Iranian Journal of Dermatology

The 10th Annual Meeting, Iranian Society of Dermatology, Tehran, 16-18 June 2010

Reza Mahmoud Robati

Volume 13, Issue 2 , 2010, , Pages 64-66

Abstract

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Exploring the efficacy of the Mycobacterium indicus pranii (MIP) vaccine in reducing the impact of the ongoing COVID-19 pandemic

Santoshdev Rathod; Raju G Chaudhary; Tarun Narang

Volume 23, Suppl.1(COVID-19) , 2020, , Pages 67-70

https://doi.org/10.22034/ijd.2020.114853

Abstract

  Vaccine makers are racing to develop COVID-19 vaccines and have advanced ten candidates into clinical trials. However, vaccine development is typically a lengthy process. A number of immuneresponse modifiers have also been explored for their efficacy in the management of COVID-19. In this ...  Read More Vaccine makers are racing to develop COVID-19 vaccines and have advanced ten candidates into clinical trials. However, vaccine development is typically a lengthy process. A number of immuneresponse modifiers have also been explored for their efficacy in the management of COVID-19. In this short communication, we explore the possibility of using Mycobacterium indicus pranii (MIP) for the management of severely ill COVID-19 patients and its plausible role in the mitigation of severe disease in mildly infected patients. The MIP vaccine has a proven role in the prevention of leprosy to house-hold contacts of lepromatous leprosy, category-II tuberculosis patients, and patients with severe septicemia and low CD4 counts. It has also been used as an immune response modifier in patients with bladder carcinoma. Notably, this vaccine may be more efficacious than the BCGvaccine. The possible benefits and risks of using such an agent are described in this article. The use of such an approach could be beneficial in resource-poor countries and countries where diseases like tuberculosis and leprosy are endemic.

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CASE: Erosive Nodule on the Vulval Skin

Soheila Nassiri; Marjan Saeedi; Sima Kavand; Nastaran Namazy; Afsaneh Maarefat

Volume 12, Issue 2 , 2009, , Pages 71-72

Abstract

  A 64-year-old Iranian woman presented with a genital erosive skin lesion that she had noticed from two years ago. On physical examination, a 20 to 25 millimeter purplish lesion was observed on the vulval skin (Figure 1). The indurated lesion showed a small central erosion measuring 3 to 5 mm. Inguinal ...  Read More A 64-year-old Iranian woman presented with a genital erosive skin lesion that she had noticed from two years ago. On physical examination, a 20 to 25 millimeter purplish lesion was observed on the vulval skin (Figure 1). The indurated lesion showed a small central erosion measuring 3 to 5 mm. Inguinal lymph nodules were not palpable. A skin biopsy specimen was obtained from the eroded lesion (Figure 2).  

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Report of a case of disabling pansclerotic morphea of childhood

Ramin Espandar; Kamran Balighi; Shideh Yazdanian; Mahmoud Farzan

Volume 10, Issue 1 , 2007, , Pages 74-77

Abstract

  Localized morphea is a disorder of unknown cause in which there is localized sclerosis of the skin. Disabling pansclerotic morphea of childhood is a rare severe mutilating form of morphea involving the dermis, fat, fascia, muscle and even bone, usually starting before the age of 14 years. Here, an eight-year-old ...  Read More Localized morphea is a disorder of unknown cause in which there is localized sclerosis of the skin. Disabling pansclerotic morphea of childhood is a rare severe mutilating form of morphea involving the dermis, fat, fascia, muscle and even bone, usually starting before the age of 14 years. Here, an eight-year-old boy with progressive sclerosis of palmar surface of wrist and hand and digits without involvement of finger tips is presented whose major signs was flexion contracture of wrist and claw hand deformity of third and fourth fingers. Due to progressive nature of the disease he was treated with prednisolone and hydroxychloroquine and the progression of the disease was controlled.

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Can lesions of ‘en coup de sabre’ progress after being quiescent for a decade?

Tasleem Arif; Imran Majid

Volume 18, Issue 2 , 2015, , Pages 77-79

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A case of contact dermatitis due to green bean

Viroj Wiwanitkit

Volume 14, Issue 2 , 2011, , Pages 79-79

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What’s Your Diagnosis?: CASE 1

Kavusi Suzan; Lajevardi Vahide; Moinedin Fateme; Barzegar Mohamad Reza

Volume 11, Issue 2 , 2008, , Pages 93-94

Abstract

  Case: A 40–year-old woman referred to the dermatological clinic of Razi hospital with painful lesions on the axillae, between her breasts and intergluteal region since adolescence. The patient had been treated with a variety of antibiotics with only minimal improvement. The lesions reappeared with ...  Read More Case: A 40–year-old woman referred to the dermatological clinic of Razi hospital with painful lesions on the axillae, between her breasts and intergluteal region since adolescence. The patient had been treated with a variety of antibiotics with only minimal improvement. The lesions reappeared with cessation of treatments. On cutaneous examination, multiple furuncle-like discharging nodules were observed over the axillae, between the breasts, buttock and gluteal region (figure 1). Other findings were giant black comedones and depressed scars which were found between the aforementioned lesions, particularly on her back (figure 2). A number of pits with 2 to 3 mm diameter were seen around the mouth (figure 3). Additionally, there were hyperpigmented macules in a reticular pattern over the axillae, inframammary area and groin (figure 4). Mucosal surfaces and nails were not pigmented. Systemic examination was normal. Laboratory data were all within normal limits. In familial history, one of her sisters, aged 50 years, had a similar pattern of pigmentation from the age of 20.

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Cluster of Contact Dermatitis Due to Dye Used in SOTUS Activity

Wiwanitkit Viroj

Volume 12, Issue 3 , 2009, , Pages 105-105

Abstract

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Dermatitis after Bathing with Well Water among a Group of Secondary Students Participating in SOTUS Activity

Viroj Wiwanitkit

Volume 13, Issue 3 , 2010, , Pages 105-105

Abstract

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Comparison of pain reduction between lidocaine-prilocaine cream and diclofenac gel in patients treated with the alexandrite laser

Rashidi Turaj; Hoseinzade Negar

Volume 15, Issue 3 , 2012, , Pages 109-110

Abstract

  Laser– assisted permanent hair removal iscommonly performed for the treatment of unwantedhair. This procedure is usually associated withpain and pain reduction has an important role inthe success of this treatment. A common methodof reducing pain is to use topical analgesics . Amixture of lidocaine ...  Read More Laser– assisted permanent hair removal iscommonly performed for the treatment of unwantedhair. This procedure is usually associated withpain and pain reduction has an important role inthe success of this treatment. A common methodof reducing pain is to use topical analgesics . Amixture of lidocaine and prilocaine (EMLA) is acommonly used and very effective topical anesthetic.Another agent is diclofenac gel. Diclofenac is anon-steroidal anti-inflammatory drug (NSAID) andis a potent inhibitor of inducible cyclo-oxygenase(COX-2) . Oral administration of this medicationcan result in adverse effects. There are no studieson its efficacy as a topical anesthetic in laser hairremoval.

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Efficacy of CICACTIVE® versus silver sulfadiazine 0.1% cream on facial wound healing in patients treated with Erbium-YAG resurfacing laser: A single-blind randomized clinical trial

Amir Houshang , Ehsani; Pedram Noormohammadpour; Milad Miresmaeli; Laleh Montaser-Kouhsari; Hamed Ahmadi; Mahboubeh sadat Hoseini

Volume 14, Issue 3 , 2011, , Pages 119-120

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Skin rash in novel H7N9 influenza infection: a concern

Beuy Joob

Volume 16, Issue 3 , 2013, , Pages 120-120

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Assessment of the psychosocial effects of hand dermatitis among healthcare workers during the COVID-19 pandemic

Mohammad Reza Pourani; Fahimeh Abdollahimajd

Volume 24, Issue 2 , June 2021, , Pages 127-131

https://doi.org/10.22034/ijd.2021.272982.1321

Abstract

  Hand hygiene is one of the most crucial measures against coronavirus disease 2019 (COVID-19) transmission; however, frequent handwashing may lead to contact dermatitis causing many problems. Occupational hand dermatitis is a relatively common but challenging issue that imposes a negative effect on the ...  Read More Hand hygiene is one of the most crucial measures against coronavirus disease 2019 (COVID-19) transmission; however, frequent handwashing may lead to contact dermatitis causing many problems. Occupational hand dermatitis is a relatively common but challenging issue that imposes a negative effect on the quality of life, work performance, and adherence to hygiene principles. We performed a cross-sectional study to assess the psychosocial impacts of hand dermatitis on healthcare workers (HCWs) using an online Persian version of the Nordic Occupational Skin Questionnaire (NOSQ-2002). Sixty-three from a total of 390 HCWs (21%) reported that hand eczema had adverse effects on their occupation, such as a necessity to use gloves (17.3%) and decreased adherence to hand hygiene (14%). HCWs reported a higher exacerbation of hand dermatitis in winter (40.3%) and fall (24.7%). Hand dermatitis exerted a significant impact on sporting activities, sleep, social life, mood, and sex in 17.7%, 43.3%, 44.3%, 66%, and 11.7% of HCWs, respectively. It seems that hand dermatitis-related impairment of the mentioned activities has increased in HCWs during the COVID-19 pandemic.

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Imaging techniques in dermatology

F Fatemi; A Asilian; AA Forouz Mehr

Volume 8, Issue 2 , 2005, , Pages 128-139

Abstract

  Since the discovery of X-rays, the use of imaging technology has continued to play an important role in medicine. Technological advancements have led to the development of various imaging modalities, most of which have been used to image organs deep within the human body. More recently, attention has ...  Read More Since the discovery of X-rays, the use of imaging technology has continued to play an important role in medicine. Technological advancements have led to the development of various imaging modalities, most of which have been used to image organs deep within the human body. More recently, attention has focused on the application of imaging technology for evaluation of the skin. A variety of techniques are currently being used to examine the skin and these include specialized photography, surface microscopy, ultrasound, laser Doppler perfusion imaging, confocal microscopy, magnetic resonance imaging and optical coherence tumography. These modalities can provide information hat can assist in the management of skin problems. Although many of these techniques are still undergoing research, they are showing promise as useful clinical tools in dermatology. In this review article we discuss about each of these technologies in brief.

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Melkersson-Rosenthal syndrome: Appropriate response to the combination treatment with intralesional triamcinolone injection and oral azithromycin

Kavoussi Hossein; Ebrahimi Ali; Ramezani Mazaher; Kavoussi Reza

Volume 18, Issue 3 , 2015, , Pages 140-143

Abstract

  Melkersson-Rosenthal syndrome is an uncommon disorder which is presented by a triad of lip swelling, facial nerve palsy, and a fissured tongue. A number of treatments have been reported for this syndrome with variable outcomes. We have reported a 38-year-old female patient with lower lip swelling and ...  Read More Melkersson-Rosenthal syndrome is an uncommon disorder which is presented by a triad of lip swelling, facial nerve palsy, and a fissured tongue. A number of treatments have been reported for this syndrome with variable outcomes. We have reported a 38-year-old female patient with lower lip swelling and a fissured tongue on clinical examination. She was also suffering from facial nerve paralysis since 8 years ago. A significant improvement of the signs was achieved with a combination of intralesional corticosteroid injection and oral azithromycin. Although our patient showed the triad, she had an atypical clinical course due to the initiation of syndrome with facial nerve palsy, resulting in a delay in definite diagnosis of her disease. The anti-inflammatory and immuno-modulatory effects of azithromycin and the therapeutic properties of the intralesional injection of corticosteroid have an important role in managing this syndrome.

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Dermatology at Shiraz University of Medical Sciences

Schwartz Robert; Ghohesani Reza

Volume 12, Issue 4 , 2009, , Pages 141-141

Abstract

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Harlequin ichthyosis (or harlequin fetus)

Homa Babaii; Aliasghar Alipour; Amirmasoud Borghei; Mahba Azizi

Volume 13, Issue 4 , 2010, , Pages 144-145

Abstract

  The pat ient was a female neonate bor n prematurely on 36 weeks of gestation by normal vaginal delivery. During pregnancy, mother had no history of fever, drug use or x-ray exposure. The mother was gravida 2 and had no history of abortion. Her first baby was well. On physical examination, the skin was ...  Read More The pat ient was a female neonate bor n prematurely on 36 weeks of gestation by normal vaginal delivery. During pregnancy, mother had no history of fever, drug use or x-ray exposure. The mother was gravida 2 and had no history of abortion. Her first baby was well. On physical examination, the skin was markedly thickened, hard and hyperkeratotic with deep crevices running transversely and vertically. She had ectropion and the globe was abnormal. The ears and nose were underdeveloped, flattened and distorted and the lips were everted and gaping (fish-mouth). Extreme inelasticity of the skin with flexion deformity of all joints was noted. The hand and foot were hard and waxy in appearance, with poorly developed distal digits (Figure 1,2). She had respiratory distress, was ill and sucked poorly. Harlequin ichthyosis (or harlequin fetus) is a rare but very severe disorder of keratinization. Inheritance is likely autosomal recessive, but new autosomal dominant mutations are possible 1. The genetic abnormality in harlequin ichthyosis has been identified as a mutation in the lipid-transporter gene ABCA12 on chromosome 2. In harlequin ichthyosis, the ABCA12 -mediated transfer of lipid to lamellar granules is absent 2. The skin of the affected infants is markedly thickened, hard (armor-like), and hyperkeratotic, with deep crevices running transversely and vertically (Figure 1). The fissures are most prominent over areas of flexion. Rigidity of the skin around the eyes results in marked ectropion, although the globe is usually normal; however, our patient had ectropion with an abnormal globe (Figure 2). The ears and nose are underdeveloped, flattened, and distorted, and the lips are everted and gaping, producing a “fish-mouth” deformity. The nails and hair are hypoplastic or absent. Extreme inelasticity of the skin is associated with flexion deformity of all joints. The hands and feet are ischemic, hard, and waxy in appearance, with poorly developed distal digits 3. Affected neonates have respiratory difficulty, suck poorly, and are subject to severe cutaneous infection 4. Common histopathological abnormalities include hyperkeratosis, accumulation of lipid droplets within corneocytes, and absence of normal lamellar granules 1,5. Prenatal diagnosis has been accomplished by fetoscopy, fetal skin biopsy, and microscopic examination of cells from amniotic fluid taken at the 17th and 21st weeks of gestation 6. We confirmed diagnosis in this report by ultrasound in the prenatal period and clinical findings during the neonatal period. Suspicion in this case was aroused only with findings of a persistently open mouth and fixed flexion deformities on two dimensional sonography whereas three dimensional sonography may disclose facial features more commonly associated with the condition, echogenic amniotic fluid, short foot length and fixed flexion deformity. Initial treatment includes high fluid intake to avoid dehydration from transepidermal water loss and use of a humidified heated incubator, emulsifying ointments, careful attention to hygiene, and oral retinoids 4. Unfortunately, our patient died because of sepsis.

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Aplasia cutis congenita

Pourarian Shahnaz; Borghei Seyed Amirmasoud; Azizi Mahba

Volume 17, Issue 4 , 2014, , Pages 146-147

Abstract

  The patient was a female neonate bornprematurely at 36 weeks of gestation by a Cesareansection. During pregnancy, the mother had nohistory of fever, drug use, or X-ray exposure.The mother was gravida 2 and had no history ofabortion. Her first child was healthy. There wasno record of birth trauma. The ...  Read More The patient was a female neonate bornprematurely at 36 weeks of gestation by a Cesareansection. During pregnancy, the mother had nohistory of fever, drug use, or X-ray exposure.The mother was gravida 2 and had no history ofabortion. Her first child was healthy. There wasno record of birth trauma. The perinatal historywas negative for intrauterine trauma, the use ofantithyroid medication, or misoprostol.

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Brooke-Spiegler Syndrome: a case report

Layegh Pouran; Sistani Nourieh Sharifi; Abadian Mohammad

Volume 10, Issue 2 , 2007, , Pages 157-161

Abstract

  Brooke-Spiegler syndrome is a rare autosomal recessive disease characterized by adnexal neoplasms, particularly trichoepithelioma, cylindroma, and occasionally spiradenoma, which usually develop in second to third decades of life. We report this syndrome in a 16-year-old woman with tumors on face and ...  Read More Brooke-Spiegler syndrome is a rare autosomal recessive disease characterized by adnexal neoplasms, particularly trichoepithelioma, cylindroma, and occasionally spiradenoma, which usually develop in second to third decades of life. We report this syndrome in a 16-year-old woman with tumors on face and scalp.

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Determination of Malassezia species isolated from patients with Pityriasis Versicolor using PCR-restriction enzyme method

SH Mir Hendi; B Tarazouei; K Zomorodian; N Jalali Zand

Volume 9, Issue 2 , 2006, , Pages 165-172

Abstract

  Background and aim: Malassezia species are part of the resident skin flora of humans. These yeasts are associated with various superficial diseases, including seborrheic dermatitis, atopic dermatitis, dandruff, and psoriasis. Various DNA-based molecular methods have been recently described to differentiate ...  Read More Background and aim: Malassezia species are part of the resident skin flora of humans. These yeasts are associated with various superficial diseases, including seborrheic dermatitis, atopic dermatitis, dandruff, and psoriasis. Various DNA-based molecular methods have been recently described to differentiate species of Malassezia. In this survey, a simple, reliable, and cost effective PCR-based method was applied for differentiation of Malassezia species isolated from pityriasis versicolor patients in Iran.Materials and Methods: In this study 83 clinical isolates from pityriasis versicolor patients were analyzed. A PCR-based technique using restriction enzyme digestion was applied for identification of Malassezia species.Results: The most frequently isolated species were M. globosa, followed by M.furfur, M. sympodialis, M. restricta and M.slooffiae. Species of M. packydermatis and M. obtusa were not seen.Conclusion: As M. sympodialis is the most prevalent species in the skin of healthy individuals, isolation of M. globosa as the dominant species from pityriasis versicolor lesions, suggests more virulent factors in this species.

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CASE 1

Rezvan Talaee; Batoul Zamani; Hasan Ehterami

Volume 11, Issue 4 , 2008, , Pages 177-178

Abstract

  A 7 – year - old Caucasian girl presented with a 3-month history of nodules on her thighs and buttocks. During a one-month period, the lesions gradually increased in size and number. They became indurate and tender. Similar nodules appeared on forearms after 4 months. The lesions gradually healed ...  Read More A 7 – year - old Caucasian girl presented with a 3-month history of nodules on her thighs and buttocks. During a one-month period, the lesions gradually increased in size and number. They became indurate and tender. Similar nodules appeared on forearms after 4 months. The lesions gradually healed with a depressed scar. On physical examination, we found many indurate areas 10-40 mm in diameter .The surface of some of them was erythematous and scaly. The lesions were not ulcerated and did not have a discharge (figure 1). On examination, she was afebrile and healthy, organs such as heart, lungs, abdomen , joints and muscles were normal. Laboratory evaluation findings including complete blood cell count, liver and renal function test values, ESR, CRP,VDRL, BUN, Creatinin, complement were all normal .The titers for FANA, Anti ds DNA, Anti Sm, Anti Scl-70, Anti –RNP, Anti-Ro, Anti-La, Anti –Jo1, Anti Phospholipid Ab, Anti cardiolipin Ab, c- ANCA , p- ANCA were negative. A skin biopsy was taken (figures 2).

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Cardiovascular risk factors in patients with psoriasis: A casecontrol study

Taheri Ahmad Reza; Sherafati Golrokh; Sadrneshin Mohsen; Poorzand Hoorak; Kiafar Bita

Volume 18, Issue 4 , 2015, , Pages 187-188

Abstract

  Recent studies suggest that psoriasis may be an independent risk factor for the development of cardiovascular diseases. Myocardial infarction, pulmonary embolism, diabetes mellitus,hypertension, and dyslipidemia have been reported in patients with psoriasis Certain risk factors for cardiovascular diseases ...  Read More Recent studies suggest that psoriasis may be an independent risk factor for the development of cardiovascular diseases. Myocardial infarction, pulmonary embolism, diabetes mellitus,hypertension, and dyslipidemia have been reported in patients with psoriasis Certain risk factors for cardiovascular diseases may be more prevalent among patients with psoriasis 3,4. The aim of this study was to define the risk factors of cardiovascular diseases in patients with psoriasis in Iran . Twentyfive patients (13 female and 12 male) over 18 years old with active plaque psoriasis regardless of its severity who were treated with psoralenultraviolet A (PUVA) in Imam Reza Dermatology Clinic were enrolled in this study. After obtainingmedical history taking and performing full physical examination, blood pressure, weight, and height of thee particinpants were measured. Then, their body mass index (BMI) was calculated and recorded. The control group consisted of 25 healthy individuals who were age and sex matched. The patients who were pregnant, and those with a history of anysystemic disease or under systemic medications were excluded from the study.

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Basal cell carcinoma superimposed on an old scar of localized cutaneous Leishmaniasis: A case report

MH Aziz Jalali; H Ansarin; S Mirzazadeh Javaheri

Volume 7, Issue 3 , 2004, , Pages 192-194

Abstract

  Basal cell carcinoma (BCC) is the most common malignant tumor of the skin, which originates from the basal cell layer of the skin. It is more common in white race with skin types I and II. Some predisposing factors are sunlight, ionizing radiation, arsenic salts, PUVA and scar. We present a case of BCC, ...  Read More Basal cell carcinoma (BCC) is the most common malignant tumor of the skin, which originates from the basal cell layer of the skin. It is more common in white race with skin types I and II. Some predisposing factors are sunlight, ionizing radiation, arsenic salts, PUVA and scar. We present a case of BCC, which appeared over an old scar of localized cutaneous leishmaniasis in a 49-year-old woman.

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A case of tegafur/gimeracil/oteracil (TS-1)-induced acral hyperpigmentation: correlation between histopathological features and dermoscopic findings

Yuichi Kurihara; Keiko Sakamoto-Tanegashima; Mitsuru Kinjo; Takeshi Nakahara; Masutaka Furue

Volume 26, Issue 4 , December 2023, , Pages 229-231

https://doi.org/10.22034/ijd.2022.283963.1364

Abstract

  Dermoscopy helps detect melanoma on the acral volar skin. A parallel ridge pattern is one of the characteristic dermoscopic findings of melanoma but is also seen in benign lesions, including drug-induced hyperpigmentation. Histological examination is therefore necessary for definitive diagnosis. A 74-year-old ...  Read More Dermoscopy helps detect melanoma on the acral volar skin. A parallel ridge pattern is one of the characteristic dermoscopic findings of melanoma but is also seen in benign lesions, including drug-induced hyperpigmentation. Histological examination is therefore necessary for definitive diagnosis. A 74-year-old Japanese man was referred to our department with irregular-shaped brown macules on his palms and soles. The pigmented lesions had a parallel ridge pattern on dermoscopic examination. The largest lesion was resected at the patient’s insistence and considering the possibility of melanoma. Histopathological examination revealed increased melanin granules in basal keratinocytes and many melanophages in the superficial dermis, especially underlying the crista profunda intermedia, agreeing with the dermoscopic findings. The patient had been receiving tegafurgimeracil- oteracil (TS-1) for advanced gastric cancer. The pigmented lesions gradually regressed after cessation of TS-1, consistent with TS-1-induced hyperpigmentation. Further studies are needed to elucidate the pathogenesis, including analyses of the relationship between acrosyringeal endothelin-1 expression and the presence of volar melanocytes in relation to potential drug metabolism.

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Treatment of chronic cutaneous graft versus host disease (GVHD) with photochemotherapy with Psoralen (PUVA): A report of five cases

SZ Ghodsi; B Bahar; K Balighi; MR Ranj Kesh

Volume 8, Issue 3 , 2005, , Pages 232-236

Abstract

  Chronic graft versus host disease (GVHD) remains the most common late complication of allogenic stem cell transplantation and the most frequent cause of morbidity and mortality in these patients. To control this condition, immunosuppressive drugs are usually administered at a high dose and for a long ...  Read More Chronic graft versus host disease (GVHD) remains the most common late complication of allogenic stem cell transplantation and the most frequent cause of morbidity and mortality in these patients. To control this condition, immunosuppressive drugs are usually administered at a high dose and for a long time, which may result in several side effects. 5 patients with clinically and histopathologically established cGVHD (3 lichenoid, 1 sclerodermoid and 1 mixed lichenoid-sclerodermoid), who failed to respond to conventional immunosuppressive therapy were treated with psoralen and UVA (PUVA). Treatment was administered in a standard protocol three times a week on non-consecutive days and were continued at least for 12 weeks. All 3 lichenoid cases showed complete improvement. In the sclerodermoid case there was partial response and in the mixed type case the partial response of sclerodermoid lesion and complete response of lichenoid lesions were observed. With the exception of a slight increase in liver transferases, no other adverse reactions occurred. In conclusion, PUVA can be a safe and effective therapy in conjunction with systemic agents for chronic GVHD especially in lichenoid form.

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