Evaluation of narrow band UVB therapeutic effect on chronic mucocutaneous graft versus host disease lesions: A case series

Balighi, Kamran; Ghodsi, Zahra; Iravani, Masoud; Rayati Damavandi, Maede; Goodarzi, Azadeh; Lajevardi, Vahide; Saburi, Sara; Faghihi Kashani, Alireza

Evaluation of narrow band UVB therapeutic effect on chronic mucocutaneous graft versus host disease lesions: A case series

Document Type : Original Article

Authors

Kamran Balighi

Zahra Ghodsi

Masoud Iravani

Maede Rayati Damavandi

Azadeh Goodarzi

Vahide Lajevardi

Sara Saburi

Alireza Faghihi Kashani

Abstract

Background: Chronic graft versus host disease (cGVHD) is a major cutaneous complication of bone marrow transplantation (BMT). Although milder forms of this process may be associated with a lower incidence of tumor recurrences, it is mandatory to develop a more efficient and less harmful therapeutic approach.
Methods: This case-series study enrolled 7 patients diagnosed with chronic mucocutaneous GVHD. We divided the patients into three major categories based on the type of skin lesions: sclerodermoid, lichenoid, and mixed. Patients received several packs of narrow band UVB (NBUVB) phototherapy. Each pack contained ten sessions of NBUVB (311 nm) with a duration of at least ten seconds and a fixed radiation dosage (6 mj/cm2) during the treatment.
Results: There were 3 patients diagnosed with lichenoid skin lesions, 2 with sclerodermoid lesions, and 2 had mixed cGVHD lesions. During the follow up period one patient was excluded due to a lower respiratory tract infection. The mean response ratio was 42% with a mean satisfaction level of 5.5 out of 10. The lichenoid group had the best, most rapid response. There were no serious adverse effects reported.
Conclusion: Narrow band UVB phototherapy is useful as an adjuvant therapeutic modality in cutaneous lichenoid and intraoral cGVHD with no serious adverse effects.

Keywords

chronic graft versus host disease

phototherapy

narrow band ultraviolet B

bone marrow transplantation