Background: Nowadays, the rapid recovery of skin lesions and functional return are among the goals of researchers. The skin is the first defensive barrier against microorganisms in the body and its failure causes infection to spread in all systems of the body. By taking into account the contradictory results of previous studies on the impact of phototherapy on wound healing and also the considerable anti-oxidative properties of curcumin, this novel study was carried out with the aim of determining the histopathological impact of compact fluorescent light (CFL) and curcumin on the process of wound healing. Methods: Forty-eight adult male wistar rats were randomly divided into four groups. The control group received 2.0 ml of ethyl oleate, and the curcumin group received only 0.2 ml curcumin daily for 15 days via intraperitoneal injection. The fluorescent group received 0.2 ml of ethyl oleate daily for 15 days via intraperitoneal injection, and were exposed to CFL for 12 hours per day for 15 days. The curcumin plus fluorescent group received 0.2 ml curcumin daily for 15 days via intraperitoneal injection, and were exposed to CFL for 12 hours per day for 15 days. The size of the wound was measured by a scale ruler, and the morphology of the wound site was assessed. Results: The results of this study showed that the best percentage of repair was observed in the fluorescent group on days 6 and 15 (50±5 and 90±2, respectively), while the least repair was seen in the group receiving fluorescent plus curcumin (33±7). In the curcumin group, the wound healing was, not significantly (P=0.872) reduced on the sixth day, compared to the control group, whereas compared to the fluorescent and fluorescent plus curcumin groups, the reduction was significant (P?0.0001 and P=0.05, respectively). On the fifteenth day, however, the wound healing was significantly decreased in the curcumin group compared to the control and fluorescent groups (P?0.0001 and P?0.0001 respectively), while it was significantly increased compared to the fluorescent plus curcumin group (P?0.0001). In the fluorescent plud curcumin group, the wound healing was significantly reduced compared to the other groups on the fifteenth day (P?0.0001). Conclusion: Fluorescent alone resulted in wound healing, in contrast to the control and curcumin plus fluorescent groups. Accelerating the repair in this group is likely due to the increase in blood flow and helping the homeostasis to return to its primary state. The absence of wound healing in the curcumin group is probably due to the high dose of curcumin. Moreover, in the fluorescent plus curcumin group, the causes of no wound healing and weight loss were probably disorders in the inflammation process and spread of infection.