Document Type: Original Article

Authors

1 Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Department of Dermatology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

3 Department of Radiology and Radiotherapy, School of Medicine, Babol University of Medical Sciences, Babol, Iran

4 Student Research Committee, Babol University of Medical Sciences, Babol, Iran

5 Clinical Research Development Center, Shahid Yahyanezhad Hospital, Babol University of Medical Sciences, Babol, Iran

6 Department of Statistic and Epidemiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

7 Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

8 Department of Dermatology, School of Medicine, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

Abstract

Background: Lichen planus is a chronic inflammatory disease associated with an increased risk of subclinical atherosclerosis and cardiovascular diseases. This study aimed to evaluate patients with lichen planus using carotid Doppler ultrasound parameters.
Methods: Forty patients with lichen planus and 40 controls were included in this study. Common carotid artery intima-media thickness (CIMT) and the number of atherosclerotic plaque were
measured and compared to the control group. Total cholesterol, triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were measured. Leptin level (Pg/ml)
was measured using the enzyme-linked immunosorbent assay (ELISA) method (Leptin ELISA kit, Orgenium, Finland).
Results: Significant difference was found between the groups in terms of CIMT (P=0.005). The median range for blood leptin level, triglyceride, cholesterol, and LDL was higher for lichen planus patients than for controls. We found a significant difference between the severity of LP and CIMT (P=0.035). No statistical difference was found between LP and the number of atherosclerotic plaque.
Conclusions: Our study suggested that measurement of the mean intima media wall thickness of the common carotid artery could be beneficial as a valuable method for early diagnosis of atherosclerosis in lichen planus.

Keywords