Amruta P. Dhotre; Sudhir P. Singh; Bhushan Madke; Adarshlata Singh; Sugat Jawade
Abstract
Background: Idiopathic guttate hypomelanosis (IGH) is characterized by discrete, multiple, round-to-oval hypopigmented macules of approximately 2-5 mm diameter, especially on the forearms and pretibial area,which increase in number with aging. Recent focus has been on therapeutic ...
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Background: Idiopathic guttate hypomelanosis (IGH) is characterized by discrete, multiple, round-to-oval hypopigmented macules of approximately 2-5 mm diameter, especially on the forearms and pretibial area,which increase in number with aging. Recent focus has been on therapeutic wounding, which stimulates melanocytes from the periphery and surrounding hair follicles to proliferate, migrate, and repigment the lesions. This study aimed to evaluate and compare the efficacy of trichloroacetic (TCA) 50% application and dermabrasion in IGH patients.Methods: Twenty patients of IGH were enrolled after considering various inclusion and exclusion criteria. IGH lesions over the right side were treated with trichloroacetic acid (TCA) 50% witha cotton-tipped applicator. IGH lesions over the left side were treated with dermabrasion.Results: Of the 153 macules in 20 patients, all 81 macules in the dermabrasion group showed some repigmentation, whereas 7 (9.7%) out of 72 macules treated with 50% TCA Touch™ showedno improvement. At the end of 3 months, repigmentation up to 25%, between 25–50%, and between 51–75% was seen in 18.5%, 66.7%, and 14.8% of lesions treated with dermabrasion, respectively. This is while TCA 50% touch-treated macules showed up to 25% and between 25–50% repigmentation in 48.6% and 41.7% of instances, respectively.Conclusion: The analysis suggested that both dermabrasion and TCA 50% Touch are effective in the treatment of IGH. Dermabrasion proved to be more effective than TCA peel and can be tried before or with the medical line of therapy in the treatment of IGH.
Khalaji Naser; Khaffafi Behrang; Mokhtari Seyed Arman Seyed; Karimipour Mojtaba; Alizadeh Hamed
Abstract
Background: Nowadays, the rapid recovery of skin lesions and functional return are among the goals of researchers. The skin is the first defensive barrier against microorganisms in the body and its failure causes infection to spread in all systems of the body. By taking into account the contradictory ...
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Background: Nowadays, the rapid recovery of skin lesions and functional return are among the goals of researchers. The skin is the first defensive barrier against microorganisms in the body and its failure causes infection to spread in all systems of the body. By taking into account the contradictory results of previous studies on the impact of phototherapy on wound healing and also the considerable anti-oxidative properties of curcumin, this novel study was carried out with the aim of determining the histopathological impact of compact fluorescent light (CFL) and curcumin on the process of wound healing. Methods: Forty-eight adult male wistar rats were randomly divided into four groups. The control group received 2.0 ml of ethyl oleate, and the curcumin group received only 0.2 ml curcumin daily for 15 days via intraperitoneal injection. The fluorescent group received 0.2 ml of ethyl oleate daily for 15 days via intraperitoneal injection, and were exposed to CFL for 12 hours per day for 15 days. The curcumin plus fluorescent group received 0.2 ml curcumin daily for 15 days via intraperitoneal injection, and were exposed to CFL for 12 hours per day for 15 days. The size of the wound was measured by a scale ruler, and the morphology of the wound site was assessed. Results: The results of this study showed that the best percentage of repair was observed in the fluorescent group on days 6 and 15 (50±5 and 90±2, respectively), while the least repair was seen in the group receiving fluorescent plus curcumin (33±7). In the curcumin group, the wound healing was, not significantly (P=0.872) reduced on the sixth day, compared to the control group, whereas compared to the fluorescent and fluorescent plus curcumin groups, the reduction was significant (P?0.0001 and P=0.05, respectively). On the fifteenth day, however, the wound healing was significantly decreased in the curcumin group compared to the control and fluorescent groups (P?0.0001 and P?0.0001 respectively), while it was significantly increased compared to the fluorescent plus curcumin group (P?0.0001). In the fluorescent plud curcumin group, the wound healing was significantly reduced compared to the other groups on the fifteenth day (P?0.0001). Conclusion: Fluorescent alone resulted in wound healing, in contrast to the control and curcumin plus fluorescent groups. Accelerating the repair in this group is likely due to the increase in blood flow and helping the homeostasis to return to its primary state. The absence of wound healing in the curcumin group is probably due to the high dose of curcumin. Moreover, in the fluorescent plus curcumin group, the causes of no wound healing and weight loss were probably disorders in the inflammation process and spread of infection.