Maryam Khalili; Saman Mohammadi; Rezvan Amiri; Romina Ahmaditabatabaei; Mahin Aflatoonian
Abstract
Background: Alopecia areata is a non-cicatricial alopecia that profoundly affects patients’ quality of life. In this study, we evaluated the influence of demographic and clinical features of alopecia areata patients on their quality of life.Methods: This cross-sectional study was performed on alopecia ...
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Background: Alopecia areata is a non-cicatricial alopecia that profoundly affects patients’ quality of life. In this study, we evaluated the influence of demographic and clinical features of alopecia areata patients on their quality of life.Methods: This cross-sectional study was performed on alopecia areata patients at the Dermatology Clinic of Afzalipour Hospital, Kerman. Firstly, demographic features and clinical data were collected. Then, the severity of alopecia areata [based on the severity of alopecia tool (SALT) score] and quality of life of the patients [using dermatology life quality index (DLQI) and child dermatology life quality index (CDLQI)] were calculated. Finally, the impacts of the patient’sdemographic and clinical features on quality of life were evaluated via multivariate logistic regression.Results: One hundred and thirty-five patients with alopecia areata were enrolled in the study. The mean SALT score was 6.63 ± 6.34 (range 2–64). Mean DLQI scores for mild and moderate cases of AA were 7.4 and 12.5, respectively (P = 0.57). Females had significantly higher DLQI scores compared to males. Furthermore, patients with negative family history of alopecia areata had significantly higher DLQI scores than patients with positive family history (P = 0.03).Conclusion: We found no significant difference in quality of life between patients with different alopecia areata severities. However, females and patients with a negative family history of alopecia experienced significantly greater negative impacts on quality of life than males and those with a positive family history.
Azadeh Mohebbi; Rezvan Amiri; Nasim Nejadsajadi; Maryam Khalili; Saman Mohammadi; Abnoos Mokhtari; Mahin Aflatoonian; Zahra Rahnama
Abstract
Background: The association of cherry angioma with metabolic syndrome and fatty liver has been proposed in a few studies. This study evaluated the prevalence of cherry angiomas in patients with type II diabetes mellitus compared with healthy adults.Methods: This cross-sectional study was conducted on ...
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Background: The association of cherry angioma with metabolic syndrome and fatty liver has been proposed in a few studies. This study evaluated the prevalence of cherry angiomas in patients with type II diabetes mellitus compared with healthy adults.Methods: This cross-sectional study was conducted on 100 patients with type II diabetes mellitus and 100 age and sex-matched healthy adults. Demographic features of the participants and the location and number of the lesions were recorded. Data were analyzed by SPSS 16. Mean ± standard deviation and frequency were used for quantitative analysis. The chi-squared test and independent t-test were utilized to evaluate the association of qualitative and quantitative data with the number of cherry angiomas, respectively.Results: Cherry angiomas were more prevalent in the diabetes group (47%) than in controls (30%) (P = 0.013). Lesions in diabetic patients were more prevalent in females than males (P = 0.042). Furthermore, the number of lesions in the diabetes group significantly increased parallel to aging (P = 0.004).Conclusion: In the present study, significantly more cherry angiomas were observed in patients with type II diabetes mellitus than in healthy controls. Furthermore, the number of lesions was higher in females and elderly subjects in the diabetes group.
Saeedeh Farajzadeh; Mahin Aflatoonian; Morvarid Amirmijani; Zahra Farahmandinia; Rezvan Amiri; Maryam Khalili
Abstract
Background: Complications of chemotherapy most commonly involve highly proliferative cells, including the skin and its appendages and mucosa. This study evaluated mucocutaneous complications of chemotherapy in children with cancer.Methods: This descriptive cross-sectional study involved 92 children who ...
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Background: Complications of chemotherapy most commonly involve highly proliferative cells, including the skin and its appendages and mucosa. This study evaluated mucocutaneous complications of chemotherapy in children with cancer.Methods: This descriptive cross-sectional study involved 92 children who received chemotherapy at the Pediatric Oncology Ward of Afzalipour Hospital, Kerman, Iran, between September 2018 and March 2019. Demographic and clinical features of the patients were collected by history, physical examination, and laboratory tests (biopsy, fungal and bacterial smears if necessary). Frequency and percentage were used for qualitative analysis. Mean ± standard deviation was used for quantitative analysis.Results: The mean age of patients was 6.60 ± 3.70 years (range 1 to 16 years). More than half of the patients (55.4%) were males. The most common malignancy was acute lymphocytic lymphoma (ALL). More than half of the children (60%) had mucocutaneous complications due to chemotherapy; these were significantly more common in boys than girls (70.6% vs. 48.8%). The mean age of children with mucocutaneous complications (7.41 ± 3.98) was significantly higher than those without complications (5.33 ± 2.84). The most common mucocutaneous side effects were, in order, alopecia, mucositis, and skin infections.Conclusion: We found that side effects of chemotherapy weresignificantly more common in older children, boys, and childrenwith leukemia. Vincristine was the most common culprit.
Rezvan Amiri; Saman Mohammadi; Saman Azizi; Abbas Pardakhty; Maryam Khalili; Mahin Aflatoonian
Abstract
Background: Conventional topical treatments for male-pattern alopecia (MPA) have limited penetration into hair follicles and unwanted side effects, resulting in low patient compliance. We aimed to evaluate the efficacy and safety of niosomal kopexil 1% lotion compared with niosomal minoxidil 2% lotion ...
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Background: Conventional topical treatments for male-pattern alopecia (MPA) have limited penetration into hair follicles and unwanted side effects, resulting in low patient compliance. We aimed to evaluate the efficacy and safety of niosomal kopexil 1% lotion compared with niosomal minoxidil 2% lotion in patients with MPA.Methods: We conducted a prospective, double-blind, randomized clinical trial at Afzalipour Hospital of Kerman University of Medical Sciences, Kerman, Iran. Thirty participants with MPA were randomized to apply 1 ml of niosomal minoxidil 2% lotion or niosomal kopexil 1% lotion twice a day for 24 weeks. We assessed the efficacy of treatments as the percentage of change in hair density in monthly sessions compared to the baseline using a dermatoscope; we also assessed patient satisfaction and side effects.Results: Thirty participants were enrolled, 29 of whom completed the study. The mean change in hair density was significantly higher with niosomal kopexil compared with niosomal minoxidil (23.2 ± 1.3 and 14.2 ± 0.2, respectively). The hair density increased by 57.6 ± 3.7% and 25.6 ± 4.2% in the kopexil and minoxidil groups, respectively (P < 0.001). Patients reported significantly greater satisfaction with niosomal kopexil than with niosomal minoxidil (P < 0.001). No side effects were reported in either group.Conclusion: Despite the lower concentration, niosomal kopexil revealed significantly higher efficacy of treatment and satisfaction of patients compared to niosomal minoxidil.
Saeedeh Farajzadeh; Mahin Aflatoonian; Saman Mohammadi; Rezvan Amiri; Maryam Khalili; Zahra Heydarimoghadam
Abstract
Background and Aim: Infantile hemangioma is the most common type of vascular tumor in childhood. Risk factors for hemangioma include female gender, low birth weight, prematurity, higher maternal age, and multiple gestations. In this study, for the first time in Kerman, we describe and compare demographic ...
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Background and Aim: Infantile hemangioma is the most common type of vascular tumor in childhood. Risk factors for hemangioma include female gender, low birth weight, prematurity, higher maternal age, and multiple gestations. In this study, for the first time in Kerman, we describe and compare demographic features of infants with hemangiomatous lesions treated with two different systemic beta-blockers (atenolol or propranolol), examining their efficacy and adverse effects.Methods: Forty-one infants with hemangiomatous lesions admitted to the pediatric dermatology ward of Afzalipour Hospital from 2011 to 2017 were enrolled in this study. Demographic features of infants and their mothers and clinical features and complications of hemangiomatous lesions were recorded. Also, we compared the efficacy and adverse effects of treatment protocols with two betablockers (atenolol and propranolol).Results: Most infants were female (70.7%), and 9.7% were premature. The majority of the lesions were superficial (53.7%) and located in the head and neck area (82.9%). Multiple hemangiomas were recorded in 4.8% of the cases. The most common complication was ulceration (29.3%). Two out of 18 patients treated with propranolol had a complete response rate. Adverse effects were observed more frequently with propranolol (26.8%) than with atenolol (14.6%).Conclusion: In our study, female gender and low birth weight were significantly more common in infantile hemangioma patients than in the normal population. Also, mothers of children with hemangioma had a significantly greater number of miscarriages than the average population. Propranolol and atenolol had no significant difference in efficacy and adverse effects.
Maryam Khalili; Saman Mohammadi; Mohamadhosein Saeidi; Rezvan Amiri; Amireh Heshmatkhah; Simin Shamsi Meymandi; Mahin Aflatoonian
Abstract
Background: Treatment failure of antimony drugs for anthroponoticcutaneous leishmaniasis (ACL) is rising. Recognizing predictivefactors of unresponsiveness to treatment can substantiallyinfluence better ACL management. The goal of this study wasto investigate predictive factors associated with treatment ...
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Background: Treatment failure of antimony drugs for anthroponoticcutaneous leishmaniasis (ACL) is rising. Recognizing predictivefactors of unresponsiveness to treatment can substantiallyinfluence better ACL management. The goal of this study wasto investigate predictive factors associated with treatment failurein ACL in Kerman, southeast Iran.Methods: This case-control study was conducted retrospectivelyon 2,128 ACL cases in Kerman over ten years from 2011 to 2020.The case group included patients whose lesions failed to resolveafter one treatment course. The control group included thosewhose lesions were cured after one treatment course.Results: Treatment failure was observed in 13.5% of cases (10.7%of systemic therapy and 16.7% of local therapy). No significantdifference was reported between the type of treatment andtreatment failure. The association of treatment failure withwinter-onset (P = 0.001, OR = 1.39, CI = 1.23–1.56), face (P = 0.001,OR = 1.86, CI = 1.38–2.49), ulceration (P = 0.01, OR = 0.51, CI = 0.30–0.85), small diameter (P = 0.005, OR = 0.57, CI = 0.38-0.84) andlong duration of lesions (P = 0.01, OR = 1.57, CI = 1.11–2.21) wasvalidated by multivariate logistic regression analysis.Conclusion: Efficient detection and timely management of ACLcases are essential to reduce resistant cases, as lesions lastinglonger than four months show poor response to treatment.Furthermore, early treatment of facial lesions with systemictherapy is suggested to optimize results and reduce the risk ofdisfiguring scars. Further surveys are required to determine thereason behind more treatment failure in winter-onset lesions.
Saman Mohammadi; Maryam Khalili; Mahin Aflatoonian; Rezvan Amiri; Zahra Sharif; Saeedeh Farajzadeh; Azadeh Mohebbi
Abstract
Background: Atopic dermatitis is a chronic relapsing inflammatoryskin disease that has possible associations with other diseases suchas allergic conditions, autoimmune skin diseases, and systemicdiseases. We evaluated the prevalence of alopecia areata andthyroid autoimmunity in children with atopic dermatitis.Methods: ...
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Background: Atopic dermatitis is a chronic relapsing inflammatoryskin disease that has possible associations with other diseases suchas allergic conditions, autoimmune skin diseases, and systemicdiseases. We evaluated the prevalence of alopecia areata andthyroid autoimmunity in children with atopic dermatitis.Methods: This was a cross-sectional study on 124 children(62 children with atopic dermatitis and 62 healthy children).Demographic features of the participants and duration of diseasein children with atopic dermatitis were recorded. Antithyroidperoxidase and thyroid stimulating hormone were evaluated inboth groups. Odds ratio (OR) and 95% confidence interval (CI)were calculated to estimate relative risk. The chi-squared testand analysis of variance test (ANOVA) were used to evaluatethe association of thyroid autoimmunity with the demographicand clinical features of patients.Results: Thyroid autoimmunity was only detected in atopicdermatitis children and not in the control group, and the differencewas statistically significant [OR = 4.32, 95% CI = 2.15–10.81,P = 0.04). Furthermore, overt thyroid disease was significantlymore common in the atopic dermatitis group compared withthe control group (OR = 4.46, 95% CI = 1.15–17.24, P = 0.03). Apersonal history of alopecia areata was also significantly morecommon in the atopic dermatitis group (OR = 4.46, CI = 1.17–15.29,P = 0.030). In addition, there was no significant difference betweenthyroid autoimmunity and overt thyroid disease in the patients’severity of atopic dermatitis and demographic features (P > 0.05).Conclusion: Patients with atopic dermatitis had a significantlyhigher percentage of thyroid autoimmunity, overt thyroid disease,and alopecia areata than the control group.
Saman Mohammadi; Nasim Askari; Maryam Khalili; Rezvan Amiri; Mahin Aflatoonian
Abstract
Background: The increased prevalence of metabolic syndrome has been established in chronic inflammatory skin diseases. Patients with metabolic syndrome have a higher mortality rate due to cardiovascular disease and malignancy. In this study, the prevalence of metabolic syndrome was evaluated in lichen ...
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Background: The increased prevalence of metabolic syndrome has been established in chronic inflammatory skin diseases. Patients with metabolic syndrome have a higher mortality rate due to cardiovascular disease and malignancy. In this study, the prevalence of metabolic syndrome was evaluated in lichen planus patients compared with a control group in Kerman, southeast Iran.Methods: This was a cross-sectional study on 90 patients with lichen planus and 90 healthy participants from the Dermatology Clinic of Afzalipour Hospital, Kerman, Iran. Demographic features of the patients and clinical features of the lesions were recorded. Then, parameters of metabolic syndrome were evaluated in both groups. The independent t-test and chi-squared test were used to compare quantitative and qualitative variables, respectively.Results: There was no significant difference in demographic features of the participants between the two groups. Metabolic syndrome was significantly more prevalent in the lichen planus group (62.6%) than in the control group (14.4%) (P = 0.001). Metabolic syndrome parameter values (except waist circumference) were significantly higher in the lichen planus group than in the control group. Lichen planus patients with metabolic syndrome had a significantly higher percentage of mucosal involvement (66.1%) than lichen planus patients without metabolic syndrome (44.1%). Lichen planus patients with metabolic syndrome were significantly older than those without metabolic syndrome.Conclusions: This study observed a higher prevalence of metabolic syndrome in lichen planus patients relative to controls. Furthermore, lichen planus patients with metabolic syndrome had significantly higher age, mucosal involvement, and body mass index than lichen planus patients without metabolic syndrome.
Rezvan Amiri; Ziba Omidvand; Saman Mohammadi; Maryam Khalili; Mahin Aflatoonian
Abstract
Background: Pityriasis versicolor is a recurrent non-inflammatory superficial fungal infection. Application of antifungal shampoo is a simple treatment modality for pityriasis versicolor that can be used on an extensive surface area. Currently, there is no study to evaluate the efficacy of climbazole ...
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Background: Pityriasis versicolor is a recurrent non-inflammatory superficial fungal infection. Application of antifungal shampoo is a simple treatment modality for pityriasis versicolor that can be used on an extensive surface area. Currently, there is no study to evaluate the efficacy of climbazole shampoo. In this study, the efficacy of 2% ketoconazole shampoo was compared to 2% climbazole shampoo in the dermatologic clinic of Afzalipour Hospital, Kerman, Iran.Methods: This triple-blind randomized clinical trial was performed on 60 patients diagnosed with pityriasis versicolor. Participants were categorized into groups A (ketoconazole shampoo) and B (climbazole shampoo) based on simple randomization. KOH smear was achieved from all participants at the baseline, four weeks after commencing treatment, and at three months follow up. Participants were instructed to apply shampoo three times a week for three weeks on all body surfaces and scalp for 10 minutes before rinsing. Evaluation of treatment was based on clinical improvement and results of KOH smears. Complete cure was defined as negative KOH smear and complete clinical improvement.Results: Seventy percent of the patients in the ketoconazole group and 43.3% of the patients in the climbazole group had negative smears four weeks after commencing treatment (P = 0.037). Complete clinical improvement at the three-month follow-up was 26.7% and 13.3% in the ketoconazole and climbazole groups, respectively (P = 0.402).Conclusion: In the present study, 2% ketoconazole shampoo had significantly greater efficacy in terms of mycological cure than climbazole shampoo among pityriasis versicolor patients.
Hamed Zartab; Behzad Iranmanesh; Rezvan Amiri; Simin Shamsi Meymandi
Abstract
Background: Alopecic and aseptic nodule of the scalp (AANS) is a rare entity characterized by the presence of sterile, culturenegative nodules/cysts and areas of non-scarring alopecia.Methods: We describe a case on the vertex of a 26-year-old man with a two-week history of a nodular, moderately-fluctuant, ...
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Background: Alopecic and aseptic nodule of the scalp (AANS) is a rare entity characterized by the presence of sterile, culturenegative nodules/cysts and areas of non-scarring alopecia.Methods: We describe a case on the vertex of a 26-year-old man with a two-week history of a nodular, moderately-fluctuant, alopecic lesion. The patient also had cutis verticis gyrata (CVG).Results: The aspirate culture was negative and histopathologic findings were nonspecific. We also performed a trichoscopy of the lesion. After eight weeks, the patient showed dramatic clinical response to doxycycline and a dose of intralesional corticosteroid.Conclusion: This is the first report of the simultaneous occurrence of AANS and primary essential CVG. AANS is a probably under-reported cause of non-scarring alopecia with a rapid and dramatic response to non-surgical treatment and a generally good prognosis.
Saman Mohammadi; Saeedeh Farajzadeh; Hossein Safizadeh; Maryam Khalili; Mahin Aflatoonian; Rezvan Amiri; Elham Mohammadrezakhani
Abstract
Background: Atopic dermatitis is the most common inflammatory skin disease in children. Severe itching may lead to an impaired quality of life in the patients. In this study, we evaluated the validity and reliability of Persian version of a questionnaire regarding the infants’ ...
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Background: Atopic dermatitis is the most common inflammatory skin disease in children. Severe itching may lead to an impaired quality of life in the patients. In this study, we evaluated the validity and reliability of Persian version of a questionnaire regarding the infants’ dermatitis quality of life in children suffering from atopic dermatitis.Methods: When the original authors approved of the Persian version of the questionnaire, the parents completed the questionnaire for their 98 children with atopic dermatitis aged less than four years. We analyzed the data by SPSS 16. Cronbach’s alpha and inter-item and calculated the correlations to evaluate the reliability and validity via Kaiser criterion and scree plot.Results: The calculated mean score of questionnaire was 9.65±5.41. The first (itching and scratching) and eight questions (treatment problems) obtained the highest and lowest scores, respectively. There was a strong, positive correlation between the severity of the disease and the quality of life score in the patients. Cronbach’s alpha was calculated as 0.88 which is a sign of good internal consistency of the items. The inter-item correlative coefficients varied between -0.004 to 0.87. We used Kaiser’s criterion and scree plot to evaluate the validity and achieve a two-factor solution.Conclusion: Persian version of infants’ dermatitis quality of life index questionnaire was valid and reliable.