Farnoosh Seirafianpour; Farzaneh Mashayekhi; Milad Dodangeh; Forough Seifi Gharabaghloo; Masoud Pourghahramani Koltapeh; Ali Jamshidi Naeini; Rohollah Valizadeh; Davood Lakestani; Samaneh Mozafarpoor; Azadeh Goodarzi
Abstract
Background: About 20% of patients with coronavirus disease2019 (COVID-19) present with mucocutaneous eruptions. Earlyskin or dermatological manifestations can help pediatriciansprevent the spread of the disease by suspecting COVID-19 inasymptomatic or minimally symptomatic patients.Methods: PubMed, Scopus, ...
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Background: About 20% of patients with coronavirus disease2019 (COVID-19) present with mucocutaneous eruptions. Earlyskin or dermatological manifestations can help pediatriciansprevent the spread of the disease by suspecting COVID-19 inasymptomatic or minimally symptomatic patients.Methods: PubMed, Scopus, Embase, Google Scholar, and theNottingham University website were searched on Sep. 1st, 2020,to retrieve studies regarding COVID-19-related mucocutaneousmanifestations in patients under the age of 18.Results: Data were extracted from 76 articles including 38,387 cases.Chilblain/pernio-like lesions were the most common dermatologicalmanifestation, followed by multisystem inflammatory syndrome inchildren (MIS-C)/Kawasaki-like syndrome. Most dermatologicalsigns were self-limited, presenting before, simultaneously with,or after other COVID-19 manifestations. In 40% of the affectedchildren, these signs were the sole presentation of COVID-19.Conclusion: During the COVID-19 pandemic, each newmucocutaneous event in children, especially acral lesions withvascular color, should be considered a possible indicator ofCOVID-19.
Mojgan Karbakhsh; Kosar Hedayat; Azadeh Goodarzi; Maryam Ghiasi; Narges Ghandi
Abstract
Background: Vitiligo is a stigmatizing, chronic, and usually progressive skin disorder that affects patients' quality of life and can interfere with their social participation. There are no studies in developing countries focusing on this aspect. Hence, we assessed social participation in patients with ...
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Background: Vitiligo is a stigmatizing, chronic, and usually progressive skin disorder that affects patients' quality of life and can interfere with their social participation. There are no studies in developing countries focusing on this aspect. Hence, we assessed social participation in patients with vitiligo and its associations with Vitiligo Quality of Life (VitiQoL), Vitiligo Area Score Index (VASI), and demographic and clinical characteristics. Methods: This cross-sectional study was conducted between 2013-2014 on 170 patients, in Razi Hospital, Tehran, Iran. In the pilot phase, the Persian version of the Participation Scale (P-scale) and VitiQoL questionnaire were validated with the backward-forward translation method. Results: Among 173 vitiligo patients, the mean participation score was 15.12 (SD=13.88, median=11). Overall, 91 patients (52.6%) had no significant restriction, 38 (22%) suffered from mild, 23 (13.3%) moderate, 20 (11.6%) severe, and 1 (0.6%) suffered from extreme restriction in participation. The association between VitiQol and P-scale was highly significant (r=0.58; p <0.001). This association was also observed with the three subscales of VitiQol, namely participation limitation (r=0.59, p <0.001), behavior (r=0.43, p <0.001), and stigma (r=0.23, P=0.002). We did not find a significant association between P-scale and demographic characteristics, overall VASI, and face, genitals, and exposed areas VASI. Conclusion: Although the majority of our patients perceived no or mild limitation in their social participation, the P-scale score was highly correlated with their quality of life and its components.
Azadeh Goodarzi; Mahsa Farshidzadeh; Elham Behrangi; Mohammadreza Ghassemi; Masoumeh Roohaninasab
Abstract
Viral skin diseases range from simple superficial exanthems to complex systemic diseases, affecting people of all ages. Careful assessment of infectious contacts and immunization status is of considerable importance along with a thorough physical examination. Recent research has linked a deficiency of ...
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Viral skin diseases range from simple superficial exanthems to complex systemic diseases, affecting people of all ages. Careful assessment of infectious contacts and immunization status is of considerable importance along with a thorough physical examination. Recent research has linked a deficiency of vitamin D to an increased risk of autoimmune, infectious, and atopic disorders. Intralesional vitamin D3 may be an effective treatment option for warts. Vitamin D3 derivatives are effective for various skin conditions, including psoriasis, transient acantholytic dermatosis, actinic porokeratosis, and keratosis palmaris et plantaris. Vitamin D3 treatment has been shown to decrease chemokine synthesis and monocyte trafficking, as well as to downregulate toll-like receptors (TLRs) 2 and 4 of monocytes. This suggests an association between TLRs and vitamin-D-mediated innate immunity. The effect of vitamin D derivatives was speculated to be derived from its potential to regulate epidermal cell proliferation and differentiation and to modulate cytokine production. According to some studies gathered here, not only we can use different forms of vitamin D as therapy for viral skin disease, but also there is an important relationship between them. Therefore, we should consider the serum level of vitamin D for better management of these disorders. Also, keeping vitamin D levels within the normal range may be a preventative healthcare strategy.
zeinab Aryanian; Mohammad Keramatipour; Nafiseh Esmaili; Azadeh Goodarzi; Arghavan Azizpour; Ifa Etesami; Maede Rayati Damavandi; Ghazaleh Zarrinrad; Somayeh Ahmadloo; Narges Ghandi
Abstract
Background: Pemphigus vulgaris (PV) is an autoimmune bullous disease of the skin and mucous membranes caused by activation and proliferation of T cells, production of Th2 cytokine profile and pathogenic antibodies. Vitamin D is a probable immunodeviator to Th2, which its actions are ...
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Background: Pemphigus vulgaris (PV) is an autoimmune bullous disease of the skin and mucous membranes caused by activation and proliferation of T cells, production of Th2 cytokine profile and pathogenic antibodies. Vitamin D is a probable immunodeviator to Th2, which its actions are mediated through the vitamin D receptor (VDR). FokI is the only single nucleotide polymorphism (SNP) leading to VDR protein with a different structure and function. For the first time, we focused on FokI VDR SNP to evaluate its potential role in the genetic susceptibility to PV, particularly in the Iranian population that has a high prevalence of pemphigus.Methods: In this case-control study, DNA samples of 122 PV patients and 233 healthy controls were extracted, and FokI genotyping was performed using the PCR-RFLP method.Results: The mean allele frequencies of F and f alleles in the PV and control groups were 75% and 25%, and 78% and 22%, respectively, showing no significant difference. The genotype frequencies for FF, Ff, and ff genotypes in the case group were 57.4%, 35.2%, and 7.4%, respectively. In the control group, the frequencies were 60%, 36%, and 4%, respectively. Statistical analysis showed no significant difference between the two groups.Conclusion: The present study concluded the frequencies of F and f alleles as approximately 77% and 23% in the gene pool of the Iranian population. Additionally, it showed no association between the FokI alleles and PV in this population.
Azadeh Goodarzi; Mahsa Farshidzadeh; Masoumeh Roohaninasab; Najmolsadat Atefi; Elham Behrangi
Abstract
Background: The use of vitamin D and its analogues in the treatment of warts has been to be effective and painless without any considerable side effects, unlike some other routine safe and effective therapeutic modalities such as cryotherapy that in some cases is really difficult ...
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Background: The use of vitamin D and its analogues in the treatment of warts has been to be effective and painless without any considerable side effects, unlike some other routine safe and effective therapeutic modalities such as cryotherapy that in some cases is really difficult to perform due to related pain, especially in the children. Owing to a probable relationship between the deficiency of serum vitamin D and warts, this research aimed to find the association between level of serum vitamin D and warts. Methods: This case-control study was conducted on 56 subjects in Rasoul Akram Hospital, Tehran, Iran, for 18 months. The subjects were randomly divided into case and control groups, including 28 age and sex-matched subjects in each of them. The required data were extracted through a questionnaire. Finally, the data were analyzed in the SPSS software V.22 using tests such as Mann-Whitney and Pearson correlation. Results: In this study, 56 people were examined, and 28 subjects were included in both case and control groups. The mean serum level of vitamin D in both case and control groups was 23.564and 31.593, respectively. The association between serum levels of vitamin D in the group with and without wart was not significant in both men and female groups. Serum vitamin D levels were compared in two groups of under 18 years old and between 18 and 50 years old, which were not statistically significant. Conclusion: According to our results, there is no significant relationship between serum vitamin D levels and existence of warts. This relationship is not statistically significant at the level of age and sex variables, and there is no difference in age and gender between the case and control groups.
Arghavan Azizpour; Zeinab Aryanian; Azita Nikoo; Maryam Nasimi; Azadeh Goodarzi; Ifa Etesami
Abstract
Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is known as an uncommon disorder of keratinization in which acrosyringium is involved; however, its causes have yet remained unknown. It is presented clinically by discrete keratotic papules on distal extremities arranged ...
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Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is known as an uncommon disorder of keratinization in which acrosyringium is involved; however, its causes have yet remained unknown. It is presented clinically by discrete keratotic papules on distal extremities arranged in a linear pattern along Blaschko lines. Histopathologically, it is characterized by cornoid lamella, which is almost always located overlying an acrosyringium. We present a case with an unusual presentation of extensive PEODDN lesions along the lower extremity. Our case was a young woman presented with multiple keratotic elevated papules on her left sole since her birth. In continuity with the lesions on her sole, a linear plaque was extended up to her buttock. Histopathology showed hyperkeratosis with cornoid lamella overlying the acrosyringium. The rarity of PEODDN and interesting presentation of the lesions on the sole of our patient with extension in a linear Blaschko pattern up to her buttock resembling verrucous linear epidermal nevus encouraged us to present this case.
Azadeh Goodarzi; Elham Behrangi; Mohammadreza Ghassemi; Golnaz Mehran; Niloofar Teymoori; Amir Pouyan Ghahremani; Maryam Biglari Abhari
Abstract
Background: Acne vulgaris is among common bothersome skin problems. Recognition of contributing factors would help to prevent acne. Some dietary and inflammatory factors are among suggested etiologies. Accordingly, in this study, the serum levels of calcium, vitamin D, phosphorous ...
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Background: Acne vulgaris is among common bothersome skin problems. Recognition of contributing factors would help to prevent acne. Some dietary and inflammatory factors are among suggested etiologies. Accordingly, in this study, the serum levels of calcium, vitamin D, phosphorous and C-reactive protein (CRP) were determined and compared in acne patients and healthy subjects. Methods: In this case-control study, 144 consecutive subjects with and without acne (moderate-very severe) referred to Rasoul Akram Hospital in 2016 were enrolled. In this regard, the serumcalcium, phosphorous, CRP, vitamin D were determined in the subjects and compared between the groups. Results: The results indicated that serum CRP, calcium, and phosphorous level were alike between the groups (P > 0.05) without any relation to acne severity except CRP. The serum vitamin D level was significantly different (P = 0.0001), but it was not associated with acne severity. Serum calcium levels of males were significantly higher in both groups. Conclusions: Based on our results, it may be concluded that calcium, phosphorous, and CRP levels are not associated with acne incidence, but the serum vitamin D is related to acne presentation. CRP levels were positively associated with acne vulgaris severity.
Azadeh Goodarzi; Masoumeh Roohaninasab; Najmol Sadat Atefi; Afsaneh Sadeghzadeh Bazargan; Mohammadreza Ghassemi; Amir Pouyan Ghahremani; Niloofar Teymoori; Maryam Biglari Abhari
Abstract
Background: Acne vulgaris is a dermatologic disorder with a wide variety of distribution and presentation. Its high prevalence and important cosmetic and psychological concerns focusing on contributing factors would be of great value for better approach and prevention of acne vulgaris. ...
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Background: Acne vulgaris is a dermatologic disorder with a wide variety of distribution and presentation. Its high prevalence and important cosmetic and psychological concerns focusing on contributing factors would be of great value for better approach and prevention of acne vulgaris. There are many articles that argue the role of some dietary and inflammatory factors in acnevulgaris. In this study, the serum levels of zinc in acne patients were determined and compared with healthy subjects. Methods: In this age and gender matched case-control study, 200 consecutive subjects with and without acne (moderate-very severe) referring to Rasoul Akram Hospital, 2016, were enrolled,and their serum zinc levels were determined and compared across the groups. Results: Serum zinc levels were alike across the groups (P > 0.05), and the severity of acne was not related to zinc level. The levels of zinc were significantly different between genders in the casegroup (men had lower levels). In female patients with acne, the level of zinc was inversely correlated with acne severity. Conclusion: Zinc is not related to acne incidence or its grade, but men with acne have lower levels of zinc compared with women. Also, acne severity in women is inversely correlated with zinc level. It can be assumed that zinc supplementation may be a good trend in men with acne or alleviate the severity of acne in women, which needs more evaluation and work up.
Azadeh Goodarzi; Masoumeh Roohaninasab; Elham Behrangi; Mohammadreza Ghassemi; Amir Pouyan Ghahremani; Niloofar Teymoori
Abstract
Skin as an outer layer of body and a main connection between the body and the environment is a way that pathogens can access the body; Therefore, it has a crucial protecting role for the body because of obstacle functioning and micobiota. Factors that seem to commonly contribute to ...
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Skin as an outer layer of body and a main connection between the body and the environment is a way that pathogens can access the body; Therefore, it has a crucial protecting role for the body because of obstacle functioning and micobiota. Factors that seem to commonly contribute to the disease are follicular hyperkeratinization, propionibacterium acnes, sebum production, and inflammation; however, pathogenesis of acne vulgaris as an inflammatory skin disorder is still poorly understood. Google Scholar and PubMed databases were searched for all related articles, using the key words of zinc, diet, vitamin D, BMI, and acne vulgaris.
Zeinab Aryanian; Hosein Shahabandaz; Meysam Abdollahzadeh Sangrody; Azar Shirzadian; Soodabeh Tirgartabari; Ali Bijani; Shabnam Fahim; Ifa Etesami; Arghavan Azizpour; Azadeh Goodarzi
Abstract
Background: Lichen planus is a chronic inflammatory disease associated with an increased risk of subclinical atherosclerosis and cardiovascular diseases. This study aimed to evaluate patients with lichen planus using carotid Doppler ultrasound parameters.Methods: Forty patients with lichen ...
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Background: Lichen planus is a chronic inflammatory disease associated with an increased risk of subclinical atherosclerosis and cardiovascular diseases. This study aimed to evaluate patients with lichen planus using carotid Doppler ultrasound parameters.Methods: Forty patients with lichen planus and 40 controls were included in this study. Common carotid artery intima-media thickness (CIMT) and the number of atherosclerotic plaque weremeasured and compared to the control group. Total cholesterol, triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were measured. Leptin level (Pg/ml)was measured using the enzyme-linked immunosorbent assay (ELISA) method (Leptin ELISA kit, Orgenium, Finland).Results: Significant difference was found between the groups in terms of CIMT (P=0.005). The median range for blood leptin level, triglyceride, cholesterol, and LDL was higher for lichen planus patients than for controls. We found a significant difference between the severity of LP and CIMT (P=0.035). No statistical difference was found between LP and the number of atherosclerotic plaque.Conclusions: Our study suggested that measurement of the mean intima media wall thickness of the common carotid artery could be beneficial as a valuable method for early diagnosis of atherosclerosis in lichen planus.
Azadeh Goodarzi
Abstract
There are many immune mediated disorders with the corroborated role of vitamin D or Vitamin D Receptor (VDR) gene polymorphisms in their pathogenesis, immunologic regulation, and disease characteristics. Therefore, in this review, we searched PubMed data base in regard to the role ...
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There are many immune mediated disorders with the corroborated role of vitamin D or Vitamin D Receptor (VDR) gene polymorphisms in their pathogenesis, immunologic regulation, and disease characteristics. Therefore, in this review, we searched PubMed data base in regard to the role of VDR gene polymorphisms in common autoimmune disorders, emphasizing on dermatologic diseases.
Azadeh Goodarzi
Abstract
There are many patients with inflammatory acne vulgaris who are not compliant or eligible to consume acne medications, such as oral antibiotics or isotretinoin. PubMed and Medline databases were searched for all related articles. All finding were summarized and chronologically presented ...
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There are many patients with inflammatory acne vulgaris who are not compliant or eligible to consume acne medications, such as oral antibiotics or isotretinoin. PubMed and Medline databases were searched for all related articles. All finding were summarized and chronologically presented in the tables. Nonmedical device-based therapies largely improve the treatment of active inflammatory acne vulgaris, especially in patients who are not compliant or eligible to consume acne medications, do not respond to these drugs over a specified period of time, or do not sustain in the remission phase.