Iranian Journal of Dermatology

Congenital diffuse Melanosis in a father and two sons

M Barzegari; SN Emadi; RM Robati

Volume 8, Issue 3 , 2005, , Pages 237-241

Abstract

  Congenital diffuse Melanosis is one of the rarest clinical manifestations of hereditary universal Melanosis and only few cases have been reported all over the world. The presented case is a 54-year-old man who presented to us complaining of erythematous annular lesions on his face and neck since 8 months ...  Read More Congenital diffuse Melanosis is one of the rarest clinical manifestations of hereditary universal Melanosis and only few cases have been reported all over the world. The presented case is a 54-year-old man who presented to us complaining of erythematous annular lesions on his face and neck since 8 months ago. Diffuse pigmentation of his skin took our attention. According to the patient, diffuse hyperpigmentation was present at birth and there was no obvious changes up to now. His mother and sister had similar hyperpigmentation. He had 2 sons with a similar hyperpigmentation, but his daughter had normal skin pigmentation. All laboratory investigation for the causes of hyperpigmentation were reported normal and investigation for causes of secondary hyperpigmentation did not reveal any abnormality. In histopathological assay, the erythematous lesion was reported to be discoid lupus erythematous and the diagnosis of hyperpigmented lesion reported as congenital diffuse Melanosis.

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Psoriatic arthritis of temporomandibular joint with ankylosis :a case report

Pezeshkpour Fakhro-Zaman; Layegh Pouran; Nahidi Yalda; Layegh Parvaneh

Volume 10, Issue 3 , 2007, , Pages 245-251

Abstract

  Psoriasis is a chronic inflammatory proliferative disorder of the skin that appears in many different forms and affect different parts of the body including the nails and joints. It may affect the quality of life by causing psychosocial stress. Psoriatic arthritis is a seronegative spondyloarthropathy ...  Read More Psoriasis is a chronic inflammatory proliferative disorder of the skin that appears in many different forms and affect different parts of the body including the nails and joints. It may affect the quality of life by causing psychosocial stress. Psoriatic arthritis is a seronegative spondyloarthropathy with involvement of axial and peripheral joints. Involvement of temporomo andibular joint is also a rare presentation of psoriatic arthritis . In this article we report a rare case of bilateral temporomandibular joint ankylosis secondary to psoriasis in a 50-year-old woman .

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Novel transdermal drug delivery systems

M Hashemi Shabestari; MN Sarbolouki

Volume 9, Issue 3 , 2006, , Pages 270-283

Abstract

  Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact ...  Read More Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Methods: This descriptive, cross sectional study was performed on patients with contact or atopic dermatitis in 2003-2004 with European Standard Series patch test containing 24 allergens.Results: In this study 223 patients were tested with a mean age of 31 years (SD=12). The most common involved location was hand (59%). The most common allergens were nickel sulphate (23/2%), cobalt (11/4%) and thiuram (8/3%).Conclusion: Nickel sulphate was the most common contact allergen in this study.

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Cutaneous Larva Migrans: A case report

D Akbari; K Balighi

Volume 7, Issue 4 , 2004, , Pages 271-273

Abstract

  Cutaneous larva migrans is a self-limited cutaneous eruption caused by larva of roundworms that do not normally parasitize humans. Ankylostoma brazielensis, the dog and cat hookworm, is the most common agent. The disease is found in tropical and subtropical regions and may be seen in travelers from these ...  Read More Cutaneous larva migrans is a self-limited cutaneous eruption caused by larva of roundworms that do not normally parasitize humans. Ankylostoma brazielensis, the dog and cat hookworm, is the most common agent. The disease is found in tropical and subtropical regions and may be seen in travelers from these regions. We report a case of a 37-year-old Iranian man who had cutaneous larva migrans after traveling to Mexico. The patient was successfully treated with oral thiabendazole.

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Treatment of Lymphangioma Circumscriptum with CO2 Laser: A case report

N Farsi; M Mandegar Fard

Volume 8, Issue 4 , 2005, , Pages 307-310

Abstract

  Lymphangioma circumscriptum is a congenital lymphatic malformation that results in gradual dilatation of lymphatic vessels and development of lymphatic cisterns. The treatment of choice is radical surgery. Other treatment methods including cryotherapy, sclerosing agent injections, radiation therapy and ...  Read More Lymphangioma circumscriptum is a congenital lymphatic malformation that results in gradual dilatation of lymphatic vessels and development of lymphatic cisterns. The treatment of choice is radical surgery. Other treatment methods including cryotherapy, sclerosing agent injections, radiation therapy and CO2 laser were suggested. We report successful treatment of a 14-year-old boy affected with lymphangioma with CO2 laser.

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Papular atrichia: report of 3 cases with uncommon presentation

Balighi Kamran; Lajevardi Vahideh; Moeineddin Fatemeh; Ghiassi Maryam; Arami Shabnam; Nikoo Azita; Mahdavi-nia Mostafa

Volume 10, Issue 4 , 2007, , Pages 338-344

Abstract

  Atrichia with papular lesions (APL) is a rare, autosomal recessive syndrome with total alopecia in which mutations in the hairless gene have been shown to underlie the phenotype. We report here three cases, two 16 and 18 years old cousins and a 15 year-old-girl with a history of shedding of scalp, eyebrow ...  Read More Atrichia with papular lesions (APL) is a rare, autosomal recessive syndrome with total alopecia in which mutations in the hairless gene have been shown to underlie the phenotype. We report here three cases, two 16 and 18 years old cousins and a 15 year-old-girl with a history of shedding of scalp, eyebrow and eye lashes in infancy. Later in life they developed numerous erythematous papules on their limbs predominantly on the knees and elbows. According to their history, clinical presentation and pathologic findings, diagnosis of atrichia with papular lesions (APL) with some different features was postulated. Comparing to the known cases of APL with scalp, facial and truncal lesions, the cases presented here do not show such lesions in these sites.

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Proteus syndrome: A case report

Espandar Ramin; Yazdanian Shideh; Balighi Kamran; Baghdadi Taghi; Tork Ali Naser

Volume 9, Issue 4 , 2006, , Pages 360-366

Abstract

  The Proteus syndrome comprises an association of asymmetrical overgrowth of almost any part of the body, verrucous epidermal naevi, vascular malformations and lipoma-like subcutaneous hamartoma. Both sexes are affected with equal frequency and severity and it is not transmitted genetically. Here a 16-year-old ...  Read More The Proteus syndrome comprises an association of asymmetrical overgrowth of almost any part of the body, verrucous epidermal naevi, vascular malformations and lipoma-like subcutaneous hamartoma. Both sexes are affected with equal frequency and severity and it is not transmitted genetically. Here a 16-year-old man with asymmetric overgrowth of the extremities, macrodactyly, cerebriform hypertrophy of the soles and various skin and bony lesions is reported diagnosed as Proteus syndrome.

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Treatment of Basal cell carcinoma with cryosurgery: Report 3 of cases

N Motamed; B Pour Dadash

Volume 8, Issue 5 , 2005, , Pages 408-418

Abstract

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Acute hemorrhagic edema of infancy: A case report

Z Javidi; M Maleki; V Mashayekhi; AR Taheri; Y Nahidi

Volume 8, Issue 6 , 2006, , Pages 506-510

Abstract

  Acute hemorrhagic edema of infancy (AHEI) is a rare skin disorder which was first described by Snow in 1913. Clinical manifestations are usually limited to cutaneous lesions and is most commonly observed in infants under the age of 1 year. Usually, there is a history of recent upper respiratory tract ...  Read More Acute hemorrhagic edema of infancy (AHEI) is a rare skin disorder which was first described by Snow in 1913. Clinical manifestations are usually limited to cutaneous lesions and is most commonly observed in infants under the age of 1 year. Usually, there is a history of recent upper respiratory tract infection and antibiotic administration. Clinical presentation of this disease includes petechia and ecchymosis on the head, face and distal extremities. Herein, a typical case of AHEI in a 10-month-old infant is reported. Differential diagnoses of AHEI is discussed.

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Report of a case of Klippel-Trenaunay syndrome associated with bilateral nevus of Ota

Amir Hooshang Ehsani; Ali Naser Tork; Shideh Yazdanian

Volume 9, suppl.1 , 2006, , Pages 12-12

Abstract

  Port-wine stain is a vascular malformation characterized pathologically by ectasia of superficial dermal capillaris and clinically by persistent macular erythema. The association of a port-wine stain on a limb with soft tissue swelling, with or without bony overgrowth, is termed klippel-Trenaunay syndrome. ...  Read More Port-wine stain is a vascular malformation characterized pathologically by ectasia of superficial dermal capillaris and clinically by persistent macular erythema. The association of a port-wine stain on a limb with soft tissue swelling, with or without bony overgrowth, is termed klippel-Trenaunay syndrome. Phakomatosis pigmento-vascularis is a combination of port-wine stain and cutaneous pigmentary abnormality.The patient who is described here is a 25-year-old man with Klippel-Trenaunay syndrome in association with bilateral Ota nevus. He can be classified as phakomatosis pigmento vascularis type IIa which is a relatively rare finding with this presentation.

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Report of a rare case of bullous mycosis fungoides

Kamran Balighi; Fatemeh Moeineddin; Ahmadreza Rajaee; Azita Nikoo; Mostafa Mahdavi-nia

Volume 10, Suppl.2 , 2007, , Pages 12-12

Abstract

  Mycosis fungicides (MF), on extremely rare occasions, can be associated with vesiculobullous eruptions. We describe a 74-year-old man with previous documented histopathologic diagnosis of poikilodermic type of MF who recently developed some flaccid acral bullae on erythemoatous MF plaque and normal skin. ...  Read More Mycosis fungicides (MF), on extremely rare occasions, can be associated with vesiculobullous eruptions. We describe a 74-year-old man with previous documented histopathologic diagnosis of poikilodermic type of MF who recently developed some flaccid acral bullae on erythemoatous MF plaque and normal skin. Histopathology and direct immunoflourscence studies revealed extensive lichenoid changes with intraepidermal bulla. Atypical lymphocyte infiltration was presented in dermoepidermal junction and bulla fluid and peripheral blood smear, but absent in lymph node and bone narrow tissue specimens. The plausible cause of blister formation in cutaneous lymphoma bullosa may be due to excessive epidermotropism or toxic effects of cytokines secrected by the tumoral infiltrate.

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Oral tolerance for delayed type hypersensitivity contribution of local and peripheral mechanisms

D Kaiserlian; C Desvignes

Volume 1, Issue 2 , 1998, , Pages 41-44

Abstract

  Oral tolerance is a physiological immune mechanism, which controls the outcome of deleterious hypersensitivity reactions to environmental antigens absorbed through the gastrointestinal tract, and maintains homeostasis. Using a mouse model of oral tolerance of delayed type hypersensitivity to contact ...  Read More Oral tolerance is a physiological immune mechanism, which controls the outcome of deleterious hypersensitivity reactions to environmental antigens absorbed through the gastrointestinal tract, and maintains homeostasis. Using a mouse model of oral tolerance of delayed type hypersensitivity to contact allergens, i.e. haptens, we have examined the mechanisms involved in the induction of oral tolerance, both locally within the gut mucosa and systemically. We showed that intestinal epithelial cells from hapten-fed mice exert a bystander inhibition of hapten-primed T cell proliferation, through the release of anti-inflammatory cytokines, which may contribute to down regulation of local immune responses to soluble antigens. Furthermore, the lack of oral tolerance induction in MHC class II or Ii knock-out mice or in normal mice treated with a depleting anti-CD4 mAb, and the ability of these mice to mount a skin DTH following oral immunization with the hapten demonstrate that MHC class II restricted regulatory CD4+T cells play a central role in oral tolerance.

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Eczema following pulsed dye Laser therapy: A report of three cases

M Mir Shams Shahshahani; AH Ehsani; S Toosi

Volume 8, suppl , 2005, , Pages 49-52

Abstract

  Port- wine stain is a congenital vascular malformation originating from superficial dermal vessels which is characterized by ectasia of the capillaries. Currently, pulsed dye laser (PDL) is used to treat these vascular lesions. To date, there are few reports of eczematous lesions due to PDL. Herein, ...  Read More Port- wine stain is a congenital vascular malformation originating from superficial dermal vessels which is characterized by ectasia of the capillaries. Currently, pulsed dye laser (PDL) is used to treat these vascular lesions. To date, there are few reports of eczematous lesions due to PDL. Herein, we report three cases of eczema following PDL, used for treatment of port- wine stain in Razi hospital. Dermatitis following laser therapy is not frequent but may be seen occasionally. Therefore, Patients should be informed on the possibility of this adverse effect before instituting the treatment.

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Disappearing Vermilion: Report of 14 cases

M Mirshams Shahshahani; Y Sedaghat

Volume 8, suppl , 2004, , Pages 59-61

Abstract

  Sometimes we see patients with disappearing vermilion totally or in some parts. It seems that the marginal skin has advanced to the lip surface with the same color. It occurs mainly in lower lip. The majority of patients had history of recurrent herpes labialis on their lips, in the same location as ...  Read More Sometimes we see patients with disappearing vermilion totally or in some parts. It seems that the marginal skin has advanced to the lip surface with the same color. It occurs mainly in lower lip. The majority of patients had history of recurrent herpes labialis on their lips, in the same location as disappearing vermilion. Disappearing vermilion is not accompanied by any change in consistency of labial skin. There is no symptom and most patients are unaware of it. Sometimes they refer to the physician for other reasons. Rarely patients, particularly women, complain of the disease. We collected a series of 14 cases of disappearing vermilion to evaluate this disease.

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Treatment of resistant and recurrent Acne Rosacea with Laser: A case report

M Mirshams Shahshahani; H Ghani Nezhad

Volume 8, Issue 1 , 2004, , Pages 70-74

Abstract

  Acne rosacea is a relatively common disease, which usually manifests in the third and fourth decades of life. It has an inflammatory condition (Papules and pustules) associated with telangiectasis, erythema and sometimes rhinophyma at the end stage of the disease. Pulsed-dye-laser (PDL), which has been ...  Read More Acne rosacea is a relatively common disease, which usually manifests in the third and fourth decades of life. It has an inflammatory condition (Papules and pustules) associated with telangiectasis, erythema and sometimes rhinophyma at the end stage of the disease. Pulsed-dye-laser (PDL), which has been designed for treatment of vascular lesions, may be used in treatment of acne rosacea. We present a 64-year-old man with a chronic and resistant form of acne rosacea, who underwent multiple sessions of PDL (Candela, Scleroplus) with pulse duration=1500?s, 600nm long waves and 13-14 J/cm² with 6-8 weeks intervals. Clinical follow up showed not only a reduction in edema, erythrosis and telangiectasis but also a control of inflammatory components and regression of rhinophyma. The patient didn’t take any medication during treatment and follow up period. PDL (585nm, 6-7.5 J/cm²) treatment of telangiectasis associated with rosacea had already be known, however it is the first report of successful management of chronic and resistant acne rosacea with PDL treatment by different parameters.

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A review on sunscreens and their efficacy in the prevention of skin cancers and melasma: Part I

SH Tabatabaei

Volume 9, Issue 1 , 2006, , Pages 71-82

Abstract

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Skin and COVID-19: is there a lack of attention and should we be concerned?

Mohammad Injamul Hoq; Shafayet Ahmed Siddiqui; Mohammed Abu Sayeed; Md. Jakaria

Volume 23, Suppl.1(COVID-19) , 2020, , Pages 74-75

https://doi.org/10.22034/ijd.2020.114855

Abstract

    Read More

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The biological debridement of bedsore with the larvae of Lucilia sericata: a case report

Kamran Akbarzadeh; Abedin Saghafipour

Volume 24, Issue 2 , June 2021, , Pages 139-142

https://doi.org/10.22034/ijd.2021.132462

Abstract

  Bedsores are caused by decreased tissue perfusion due to prolonged pressure on the skin and represent one of the problems of immobilized patients, including hospitalized ones. This study reports the successful treatment of a patient with bedsore wounds using the larvae of the fly Lucilia sericata. The ...  Read More Bedsores are caused by decreased tissue perfusion due to prolonged pressure on the skin and represent one of the problems of immobilized patients, including hospitalized ones. This study reports the successful treatment of a patient with bedsore wounds using the larvae of the fly Lucilia sericata. The study focused on a 64-year-old man residing in Qom (a city in central Iran), who was hospitalized for 45 days at Qom Shahid Beheshti Hospital in November 2019 because of cardiovascular disease and chronic obstructive pulmonary disease (COPD). He had a pressure ulcer of about 9.5 cm in diameter on the skin overlying the sacrum. After showing resistance to honey dressing and conventionalantibiotic treatments, maggot therapy was recommended. This procedure was done by releasing the larvae of L. sericata 12 times every three days. The removal of necrotic tissues and the appearance of the granulated tissues were recorded using a ruler as an indicator of healing. After 12 sessions of larval treatment, the wound surface considerably reduced and was finally healed. Thus, it can be argued that maggot debridement therapy (MDT) is an effective treatment for bedsores and can be recommended to physicians as an adjuvant treatment for complex and resistant ulcers.

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Keratoderma Palmoplantaris Transgrediens (Mal de Meleda): A case report

S Kavusi; AH Ehsani; S Toosi; A Naser Tork

Volume 8, Issue 2 , 2005, , Pages 145-148

Abstract

  Mal de meleda (Keratoderma plamoplantaris transgrediens) is a rare autosomal recessive form of palmoplantar keratoderma with hyperkeratosis of palms and soles, which appears soon after birth and progressively involves other areas (Transgrediens) of the skin especially dorsal aspects of hands and feet. ...  Read More Mal de meleda (Keratoderma plamoplantaris transgrediens) is a rare autosomal recessive form of palmoplantar keratoderma with hyperkeratosis of palms and soles, which appears soon after birth and progressively involves other areas (Transgrediens) of the skin especially dorsal aspects of hands and feet. We report a 20-year-old woman with mal de meleda with some unusual clinical features, i.e. peculiar finger nail anomalies and pseudoainhum on all her fingers.

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Granulomatous lobular mastitis as a rare cause of Erythema Nodosum: Report of two cases

S Rassaei; R Yaghoobi; A Vaezi; M Azar Beig; T Rajabi; N Emad Mostofi

Volume 9, Issue 2 , 2006, , Pages 179-184

Abstract

  Granulomatous lobular mastitis (GLM) is a rare and benign condition of unknown etiology, which has been described recently. It primary affects young parous women and usually presents with a unilateral and extra-areolar breast mass. The condition may clinically mimic breast cancer, sometimes leading to ...  Read More Granulomatous lobular mastitis (GLM) is a rare and benign condition of unknown etiology, which has been described recently. It primary affects young parous women and usually presents with a unilateral and extra-areolar breast mass. The condition may clinically mimic breast cancer, sometimes leading to misdiagnosis resulting in unnecessary breast surgery.We report two cases of GLM associated with erythema nodosum and oligoarthritis, which were treated with systemic steroids and surgery. After one year of follow up, there were no recurrency.

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Clinically amyopathic dermatomyositis during the COVID-19 pandemic

Beatrice Raone; Filippo Viviani; Marco Fusconi; Luigi Muratori

Volume 26, Issue 4 , December 2023, , Pages 232-236

https://doi.org/10.22034/ijd.2022.309303.1443

Abstract

  We report a case of clinically amyopathic dermatomyositis (CADM) with anti-MDA5 positivity associated with rapidly progressive interstitial lung disease. The analogies between CADM-associated interstitial lung disease and coronavirus disease 2019 (COVID-19) pneumonia may hinder the diagnosis and delay ...  Read More We report a case of clinically amyopathic dermatomyositis (CADM) with anti-MDA5 positivity associated with rapidly progressive interstitial lung disease. The analogies between CADM-associated interstitial lung disease and coronavirus disease 2019 (COVID-19) pneumonia may hinder the diagnosis and delay the start of immunosuppressive therapy. High-resolution computed tomography revealed an evident worsening of the bilateral consolidation, interlobular septal thickening, and ground-glass opacities, highlighting the diagnosis of rapidly progressive interstitial lung disease. The radiological presentation, combined with the laboratory findings, underscored the diagnosis of CADM. In the following days, the respiratory failure progressed, and the patient required extracorporeal membrane oxygenation and lung transplantation. The typical cutaneous rash of dermatomyositis and non-pulmonary clinical differences can help the physician reach a correct diagnosis. Assessing patients with interstitial lung diseases during the COVID-19 pandemic is difficult. Through experience with systemic autoimmune diseases such as clinically amyopathic dermatomyositis, we can develop new pathophysiology models and therapeutic strategies for COVID-19.

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Association of Pemphigus Vulgaris and Tuberous Sclerosis: A case report

K Balighi; Sh Yazdanian; N Ghandi

Volume 9, Issue 3 , 2006, , Pages 284-288

Abstract

  Pemphigus vulgaris is a blistering autoimmune disease with suprabasal cleft formation, which is the most common autoimmune blistering disease in eastern countries, such as Middle East. Predisposition to pemphigus is linked to genetic factors. Tuberous sclerosis is also a genetic disorder of hamartoma ...  Read More Pemphigus vulgaris is a blistering autoimmune disease with suprabasal cleft formation, which is the most common autoimmune blistering disease in eastern countries, such as Middle East. Predisposition to pemphigus is linked to genetic factors. Tuberous sclerosis is also a genetic disorder of hamartoma formation in many organs, particularly the skin, brain, eye, kidney and heart. We report a 17-year-old boy with pemphigus vulgaris associated with tuberous sclerosis, which to our knowledge the first report of this association.

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Myiasis of scalp due to Chrysomya Bezziana: A case report

MH Davami; A Kiani; M Salimi; E Farhadi

Volume 8, Issue 4 , 2005, , Pages 311-315

Abstract

  Myiasis is the invasion of animal or human tissues by the larval stage of flies (Diptera). It is an accidental infestation in human. In this report a rural fifty-six-year old patient with myiasis on the scalp is presented. He was referred to clinic with a mass on his left temporo-occipital area. There ...  Read More Myiasis is the invasion of animal or human tissues by the larval stage of flies (Diptera). It is an accidental infestation in human. In this report a rural fifty-six-year old patient with myiasis on the scalp is presented. He was referred to clinic with a mass on his left temporo-occipital area. There was no history of trauma to his head or presence of ulcer on his scalp. In physical examination an ulcer sized 2×3 centimeters full of larvae was observed. The diagnosis of myiasis was made. Larvae were removed, tetanus vaccine was inoculated and oral antibiotics were prescribed. Parasitological examination determined the causative agent as chrysomya bezziana.

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Sulphur mustard induced poikiloderma: a case report

Emadi Seyed Naser; Sorush Mohammadreza; Moeineddin Fatemeh; Davudi Seyed Masoud; Jalalian Hamid Reza; Ardakani Mohammadreza Khodaeeyani

Volume 10, Issue 4 , 2007, , Pages 345-352

Abstract

  Sulphur Mustard is a potent chemical warfare agent that was widely used during first world war and Iran ‌Iraq conflict. Over 100,000 Iranians were injured by sulphur mustard and one-third is of them were suffering from late effects until today. This vesicant agent has a lot of acute and chronic destructive ...  Read More Sulphur Mustard is a potent chemical warfare agent that was widely used during first world war and Iran ‌Iraq conflict. Over 100,000 Iranians were injured by sulphur mustard and one-third is of them were suffering from late effects until today. This vesicant agent has a lot of acute and chronic destructive effects on the skin, eye and respiratory system. Sulphur mustard via the alkylations of several cellular proteins (structural, cytoplasmic and enzymes) and cell nuclei, produce several toxic, mutagenic and carcinogenic effects on epidermis, dermis, dermal appendages and hypodermis. We report a 41-year-old man who was poisoned with sulphur mustard in 1988.After exposure he developed severe skin blisters on upper trunk, posterior aspect of both hands and genitalia along with ocular and respiratory complications. He also had atrophy, pigmentation and vascular changes on skin of penis with pigmentation, atrophy and related findings in histopathologic studies, so the diagnosis of "sulphur mustard induced poikiloderma" was postulated. The absence of any complication on palms despite of their recurrent exposure to sulphur mustard is another remarkable finding in this case. It has been suggested that palms can act as a transport vector of sulphur mustard to other sites of skin.

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Recurrent local palmer peeling associated with Port-Wine stain

A Rasi; H Ansarin

Volume 8, Issue 5 , 2005, , Pages 419-422

Abstract

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