Hamideh Moravvej; Maryam Yousefi; Nahid Mohtasham; Nelda Saadat; Hamid Reza Haghighatkhah
Volume 11, Issue 3 , 2008, , Pages 108-112
Abstract
Background: Few studies have investigated on vitamin D metabolites Serum levels, and calcium homeostasis in humans receiving retinoids, despite a substantial amount of literature concerning retinoid-induced osteoporosis in animals. We prospectively measured vitamin D metabolites serum levels and calcium ...
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Background: Few studies have investigated on vitamin D metabolites Serum levels, and calcium homeostasis in humans receiving retinoids, despite a substantial amount of literature concerning retinoid-induced osteoporosis in animals. We prospectively measured vitamin D metabolites serum levels and calcium homeostasis and radiographic bone changes in short course treatment with oral isotretinoin in severe acne.Methods: 1,25-dihydroxy vitamin D and 25-hydroxy vitamin D, calcium, phosphate, Parathyroid hormone and axial spine , femoral neck radiographies were measured in 30 nodulocystic acne patients ( 17 -28 years ) before and after twenty weeks of treatment with oral isotretinoin at the recommended dose (0.75 -1 mg/kg/day) .Results: vitamin D metabolites, calcium, phosphate, Parathyroid-hormone did not change significantly and hyperostosis and other sclerotic change were not observed in any patients.Conclusion: Short course treatment with oral isotretinoin at the recommended dose did not lead to any significant changes in serum vitamin D metabolites, calcium, phosphate and Parathyroid hormone and has no effects on bone radiography in acne patients.
Das Kuntal; Dang Raman; Machale Manjunath U
Volume 12, Issue 4 , 2009, , Pages 117-122
Abstract
Background: The aim of this study was to formulate and evaluate the noble herbal moisturise gel containing Stevia extract. Methods: The cosmetic gel formulation was designed by using aqueous extract of Stevia rebaudiana leaves in varied concentrations (2.5% and 5.0%) and evaluated using physiological ...
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Background: The aim of this study was to formulate and evaluate the noble herbal moisturise gel containing Stevia extract. Methods: The cosmetic gel formulation was designed by using aqueous extract of Stevia rebaudiana leaves in varied concentrations (2.5% and 5.0%) and evaluated using physiological measurements in comparision with a control placebo gel. The initial physicochemical parameters of formulations SF-I and SF-II, i.e. pH, viscosity, spreadability, extrudability and stability were examined. Furthermore, both formulations were studied for toxicity and skin irritancy on animal model. Results: This study revealed that the formulation containing 2.5% Stevia extract showed comparatively better stability than other formulations and the control sample. Results showed that there were no toxicity and no skin irritation according to evaluated various parameters when compared to the control formulation. Conclusion: This formulation of Stevia extract could be suggested as a safe and beneficial moisturiser.
Nafiseh Esmaily; Amirhooshang Ehsani; Pedram Noormohammadpour; Iman Baiagouy; Shima Sayanjali
Volume 13, Issue 4 , 2010, , Pages 118-121
Abstract
Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease with a high rate of morbidity and mortality without treatment. Until now, treatments consist mostly of the use of corticosteroid and immunosuppressive drugs. Optimum dosage for corticosteroid therapy is yet to be determined. ...
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Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease with a high rate of morbidity and mortality without treatment. Until now, treatments consist mostly of the use of corticosteroid and immunosuppressive drugs. Optimum dosage for corticosteroid therapy is yet to be determined. The aim of the present study was to clear whether different initial corticosteroid therapeutic dosages change the recurrence rate of the disease.Methods: Patients hospitalized with confirmed PV from 2000 to 2006 were enrolled if they received systemic corticosteroids without any adjuvant therapy for no more than three weeks when hospitalized, received their first treatment in the period of the study and were followed for at least two years in the PV clinic of Razi Hospital periodically. Initial steroid dosage as well as the number and type of the recurrence(s) were documented and analyzed.Results: A total of 62 patients with a mean age of 46.8 (± 15.9) were enrolled. Twenty-one patients were female (33.9%) and 41 patients (66.1%) were male. According to the initial dose of systemic corticosteroid, patients were divided into two groups: group A included patients treated with less than 2mg/kg (10 patients or 16.1%) while group B included patients treated with 2mg/kg systemic steroids (52 patients or 83.9%). There was no significant difference in the recurrence rate between the two groups. Recurrence rate was 40% in group A and 51% in group B (P>0.05). According to the type of recurrence, there was a significant difference between the two groups; in group A, the first recurrence was major in 33% of the patients while in group B, this rate was about 28.8% (P<0.05).Conclusion: According to the present study, initial therapeutic dosage did not influence the recurrence rate although the type of recurrence was influenced. Patients treated with higher initial steroid dosages experienced their first episode as a minor recurrence while patients treated with lower initial steroid dosages experienced major recurrences with a higher probability as their first episode.
Ehsani Amir Hooshang; Noormohammadpoor Pedram; Sadeghinia Ali; Hemmati Sara; Ahmadi Maedeh; Sotoudeh Sara; Azizpour Arghavan; Nasimi Maryam
Volume 20, Issue 4 , 2017, , Pages 118-121
Abstract
Background: Basal cell carcinoma (BCC), the most common form of skin cancer, usually occurs in the sun-exposed areas of the body like head and neck, yet is also seen in unexpected sites. Myriad studies have mentioned a lower limb BCC incidence rate of 1.5-13.5%.Methods: The present retrospective cross-sectional ...
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Background: Basal cell carcinoma (BCC), the most common form of skin cancer, usually occurs in the sun-exposed areas of the body like head and neck, yet is also seen in unexpected sites. Myriad studies have mentioned a lower limb BCC incidence rate of 1.5-13.5%.Methods: The present retrospective cross-sectional study was conducted on 650 BCC patients, who were referred to the dermatology tumor clinic of Razi hospital from 2008 to 2012 with confirmed biopsy results of BCC. Patient characteristics including age, sex, relevant history and physical examination and tumor characteristics such as location and pathological subtypes were recorded.Results: The prevalence of lower limb BCC was 1.53% with the mean age of 69.5 years and a male to female ratio of 2.33:1. Of 10 cases with BCC on the lower extremities, 6 were on the legs, 3 on the thighs and 1 on the foot. The most frequent pathological type was nodular and constant UV exposure was the most important risk factor (60%). Other underlying factors were chemical exposure, chronic ulcer and history of radiation.Conclusion: BCC of the lower limbs is more prevalent in men compared with women. Moreover, UV exposure is the most important risk factor for BCC. On the other hand, factors like ulcers, radiation and chemical exposure have to be further considered.
Shahidi-Dadras Mohammad; Abdollahimajd Fahimeh; Younespour Shima; Nikvar Mohammad
Volume 19, Issue 4 , 2016, , Pages 119-124
Abstract
Background: Psoriasis is a chronic disease with multiple biochemical and vascular abnormalities. Several studies have evaluated circulating levels of vascular endothelial growth factor (VEGF) in psoriasis, but none of them evaluated it after reaching a PASI-75 response, as a practical treatment goal. ...
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Background: Psoriasis is a chronic disease with multiple biochemical and vascular abnormalities. Several studies have evaluated circulating levels of vascular endothelial growth factor (VEGF) in psoriasis, but none of them evaluated it after reaching a PASI-75 response, as a practical treatment goal. The aim of this study was to evaluate serum levels of VEGF in moderate to severe psoriatic patients before and after treatment compared with healthy controls.Methods: This study was approved by the Ethics Committee of Shahid Beheshti University of Medical Sciences. Fifty-eight patients with moderate- severe psoriasis and 60 age-and gender-matched healthy controls were recruited to this study. Serum VEGF levels (pg/ml) of both groups were measured. We used Psoriasis Area and Severity Index (PASI) scoring to assess disease activity in patients. According to the disease severity, the patients received proper treatment. When they reached a PASI-75 response, serum VEGF levels were measured once more.Results: In our study, the median serum VEGF level was significantly higher in psoriatic patients (before and after treatment) as compared to healthy controls. Moreover, patients showed a significant reduction in their serum VEGF levels after reaching PASI-75. The median time of therapeutic effect (reaching a PASI- 75 response) was four months. Furthermore, our study showed a significant correlation between the serum VEGF level and age, BMI, PASI, and disease duration (P
Talat Humaira; Wahid Zarnaz; Mirza Reema
Volume 15, Issue 4 , 2012, , Pages 122-126
Abstract
Background: This study was conducted because up to now,the investigations performed on cutaneous manifestations ofantihypertensive agents’ reactions, especially in Pakistan, arenegligible even though these drugs are taken by a large numberof people. The aim of this study was to determine the cutaneousmanifestations ...
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Background: This study was conducted because up to now,the investigations performed on cutaneous manifestations ofantihypertensive agents’ reactions, especially in Pakistan, arenegligible even though these drugs are taken by a large numberof people. The aim of this study was to determine the cutaneousmanifestations of different antihypertensive agents in terms ofdosage and duration.Method: The study was carried out at the Departments ofDermatology and Cardiology, Civil Hospital, Karachi. The studywas carried out from June 2007 to December 2007. The inclusioncriteria included all patients taking a single antihypertensive agentwith cutaneous manifestations. Patients taking antihypertensivedrugs but suffering from some other dermatological diseases andthose taking more than one drug were excluded. After informedconsent, history, specifically regarding the type of drug dosageand duration of drug intake was taken. Specific investigationssuch as biopsy were done if indicated.Result: Out of 100 patients, 37 were male and 63 were female.Most of the patients were in the age group 46–60 years. Themajority (97%) of patients experienced the onset of lesions between4–8 weeks of therapy and only 2% had lesions within 4 weeks.Moderate lesions were markedly more common and were foundin 65% followed by mild lesions in 26%, severe in 6%, and lethalin 3% of the patients. The most common lesions were pruritisand eczema, followed by flushing, lichenoid eruptions, oralulcers, purpuras, psoriasis, exanthematous reactions, urticaria,gingival hyperplasia, lichen planus, morbilliform rashes, orallichen planus and butterfly rash.Conclusion: No relation was noted between a drug dose andthe severity of skin lesions. Most patients started having skinlesions 4 to 8 weeks after therapy..
Banihashemi Mahnaz; Pezeshkpoor Fakhrozaman; Hadis Yousefzadeh; Fatemeh Livani; Gholamreza Ghandeharian
Volume 17, Issue 4 , 2014, , Pages 126-129
Abstract
Background: The diagnosis of herpes simplex virus may requirevirological confirmation. Tzanck smear is an old, rapid, costeffective but nonspecific method that has been recently re-evaluatedas a method for the diagnosis of herpes virus infection. This studywas conducted to compare Tzanck smear and viral ...
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Background: The diagnosis of herpes simplex virus may requirevirological confirmation. Tzanck smear is an old, rapid, costeffective but nonspecific method that has been recently re-evaluatedas a method for the diagnosis of herpes virus infection. This studywas conducted to compare Tzanck smear and viral culture in thediagnosis of herpes simplex virus infection in patients clinicallysuspected to be infected with this virus.Method: Materials obtained from a fresh vesicle were used toprepare Tzanck smears and viral cultures.Result: In this study, 40 (71.4%) of the 56 samples were culturepositive while Tzanck smears were positive in 36 (64.3%) patients.We found that the sensitivity and specificity of the Tzanck testwas 90% and 100% respectively when compared to cell culture.Moreover, the positive predictive value (PPV) and negativepredictive value (NPV) of the Tzanck test was 100% and 80%,respectively.Conclusion: The Tzanck smear has its limitations but is still asuitable rapid, easy, and cost effective diagnostic method forherpes simplex virus infections, especially when viral cultureor other virological methods are not available.
H Edalat Khah; AR Mohebbi Pour; F Eghtedari
Volume 9, Issue 2 , 2006, , Pages 127-131
Abstract
Background and aim: Pyogenic granuloma is a small, red, benign vascular tumor usually occuring after penetrating injury in skin. Different therapies such as laser, surgery and electro surgery have been offered for its treatment. Each of these therapies has advantages and disadvantages. In this study, ...
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Background and aim: Pyogenic granuloma is a small, red, benign vascular tumor usually occuring after penetrating injury in skin. Different therapies such as laser, surgery and electro surgery have been offered for its treatment. Each of these therapies has advantages and disadvantages. In this study, we evaluated the therapeutic effects of cryotherapy and electrocautery on pyogenic granuloma.Materials and Methods: This clinical trial was performed on 50 patients who had pyogenic granuloma. In 25 patients cryotherapy was used with liquid nitrogen every ten days for a maximum of 3 sessions. Electrocautery was done by another dermatologist, and the lesion was destroyed in one session. Patients were followed for one month after treatment. T test and X2 were used for data analysis.Results: The mean age of patients in cryotherapy group and in electrocautery group were 21.8±17/1 and 28/7±17/7 years , respectively (P>0.05). Number of treatment sessions were 2.2±0.8 in cryotherapy and 1/1±0.3 in electrocautery group (P<0.0001). Cure was observed in 100% of patients treated by electracautery method and in 77% treated by cryotherapy method (P=0.01).Conclusion: Electrocautery is more effective than cryotherapy, but treatment with cryotherapy also is very effective, and can be used mainly in children, pregnant women, large lesions and those who are afraid from electrocautery.
Banihashemi Mahnaz; Nahidi Yalda; Meibodi Naser Tayyebi; Jarrahi Lida; Livani Fatemeh; Seifnia Sahar
Abstract
Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease of the skin and mucous membranes. Because vitamin D deficiency is associated with many immune disorders, we compared the levels of vitamin D between PV patients and healthy controls. Methods: Vitamin D level of 20 patients with ...
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Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease of the skin and mucous membranes. Because vitamin D deficiency is associated with many immune disorders, we compared the levels of vitamin D between PV patients and healthy controls. Methods: Vitamin D level of 20 patients with PV was compared with 20 healthy individuals matched for age, gender, hours spent in the sun, body mass index (BMI) and daily vitamin D intake at the same time interval. The severity of the disease was estimated according to ABSIS score. The serum level of 25-hydroxyvitamin D (25OHD) was measured by a commercial ELISA test. Results: Vitamin D deficiency in the pemphigus vulgaris group (75%) was higher than healthy controls (45%) (P = 0.053). Mean level of vitamin D in PV patients was significantly lower than healthy controls, and was in the range of vitamin deficiency (P ? 0.05). No significant relationship was observed between the severity of the PV disease and vitamin D levels (P > 0.05). Conclusions: Based on the results of the present study, the mean level of vitamin D in patients with PV was significantly lower than healthy people. Based on our findings and given the important role of vitamin D in preventing inflammatory and autoimmune diseases, vitamin D deficiency can be considered as a factor triggering the onset of PV.
Farhad Malekzad; Mohammad Saeedi; Azin Ayatollahi
Volume 14, Issue 4 , 2011, , Pages 131-135
Abstract
Background: Lichen planus is a common inflammatory disease that can involve the skin, nails, mucous membrane, and hair follicles. There is a long list of topical and systemic therapies for its treatment. Methotrexarte has some characteristics that make it a good choice for generalized lichen planus. ...
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Background: Lichen planus is a common inflammatory disease that can involve the skin, nails, mucous membrane, and hair follicles. There is a long list of topical and systemic therapies for its treatment. Methotrexarte has some characteristics that make it a good choice for generalized lichen planus. Aim: The goal of this study was to assess the effect of low dose methotrexate in generalized lichen planus. Method: Eighteen patients (8 male and 10 female, mean age: 51.1, range: 22-80, SD: 14.9) with generalized lichen planus were enrolled in the study. After basic evaluations, low dose methotrexate (7.5-10 mg weekly) initiated. The response rate was appraised after 2, 4 and 8 weeks. Six-month follow-up was done for evaluating the recurrence rate. Result: At the end of the 8th week, 75% of the patients had more than 75% improvement. After six months, no case of recurrence was reported. Adverse effects were limited to laboratory abnormalities in two patients (abnormal liver function tests in one case and decreased hemoglobin in the other case). Conclusion: Low dose methotrexate is a very good and safe treatment for generalized lichen planus, especially when there is concern regarding the steroids undesired effects or when the disease is resistant to corticosteroids.
Yousefi Maryam; Nabaei Leyla; Ghasemnia Hassan; Abolhasani Ehsan; Rahgoshai Rayhaneh; Barikbin Behrooz
Volume 16, Issue 4 , 2013, , Pages 132-136
Abstract
Background: Seborrheic keratosis is a common benign tumor and many modalities are used to treat it. No convincing data favors the therapeutic effect of calcipotriol on seborrheic keratosis. We aimed to assess the efficacy of calcipotriol in the treatment of this tumor.Method: Eligible patients aged over ...
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Background: Seborrheic keratosis is a common benign tumor and many modalities are used to treat it. No convincing data favors the therapeutic effect of calcipotriol on seborrheic keratosis. We aimed to assess the efficacy of calcipotriol in the treatment of this tumor.Method: Eligible patients aged over 40 years with seborrheic keratosis (size: 5-15mm) were instructed to apply 50?g/g calcipotriol ointment twice a day for 12 weeks. The size of the tumor was measured at baseline and after the 12-week period. The size change and improvement were assessed. Result: Thirty out of fifty screened patients were eligible for the study and completed the 12-week course of the study. The mean baseline size of the tumors was 9.30±2.95 mm that decreased to the mean size of 2.02±1.94 mm (P
Zeinab Aryanian; Hosein Shahabandaz; Meysam Abdollahzadeh Sangrody; Azar Shirzadian; Soodabeh Tirgartabari; Ali Bijani; Shabnam Fahim; Ifa Etesami; Arghavan Azizpour; Azadeh Goodarzi
Abstract
Background: Lichen planus is a chronic inflammatory disease associated with an increased risk of subclinical atherosclerosis and cardiovascular diseases. This study aimed to evaluate patients with lichen planus using carotid Doppler ultrasound parameters.Methods: Forty patients with lichen ...
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Background: Lichen planus is a chronic inflammatory disease associated with an increased risk of subclinical atherosclerosis and cardiovascular diseases. This study aimed to evaluate patients with lichen planus using carotid Doppler ultrasound parameters.Methods: Forty patients with lichen planus and 40 controls were included in this study. Common carotid artery intima-media thickness (CIMT) and the number of atherosclerotic plaque weremeasured and compared to the control group. Total cholesterol, triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were measured. Leptin level (Pg/ml)was measured using the enzyme-linked immunosorbent assay (ELISA) method (Leptin ELISA kit, Orgenium, Finland).Results: Significant difference was found between the groups in terms of CIMT (P=0.005). The median range for blood leptin level, triglyceride, cholesterol, and LDL was higher for lichen planus patients than for controls. We found a significant difference between the severity of LP and CIMT (P=0.035). No statistical difference was found between LP and the number of atherosclerotic plaque.Conclusions: Our study suggested that measurement of the mean intima media wall thickness of the common carotid artery could be beneficial as a valuable method for early diagnosis of atherosclerosis in lichen planus.
G Faghihi; N Ghanei; P Rajabi; D Taheri
Volume 7, Issue 3 , 2004, , Pages 145-151
Abstract
Background: P53 tumor suppressor gene mutation is one of the most common genetic alterations in human malignancies. The mutated from of the gene is stable and can be detected with immunohistochemistry methods. There is much controversy about the expression rate of this gene in malignant melanoma. Objective: ...
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Background: P53 tumor suppressor gene mutation is one of the most common genetic alterations in human malignancies. The mutated from of the gene is stable and can be detected with immunohistochemistry methods. There is much controversy about the expression rate of this gene in malignant melanoma. Objective: To determine the frequency of the P53 antigen expression by sex, age, type and thickness of melanoma, and site of the antigen expression. Patients and methods: Paraffin embedded blocks of 50 patients (45 primary and 5 metastatic) with documented diagnosis of melanoma were deparaffinized and immunostained with D0-7 monoclonal antibody. The lesions were divided depending on the degree of the staining as follows: 1) (No staining), 2) Mild (Less than 10%), 3) Moderate (10%-50%), 4) Severe (More than 50%). Results: Of 50 cases, 27 (54%) evaluated skin biopsy specimens belonged to female patients and 23 (46%) skin biopsies were related to male patients. 40% of lesions were graded as no staining. 36% of lesions showed mild staining, 14% moderate and 10% severe staining. Site of expression was exclusively in the cytoplasm. There was no meaningful statistical relationship between severity of staining and the age group, and sex of the patients, type and thickness of melanoma (P>0.05). Conclusion: Mutation in P53 tumor suppressor gene probably occurs in the early stages of melanoma.
Mapar Mohammad Ali; Mali Behrooz
Volume 11, Issue 4 , 2008, , Pages 147-150
Abstract
Background: Scabies is a common skin disease and a public health problem. The topical antiscabietics have a poor compliance. The aim of this study was to compare the efficacy of oral Ivermectin with topical Lindane solution in the treatment of scabies. Methods: This was a prospective comparative open ...
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Background: Scabies is a common skin disease and a public health problem. The topical antiscabietics have a poor compliance. The aim of this study was to compare the efficacy of oral Ivermectin with topical Lindane solution in the treatment of scabies. Methods: This was a prospective comparative open study. Fifty seven patients were randomized in two groups. One group (32 patients) received 200µg/kg body weight of Ivermectin in two oral doses with a one-week interval, and the second group, (25 patients) received 2 consecutive weekly topical applications of Lindane. All patients were followed up for 2 weeks. Results: A single oral dose of Ivermectin cured 72% of patients and 91% of the patients were cured after the second dose. Two applications of Lindane with a one-week interval cured 92% of cases. Conclusion: Compared to topical Lindane in the treatment of scabies, Ivermectin was at least as effective as Lindane.
Taheri Ahmadreza; Tanipour Mohammad Hossein; Khorasani Zahra Kafami; Kiafar Bita; Layegh Pouran; Hashemy Seyed Isaac
Volume 18, Issue 4 , 2015, , Pages 156-162
Abstract
Background: Pemphigus diseases including pemphigus vulgaris (PV) and bullous pemphigoid (BP) are autoimmune diseases that cause severe blistering of the skin and mucous membranes. Among inflammatory mediators, reactive oxygen species (ROS) are involved in the pathogenesis of a wide variety of diseases ...
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Background: Pemphigus diseases including pemphigus vulgaris (PV) and bullous pemphigoid (BP) are autoimmune diseases that cause severe blistering of the skin and mucous membranes. Among inflammatory mediators, reactive oxygen species (ROS) are involved in the pathogenesis of a wide variety of diseases through oxidative stress for which protein carbonyl (PC) and total antioxidant capacity (TAC) are two important markers.Methods: We utilized PC and TAC in this study to compare the serum redox status of PV and BP patients with healthy subjects to investigate the possible ro
H Mortazavi; M Reziei; SN Emadi; MJ Nakhaei; MR Soroush; P Noor Mohammadpour; S Toosi
Volume 8, Issue 3 , 2005, , Pages 177-189
Abstract
Background: Mustard gas is a disabling chemical weapon and was widely used in first world war and Iraq-Iran war. Its toxic effects could be acute or chronic and they could particularly affects lungs, eyes and skin. Objective: To study the frequency of chronic complications of sulfure Mustard gas in Iranian ...
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Background: Mustard gas is a disabling chemical weapon and was widely used in first world war and Iraq-Iran war. Its toxic effects could be acute or chronic and they could particularly affects lungs, eyes and skin. Objective: To study the frequency of chronic complications of sulfure Mustard gas in Iranian victims 14 to 20 years after exposure. Patients and Methods: This descriptive cross-sectional study was performed on 800 patients that were randomly selected from different provinces of Iran, who had been exposed to sulfure Mustard gas during 1983 to 1988. These patients were clinically re-evaluated in 2002-03 and laboratory tests were performed if necessary. Results: The mean age of the patients at the time of study was 39.3 (±9.8) years. 3 types of skin lesions were observed. Non-specific lesions including 39.6% xerosis, 19% pigmentary disorders, 17.4% cherry angioma, 12.7% seborrheic dermatitis, 12.2% eczema (Dermatitis), 11.6% acneiform lesions, 7% tinea versicolor, 5.1% urticaria, 3.6% vitiligo, 2.5% alopecia areata, 2% psoriasis, and 1.3% aphthous stomatitis. Specific skin lesion called mustard scar was defined according to morphology, location, history and observed in 44 (5.5%) patients. Malignant neoplasms including basal cell carcinoma, Bowen’s disease, squamous cell carcinoma, mycosis fungoides and dermatofibrosarcoma protuberans occurred in 9 victims (1.1%). Conclusion: Mustard gas can cause acute and late-onset skin lesions. Specific lesion of Mustard gas called Mustard scar is the most important finding of this study.
Firooz Alireza; Nassiri-Kashani Mansour; Gorouhi Farzam; Davari Parastoo; Yaghoubi Reza; Farshchian Mahmoud; Esfandiarpour Iraj; Golchai Mohammad Javad; Dowlati Yahya
Volume 10, Issue 3 , 2007, , Pages 187-195
Abstract
Background and aim: The frequency of sensitization to contact allergens varies in different countries because of both genetic and, more importantly, allergen exposure variations. The objective is to determine the frequency of sensitization to contact allergens in Iranian patients with dermatitis.Materials ...
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Background and aim: The frequency of sensitization to contact allergens varies in different countries because of both genetic and, more importantly, allergen exposure variations. The objective is to determine the frequency of sensitization to contact allergens in Iranian patients with dermatitis.Materials and methods: Four hundreds and one patients with a clinical diagnosis of contact dermatitis and/or atopic dermatitis were evaluated with a 24-allergen European standard series in four major cities in Iran. The patches were applied on the back of the patients, removed after 24 hours and the readings were taken on 24, 48 and 72 hours after application.Results: One hundred and seventy six patients (43.8%) showed at least 1 positive reaction with a total positive reactions of 268, and 64 patients (15.9%) had 2 or more positive reactions. The 5 most common allergens were nickel sulfate [64 (15.9%)], potassium dichromate [40 (10.0%)], thiuram mix [27 (6.7%)], cobalt chloride [23 (5.7%)], and Balsam of Peru [17 (4.2%)]. Contact allergy to nickel sulfate was significantly more common in female patients and in patients under 40 years of age (P<0.001).Conclusion: Nickel sulfate is the most common contact allergen in Iran, mostly affecting women and younger patients probably because of more exposure. Thiuram had a significant increase in its prevalence during the previous years and further studies need to distinguish its causes.
Ali Asilian; Fariba Iraji; Saba Khalilian; Zabihollah Shahmoradi; Mina Saber
Abstract
Background: Psoriasis is an immune-mediated inflammatory disease with unclear pathophysiology. Although diverse medications have been applied, a paucity of knowledge is accessible regarding the use of corticosteroids for psoriasis management. We evaluated the efficacy of corticosteroid pulse therapy ...
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Background: Psoriasis is an immune-mediated inflammatory disease with unclear pathophysiology. Although diverse medications have been applied, a paucity of knowledge is accessible regarding the use of corticosteroids for psoriasis management. We evaluated the efficacy of corticosteroid pulse therapy in combination with methotrexate versus methotrexate alone for psoriasis treatment.Methods: This cohort study was conducted on 51 hospitalized patients with erythrodermic or pustular psoriasis who were assigned to one of the therapeutic interventions of subcutaneous methotrexate alone (n = 33) or in combination with betamethasone pulse therapy (n = 18). The first group was treated with weekly 15 mg subcutaneous methotrexate for six weeks, and the second group received a similar dose of methotrexate plus 3 mg oral betamethasone weekly. The patients were followed for six months and assessed regarding the disease remission, relapses, the interval between the medication and relapse incidence, and patient satisfaction with the regimens.Results: The studied groups were similar regarding gender (P = 0.296), age(P = 0.561), and the type of cutaneous lesions (P = 0.807). Six months follow-up of the two therapeutic interventions revealed insignificant differences in terms of early response to the treatment (P = 0.993), the incidence (P = 0.142) and frequency of relapses (P = 0.928), and the interval period between the treatment and relapse (P = 0.213). Besides, the patients’ treatment satisfaction did not differ between the groups (P = 0.453).Conclusion: Based on this study, combining methotrexate and lowdose corticosteroid pulse therapy does not lead to better outcomes than methotrexate alone for managing pustular and erythrodermic psoriasis. Further studies are strongly recommended.
SM Davoudi; P Rostami; SN Emadi; B Sadr; E Khabiri
Volume 9, Issue 3 , 2006, , Pages 217-220
Abstract
Background and aim: Paederus dermatitis is an acute self-healing blistering disease caused by an insect from the genus Paederus species. Although it is a self-limited disease, it can cause disablement and suffering. The objective of this study was to investigate the efficacy of fluocinolone cream, triclocarban(TCC) ...
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Background and aim: Paederus dermatitis is an acute self-healing blistering disease caused by an insect from the genus Paederus species. Although it is a self-limited disease, it can cause disablement and suffering. The objective of this study was to investigate the efficacy of fluocinolone cream, triclocarban(TCC) soap and betamethasone lotion in comparison with placebo in the treatment of paederus dermatitis.Materials and Methods: This study was a randomized single blind placebo controlled trial which was performed in Behshahr hospitals during a period of two months. Seventy-seven patients with paederus dermatitis were randomized to treatment with fluocinolone cream, TCC soap, betamethansone lotion or a placebo. The conditon of each patient was checked three times; i.e., on their first, fifth and twelfth day of receiving treatment. Finally, depending on their response to treatment, they were divided into two groups, those who fully recovered and those failing to recover.Results: Of the 77 patients studied, 18 were treated with a placebo, 17 with betamethasone lotion, 24 with fluocinolone cream and 17 with TCC soap. Complete recovery at the end of treatment was fluocinolone 100% , betamethasone 100%, TCC 58.8% and placebo 33.3%. Significant differences were observed between two first groups and the placebo group (P=0.0001) but no significant difference was observed between TCC soap and placebo.Conclusion: Topical corticosteroids displayed a relative and significant improvement in paederus dermatitis.
Z Pourpak; M Mesdaghi; AR Zarinara; Sh Shahabi; B Rajabi; M Heidar Zadeh; A Kazemnejad; A Kouhkan; Gh.A Kardar
Volume 7, Issue 4 , 2004, , Pages 219-230
Abstract
Background: Latex allergy is a major occupational disease with prevalence nearly 5-17% among the health care workers. Objective: To determine the prevalence of latex glove allergy and its contributing factors among operation room staff. Patients and Methods: In this study, 512 operation room staff were ...
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Background: Latex allergy is a major occupational disease with prevalence nearly 5-17% among the health care workers. Objective: To determine the prevalence of latex glove allergy and its contributing factors among operation room staff. Patients and Methods: In this study, 512 operation room staff were evaluated for latex allergy, using a complete questionnaire. Those suspected to have latex allergy underwent these tests: Eosinophils counting, measurement of serum total and latex specific IgE, latex skin prick test, latex and glove additives patch test. Results: From evaluated staff, 178 (34.8%) had a history of sensitivity to latex gloves, from which 59 persons underwent the tests voluntarily. According to the results of the tests, 13 (22%) had type I allergy to latex, 3 (5.1%) had type IV allergy to latex and 9 (15.3%) had both allergies. There were no significant relationship between latex allergy and age, sex, job, season, family and personal history of allergies. Significant relationship was found between type I allergy to latex and allergy to kitchen gloves and also between type IV allergy and allergy to other plastic clothing. Conclusion: Prevalence of latex allergy in this study is much higher than similar studies, which demands more evaluation to determine the contributing factors.
M Bakhshi Zadeh; SH Hejazi; M Baghaei; F Jafari; Z Ghayour; A Khamesi Pour
Volume 8, Issue 4 , 2005, , Pages 260-265
Abstract
Background an objective: Leishmaniasis is a common disease endemic in some parts of Iran. Chemical or physical treatments or a combination of both are used for treatment of the disease. Nitric oxide (NO) is important for healing of leishmaniasis in human and animal. This study was designed to evaluate ...
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Background an objective: Leishmaniasis is a common disease endemic in some parts of Iran. Chemical or physical treatments or a combination of both are used for treatment of the disease. Nitric oxide (NO) is important for healing of leishmaniasis in human and animal. This study was designed to evaluate the beneficial effects of a NO releasing cream on cutaneous leishmaniasis in an animal model. Materials and Methods: Balb/c mice were infected with leishmania major by injecting promastigotes into the base of tails of mice to induce the lesion. Then the animals were divided into 3 groups (Control, placebo and treatment). Mice were treated with the drugs one time daily. The diameter of lesions were measured on days 0, 5, 10, 15, 20, 25, and 30 after the appearance of the lesions. Data were analyzed using one-way ANOVA test and (P<0.05) considered as significant. Results: The diameter of lesions were significantly reduced in 15, 20, 25 and 30 day in NO cream treated animals compared to control and placebo groups (P<0.05). Conclusion: NO releasing compounds may be effective in the treatment of leishmaniasis.
Rahmat-allah Salmanpour; Mohammad Bahmani
Volume 10, Issue 4 , 2007, , Pages 278-282
Abstract
Background and aim: Cutaneous leishmaniasis is a common disease in the world and is an endemic disease in Iran. Highly variable results of systemic treatment of cutaneous leishmaniasis with levamisole have been reported in literature so far. The purpose of this study was to evaluate the efficacy and ...
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Background and aim: Cutaneous leishmaniasis is a common disease in the world and is an endemic disease in Iran. Highly variable results of systemic treatment of cutaneous leishmaniasis with levamisole have been reported in literature so far. The purpose of this study was to evaluate the efficacy and tolerability of levamisole as an adjuvant therapy with intralesional Glucantime.Materials and methods: Sixty patients with cutaneous leishmaniasis were included in this clinical trial. The patients were divided randomly in two groups. Thirty patients in group 1 received intralesional Glucantime along with placebo (vitamin B complex tablets, 1 tablet every 8 hours for 2 successive days per week) and 30 patients in group 2 received intralesional Glucantime plus levamisole 150 mg tablet every 8 hours in two successive days per week in adults and 3-5 mg/kg for children under 30 kg for 6 weeks.Results: The clinical response of combination therapy (78%) was significantly better then group 1 (64%), the difference was statistically significant (p<0.001). The difference in rate of re-epithelization between the two groups was also statistically significant (p<0.01).Conclusion: This study demonstrated that levamisole can he used as an adjuvant therapy in combination with intralesional Glucantime for the treatment of cutaneous leishmaniasis.
Edalatkhah Hassan; Khalilollahi S. Hojat; Sani Nayyereh Amini; Taher Athar
Volume 9, Issue 4 , 2006, , Pages 313-318
Abstract
Background and aim: Warts are the most common clinical presentation of human papilloma virus infection of human skin and mucosa. They are more common on hand, foot, face and genital area. They are benign skin colour lesions with different clinical forms. There is no specific treatment for them. In this ...
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Background and aim: Warts are the most common clinical presentation of human papilloma virus infection of human skin and mucosa. They are more common on hand, foot, face and genital area. They are benign skin colour lesions with different clinical forms. There is no specific treatment for them. In this trial the therapeutic effect of intralesional injection of bleomycin and cryotherapy on common warts of hands and feet was compared.Materials and Methods: Fifty-two subjects entered the study but 44 patients completed the trial. Warts were treated by intralesional injection of bleomycin 0.5 mg/ml or liquid nitrogen on symmetric aspects of both hands and feet. We used cryo-spray gun for application of liquid nitrogen. Treatment was repeated every 2 weeks for a maximum of three times. Treatment was done by a dermatologist and treatment response was evaluated by another dermatologist. Collected data were analyzed by SPSS software.Results: In this trial 23 female and 21 male patients were studied. Totally, 253 warts were treated by cryotherapy and 226 warts by intralesional bleomycin. Cure rate was 73.1% for cryotherapy and 87.6% for intralesional bleomycin (P<0.001).Conclusion: Cure rate for intralesional bleomycin was higher than cryotherapy. Intrelesional bleomycin therapy is an effective and safe treatment for common warts.
A Rasi; AR Taghi Zadeh
Volume 8, Issue 5 , 2005, , Pages 353-357
A Vali; A Asilian; E Khalesi; L Khodami; MA Shah Talebi
Volume 8, Issue 6 , 2006, , Pages 462-465
Abstract
Background and aim: Psoriasis is one of the most common papulosquamous diseases that often requires long-term maintenance therapy. Long-term use of topical corticosteroids on the face and intertriginous areas will increase the risk of steroids side effects such as striae and atrophy development. A safe, ...
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Background and aim: Psoriasis is one of the most common papulosquamous diseases that often requires long-term maintenance therapy. Long-term use of topical corticosteroids on the face and intertriginous areas will increase the risk of steroids side effects such as striae and atrophy development. A safe, effective and inexpensive modality in topical therapy of inverse psoriasis is required. adrenergic antagonists has been reported to exacerbate existing plaque psoriasis because of increasing concentration of intracellular cAMP. On the other hand, caffeine is a methylxanthin that inhibits phosphodiesterase enzyme and results in a higher concentration of intracellular cAMP. We evaluated the efficacy of topical caffeine 10% in the treatment of psoriasis.Materials and Methods: This randomized, double blind, controlled clinical trial was performed on 39 patients with typical lesions of psoriasis vulgaris who referred to dermatology clinics of Isfahan University of Medical Sciences from December 2002 to July 2003. These patients were randomized in two groups and treated by topical application of drug or placebo, three times per day. The patients were seen in two-week intervals for 8 weeks, and their PASI score was assessed in each visit.Results: The decrease of PASI score after 2,4,6 and 8 weeks compared to the first visit in caffeine treated group were 23%, 41%, 54%, and 62% and in placebo treated group were 15%, 19%, 25%, and 29% respectively(P<0.05).Conclusion: Topical caffeine may be an effective, safe and inexpensive therapy in psoriasis but its onset of action is late.
