Pemphigus foliaceus is an autoimmune blistering condition more often than not associated with generalized lesions. Localized Pemphigus foliaceus is a rare entity. Herein, we report a case of pemphigus foliaceus localized on the face. A 64-year-old woman was referred to our clinic with a 2-year history of erythematous plaque on the right side of her face. The histology report was compatible with pemphigus foliaceus. The lesion improved completely in response to oral prednisolone at 40 mg daily. Pemphigus foliaceus has to be suspected in presumed eczema that is refractory to appropriate topical corticosteroid treatment. A histopathologic study is required to establish localized pemphigus foliaceus.