeterminate. The goal of this studywas to evaluate the relationship between clinicoepidemiologicalcharacteristics ...
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Background: Melasma is a common acquired hyperpigmentationdisorder often appearing on the face of young women. Melasmais classified into four groups based on Wood’s lamp examination:epidermal, dermal, mixed, and indeterminate. The goal of this studywas to evaluate the relationship between clinicoepidemiologicalcharacteristics of melasma and the level of involvement underWood’s lamp examination.Method: In a cross sectional study, 50 melasma patients whowere visited at the dermatology clinic of Imam Reza Hospitalfrom March 2010 to September 2011 were studied. The levelof melasma involvement in all patients was determined usinga Wood’s lamp, and the patients’ information such as age,occupation, location of melasma, marital status, pregnancy, oralcontraceptive pill consumption and Fitzpatrick skin type wascollected in a questionnaire.Result: In single patients, dermal involvement and in marriedpatients, epidermal involvement was more common. Involvementwas more frequently dermal in jobs with exposure to sun andmore epidermal in indoor jobs. In the malar region, epidermalinvolvement was more common. In patients with a history ofpregnancy, epidermal involvement was more prevalent as well,while in the participants without a history of pregnancy, dermalinvolvement was more frequent. In the pregnant patients withmelasma, epidermal involvement was more frequent. In patientswithout a family history of melasma, epidermal involvement wasmore frequently observed than the other two levels of involvement.Conclusion: Based on the findings of this study, melasma in caseswith the involvement of the malar region, starting in pregnancy,in patients without a family history of melasma, and in theindividuals who have indoor occupations is most likely to beepidermal and may have a better response to treatment. On theother hand, melasma in single persons and in those who haveoutdoor occupations and are exposed to sun light is mostly dermalwith a worse response to treatment according to previous studies.
Hassan Seirafi; Maryam Daneshpazhouh; Somayeh Khezri; Pardis Kiani; Sara Sabouri Rad; khadijeh Moghadam; Farzaneh Khezri
Volume 14, Issue 2 , 2011, , Pages 58-63
Abstract
Background: There is a large variety of therapeutic agents for the treatment of vitiligo, but it still remains a challenge. Narrow-band UVB phototherapy and 308-nm excimer laser have been shown to be safe and effective for the treatment of vitiligo. Topical calcipotriol has recently been reported to ...
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Background: There is a large variety of therapeutic agents for the treatment of vitiligo, but it still remains a challenge. Narrow-band UVB phototherapy and 308-nm excimer laser have been shown to be safe and effective for the treatment of vitiligo. Topical calcipotriol has recently been reported to enhance the efficacy of phototherapy, especially 8-methoxypsoralen plus UVA (PUVA). The goal of this study was to evaluate whether the addition of topical calcipotriol enhances the efficacy of 308-nm excimer laser in the treatment of vitiligo. Methods: The patients with symmetrical vitiliginous lesions received 308-nm excimer laser plus Calcipotriol ointment 0.005% (Daivonex®) as the intervention group and 308 nm excimer laser plus vaselin as the control group on the lesions of the right side. All patients in the two groups applied vaselin on the lesions of the left side. The evaluation of the patients was performed at baseline and at 12th week (the last laser session). SPSS version 15.0 package software was used for statistical analysis. P-values< 0.05 were accepted as statistically significant. Results: Seventy out of 83 patients completed the study. The diameter of the right side lesions (308nm excimer laser + calcipotriol) changed from 27.21 cm2 to 15.82 cm2 in the intervention group and from 27.86 cm2 to 16.02 cm2 in the control group; This difference was not statistically significant (p-value=0.74). Conclusion: Our findings showed that 308-nm excimer laser was effective and safe in the treatment of vitiligo, and that topical calcipotriol had no additive or synergistic effect.
Lajevardi Vahideh; Nazemi Mohammad Javad; Khodashenas Zohreh; Ebadi Mohammad-Sadegh
Volume 17, Issue 2 , 2014, , Pages 59-62
Abstract
Background: Generalized vitiligo is characterized by autoimmunedestruction of melanocytes, which results in patches of thedepigmented skin and the overlying hair. Vitamin D is an essentialhormone synthesized in the skin and is responsible for skinpigmentation. Low vitamin D levels have been noted in ...
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Background: Generalized vitiligo is characterized by autoimmunedestruction of melanocytes, which results in patches of thedepigmented skin and the overlying hair. Vitamin D is an essentialhormone synthesized in the skin and is responsible for skinpigmentation. Low vitamin D levels have been noted in patientswith a variety of autoimmune diseases. A recent study showedthat low vitamin D levels may be associated with vitiligo. Theaim of this study was to compare 25-hydroxyvitamin D (25[OH]D) levels in Iranian patients with vitiligo with normal controls.Method: In this case-control study, we studied 30 newly diagnosedpatients with vitiligo and 30 healthy controls through a casecontrol design. Two groups were matched for gender, age, andthe season in which the serum levels of 25-hydroxy vitamin Dwere measured. The serum levels were categorized as sufficient,insufficient and deficient.Result: The mean serum level of vitamin D was 10.24±1.27 ng/mL in patients compared to 18.31±7.39 ng/mL in the controlgroup. Male patients had lower levels of vitamin D compared tocontrols (7.25 ng/mL vs. 13.31ng/mL, P=0.03), while no significantdifference was observed between females and controls (14.12 ng/mL vs. 16.25 ng/mL, P=0.51).Conclusion: The present study demonstrated that there may be anassociation between low levels of Vitamin D3 and vitiligo in men.
Barzegari Massoume; Valikhani Mahin; Esmaili Nafiseh; Naraghi Zahra; Nikoo Azita; Kamyab Kambiz; Ghanadan Ali; Tamizifar Banafshe
Volume 11, Issue 2 , 2008, , Pages 64-66
Abstract
Background: Pemphigus vulgaris (PV) is an autoimmune blistering disease, caused by autoantibodies against desmoglein (Dsg) 3 and / or Dsg1 which induce the loss of adhesion between keratinocytes. Nikolsky's sign is the ability to induce peripheral extension of a blister as a consequence of applying lateral ...
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Background: Pemphigus vulgaris (PV) is an autoimmune blistering disease, caused by autoantibodies against desmoglein (Dsg) 3 and / or Dsg1 which induce the loss of adhesion between keratinocytes. Nikolsky's sign is the ability to induce peripheral extension of a blister as a consequence of applying lateral pressure to the border of an intact blister. If the weakening of the intercellular adhesion is present but not marked, then the damage may be demonstrated only microscopically (microscopic Nikolsky’s sign and can increase the sensitivity of the histopathological studies. Methods: We studied 40 patients and divided them randomly into two groups (A, B). Group A were subjected to the tangential pressure over the perilesional skin before a biopsy specimen was taken from that site; group B patients were subjected to a biopsy without the tangential pressure technique. Results: Histopathological changes of pemphigus vulgaris were present in 30% of the patients in group A and 5% of the patients in group B. They were not statistically different. The presence of microscopic Nikolsky’s sign was significantly higher in patients with generalized disease. Conclusion: Microscopic Nikolsky sign can increase the sensitivity of histologic diagnosis of PV.
Azadeh Goodarzi; Mahsa Farshidzadeh; Masoumeh Roohaninasab; Najmolsadat Atefi; Elham Behrangi
Abstract
Background: The use of vitamin D and its analogues in the treatment of warts has been to be effective and painless without any considerable side effects, unlike some other routine safe and effective therapeutic modalities such as cryotherapy that in some cases is really difficult ...
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Background: The use of vitamin D and its analogues in the treatment of warts has been to be effective and painless without any considerable side effects, unlike some other routine safe and effective therapeutic modalities such as cryotherapy that in some cases is really difficult to perform due to related pain, especially in the children. Owing to a probable relationship between the deficiency of serum vitamin D and warts, this research aimed to find the association between level of serum vitamin D and warts. Methods: This case-control study was conducted on 56 subjects in Rasoul Akram Hospital, Tehran, Iran, for 18 months. The subjects were randomly divided into case and control groups, including 28 age and sex-matched subjects in each of them. The required data were extracted through a questionnaire. Finally, the data were analyzed in the SPSS software V.22 using tests such as Mann-Whitney and Pearson correlation. Results: In this study, 56 people were examined, and 28 subjects were included in both case and control groups. The mean serum level of vitamin D in both case and control groups was 23.564and 31.593, respectively. The association between serum levels of vitamin D in the group with and without wart was not significant in both men and female groups. Serum vitamin D levels were compared in two groups of under 18 years old and between 18 and 50 years old, which were not statistically significant. Conclusion: According to our results, there is no significant relationship between serum vitamin D levels and existence of warts. This relationship is not statistically significant at the level of age and sex variables, and there is no difference in age and gender between the case and control groups.
Taheri Ahmad-Reza; Boroumand Nadia; Ebrahimi Safieh; Hosseini Elias; Roohani Mina; Hashemy Seyed Isaac
Abstract
Background: Psoriasis is a chronic-relapsing inflammatory skin disorder, in whose pathogenesis oxidative stress is suggested to be involved. Among different enzymes that play a role in maintaining the cellular redox balance, we aimed to assess the alteration of glutathione peroxidase (GPX) activity in ...
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Background: Psoriasis is a chronic-relapsing inflammatory skin disorder, in whose pathogenesis oxidative stress is suggested to be involved. Among different enzymes that play a role in maintaining the cellular redox balance, we aimed to assess the alteration of glutathione peroxidase (GPX) activity in cutaneous lesions and its correlation with the disease severity, firstly, to support the possible candidacy of this enzyme for future topical therapeutic regimens, and secondly, to move forward in understanding the etiology of the disease and the pathogenic mechanisms involved in cutaneous lesions so as to pave the way for further investigations. Methods: The clinical severity of disease was determined according to Psoriasis Area and Severity Index (PASI) scoring system. The level of GPX activity in the skin biopsies from 20 psoriatic patients was measured using Cayman’s glutathione peroxidase assay kit, and its association with disease severity was assessed in each patient. Results: Tissue GPX activity was significantly higher in patients with mild psoriasis (149.02 ± 24.213 nmol/min/ml) compared to patients with moderate psoriasis (120.58±21.038 nmol/min/ ml) (p-value < 0.05). There was a significant negative correlation between the activity of GPX and each PASI-associated criterion, including redness, scaling and thickness. Among all the criteria of PASI, scaling was independently correlated with the activity of GPX (p-value < 0.05). Conclusion: The reduced activity of GPX in dermal lesions might be associated with the disease pathogenesis, having a valuable role in diagnosis and therapy.
Zohreh Tehranchinia; Hoda Rahimi; Mansour Moradloo
Volume 13, Issue 3 , 2010, , Pages 82-86
Abstract
Background: Benign pigmented lesions, including freckles, are common and various treatment modalities including lasers and peeling have been evaluated for their effectiveness in their treatment.Objective: To compare the clinical effects of focal peeling with Trichloroacetic Acid (TCA) and Nd:YAG (532 ...
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Background: Benign pigmented lesions, including freckles, are common and various treatment modalities including lasers and peeling have been evaluated for their effectiveness in their treatment.Objective: To compare the clinical effects of focal peeling with Trichloroacetic Acid (TCA) and Nd:YAG (532 nm) laser on freckles.Methods: Twenty patients with freckles were treated with focal peeling with TCA 25% on their left-sided lesions and Nd:YAG (532 nm, Fluence 9.5 J/cm2, spot size 1.5 mm) on their right-sided lesions. Photographs were taken prior to treatment and at follow-up visits and were evaluated by three dermatologists and the results were analyzed.Results: Eighteen out of the 20 patients (90%) with freckles manifested more than 50% improvement in laser treated areas whereas clinical improvement in focal peeling treated areas was observed in 15 out of 20 (75%). The mean improvement rate for laser and focal peeling was 66.50±12% and 58.3±15%, respectively. No significant difference was observed in the treatment results between these modalities.Conclusion: Focal peeling with TCA 25% could be as effective as frequency-doubled Nd:YAG (532 nm) laser in the treatment of freckles.
Farhad Handjani; Nasrin Saki; Motahareh Hosseini; Taraneh Tadayon
Volume 20, Issue 3 , 2017, , Pages 84-88
Abstract
Background: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are 2 inflammatory indicators that increase in many pathologic and physiologic conditions. Pemphigus vulgaris (PV) is an autoimmune skin disease in which autoantibodies against desmogleins cause acantholysis. In this study ...
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Background: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are 2 inflammatory indicators that increase in many pathologic and physiologic conditions. Pemphigus vulgaris (PV) is an autoimmune skin disease in which autoantibodies against desmogleins cause acantholysis. In this study we have measured ESR and CRP levels in patients with PV to evaluate the relationship between an increase in these markers and disease severity.Methods: In this cross-sectional study, we selected patients with proven diagnosis of PV who referred to the Dermatology referral clinic, Faghihi hospital, Shiraz, Iran during a one year period. There were 30 patients enrolled in this study who provided blood samples to measure their ESR and CRP levels. We usedthe Mahajan scoring system to determine the disease severity. Results: In 27 (90%) cases, ESR was normal and 20 (66.7%) cases had negative CRP. There was a significant correlation between CRP and PV severity (P=0.015); however, there was no correlation between ESR and disease severity (P=0.126). Conclusion: A correlation existed between CRP and severity of PV. Further studies must be undertaken to prove the prognostic role of CRP in PV. The discovery of new prognostic factors can change the treatment strategy and protocol for PV.
Sajjadian Negar; Hashemian Farshad; Kadivar Maliheh; Sohani Sogand; Taheri Paymaneh Alizadeh
Volume 15, Issue 3 , 2012, , Pages 85-88
Abstract
Background: Diaper rash is a common but non life threateningcondition during infancy. Different modalities of treatmentare suggested. Sucralfate acts as a physical barrier to irritantsand has antibacterial activities. Promising reports of the effectof topical sucralfate on wound epithelialization along ...
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Background: Diaper rash is a common but non life threateningcondition during infancy. Different modalities of treatmentare suggested. Sucralfate acts as a physical barrier to irritantsand has antibacterial activities. Promising reports of the effectof topical sucralfate on wound epithelialization along with itsbacteriostatic properties led us to carry out a trial to evaluateits role as a topical agent in the treatment of diaper dermatitisand compare its efficacy with topical zinc oxide.Method: This double blind randomized clinical trial was conductedin Shariati hospital from April 2008 to September 2009. Sucralfateand zinc oxide were formulated as 20% ointments with the sameexcipients. All patients were randomly treated topically witheither sucralfate (N=25) or zinc oxide (N=21) for 7 days. Diaperseverity scores were obtained before treatment and at days 3, 5,7 by the authors.Result: A total of 46 infants (54.3% female and 45.7% male) withmean age of 4.4±6.5 months entered the study. The mean age,sex, frequency of diaper change (per day) and severity of diaperrash showed no statistically significant difference between twogroups. Sucralfate 20% ointment was significantly superior inhealing diaper dermatitis at days 5 and 7 (p < 0.05 and 0.01respectively) and showed a significantly shorter healing time(3.24+/-2.02 days) in comparison with zinc oxide 20% ointment(5.42+/-2.39 days) (P = 0.002).Conclusion: Since sucralfate in topical formulations acts as aphysical barrier with proved safety and no noticeable absorption,it may be used as a potential treatment for diaper dermatitis.
Mousavi Seyed Reza; Beygi Arash Najaf; Raeeszadeh Mohammad
Volume 12, Issue 3 , 2009, , Pages 86-89
Abstract
Background: Ingrown toenails are a common condition which, when recurrent and painful, are often treated surgically. This study proposes a new simple surgical technique for ingrown toenails with good results.Method: We selected 150 patients with 185 affected toes who were surgically treated by our techniques ...
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Background: Ingrown toenails are a common condition which, when recurrent and painful, are often treated surgically. This study proposes a new simple surgical technique for ingrown toenails with good results.Method: We selected 150 patients with 185 affected toes who were surgically treated by our techniques carried out from April 1995 to March 2004. This technique consisted of marginal nail elevation combined with surgical excision of the granulation tissue. To fix the nail margin on the toe, we have done one bite suture by Nylon 3-0 and remove it after 3 weeks.Results: Recurrence occurred only in 1.08% (2 of 185 toenails), and only one toe required further surgical treatment. Failure of technique in overall is 1.7% and successful surgical treatment is over 98%.Conclusions: This study shows higher cure rate, shorter postoperative pain, lower risk of postoperative infection, and remarkable cosmetic result without any deformity because we excise the granulation tissue and elevate margin of nail over the skin with this simple technique. Therefore, this technique could be considered as an alternative method of ingrown toenail treatment.
Kamyab Kambiz; Firooz Alireza; Kohsari Laleh Montaser; Noorian Negin; Khorshid Hamidreza Khorram; Khatami Alireza; Estarabadi Ali Rajabi
Volume 19, Issue 3 , 2016, , Pages 86-88
Abstract
Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment ...
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Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment of sarcoidosis. We aimed to evaluate the role of this gene in patients with skin sarcoidosis in comparison with skin sarcoidal reaction patients and those with normal skin. Methods: The nucleotide sequence of rs2076530 allele in exon 5 of BTNL2 gene was compared among the paraffin-embedded blocks of 34 patients with a histologic diagnosis of sarcoidosis, 14 patients with skin sarcoidal reaction (tattoo, foreign body), and 27 patients with normal skin (excised during cosmetic surgery) using polymerase chain reaction. Results: There was no statistically significant difference in the frequency of 3 genotypes of AA, AG, and GG in rs2076530 allele among skin sarcoidosis, skin sarcoidal reaction, and normal skin. Conclusion: The expression of rs2076530 allele of BTNL2 gene in skin sarcoidosis or sarcoidal reaction does not differ with its expression in the normal skin.
M Mohebali; P Yaghoobi; B Hooshmand; A Khamesipour
Volume 7, Issue 2 , 2004, , Pages 88-94
Abstract
Background: Considering the difficulties, adverse effects and unsuitable response to commonly used drugs; it is essential to find an alternative, particularly local treatment for cutaneous leishmaniasis (CL). Objective: Determination of efficacy of topical paromomycin (Paromo-U ointment) against CL caused ...
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Background: Considering the difficulties, adverse effects and unsuitable response to commonly used drugs; it is essential to find an alternative, particularly local treatment for cutaneous leishmaniasis (CL). Objective: Determination of efficacy of topical paromomycin (Paromo-U ointment) against CL caused by L.major in mouse model. Materials and Methods: Skin lesions were created 1 to 3 months after inoculation of L.major promastigotes to the base of tail of small, white mice (Outbreed). Then the mice were randomly divided to three groups including interventional (Treatment by Paromo-U), control 1 (Treatment by urea) and control 2 (Treatment by distilled water) groups. The mice were treated topically twice a day for 8 weeks. Results: The mean lesion diameter of the lesions prior to treatment in interventional and control groups (Urea and distilled water) were measured 10.9, 5.9 and 6.0 mm respectively and changed to 4.0, 12.7 and 14.3 mm 8 weeks after treatment. No Leishman bodies were observed within the lesions of interventional group, whereas they were seen in all control groups. Conclusion: Paromo-U ointment was effective in the treatment CL caused by L.major in mouse model.
Kumar Piyush; Tiwary Anup Kumar; Akhtar Danish; Fatima Talat
Abstract
Syringocystadenoma papilliferum is an uncommon benign apocrine gland tumour, mostly of congenital or early childhood onset, affecting head and neck. In addition, nevus sebaceous is commonly associated with this tumor. Here, we document three cases of syringocystadenoma papilliferum with many atypical ...
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Syringocystadenoma papilliferum is an uncommon benign apocrine gland tumour, mostly of congenital or early childhood onset, affecting head and neck. In addition, nevus sebaceous is commonly associated with this tumor. Here, we document three cases of syringocystadenoma papilliferum with many atypical features, such as the involvement of rare sites (abdomen, axilla and thigh), absence of nevus sebaceous and coexistence of tubular apocrine adenoma. The histopathologic characteristics were consistent with the diagnosis in all three cases.
Yalda Nahidi; Elahe Abdali; Masoud Maleki; Azadeh Saki; Pouran Layegh
Abstract
Background: Striae is a common condition that is relatively difficult to treat. Recently, carboxytherapy was proposed as a treatment modality. This study aimed to evaluate the therapeutic effect of carboxytherapy in patients with striae.
Methods: This was a pilot clinical study. Patients were treated ...
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Background: Striae is a common condition that is relatively difficult to treat. Recently, carboxytherapy was proposed as a treatment modality. This study aimed to evaluate the therapeutic effect of carboxytherapy in patients with striae.
Methods: This was a pilot clinical study. Patients were treated with 10 sessions of carboxytherapy every week. The patients were photographed at the onset of the treatment course, before each treatment session, and three months after the last ones. Two dermatologists compared the images of each patient before and three months after treatment and evaluated the treatment response based on the following scores: I, no improvement (0%);II, poor (1% to 25%); III, fair (26% to 50%); IV, good (51% to 75%); and V, excellent improvement (76% to 100%). Furthermore, patients’ satisfaction with therapy outcome was recorded on a scale of 0 to 10.
Results: 15 patients were enrolled in this study; 2 (13.4%) were male and 13 (86.6%) were female. Three patients (20%) showed good response, one (6.7%) had a relatively good response, two showed (13.3%) poor response, and seven (46.6%) had no response to treatment. Analysis of the association of carboxytherapy outcomewith different patients’ characteristics showed no statistically significant correlation (P > 0.05).
Conclusions: Although carboxytherapy therapy did not result in a significant response in the majority of our patients, it is somehow capable of improving the striae in some patients. Further studies with bigger sample sizes may be required to ensure the efficacy of this modality in the treatment of striae.
Balighi Kamran; Jamshidi Samaneh; Daneshpajooh Maryam; Lajevardi Vahideh; Aalami Harandi Sima; Ghassemi Hamed
Volume 14, Issue 3 , 2011, , Pages 95-99
Abstract
Background: Treatment of acne scars is a therapeutic challenge that may require multiple modalities. Subcision is a procedure that has been reported to be beneficial in the treatment of acne scars. Although subcision is a valuable method, its efficacy is mild to moderate due to the high recurrence rate. ...
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Background: Treatment of acne scars is a therapeutic challenge that may require multiple modalities. Subcision is a procedure that has been reported to be beneficial in the treatment of acne scars. Although subcision is a valuable method, its efficacy is mild to moderate due to the high recurrence rate. This study aimed to evaluate the novel complementary treatment of repeated suction sessions plus subcision at the recurrence period of subcised scars. Methods: The standard technique of subcision was applied to treat scars in 12 patients; then, one side of the face underwent repeated suctioning for 2 weeks. All patients completed treatment and the follow-up period. The patients’ and investigators’ assessments of improvement were both recorded. Results: According to patients and investigators, subcision plus suction showed 81% and 65% improvement after 3 month, respectively. Subcision alone, after 3 month, was associated with 62% and 33.3% improvement according to patients and investigators, respectively. The rate of response showed a significant difference with the use of repeated suctioning. The side-effects of local edema and bruising were all transient. Conclusion: Subcision plus frequent suctioning at the recurrence period of subcision appears to be a safe technique that increases the efficacy of subcision without considerable complications.
Anchal Jindal; Rushikesh Shah; Neela Patel
Volume 17, Issue 3 , 2014, , Pages 96-100
Abstract
Background: Immunobullous diseases are morphologically heterogeneous and the differentiation between various subtypes is essential for proper treatment and prognosis. The aim of our study was to analyze and correlate clinical, histopathological, and immunofluorescence findings in ...
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Background: Immunobullous diseases are morphologically heterogeneous and the differentiation between various subtypes is essential for proper treatment and prognosis. The aim of our study was to analyze and correlate clinical, histopathological, and immunofluorescence findings in autoimmune bullous diseases.Method: A cross-sectional study was conducted over a period of two years (2010-2012) after receiving the ethics committee approval. Sixty patients who met the inclusion criteria of immunobullous disease were included in the study. Skin biopsy for histopathological and direct immunofluorescence (DIF) examination was taken. DIF was also done in a few of the cases using the salt-split technique. The final diagnosis was based on clinical, histopathological, and DIFfindings.Result: Sixty cases with a clinical diagnosis of autoimmune bullous diseases were evaluated. In 95% of the cases, the histopathological diagnosis was consistent with the clinical diagnosis and in 75% of the cases, the DIF diagnosis was consistent with the clinical diagnosis. A positive relationship was seen between clinical and DIF findings with r = 0.67 and between histopathologic and DIF findings with r = 0.76. DIF positivity was seen in 100% of the cases of bullous pemphigoid (BP), 100% of the cases of pemphigus foliaceus, and 94.7% of the cases of pemphigus vulgaris which was statistically significant with P < 0.05.Conclusion: Our study provides evidence-based guidance for the diagnosis and classification of various immunobullous disorders. DIF test should be done in conjunction with histopathology tomake a definite diagnosis and minimize both false-positive and false-negative results.
SZ Famili; F Pezeshk Poor; V Sepehr; M Vahedian
Volume 8, Issue 2 , 2005, , Pages 97-100
Abstract
Background: Cutaneous leishmaniasis is an important skin parasitic disease. Ideal treatment is not found yet and seeking for proper drugs continues. Objective: Comparison of the efficacy of fluconazole with systemic glucantime in patients with acute cutaneous leishmaniasis in Ghaem hospital in Mashhad ...
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Background: Cutaneous leishmaniasis is an important skin parasitic disease. Ideal treatment is not found yet and seeking for proper drugs continues. Objective: Comparison of the efficacy of fluconazole with systemic glucantime in patients with acute cutaneous leishmaniasis in Ghaem hospital in Mashhad in 2002. Patients and Methods: During one year of study, all patients with cutaneous leishmaniasis were divided to two group. Thirty-one patients were treated with oral fluconazole (100 mg twice a day) for 6 weeks and 29 patients were treated with intra-muscular glucantime (20 mgSb/kg) for 21 days. Both groups were evaluated 3 and 6 weeks after onset of treatment. T-test and Chi-square test were used for statistical analyses and (P0.05). Conclusion: It seems that efficacy of fluconazole in acute cutaneous leishmaniasis is lower than glucantime. A larger clinical trial is recommended.
Layegh Pouran; Nahidi Yalda; Malekzadeh Iman; Shakeri Mohammad Taghi
Volume 16, Issue 3 , 2013, , Pages 100-104
Abstract
Background: Pemphigus is a rare autoimmune disease causedby autoantibodies against desmoglein. It clinically presents withpainful blisters and erosions on the skin and mucous membranes.Few studies have been conducted on the quality of life inpemphigus patients which have all indicated the strong impactof ...
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Background: Pemphigus is a rare autoimmune disease causedby autoantibodies against desmoglein. It clinically presents withpainful blisters and erosions on the skin and mucous membranes.Few studies have been conducted on the quality of life inpemphigus patients which have all indicated the strong impactof the disease on emotional and physical status of the patients.According to evident differences in the culture and quality oflife between our society and western societies, we assessed thequality of life in patients with pemphigus in the Northeast of Iran.Method: This study was conducted on 78 pemphigus vulgarispatients who were visited or hospitalized in the dermatologyclinics of Qaem and Imam Reza Hospitals in Mashhad, Iran.Data collection was done by the Dermatology Life Quality Index(DLQI) questionnaire in patients with pemphigus vulgaris.Statistical analysis was performed using SPSS 11.5 software withChi-square, T-test and ANOVA statistical tests.Result: The disease had a significant impact on the quality oflife in the majority of patients (31 (39.7%) patients). Hospitalizedand newly diagnosed cases and those receiving higher doses ofsteroid had lower quality of life. The patient’s age, sex, educationlevel, and therapeutic regimen did not have a significant effecton the quality of life.Conclusion: Pemphigus is not just a physical disease and hasvarious aspects. It is responsible for many changes in healthrelatedquality of life in patients. Therefore, we will be successfulin treating this disease only when psychological and social aspectsof pemphigus are considered in addition to clinical improvementof the patients.
Nitin Joseph; Deepti D’Souza; Matthew Antony Manoj; Shajimon Priya Varsha; Tanya Singh; Archit Gupta; Akshiti Kaushik
Abstract
Background: Psoriasis is an immune-mediated chronic skin disorder. Information regarding its clinic-epidemiological manifestations is limited in parts of Asia. This study was conducted to determine the risk factors, clinical presentation, and management of psoriasis among patients in Mangalore, India. ...
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Background: Psoriasis is an immune-mediated chronic skin disorder. Information regarding its clinic-epidemiological manifestations is limited in parts of Asia. This study was conducted to determine the risk factors, clinical presentation, and management of psoriasis among patients in Mangalore, India. Methods: The medical records of 225 psoriasis patients over the past ten years (from January 2009 till March 2019) were examined by the investigators. Data were collected using a semi-structured form. Results: The mean age at diagnosis of psoriasis was 42.2 ± 16.0 years. Nail psoriasis and psoriatic arthritis (PsA) were present in 66 (29.3%) and 21 (9.3%) patients, respectively. Relapse of psoriasis was seen more among patients with a history of disease exacerbation in winter (P=0.009) or in rainy seasons (P=0.031). Systemic therapy with methotrexate and topical therapy with steroids were used in the management of 52 (23.1%) and 72 (32%) patients, respectively. Phototherapy (n=11) was the most common modality used among the 18 patients with extensive psoriasis. Co-morbidities like diabetes mellitus (P=0.02) and complications like PsA (P=0.008) were associated with greater disease durations among the patients. Conclusion: The proportion of patients with extensive psoriasis was high in the current setting probably because of delayed diagnosis. Awareness about the disease and its clinical manifestations might help in its early identification. Seasonal exacerbation was an important risk factor for psoriasis and it was associated with its relapse. The most common management modalities were topical steroids for psoriasis and phototherapy for extensive psoriasis.
Daniel Henry; Adarshlata Singh; Bhushan Madke; Palak Kedia
Abstract
Tinea corporis is a superficial dermatophyte infection. This is a case report of a 45-year-old female presenting with a history of erythematous raised lesions with itching all over the body since one year ago. Based on clinical findings, the lesions were diagnosed as tinea corporis. ...
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Tinea corporis is a superficial dermatophyte infection. This is a case report of a 45-year-old female presenting with a history of erythematous raised lesions with itching all over the body since one year ago. Based on clinical findings, the lesions were diagnosed as tinea corporis. A KOH smear was carried out and results were negative probably due to application of steroids, and a histopathological examination was done. On histopathological examination, the patient was proved to have dermatophytosis caused by Trichophyton mentagrophytes. The patient was successfully treated with oral itraconazole 200mg once a day and griseofulvin 250 mg once a day along with 2 % ketoconazole for topical application.
Roudsari Mohammad Rahmati; Malekzad Farhad; Sabeti Shahram; Ershadi Sarah; Yousefi Forough; Tonkaboni Mihan Pourabdollah
Volume 18, Issue 3 , 2015, , Pages 108-115
Abstract
Background: Scarring (cicatricial) alopecia represents a complex group of inflammatory disorders, mainly characterized by destruction of the hair follicle unit. Lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) are the two main causes of primary cicatricial alopecia (PCA), both leading ...
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Background: Scarring (cicatricial) alopecia represents a complex group of inflammatory disorders, mainly characterized by destruction of the hair follicle unit. Lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) are the two main causes of primary cicatricial alopecia (PCA), both leading to hair follicle destruction and irreversible alopecia. However, they are different in pathogenesis and sometimes are diagnostically challenging.Methods: Twenty-eight formalin-fixed paraffin-embedded (FFPE) specimens of skin biopsies from 17 patients with a clinicopathologic diagnosis of LPP and 11 patients diagnosed as DLE were included. Histopathological study was performed with Haematoxylin and Eosin (H&E)-stained slides; then, immunohistochemical staining (IHC) was performed against CD20, CD3, CD4, and CD8 to evaluate and compare the type and distribution pattern of dermal inflammatory infiltrate.Results: Immunohistochemical findings showed a predominance of T-cells in both groups. CD8+ T-cells were significantly more abundant in LPP (15 cases with 10-50% of infiltration) than DLE (11 cases with
Chams-Davatchi Cheyda; Balighi Kamran; Yazdanian Shideh; Nabaii Behruz
Volume 10, Issue 2 , 2007, , Pages 111-118
Abstract
Background and aim: Pemphigus vulgaris is an autoimmune vesiculobullous disorder. Prior to the advent of glucocorticoid therapy, it was often fatal. Now its mortality and morbidity is due to highdose glucocorticoid complications rather than the disease itself. This study was aimed to determine the effect ...
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Background and aim: Pemphigus vulgaris is an autoimmune vesiculobullous disorder. Prior to the advent of glucocorticoid therapy, it was often fatal. Now its mortality and morbidity is due to highdose glucocorticoid complications rather than the disease itself. This study was aimed to determine the effect of dapsone as a second adjuvant in the treatment of pemphigus vulgaris.Materials and methods: In this quasi-experimental open prospective study, 22 patients with moderate to severe pemphigus vulgaris were treated with prednisolone, azathioprine and dapsone. They were observed for 12-18 months.Results: Patients consisted of 10 females and 12 males with mean age of 41.71 years. The mean duration to reach to the maintenance dose of prednisolone (7.5 mg daily) was 13 months. No major relapse was observed but minor relapses were seen in 6 patients with mean prednisolone dose of 13.8 mg daily. Hemolysis was detected in only one patient and 4 patients had a little drop in hemoglobin level. We observed no other severe dapsone induced adverse reaction.Conclusion: These findings suggest that dapsone can be used as a second adjuvant for more rapid tapering of steroid dosage without significant flare of the disease.
Hosseini Mahboobeh-Sadat; Ehsani Amir Hooshang; Hosseinpanah Farhad; Azizi Fereydoon; Salami Maryam; Khedmat Hossein
Volume 11, Issue 3 , 2008, , Pages 113-117
Abstract
Bachground: Skin lesions are common in type 2 diabetic patients and its association with microvascular complications been reported. Methods: In this study, 1135 type-2 diabetic patients were included and examined by a dermatologist for diabetes mellitus related skin lesions, skin infections and cutaneous ...
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Bachground: Skin lesions are common in type 2 diabetic patients and its association with microvascular complications been reported. Methods: In this study, 1135 type-2 diabetic patients were included and examined by a dermatologist for diabetes mellitus related skin lesions, skin infections and cutaneous complications of the treatment. Smear, culture and biopsy of the lesions were done for definite diagnosis. Weight, height, blood pressure were also done. FBS and HbA1C were measured for all patients Results: The mean age of the study population was 54±11 years; 619 were (55%) female and 516 were (45%) male. Mean duration of the disease was 9±7 years and HbA1c was 7.8±1.6. The prevalence of skin lesions was 64% (95%CI: 61.2-66.8). The most common solitary skin lesion was diabetic dermopathy (32.3%) while the most common condition observed overall was skin infections (41.5%). Acanthosis nigricans with a prevalence of 26.4% was the third most common lesion. Other skin conditions had a prevalence of less than 12%. Skin disorders were apparently more prevalent in male than in female patients.Conclusion: More than sixty percent of patients with type-2 diabetes mellitus have skin lesions.
