Beena Gidwani; RN Alaspure; NJ Duragkar; Vijay Singh; Prakash Rao S; SS Shukla
Volume 13, Issue 4 , 2010, , Pages 122-127
Abstract
Background: We studied the efficacy of an herbal semisolid formulation, prepared from hexane extract of seeds of Psoralea Corylifolia, which has anti-inflammatory and antimicrobial properties, in the treatment of eczema. Methods: Extraction of seeds of Psoralea Corylifolia was done in Soxhlet apparatus ...
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Background: We studied the efficacy of an herbal semisolid formulation, prepared from hexane extract of seeds of Psoralea Corylifolia, which has anti-inflammatory and antimicrobial properties, in the treatment of eczema. Methods: Extraction of seeds of Psoralea Corylifolia was done in Soxhlet apparatus using hexane as the solvent. Furthermore, Oil in Water (O/W) cream was formulated with a stearic acid base and was evaluated for various parameters like pH, viscosity, rheology, etc. This cream was then utilized for the treatment of eczema. Results: The formulation was effective in treating eczema in this open clinical trial. Thirty patients suffering from eczema were treated for 1 month, out of whom twenty five completed the study. The patients recovered from their symptoms using the cream twice daily and were assessed every week for 1 month. It was observed that the symptoms score reduced at the end of 2 weeks onwards. At the end of the study, the symptom score for eczema reduced from 6.367±1.098 to 0.333 ± 0.279 for length of the lesion, from 1.333 ± 0.994 to 0.165 ± 0.087 for exudation rate, and from 2.567 ± 0.504 to 0.165 ± 0.132 for the rate of itching. Conclusion: The plant Psoralea Corylifolia has been used in treatment of various skin disorders, and the present research concluded that this plant could be effectively used for the treatment of eczema.
Zabolinejad Naghmeh; Hoseininejad Masoumeh; Jannatipour Maryam; Layegh Pouran
Volume 20, Issue 4 , 2017, , Pages 122-126
Abstract
Background: Hair loss is a major cause of dermatology visits resulting in considerable anxiety and distress for patients. The objective of the current research was to investigate the association among various diagnostic methods related to non-scarring hair loss in women. Methods: After obtaining the ...
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Background: Hair loss is a major cause of dermatology visits resulting in considerable anxiety and distress for patients. The objective of the current research was to investigate the association among various diagnostic methods related to non-scarring hair loss in women. Methods: After obtaining the complete history, clinical examination was carried out on women suffering from diffuse nonscaring alopecia. Laboratory tests and histo-pathologic study were conducted for each patient, and ultimately, data were analyzed by SPSS version 16. Result: Forty-one women were enrolled with the average age of 28.1±8.4 years (16-48). Mean duration of hair loss was 6.2 years (2 months-20 years). The most prevalent type of hair loss was androgenetic alopecia. The sensitivity and specificity with which the clinical examination was done to detect this common ilk of hair loss was 94% and 25%, respectively. No acceptable correlation existed between laboratory test results (such as testosterone, DHEAS, ferritin and TSH) and clinical diagnosis. Data were further assessed through the use of IBM SPSS software version 22 using fisher exact test and Kappa coefficient. The significance level was set at p<0.05. Conclusion: Clinical examination is an accurate approach to diagnosing certain types of non-scarring hair loss in women, eliminating the necessity to perform various endocrinology and laboratory tests; however, it is only through histopathologic studies that an exact diagnosis is specified.
Nasiri Soheila; Rahimi Hoda; Farnaghi Ali
Volume 12, Issue 4 , 2009, , Pages 123-126
Abstract
Background: Cutaneous drug reaction is a common side effect of antiepileptic drugs (AEDs). In recent years, a significant increase in cases of cutaneous drug reaction due to AEDs and some changes in its pattern in our department have been noticed. Therefore, we carried out this study to present clinical ...
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Background: Cutaneous drug reaction is a common side effect of antiepileptic drugs (AEDs). In recent years, a significant increase in cases of cutaneous drug reaction due to AEDs and some changes in its pattern in our department have been noticed. Therefore, we carried out this study to present clinical and paraclinical characteristics of these cases. Methods: All records of patients who were hospitalized at our hospital with a diagnosis of cutaneous drug reaction due to anticonvulsant therapy between March 2006 and September 2009 were reviewed. Results: The most common offending drug was lamotrigine. The main indication of anticonvulsant therapy was for idiopathic seizures. The most frequent type of cutaneous reaction was maculopapular and/or erythrodermic rash. Eosinophilia was detected in 56.5% of the patients. Conclusions: Although serious reactions with AEDs are not common, they may be life threatening. So, timely and accurate diagnosis can prevent fatal reactions and affects subsequent anticonvulsant treatment options.
Zahra Hallaji; Vahideh Lajevardi; Robabeh Abedini; Amir Soleymani; Azadeh Goodarzi; Mehrnaz Salehi-Taleghani; Sara Beygi
Volume 19, Issue 4 , 2016, , Pages 125-130
Abstract
Background: The prevalence of non-alcoholic fatty liver disease is higher in patients with psoriasis than in the normal population. Serum leptin levels are higher in patients with psoriasis and in patients with non-alcoholic fatty liver. The purpose of this study was to determine the serum levels of ...
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Background: The prevalence of non-alcoholic fatty liver disease is higher in patients with psoriasis than in the normal population. Serum leptin levels are higher in patients with psoriasis and in patients with non-alcoholic fatty liver. The purpose of this study was to determine the serum levels of leptin in psoriatic patients with and without non-alcoholic fatty liver.Methods: This cross-sectional study was conducted at Razi Dermatology Hospital, Tehran, Iran in 2013. A total of 50 patients with psoriasis were enrolled in the study. Fatty liver grade was assessed via ultrasonography and serum leptin levels were measured using the ELISA method.Results: Ten patients had normal livers and 40 had fatty livers with different grades. The median serum leptin level was significantly higher in psoriatic patients with fatty liver (11.75ng/mL) in comparison to those without fatty liver (2.80 ng/ml). Moreover, there was a direct correlation between the leptin level and the grade of fatty liver.Conclusion: serum leptin can be elevated in the course of psoriasis and may have a role in the pathogenesis of non-alcoholic fatty liver disease and other metabolic co morbidities in psoriatic patients.
Zahra Fazel; Mahnaz Banihashemi; Mohammad-Javad Yazdanpanah; Hadis Yousefzadeh
Volume 15, Issue 4 , 2012, , Pages 127-130
Abstract
Background: Various kinds of sensitizers are administrated foralopecia areata treatment. The aim of this study was to evaluatetreatment response to Dinitrochlorobenzene (DNCB) in alopeciaareata patients.Method: In this study, 117 patients were treated with DNCBunder a specific checklist. All patients ...
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Background: Various kinds of sensitizers are administrated foralopecia areata treatment. The aim of this study was to evaluatetreatment response to Dinitrochlorobenzene (DNCB) in alopeciaareata patients.Method: In this study, 117 patients were treated with DNCBunder a specific checklist. All patients were sensitized with a 2%DNCB and then treated with ascending DNCB concentrations(0.001%-2%). Response to treatment was categorized as none,mild, moderate and marked improvement.Result: Thirty three (27.5%) patients showed no response, 49(40.8%) had relapse 6 months after improvement, 29 (24.2%)had no relapse 6 months after the treatment and 6 patientswere excluded because they did not return for follow-up visits.Response to treatment in patients without eyelash and eyebrowinvolvement increased significantly (P=0.01). We did not observeany side effects except for localized dermatitis seen in 5% of thepatients.Conclusion: With respect to the suitable response to DNCBapplication and its availability, the authors suggest that DNCBbe reconsidered in alopecia areata. However, attention must bepaid to its mutagenicity..
Ebrahimzadeh Mohammad; Dehghani Farideh; Amirniroumand Niloofar
Volume 17, Issue 4 , 2014, , Pages 130-133
Abstract
Background: Lichen planus is a chronic inflammatory disease ofunknown etiology that may involve mucocutaneous tissues. Themain aim of our study was to evaluate the frequency of oral andgenital lichen planus in men and women affected by skin lesions.Method: A total of 132 patients with clinical and histopathologicaldiagnosis ...
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Background: Lichen planus is a chronic inflammatory disease ofunknown etiology that may involve mucocutaneous tissues. Themain aim of our study was to evaluate the frequency of oral andgenital lichen planus in men and women affected by skin lesions.Method: A total of 132 patients with clinical and histopathologicaldiagnosis of lichen planus were evaluated for oral and genitalinvolvement. All data was analyzed by SPSS version 19. Chisquare test and t-test were used for statistical analysis.Result: Of 132 patients enrolled in this study, 72 were men and60 were women. Genital and oral lichen planus
Yalda Nahidi; Naser Tayyebi Meibodi; Pooran Layegh; Sara Sharifi
Abstract
Background: Lichen planus (LP) is a chronic inflammatory disease involving the skin, mucous membranes and appendages. Like other chronic inflammatory diseases, it may be associated with metabolic disorders and dyslipidemia. Due to the discrepancies in the results of previous studies and lack of a similar ...
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Background: Lichen planus (LP) is a chronic inflammatory disease involving the skin, mucous membranes and appendages. Like other chronic inflammatory diseases, it may be associated with metabolic disorders and dyslipidemia. Due to the discrepancies in the results of previous studies and lack of a similar study on an Iranian population, we decided to investigate and compare the serum lipid levels of LP patients and normal healthy subjects.Methods: In this case-control study, 71 patients with lichen planus confirmed by clinical and pathological examination who referred to dermatology clinic were recruited; further included were 71 subjects selected from attendants without any skin diseases matched for age, gender and BMI.with patients; the well-being of the healthy subjects was confirmed by laboratory tests, physical examination and medical history..After filling the questionnaire, triglyceride, cholesterol, HDL and LDL levels were measured for patients and healthy subjects..The collected data were then analyzed.Results: Mean age of patients in the case group was 40.63 ± 11.41 years, 50.6% of whom were men, while 49.4% were women. Cholesterol, triglyceride and LDL levels in patients were significantly higher than the control group; it was only regarding HDL levels that no significant difference was observed between the two groups. HDL and triglyceride levels were significantly higher in patients with generalized disease. There was a recognizable correlation between elevated levels of LDL and cholesterol and disease duration.Conclusions: In this study, a disrupted lipid profile was observed in LP patients, which can be associated with disease severity. This study proposes measuring lipid serum levels prior to commencing the treatment in all known cases of lichen planus so as to preclude cardiovascular diseases if there is a problem with the lipid profile.
M Maleki; Z Javidi; V Mashayekhi; MT Shakeri; Y Nahidi; MA Hamed Shojaei; M Hanifeh Zadeh
Volume 9, Issue 2 , 2006, , Pages 132-138
Abstract
Background and aim: In spite of the existance of different types of treatment for cutaneous leishmaniasis, an efficient, safe and cheap treatment has not been found yet. There are some studies showing antiparasiticidal effect of direct current electricity both in vivo and in vitro. The objective of this ...
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Background and aim: In spite of the existance of different types of treatment for cutaneous leishmaniasis, an efficient, safe and cheap treatment has not been found yet. There are some studies showing antiparasiticidal effect of direct current electricity both in vivo and in vitro. The objective of this study was to evaluate the effect of electrotherapy in treatment of cutaneous leishmaniasis.Materials and Methods: This trial was done on 16 patients referred to dermatology clinics of Mashhad University of Medical Sciences with cutaneous leishmaniasis. Twenty-seven lesions were treated in six weekly sessions for 10 minutes, by direct current electricity. The intensity ranged from 5 to 15 mA, and the voltage was kept below 40 volts. Ten lesions were left untreated as control group. At each session the size of induration was measured and recorded.Results: At the end of the trial, in the study group, the average of the induration size decreased 55±30% , however, in the control group the induration size increased 20±20% (P<0.05).Conclusion: Direct current electricity was effective in the treatment of cutaneous leishmaniasis to some extent. Further studies with alteration in method of this treatment are needed.
Farhad Malekzad; Reza Robati; Hamidreza Abaei; Somayeh Hejazi; Azin Ayatollahi; Shima Younespour
Volume 14, Issue 4 , 2011, , Pages 136-139
Abstract
Background: Recent studies suggest that psoriasis may be a pathogenic factor for the metabolic syndrome and atherosclerosis. The aim of our study was to investigate the metabolic state in psoriatic patients in order to clarify the association between psoriasis and insulin resistance.Methods: This single-centre, ...
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Background: Recent studies suggest that psoriasis may be a pathogenic factor for the metabolic syndrome and atherosclerosis. The aim of our study was to investigate the metabolic state in psoriatic patients in order to clarify the association between psoriasis and insulin resistance.Methods: This single-centre, case- control study was performed between 2008 and 2010 to evaluate the metabolic state of thirty chronic plaque type psoriatic patients in comparison with the control group. The criteria of insulin resistance (Body Mass Index (BMI), Systolic Blood Pressure, Fasting Plasma Glucose, Oral Glucose Tolerance Test (OGTT), Serum Insulin and Lipid Profile) were assessed for each participant.Results: Thirty psoriatic patients with a mean disease duration of 3.94 + 2.96 years and 30 healthy controls were recruited for the study. Only one patient in each group filled the criteria of insulin resistance, and there was no significant difference between the two groups. The mean Fasting Plasma Glucose (FPG), Triglyceride (TG) and Systolic Blood Pressure (SBP) levels were significantly higher in psoriasis patients as compared to the controls (p=0.044, p=0.014 and p=0.001, respectively). In contrast, no statistically significant differences were observed in mean BMI, OGTT, insulin and HDL levels between the two groups.Conclusion: Despite the absence of any significant association between insulin resistance and psoriasis, it could be concluded that psoriasis may be an independent risk factor for diseases such as Ischemic Heart Disease (IHD) and Diabetes Mellitus (DM), hypertension and obesity.
Ghiasi Maryam; Lajevardi Vahide; Mortazavi Hossein; Damavandi Maedeh Raiyati
Volume 16, Issue 4 , 2013, , Pages 137-140
Abstract
Background: Systemic isotretinoin is a very effective medication for the treatment of acne, but it has some side effects. One of its side effects is musculoskeletal problems such as increased levels of creatine phosphokinase (CPK), myalgia, and serious muscle damage such as rhabdomyolysis. The aim of ...
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Background: Systemic isotretinoin is a very effective medication for the treatment of acne, but it has some side effects. One of its side effects is musculoskeletal problems such as increased levels of creatine phosphokinase (CPK), myalgia, and serious muscle damage such as rhabdomyolysis. The aim of this study was to evaluate the incidence of myalgia and its relationship with the elevation of serum CPK levels in patients treated with isotretinoin.Method: This study was done on forty acne patients in Razi Hospital. Isotretinoin was administered at a dose of 0.25 mg/kg in all patients. Serum CPK levels were measured before the treatment and every 2 months during treatment. On each visit, the patients were asked about muscular symptoms such as myalgia.Result: Twenty-eight (70%) patients were female. The mean age of the patients was 22.6±5.4 years. The mean serum CPK level did not increase during treatment with isotretinoin. However, 2.5%, 36.8% and 31.5% of the patients had myalgia 2, 4, and 6 months after the initiation of isotretinoin, respectively. There was no significant difference in the mean CPK level of those who had myalgia after treatment with isotretinoin and those who were asymptomatic.Conclusion: It seems that low dose isotretinoin does not induce the elevation of CPK, but can cause myalgia in some patients irrespective of the CPK level. Myalgia in patients under treatment with low dose isotretinoin is a benign phenomenon and is not an alarm for serious muscle damage. Therefore, routine measurement of the CPK level in patients receiving low dose isotretinoin is not recommended.
Saman Mohammadi; Saeedeh Farajzadeh; Hossein Safizadeh; Maryam Khalili; Mahin Aflatoonian; Rezvan Amiri; Elham Mohammadrezakhani
Abstract
Background: Atopic dermatitis is the most common inflammatory skin disease in children. Severe itching may lead to an impaired quality of life in the patients. In this study, we evaluated the validity and reliability of Persian version of a questionnaire regarding the infants’ ...
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Background: Atopic dermatitis is the most common inflammatory skin disease in children. Severe itching may lead to an impaired quality of life in the patients. In this study, we evaluated the validity and reliability of Persian version of a questionnaire regarding the infants’ dermatitis quality of life in children suffering from atopic dermatitis.Methods: When the original authors approved of the Persian version of the questionnaire, the parents completed the questionnaire for their 98 children with atopic dermatitis aged less than four years. We analyzed the data by SPSS 16. Cronbach’s alpha and inter-item and calculated the correlations to evaluate the reliability and validity via Kaiser criterion and scree plot.Results: The calculated mean score of questionnaire was 9.65±5.41. The first (itching and scratching) and eight questions (treatment problems) obtained the highest and lowest scores, respectively. There was a strong, positive correlation between the severity of the disease and the quality of life score in the patients. Cronbach’s alpha was calculated as 0.88 which is a sign of good internal consistency of the items. The inter-item correlative coefficients varied between -0.004 to 0.87. We used Kaiser’s criterion and scree plot to evaluate the validity and achieve a two-factor solution.Conclusion: Persian version of infants’ dermatitis quality of life index questionnaire was valid and reliable.
Davoudi Seyyed Masoud; Keshavarz Saeed; Sadr Bardia; Shohrati Majid; Naghizadeh Mohammad Mehdi; Farsinejad Khalil; Rashighi-Firouzabadi Mehdi; Zartab Hamed; Firooz Alireza
Volume 11, Issue 4 , 2008, , Pages 151-155
Abstract
Background: Sulfur mustard gas is a chemical agent that has been used in many wars, especially in Iran-Iraq war. This chemical agent affects many organs including lungs, eyes and skin, causing numerous acute and chronic lesions including erythema and hyperpigmentation, respectively. This study was conducted ...
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Background: Sulfur mustard gas is a chemical agent that has been used in many wars, especially in Iran-Iraq war. This chemical agent affects many organs including lungs, eyes and skin, causing numerous acute and chronic lesions including erythema and hyperpigmentation, respectively. This study was conducted to evaluate erythema and melanin in subjects with a history of exposure to sulfur mustard.Methods: This case-control study was done on 309 subjects. They were divided into four groups: sulfur mustard-exposed patients with skin lesions (n=87), sulfur mustard-exposed cases without current skin lesions (n=71), non sulfur mustard-exposed patients with dermatitis (n=78) and normal controls (n=74). Erythema and melanin were measured in 4 areas (forehead, suprasternal, palm and back of hands) by Mexameter MX18 (Courage-Khazaka, Germany).Results: Erythema was significantly lower in suprasternal and palmar aspect of hands in sulfur mustard-exposed patients with dermatitis (P<0.05) while there was no significant difference in other areas. In terms of melanin, there was a significant difference in the dorsal aspect of hands in all four groups (P<0.05), where patients with dermatitis (both sulfur mustard exposed and normal population) had higher levels of melanin, probably due to pruritus in such areas. Forehead melanin of the normal population was also significantly lower than other three groups (P<0.05) while there was no significant difference between the melanin level of sulfur mustard exposed subjects (with or without dermatitis) and patients with dermatitis.Conclusion: Sulfur mustard contact can affect erythema and melanin content of the skin.
T Rashidi; A Alamdari Mahd; A Hamzeh Zadeh; R Talebi
Volume 7, Issue 3 , 2004, , Pages 152-155
Abstract
Background: Recurrent aphthous stomatitis (RAS) is a common disease, which several etiologic factors have been considered for it. The infectious agents and immunological factors are the most suspected causes. Recently a few studies with varied results have been done to clarify the role of Helicobacter ...
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Background: Recurrent aphthous stomatitis (RAS) is a common disease, which several etiologic factors have been considered for it. The infectious agents and immunological factors are the most suspected causes. Recently a few studies with varied results have been done to clarify the role of Helicobacter Pylori (H.pylori) in etiology of RAS. Objective: To find correlations between serum IgG and IgA levels to Helicobacter Pylori and RAS. Patients & methods: A total number of 29 patients with RAS referred to Urmia skin hospital were included in this case-control study. Control group consisted of 57 persons and was chosen from healthy individuals. Blood samples were taken and blood levels of IgG and IgA antibodies of patients and control were measured by ELISA method and collected data were analyzed by chi-square test. Results: IgG antibodies to H.pylori were found in the sera of 75.9% of RAS patients and 66.7% of controls. IgA antibodies were detected in 51.9% of RAS and 70.9% of controls. These differences were not statistically significant. Conclusion: There was no significant difference between IgG and IgA levels to Helicobacter Pylori in patients with RAS compared to control group.
Nahidi Yalda; Meibodi Naser Tayyebi; Ghazvini Kiarash; Esmaeeli Habiballah; Nahidi Mahsa
Volume 18, Issue 4 , 2015, , Pages 163-168
Abstract
Background: Mycosis fungoides is the most common type of primary cutaneous T-cell lymphoma. Its etiopathogenesis, despite numerous studies, remains unclear. Environmental, viral, and genetic factors have been proposed as its potential etiologic factors. In recent years, viral agents of herpes virus family ...
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Background: Mycosis fungoides is the most common type of primary cutaneous T-cell lymphoma. Its etiopathogenesis, despite numerous studies, remains unclear. Environmental, viral, and genetic factors have been proposed as its potential etiologic factors. In recent years, viral agents of herpes virus family such as human herpes virus 8 (HHV-8) have been noticed.Objective: The aim of this study was to evaluate the association between the presence of HHV-8 and mycosis fungoides.Methods: This case-control study was done on skin biopsies of 42 mycosis fungoides cases referred to the Department of Pathology, Imam Reza Hospital, Mashhad, Iran from 2004 to2012, and 42 age and sex matched samples of melanocytic nevi. PCR was performed to detect HHV-8 in biopsy samples of the patients and the control group. Statistical analysis was done using the IBM SPSS Statistics (IBM Corp., Armonk, NY, USA) 20.Results: Of 42 patients with MF, 25 were male and 17 were female with a male to female ratio of 1.4. The mean age of the patients was 51.2 years. Most of the patients were in the age group over 60 years. Clinical lesions of the majority of the patients were papules and plaques. HHV-8 DNA was not found in any of the mycosis fungoides samples using the PCR method.Conclusion: Based on our study results, HHV-8 does not play an important role in the pathogenesis of mycosis fungoides.
Ghalamkarpour Fariba; Niknafs Faranak; Younespour Shima
Volume 19, Issue 75 , 2016, , Pages 169-173
Abstract
Background: Erythroderma is an inflammatory disorder. It has various differential diagnoses, among which one of the most important is mycosis fungoides. Erythroderma itself can be a challenging disorder. Diagnosis of a mycosis fungoides patient presenting with erythroderma specially requires a careful ...
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Background: Erythroderma is an inflammatory disorder. It has various differential diagnoses, among which one of the most important is mycosis fungoides. Erythroderma itself can be a challenging disorder. Diagnosis of a mycosis fungoides patient presenting with erythroderma specially requires a careful assessment of the peripheral blood. Studies such as CD markers can lead to a more accurate diagnosis of mycosis fungoides.Methods: In this study, we evaluated ten erythrodermic patients in order to identify the source of their erythema. The underlying causes were both benign such as eczema, psoriasis, pityriasis rubra pilaris, acute generalized exanthematous pustulosis and malignant like hypereosinophilic syndrome and mycosis fungoided. Results: The CD4/CD8 ratio was greater than 10 in 2 out of 10 erythrodermic patients. These patients had decreased levels of CD7 and CD26 expression. While one of the two patients fulfilled the criteria of hypereosinophilic syndrome, the other one did not have a documented clincopathologic diagnosis and had a pathology report of lichenoid tissue reaction with eosinophilia in favor of drug reaction. Both patients had decreased levels of CD7 and CD26 expression.Conclusion: Since pathology is usually non-specific and cannot differentiate between the causes of erythroderma in erythrodermic patient with CTCL, peripheral blood findings including flow cytometry and the analysis of CD4/CD8, CD7, CD26 and CD27 expression are useful techniques which can be used for a prompt diagnosis.
MT Noor Bala; N Poursina
Volume 8, Issue 3 , 2005, , Pages 190-194
Abstract
Background: Getting access to information about expansion and spread of skin diseases and determination of common types of them in any specific area has particular importance. There is no doubt that cultural, social and genetic factors by an important role in the epidemiology of skin diseases. Objective: ...
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Background: Getting access to information about expansion and spread of skin diseases and determination of common types of them in any specific area has particular importance. There is no doubt that cultural, social and genetic factors by an important role in the epidemiology of skin diseases. Objective: To determine the frequency of various skin diseases in patients referred to Sadooghi hospital in Yazd in the summer of year 1999. Patients and Methods: This descriptive study was done on 1000 patients who referred to the skin clinic. Final clinical diagnosis of patients were classified according to ICD 10. Results: According to ICD 10, more than 60 diseases were diagnosed among which infectious diseases of skin were the commonest (23%) and viral diseases formed about one third of total infections. 19% of cases had dermatitis of which 2 third were contact dermatitis. 10.8% of cases had acne and 7.8% had melasma. In patients under 15 years of age infectious diseases and in patients 15-25 years of age acne were the most commonly found diseases. Cutaneous leishmaniasis, which is endemic in the study area, was the most common parasitic skin infection. Conclusion: Infectious diseases and dermatitis are among the most commonly diagnosed skin diseases in Yazd and need to be considered carefully to make a comprehensive plan to control.
Maryam Akhyani; Cheyda Chams-Davatchi; Zahra Safai Naraghi; Maryam Daneshpazhooh; Siavash Toosi; Masoud Asgari; Fatemeh Malek Hami
Volume 10, Issue 3 , 2007, , Pages 194-202
Abstract
Background and aim: Pemphigus vulgaris (PV) is an autoimmune blistering disease which is known to involve the female genital tract but the frequency at which this occurs is unknown. There are relatively few reports in the literature of the cytological appearance of PV on cervicovaginal smears. Our aim ...
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Background and aim: Pemphigus vulgaris (PV) is an autoimmune blistering disease which is known to involve the female genital tract but the frequency at which this occurs is unknown. There are relatively few reports in the literature of the cytological appearance of PV on cervicovaginal smears. Our aim was to evaluate involvement of the female genital tract and cervicovaginal Papanicolaou (Pap) smears in PV.Materials and methods: The study included 77 patients with PV visited from April 2005 to February 2007. Each patient was subjected to gynecological examination and cervicovaginal Pap smear.Results: The mean age of patients was 44.7±13 years. Genital lesions were observed in 39 patients (50.6%). Labia minor was involved in 36 patients (92.3%), while labia major in 11 (28.2%), vagina in 14 (35.8%), and cervix in six (15.3%). Cervicovaginal smears of 20 patients (25.9%) showed PV. Among 72 satisfactory smears, cervical Pap smears were normal in 25 patients (34.7%), inflammatory in 43 patients (59.7%), and dysplastic (low-grade cervical intra-epithelial neoplasia [CIN I]) in four patients (5.5%). In 2 of these patients, Pap smears was normal repeated when patients were in remission.Conclusion: Involvement of the female genital tract might not be as infrequent as was previously thought and it is probably the second most common mucosal site of PV after oral mucosa. Genital lesions may be missed and the need for thorough pelvic examination should not be overlooked.
Alireza Ghanadan; Kambiz Kamyab; Ali Nili; Hamidreza Mahmoudi; Vahidehsadat Azhari; Anahita Borzouei; Shirin Taraz Jamshidi
Abstract
Background: Pilomatricoma is a benign skin adnexal neoplasm. Various histological features are observed on microscopic examination. We aimed to evaluate this tumor’s demographic and histological features in detail.Methods: One hundred cases with a diagnosis of pilomatricoma were selected, and demographic ...
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Background: Pilomatricoma is a benign skin adnexal neoplasm. Various histological features are observed on microscopic examination. We aimed to evaluate this tumor’s demographic and histological features in detail.Methods: One hundred cases with a diagnosis of pilomatricoma were selected, and demographic and clinical data were entered into a checklist. The pathology slides were reviewed to confirm the diagnosis. The demographic profile of all patients, including age and gender, primary clinical impression, multiplicity of the tumor, microscopic features, and location of tumoral involvement, were extracted. Qualitative data were summarized using frequencies and percentages. Regarding descriptive analysis, the frequency of each histopathologic feature was calculated.Results: Two groups of patients were identified regarding age. This tumor was more common in males among adult patients, while a female preponderance was seen in those under 18. Most lesions were located on the face (40%), followed by upper (32%) and lower (10%) limbs. In addition to well-known histological features, we observed intraepidermal pilomatricoma in two cases presenting unique histopathologic features. Both showed foci of suprabasal cleft formation, while one showed the Borst-Jadassohn phenomenon. These features, in addition to sebaceous differentiation and acantholysis of ghost cells, were not addressed in previous literature.Conclusion: Understanding the diverse and new histological features of pilomatricoma is necessary for differentiating it from other adnexal and soft tissue tumors.
MA Nilforoush Zadeh; Sh Moradi; R Derakhshan; E Haft Baradaran; F Jafari
Volume 9, Issue 3 , 2006, , Pages 221-226
Abstract
Background and aim: Cutaneous leishmaniasis (CL) is an edemic disease widely spread in Iran. Although several treatments have been tried, none has been found as simple and effective. Honey has been used in the treatment of chronic ulcers and its anti-leishmanial effects have also been reported. So we ...
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Background and aim: Cutaneous leishmaniasis (CL) is an edemic disease widely spread in Iran. Although several treatments have been tried, none has been found as simple and effective. Honey has been used in the treatment of chronic ulcers and its anti-leishmanial effects have also been reported. So we assessed the efficacy of honey in acute CL.Materials and Methods: In a randomized clinical trial, 100 patients with CL referred to Skin and Leishmaniasis Research Center were treated with either weekly intra-lesional injection of Glucantime alone or combined with twice daily topical application of honey. The patients were evaluated clinically 2 ,3 and 4 months after treatment.Results: Ninety patients completed the study, forty-five patients were treated in each group. At the end of trial, 32 patients (71/1%) of these treated with Glucantime alone and 23 patients (51/1%) treated with honey were cured (P=0.04).Conclusion: Drug interference and inhibition of bioavailability of Glucantime by honey may decrease the efficacy of Glucantime in treatment of CL.
P Toosi; F Hosseinzadeh; M Rahmati Roodsari; L Gachkar; Sh Manighalam
Volume 7, Issue 4 , 2004, , Pages 231-236
Abstract
Background: Various environmental factors can induce or exaggerate hand eczema. Objective: Evaluation of patch test results in hand eczema patients. Patients and Methods: In this descriptive study 100 patients with hand eczema referred to Loghman Hakim and Booali Hospital in Tehran underwent patch testing ...
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Background: Various environmental factors can induce or exaggerate hand eczema. Objective: Evaluation of patch test results in hand eczema patients. Patients and Methods: In this descriptive study 100 patients with hand eczema referred to Loghman Hakim and Booali Hospital in Tehran underwent patch testing with 23 allergens obtained from Hermal company. Results: 240 positive reactions observed in 86 patients. The most common positive reactions were related to nickel sulfate (30 patients, 13.5%) and potassium dichromate (28 patients, 11.7%). In positive group 28 patients were male and 58 were female. In negative group 3 patients were male and 11 were female (P>0.05). The mean age was 31.7±11.9 years and 24.8±9.2 years for positive group and negative group, respectively (P0.05). Conclusion: Performing patch test, the allergens involved in hand eczema can be detected. Detecting type of allergens, patients will be able to avoid those materials, which can lead to improvement of disease.
S Nassiri; S Taghavian Pour; A Sadiqha
Volume 8, Issue 4 , 2005, , Pages 266-271
Abstract
Background an objective: Several studies have indicated that vertex type androgenetic alopecia have a higher-than-normal risk for coronary heart disease but few studies focused on lipid profiles which are important in the pathogenesis of coronary heart disease. This study was designed to investigate ...
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Background an objective: Several studies have indicated that vertex type androgenetic alopecia have a higher-than-normal risk for coronary heart disease but few studies focused on lipid profiles which are important in the pathogenesis of coronary heart disease. This study was designed to investigate the relation between vertex type androgenetic alopecia (Grade III and higher according to Hamilton-Norwood) and hyperlipidemia.Materials and Methods: In this case-control study, lipid parameters (Total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, total cholesterol/HDL cholesterol ratio) of 50 men with vertex type androgenetic alopecia (Study group) were compared with 50 men with normal hair status (Control group). Study group matched according to the age, BMI and habit of smoking with control group.Results: Study group had a higher triglyceride and lower HDL cholesterol levels than control group. Total cholesterol/HDL cholesterol ratio was significantly higher in study group (P<0.05).Conclusion: Vertex type androgenetic alopecia could be a clinical marker of hyperlipidemia and dermatologists should investigate lipid profile in these patients.
Esfandiarpour Iraj; Rahpima Maryam
Volume 10, Issue 4 , 2007, , Pages 283-289
Abstract
Background and aim: Lichen planus (LP) is an inflammatory papulosquamous disease that affects skin, mucous membranes, nails and hair. As the disease presents in various clinical types, the objective of this study was to determine the frequency of clinical variants of LP in dermatological out-patients ...
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Background and aim: Lichen planus (LP) is an inflammatory papulosquamous disease that affects skin, mucous membranes, nails and hair. As the disease presents in various clinical types, the objective of this study was to determine the frequency of clinical variants of LP in dermatological out-patients in Kerman. Materials and methods: In this study 300 patients with LP were evaluated during 1382-83 in dermatological out-patients in Kerman. Diagnosis was based on clinical features and skin biopsy. The demographic features including age, sex, and the clinical pictures of the disease including clinical types, site of involvement, duration of the disease and associated diseases were assessed. The hepatitis B surface antigen, anti hepatitis B core antibody, hepatitis C antibody and liver function tests were measured. Results: Patients consisted of 167 men (55.5%) and 133 women (44.5%) with a mean age of 32.4 years and a mean duration of 11.6% months. The age of patients ranged from 4 to 78 years, most being in the age range from 30 to 50 years. The majority of patients (70.6%) had classical lesions followed by mucosal (65%), annular (21%), hypertrophic (19%), and lichen nitidus (18%). The dermatomal type obtained the least frequency (2.6%). Upper extremity was the most frequent site of onset (70.6%). Mucosal involvement was observed in 65% and nail and hair changes were observed in 33.6% and 6.6% of patients, respectively. Pruritus was the chief complaint of the majority of patients. Conclusion: Classic LP was the most common type and extremities were the most common site of involvement in this study.
Davoudi Seyyed Masoud; Behnia Fereydoun; Gorouhi Farzam; Saeed Keshavarz; Mansour Nassiri Kashani; Alireza Firooz
Volume 9, Issue 4 , 2006, , Pages 319-323
Abstract
Background and aim: Laser is one of the most recent techniques which has widespread use in the treatment of many skin diseases. This technique has been successfully used to remove unwanted hairs in hirsutism. The aim of this study was to evaluate and compare the efficacy and safety of long-pulsed 755 ...
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Background and aim: Laser is one of the most recent techniques which has widespread use in the treatment of many skin diseases. This technique has been successfully used to remove unwanted hairs in hirsutism. The aim of this study was to evaluate and compare the efficacy and safety of long-pulsed 755 nm alexandrite and long-pulsed 1064 nm Nd: YAG lasers individually and in combination for permanent hair removal. Materials and Methods: This single-blind randomized clinical trial was conducted on 25 patients. They were treated by alexandrite or Nd: YAG or combination of them in 4 sessions with 8 weeks intervals. The treatment was applied on their medial and lateral sides of both legs. All the parameters of the systems were set on the company defaults. Subjects were evaluated 1 and 8 months after completion of the treatment. Hair count was measured by Visiomed device and digital camera photographs every session. To calculate mean hair reduction, the difference between hair count before and after treatment was divided by hair count before treatment. Pain severity, measured by Visual Analogue Scale (VAS), and side effects (bullae, scar and pigmentation changes) were recorded every session. The data were analyzed with ANOVA, post hoc Tukey and chi square tests. Results: Fifteen patients completed the study and 10 patients were excluded due to appearance of bullae in 2 patients and refuse to continue in 8 patients. The mean hair reduction measured by Visiomed 8 months after last treatment was: 61.96 ±21.09, 60.03±23.40 and 68.05±21.23 percent for alexandrite, Nd: YAG and combination therapy, respectively. When digital camera photos were used for measurement of hair reduction these values were 85.99±11.62, 73.60±16.57 and 79.61±18.08 percent, respectively. The differences between the systems were not significant (ANOVA, P>0.05). In paired comparison of the systems, no significant differences were observed either (Tukey test). The incidence of adverse effects (hyperpigmentation) and pain severity were significantly greater in area received combination therapy (P=0.001).Conclusion: Both alexandrite and Nd:YAG laser systems were effective in hair removal. In contrast, combination therapy did not have more efficacy and also caused more side effects.
MA Nilforoush Zadeh; F Jafari; Sh Rafiei
Volume 8, Issue 5 , 2005, , Pages 358-362
G Sadeghian; MA Nilfroush Zadeh; M Amini
Volume 8, Issue 6 , 2006, , Pages 466-470
Abstract
Background and aim: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin can have a role in the pathogenesis of this disease and hyperinsulinemia as a consequence of insulin resistance may stimulate the formation of the characteristic plaques of ...
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Background and aim: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin can have a role in the pathogenesis of this disease and hyperinsulinemia as a consequence of insulin resistance may stimulate the formation of the characteristic plaques of AN. In this study insulin resistance was compared in obese women with and without AN.Materials and Methods: Glucose tolerance test (GTT) and fasting blood insulin were measured in two groups of obese women (BMI>30 kg/m2) with AN (32 cases) and without AN (34 cases) and insulin resistance was determined using HOMA formula.Results: The mean fasting blood insulin in two groups with and without AN were 15.5±8.5 and 12.2±4.1 IU/mL; respectively (P<0.05). The mean of insulin resistance in two groups with and without AN were 3.5±1.9 and 2.6±0.9; respectively (P<0.05). The results of GTT showed that the mean fasting blood sugar was 89.5±12 mg/dl and following using glucose were 144±7 mg/dl after 30 minutes, 132±45 mg/dl after 60 minutes, 107±30 mg/dl after 120 minutes in persons with AN and in the other group were 87±8, 130±3, 122±26 and 100±26 mg/dl; respectively. The difference between two groups was only significant after 60 minutes.Conclusion: Acanthosis nigricans maybe a marker of insulin resistance in obese women.
