Mohammad Ebrahimzadeh Ardakani; Ehsan Zarepur; Vajihe Kooshamoghadam
Abstract
Deep vein thrombosis (DVT) is a common disorder that can lead to severe complications. Many factors can increase the risk of developing this disease. As we know, bulla formation due to DVT is extremely rare. A 45-year-old woman was referred to Shahid Sadoughi Hospital (Yazd, Iran) with pain and ...
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Deep vein thrombosis (DVT) is a common disorder that can lead to severe complications. Many factors can increase the risk of developing this disease. As we know, bulla formation due to DVT is extremely rare. A 45-year-old woman was referred to Shahid Sadoughi Hospital (Yazd, Iran) with pain and swelling of the left lower limb from one day beforehand. One day after admission, a large bulla (13 x 19 cm) appeared on the posterior part of her left leg. She had used the low-dose estrogen type of oral contraceptive pills ten days earlier. Color doppler sonography confirmed the presence of DVT. Heparin therapy was done and the patient was discharged in good condition. Bulla formation due to DVT is a very rare complication. It should be considered in patients of low socioeconomic classes and those using oral contraceptive pills. After the occurrence of DVT, we must rapidly move to avert its complications and prevent pulmonary embolism.
Fatemeh Parvizifard; Massoumeh Zargaran; Verisheh Rastin
Abstract
Background: Basal cell carcinoma (BCC), the most common human malignancy, can cause significant morbidity through extensive tissue destruction. This study aimed to determine the frequency and clinicopathological features of BCC in an Iranian population.Methods: Histopathological reports with a definitive ...
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Background: Basal cell carcinoma (BCC), the most common human malignancy, can cause significant morbidity through extensive tissue destruction. This study aimed to determine the frequency and clinicopathological features of BCC in an Iranian population.Methods: Histopathological reports with a definitive diagnosis of BCC in all pathology centers of Sanandaj, Kurdistan province, during 2009–2019 were reviewed. Data on age, gender, site, size, and clinical and histopathological types of tumors were collected and analyzed using SPSS software. P-values < 0.05 were consideredsignificant.Results: We found 832 BCC lesions in 779 patients, including 453 males and 326 females aged 65.36 ± 14.35 years and 62.77 ± 13.79 years, respectively. The mean tumor size was 14.52 ± 10.08 mm in men and 11.79 ± 7.89 mm in women. The most common location was the head (95.23%), with the nose representing the most involved area. Males and females differed regarding age (P = 0.012), tumor size (P < 0.001), and the anatomical distribution of tumors on various parts of the head (P < 0.001). Ulcerative (58.36%) and nodular (54.45%) BCCs were the most frequent clinical and histopathological types, respectively, both in males and females, without a significant difference between the genders (P > 0.05).Conclusions: Our findings suggest that age, gender, and the tumor site in various head areas could be risk factors for BCC. Appropriate knowledge of BCC and its risk factors can help design prevention strategies and provide the necessary training for healthcare staff and the public to identify the disease in susceptible individuals.
Nasrin Saki; Seyedeh Yasamin Parvar; Saba Fazel; Fatemehsadat Pezeshkian
Abstract
Genital warts are epithelial tissues infected with human papillomaviruses, the most prevalent sexually transmitted disease worldwide. Topical treatments focus on removing warts rather than eliminating the virus. Curcumin, as a therapeutic option, has been shown to have antiviral activity in treating ...
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Genital warts are epithelial tissues infected with human papillomaviruses, the most prevalent sexually transmitted disease worldwide. Topical treatments focus on removing warts rather than eliminating the virus. Curcumin, as a therapeutic option, has been shown to have antiviral activity in treating a variety of skin diseases, including vitiligo and psoriasis. The present study compared the effectiveness of cryotherapy plus oral curcumin to cryotherapy alone in treating genital warts. This randomized, double-blinded, placebo-controlled trial was performed on patients diagnosed with genital warts, who were divided into two groups. Patients underwent 5-7 sessions of cryotherapy plus oral curcumin or placebo. Outcome measures included the number of warts, the visual analog scale (VAS), and the Persian version of the Dermatology Life Quality Index (DLQI). The data were analyzed using SPSS software, version 21.Twenty-seven patients with a mean age of 34.3 ± 10.3 years were included in each group. The median number of genital warts, DLQI, and VAS improved significantly in both groups. The effect of curcumin was more prominent in a short period, although it was not statistically significant compared to the placebo group. Using curcumin as an adjuvant drug in conjunction with cryotherapy was shown to be ineffective in treating genital warts. According to The Dermatology Life Quality Index, clinical improvement was observed; however, it was not statistically significant. Further studies should be carried out with higher doses of oral curcumin or topical vaginal creams containing curcumin to determine the role of curcumin in treating genital warts.
Alireza Firooz; Azin Ayatollahi; Kambiz Kamyab
Shrutakirthi D. Shenoi; Punya Suvarna; Shibani Bhatia; Sukriti Arora
Abstract
Pemphigus vulgaris is one of the most common autoimmune blistering disorders, with most patients presenting in late stages with severe and extensive erosions over the skin. Along with systemic management of the disease, it is important to provide local wound care to prevent secondary infection. Here, ...
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Pemphigus vulgaris is one of the most common autoimmune blistering disorders, with most patients presenting in late stages with severe and extensive erosions over the skin. Along with systemic management of the disease, it is important to provide local wound care to prevent secondary infection. Here, we report the case of a patient who presented with extensive erosions and showed no response to standard dressing protocols. Thus, it is important to review alternate, easily available, environmentfriendly dressing materials. This case report discusses how banana leaves and gentian violet were used to manage severe and extensive erosions in a pemphigus patient who showed no improvement with modern-day dressings. We also compared the costs of modern-day dressings with the banana leaf dressing used in our setup. Following the success of this methodology, we have been using banana leaves for various chronic non-healing wounds and ulcers.
Afshar Ramezanpour; Maryam Babaei
Rezvan Amiri; Saman Mohammadi; Saman Azizi; Abbas Pardakhty; Maryam Khalili; Mahin Aflatoonian
Abstract
Background: Conventional topical treatments for male-pattern alopecia (MPA) have limited penetration into hair follicles and unwanted side effects, resulting in low patient compliance. We aimed to evaluate the efficacy and safety of niosomal kopexil 1% lotion compared with niosomal minoxidil 2% lotion ...
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Background: Conventional topical treatments for male-pattern alopecia (MPA) have limited penetration into hair follicles and unwanted side effects, resulting in low patient compliance. We aimed to evaluate the efficacy and safety of niosomal kopexil 1% lotion compared with niosomal minoxidil 2% lotion in patients with MPA.Methods: We conducted a prospective, double-blind, randomized clinical trial at Afzalipour Hospital of Kerman University of Medical Sciences, Kerman, Iran. Thirty participants with MPA were randomized to apply 1 ml of niosomal minoxidil 2% lotion or niosomal kopexil 1% lotion twice a day for 24 weeks. We assessed the efficacy of treatments as the percentage of change in hair density in monthly sessions compared to the baseline using a dermatoscope; we also assessed patient satisfaction and side effects.Results: Thirty participants were enrolled, 29 of whom completed the study. The mean change in hair density was significantly higher with niosomal kopexil compared with niosomal minoxidil (23.2 ± 1.3 and 14.2 ± 0.2, respectively). The hair density increased by 57.6 ± 3.7% and 25.6 ± 4.2% in the kopexil and minoxidil groups, respectively (P < 0.001). Patients reported significantly greater satisfaction with niosomal kopexil than with niosomal minoxidil (P < 0.001). No side effects were reported in either group.Conclusion: Despite the lower concentration, niosomal kopexil revealed significantly higher efficacy of treatment and satisfaction of patients compared to niosomal minoxidil.
Akbar Mokhtarpour Neilagh; Majid Sadeghilar; Mehdi Aghazadeh Barenji; Shahin Behrouz Sharif; Amin Sedokani
Shivam Goyal; Smitha Prabhu S
Abstract
Genital herpes has superseded the bacterial sexually transmitted diseases (STD) as the most prevalent STD seen worldwide, with an estimated 491 million being affected. It is encountered with an increasing frequency, with a prevalence of 11.9% in the USA, and can present in atypical and severe ulcerative ...
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Genital herpes has superseded the bacterial sexually transmitted diseases (STD) as the most prevalent STD seen worldwide, with an estimated 491 million being affected. It is encountered with an increasing frequency, with a prevalence of 11.9% in the USA, and can present in atypical and severe ulcerative forms, especially in human immunodeficiency virus (HIV)-infected individuals. Though a definitive antiviral treatment with acyclovir, valacyclovir or other derivatives exists, the property of latency and reactivation leads to its increasing incidence and prevalence. The common sites of involvement in the males are the glans, prepuce, and shaft of the penis. The male condom, if used appropriately, is the most effective among the barrier methods of contraception, with an additional advantage of protection from STDs. However, it has a failure rate of up to 13%. The efficacy of condoms in preventing herpes simplex virus 2 (HSV-2) transmission has been studied in several contexts; condoms are often associated with a decreased risk of HSV-2 transmission, yet fallacies can occur. Here, we describe a male who developed a primary episode of genital herpes at the base of the penis, despite proper usage of condoms during intercourse. This presentation can be likened to condom chancre, a much-described entity of primary syphilis.
Saurabh Sharma; Vinay Kajal; Parwaaz Matharoo; Roopam Bassi
Abstract
Acute blue finger syndrome is a rare benign condition with an unknown etiology. It predominantly affects middle-agedfemales and may be associated with pain, itching, or a burning sensation. The bluish discoloration is usually idiopathic, and it is necessary to rule out other causes of blue fingers. The ...
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Acute blue finger syndrome is a rare benign condition with an unknown etiology. It predominantly affects middle-agedfemales and may be associated with pain, itching, or a burning sensation. The bluish discoloration is usually idiopathic, and it is necessary to rule out other causes of blue fingers. The syndrome is a diagnosis of exclusion and has a good prognosis. The sudden color change can lead to patient anxiety, but the physician’s insight regarding the benign nature can alleviate unnecessary distress. We present the case of an adult female with bluish discoloration of the proximal phalanx of the left index finger, which was sudden in onset and asymptomatic. Following a thorough history and workup, the patient was counseled, and on follow-up, a spontaneous resolution was observed. We intend to report this case due to the rarity of blue finger syndrome as well as to highlight the significance of its benign nature and spontaneous resolution.
Zeinab Aryanian; Azar Shirzadian; Faezeh Bakhshinasab; Soheil Ebrahim Pour; Arefeh Babazadeh; Zeinab Mohseni Afshar; Azadeh Goodarzi; Zahra Nikyar; Parvaneh Hatami
Abstract
Background: During the recent coronavirus disease 2019 (COVID-19) pandemic, we witnessed an increased incidence of contact dermatitis in the hands and other body areas of healthcare workers secondary to using antiseptics and personal protective equipment. This study aimed to investigate the prevalence ...
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Background: During the recent coronavirus disease 2019 (COVID-19) pandemic, we witnessed an increased incidence of contact dermatitis in the hands and other body areas of healthcare workers secondary to using antiseptics and personal protective equipment. This study aimed to investigate the prevalence of skin lesions in healthcare workers in hospitals affiliated with Babol University of Medical Sciences during the COVID-19 pandemic.Methods: In a cross-sectional study, the healthcare workers of Ayatollah Rouhani, Shahid Yahya Nejad, and Shahid Beheshti hospitals in Babol, Iran, were asked to fill out information collection forms about cutaneous lesions during the COVID-19 pandemic.Results: Three hundred healthcare workers were included in the study. Skin lesions were seen in 240 patients (80%), and the hands were the most common site of involvement (36.7%). Skin lesions in healthcare workers had no statistically significant relationship with the variables of age (P = 0.84), sex (P = 0.52), and COVID-19-dedicated wards (P = 0.16). However, skin lesions were more common in those with more working hours (P = 0.01) and increased handwashing frequency (P < 0.001).Conclusion: The present study showed a high prevalence of skin lesions among hospital healthcare workers during the COVID-19 pandemic. Therefore, preventive measures are recommended.
Ravindranath B Chavan; Vasudha A Belgaumkar; Nitika S Deshmukh; Ranjitha Krishnegowda
Abstract
Papulosquamous disorders constitute one of the common pediatric dermatoses. They are a heterogeneous group consisting of psoriasis, eczema, pityriasis rubra pilaris, and other conditions, where the differential diagnoses are close to each other clinically. Moreover, the presentation of the same disease ...
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Papulosquamous disorders constitute one of the common pediatric dermatoses. They are a heterogeneous group consisting of psoriasis, eczema, pityriasis rubra pilaris, and other conditions, where the differential diagnoses are close to each other clinically. Moreover, the presentation of the same disease in children can differ from that occurring in adults. We report two infants with erythematous scaly papules and plaques diagnosed as two different disorders, albeit with a grossly similar appearance. Both these dermatoses are considered to be quite uncommon in infancy and can pose significant challenges in management. These disorders sometimes present with atypical variants, rendering it increasingly difficult to distinguish them. Some of these disorders tend to progress to erythroderma, and the infant may occasionally present directly in the erythrodermic stage, further compounding the conundrum. In such situations, identification of subtle clinical and histopathological clues allows accurate diagnosis, which is imperative for appropriate prognostication and treatment. This article illustrates the importance of histopathology and immunohistochemistry in aiding diagnosis and outlines the management of these disorders while emphasizing the importance of timely intervention in averting inadvertent complications in these young individuals.
Maryam Khalili; simin Shamsi Meymandi; Saman Mohammadi; Mahin Aflatoonian; Elahe Kooshesh
Abstract
Background: Granulomatous skin lesions are characterized by aggregation of activated histiocytes. Granulomatous skin lesions are classified as xanthomatous, necrobiotic, tuberculoid, sarcoidal, and foreign body types. This study evaluates the clinicopathological features of patients with granulomatous ...
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Background: Granulomatous skin lesions are characterized by aggregation of activated histiocytes. Granulomatous skin lesions are classified as xanthomatous, necrobiotic, tuberculoid, sarcoidal, and foreign body types. This study evaluates the clinicopathological features of patients with granulomatous skin lesions.Methods: We conducted a cross-sectional study of 232 skin biopsies diagnosed as granulomatous skin lesions over ten years from patients referred to Afzalipour Hospital, Kerman, Iran. Demographics, clinical features of lesions, and pathological characteristics were recorded. Then, the correlation of the final diagnosis with the demographic and clinical features of the patients was assessed via the independent t-test and chi-squared test.Results: Most patients were in their third decade of life, with a male-to-female ratio of 1.05 to 1. The most common types of granuloma were tuberculoid (60.3%), necrobiotic (12.5 %), and foreign body type (11.2%). Infectious disease was the most common cause of granulomatous lesions (64.2 %); leishmaniasis constituted approximately 96% of cases. The most common causes of noninfectious granulomatous skin diseases were foreign body granuloma (26.2%), granuloma annulare (23.2%), and xanthogranuloma (12.1%). There was a significant correlation between dermatologic disease type and disease duration (P = 0.024).Conclusion: In the current study, the most common type of granuloma was tuberculoid, followed by necrobiotic and foreign body type granulomas. Infectious diseases were the most common cause of granulomatous skin lesions. Furthermore, the most common granulomatous skin diseases were leishmaniasis, foreign body granuloma, and granuloma annulare. The least common granulomatous skin lesions were sporotrichosis and gout.
Ahmad Ibrahim Yahaya; Akmal Hisham; Shah Jumaat Mohd Yussof; Chooi Lai Kuan; Salina Ibrahim
Abstract
Once popularly known as whiskey nose or rum blossom, rhinophyma is a permanent thickening of the nasal skin composed of confluent erythematous papules and prominent follicles. The etiology is not fully known, but many authors describe rhinophyma as the fourth stage of acne rosacea, a chronic inflammatory ...
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Once popularly known as whiskey nose or rum blossom, rhinophyma is a permanent thickening of the nasal skin composed of confluent erythematous papules and prominent follicles. The etiology is not fully known, but many authors describe rhinophyma as the fourth stage of acne rosacea, a chronic inflammatory cutaneous disease characterized by erythema, telangiectasia, papules, pustules, and edema. It is benign yet disfiguring and can be stigmatizing. Here, we report the case of a 54-year-old man who presented with a mass on the nose that had slowly grown over the prior two years. He had a history of acne, treated with isotretinoin 10 mg daily by a dermatologist, one year before the onset of this mass. Examination from the frontal view revealed asymmetric, diffuse, multilobulated skin hypertrophy over the middle and lower nasal vault. On the basal view, there was a 10 x 7 mm epithelizing ulceration over the right alar rim. He underwent a partial-thickness resection of the hypertrophied nasal skin, and the resulting wound was left to heal via secondary intention, with a good cosmetic outcome.
Beuy Joob; Viroj Wiwanitkit
Ravindranath Brahmadeo Chavan; Vasudha A Belgaumkar; Nitika Deshmukh; Balakrishna Nikam; Vijay Deepak Joshi
Abstract
Proliferating trichilemmal tumors are rare, generally solitary, benign tumors arising from the hair’s outer root sheath with trichilemmal keratinization. These tumors are predominantly found on the head, neck, and face of elderly females; the inguinal region is a highly unusual site of involvement. ...
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Proliferating trichilemmal tumors are rare, generally solitary, benign tumors arising from the hair’s outer root sheath with trichilemmal keratinization. These tumors are predominantly found on the head, neck, and face of elderly females; the inguinal region is a highly unusual site of involvement. Malignant change in this tumor is rare, histologically mimicking squamous cell carcinoma. Metastatic malignant proliferating trichilemmal tumor requires a high index of suspicion for diagnosis and accurate histopathological reporting for timely intervention. Here, we report the case of a 65-yearold man presenting with nodular-ulcerative lesions in the groin, clinically confused with hidradenitis suppurativa and histologically with squamous cell carcinoma. He was finally diagnosed with an inoperable metastatic stage of malignant proliferating trichilemmal tumor and was treated with palliative care. This case highlights the innocuous clinical appearance of such lesions that might delay the management of this fulminant tumor.
Neda Faraji; Hadiseh Hosamirudsari; Narjes Zarei Jalalabadi; Forough Goudarzi
Muhammed Mukhtar
Kara Adistri; Windy Keumala Budianti; Rhida Sarly Amalia
Abstract
Pityriasis lichenoides chronica (PLC) is a chronic skin disorder with unknown etiology. This disorder still poses difficulty in diagnosis and treatment. Currently, there is no guideline established for the treatment of PLC. Most of the proposed therapy show transient or limited effects. Combination therapy ...
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Pityriasis lichenoides chronica (PLC) is a chronic skin disorder with unknown etiology. This disorder still poses difficulty in diagnosis and treatment. Currently, there is no guideline established for the treatment of PLC. Most of the proposed therapy show transient or limited effects. Combination therapy is usually the best approach. A 40-year-old man presented with erythematous papules appearing recurrently in crops in the last nine months localized mainly to the trunk and proximal extremities. A complete response was not achieved with topical and systemic corticosteroids. The combination of narrowband UVB phototherapy and cyclosporine showed satisfying results following a short duration of therapy. A complete response was seen after eight sessions of narrowband UVB phototherapy. No side effects were observed. The combination therapy of phototherapy and cyclosporine is a potential choice that needs to be considered in the management of PLC.
Elham Behrangi; Azadeh Goodarzi; Mohamadreza Ghasemi; Fatemeh Zahra Mohamadi; Parvaneh Hassani; Reza Gharajeh; Zahra Azizian
Abstract
Background: Acne scarring can significantly affect patients’ quality of life, particularly when it involves the face. This study aimed to compare the efficacy of microneedling with and without platelet-rich plasma (PRP) versus fractional CO2 laser therapy in treating acne scarring.Methods: This ...
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Background: Acne scarring can significantly affect patients’ quality of life, particularly when it involves the face. This study aimed to compare the efficacy of microneedling with and without platelet-rich plasma (PRP) versus fractional CO2 laser therapy in treating acne scarring.Methods: This randomized clinical study was performed on 90 patients with acne scarring. All the patients were divided into three groups (n = 30 per each): group A received microneedling, group B received microneedling plus PRP, and group C was treated by fractional CO2 laser. Each patient underwent three treatment sessions across three week intervals. The severity and depth of acne scars were graded using Goodman and Baron’s scale and Visio Face systems, respectively.Results: Out of 90 patients, 30 in group A, 22 in group B, and 26 in group C completed the trial. Analysis was done based on the per-protocol method on a total of 78 patients. Regarding the severity of acne scarring, significantly better results were obtained for groups A and B than for group C (P ≤ 0.001), while no meaningful difference was seen between groups A and B. Also, there was a significant difference between group B and other groups in terms of patients’ satisfaction (P = 0.04). The Visio Face systems showed that the depth of acne scars in group B had better improvement than in other groups (P = 0.02).Conclusion: Microneedling plus PRP led to the most patient satisfaction and highest improvement in acne scar depth. However, considering the fewer side effects and acceptable cost-benefit profile of microneedling alone compared with fractional CO2 laser or microneedling plus PRP, isolated microneedling could be considered the first choice for treating acne scars.
Delara Babaie; Shabnam Eskandarzadeh; Rudolf Valenta; Mehrnaz Mesdaghi
Abstract
Atopic dermatitis (AD) is a chronic allergic inflammation of the skin. Precise identification of the causative allergen is an important step in the successful treatment of patients with moderate to severe AD. Common diagnostic methods in allergy assess the presence or absence of allergen-specific sensitization, ...
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Atopic dermatitis (AD) is a chronic allergic inflammation of the skin. Precise identification of the causative allergen is an important step in the successful treatment of patients with moderate to severe AD. Common diagnostic methods in allergy assess the presence or absence of allergen-specific sensitization, but none exhibits a complete clinical correlation. Component-resolved diagnostics (CRD) is a new precise method for identifying the culprit allergen. Here, we report the case of a nine-year-old boy with severe AD. He was polysensitized (based on a skin prick test), with a poor response to routine AD therapeutic measures and food elimination diets. He had experienced recurrent flares while under treatment. Skin biopsy confirmed AD. Systemic therapy with cyclosporine (200 mg per day) was initiated and caused significant symptom relief within eight weeks. However, he had a flare when the dose was decreased to 150 mg daily. The causative allergen was diagnosed based on CRD, and he was successfully treated by allergen immunotherapy. CRD can determine the causative allergen in selected polysensitized patients with AD with poor response to treatment. The application of allergen-specific immunotherapy in AD management is controversial, but highly sensitized patients could benefit from it once the diseasecausing allergen is identified.
Elham Behrangi; Azadeh Goodarzi; Amir Heydarian; Mohammadreza Ghasemi; Zahra Azizian; Parvaneh Hassani; Behrad Dalvand; Nima Hajiha
Abstract
Background: Among different treatments for periorbital hyperpigmentation (POH), both semi-invasive protocols of fractional CO2 laser and platelet-rich plasma (PRP) are favored among clinicians and rarely cause complications; however, the level of patients’ satisfaction seems to differ across these ...
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Background: Among different treatments for periorbital hyperpigmentation (POH), both semi-invasive protocols of fractional CO2 laser and platelet-rich plasma (PRP) are favored among clinicians and rarely cause complications; however, the level of patients’ satisfaction seems to differ across these methods.Methods: This randomized clinical trial was conducted on 100 patients (98 women; 2 men) between 28 to 62 years of age who complained of POH and referred to the Dermatology Clinic of Rasool Akram Medical Complex located in Tehran in 2017. The patients were randomly assigned to two groups receiving fractional CO2 laser (group C) and adding PRP treatments plus laser therapy (group CP). The outcome of both treatment protocols was followed 3 and 6 months after the last treatment by standard photography.Results: The time for swelling after treatment in the C and CP groups was 4.58 ± 0.61 days and 2.94 ± 0.68 days, respectively, which was significantly shorter in group CP (P < 0.001). The mean time for erythema disappearance was also shorter in group CP (5.20 ± 0.76 days vs. 3.40 ± 0.76 days, P < 0.001). Regarding the trend of the change in the ΔE parameter, it fell significantly in both groups within the follow-up period (P < 0.001); however, the mean ΔE was significantly higher in the CP group when compared with the control group (P < 0.001). There were no significant or resistant side effects in either treatment group.Conclusion: Although both therapies are effective and safe, the concurrent use of CO2 laser and PRP can more effectively reduce the severity of POH with a shorter duration of post-treatment swelling and erythema. Hence, this combination is a superior modality for the treatment of POH as compared to laser therapy alone.
Muhammed Mukhtar
Yalda Nahidi; Naser Tayyebi Meibodi; Farahnaz Abdolhosseinzadeh; Mostafa Izanlu; Sima Davoodi
Abstract
Background: Psoriasis is a chronic inflammatory skin disease with extensive systemic effects. The role of sex hormones in the pathogenesis of psoriasis remains unknown. Therefore, in this study, the level of sex hormones in male chronic plaque psoriasis patients was evaluated.Methods: This study was ...
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Background: Psoriasis is a chronic inflammatory skin disease with extensive systemic effects. The role of sex hormones in the pathogenesis of psoriasis remains unknown. Therefore, in this study, the level of sex hormones in male chronic plaque psoriasis patients was evaluated.Methods: This study was descriptive-analytic of the cross-sectional type, done with a total population of 60, including 30 patients with chronic plaque psoriasis and 30 healthy subjects in the control group. Serum levels of testosterone, estradiol, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured in patients and the control group who did not have psoriasis. The two groups were matched based on the grouped matching technique. The two groups were matched for age (34 ± 9 years) and BMI (30 ± 3 kg/m2), and the effects of these two variables on hormonal levels were eliminated. According to the results of the Kolmogorov-Smirnov test, the data had a normal distribution. The independent t-test and Pearson correlation coefficient were used for data analysis. A P-value less than 0.05 was considered significant.Results: The levels of LH and FSH were significantly higher in the patient group than in the healthy group (P = 0.01 and P < 0.001, respectively). Testosterone and estradiol serum levels were lower in the patient group than in the healthy group (P < 0.001).Conclusion: Our study suggests that male patients with chronic plaque psoriasis have higher levels of LH and FSH and lower levels of testosterone and estradiol than the general male population.
Prodip Sarkar; Karunamoy Chakraborti; Sudeshna Mondal; Loknath Ghoshal; Debabrata Bandyopadhyay
Abstract
Background: Androgenetic alopecia is defined as patterned hair loss caused by androgens in genetically susceptible individuals. Metabolic syndrome is a cluster of interrelated risk factors that increase the risk of coronary artery disease. Androgenetic alopecia is associated with metabolic syndrome components ...
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Background: Androgenetic alopecia is defined as patterned hair loss caused by androgens in genetically susceptible individuals. Metabolic syndrome is a cluster of interrelated risk factors that increase the risk of coronary artery disease. Androgenetic alopecia is associated with metabolic syndrome components including insulin resistance, dyslipidemia, and obesity. This study aimed to compare the prevalence of metabolic syndrome in androgenetic alopecia patients with controls.Methods: The study groups consisted of 50 androgenetic alopecia patients and 50 controls who agreed to participate. Following recruitment into the study, history taking, clinical examination, and laboratory investigations were carried out, and details of each individual were recorded into a pre-structured case record sheet.Results: The groups were not statistically different in terms of age or sex distribution, height and weight, glucose levels, thyroid hormone level, blood counts, and lipid levels. We found that 26% of patients in the case group and 6% in the control group satisfied the definition of metabolic syndrome; this difference was significant (P = 0.007). We observed a statistically significant difference in LDL and HDL levels between the cases and controls (P = 0.0027 and 0.0091, respectively).Conclusion: Patients with androgenetic alopecia have an increased likelihood of having metabolic syndrome and must be routinely screened for hypertension, diabetes mellitus, and dyslipidemia. They should be made conscious of the more serious implications of the apparently cosmetic disorder.
